JP7662644B2 - 化合物 - Google Patents

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Publication number
JP7662644B2
JP7662644B2 JP2022537022A JP2022537022A JP7662644B2 JP 7662644 B2 JP7662644 B2 JP 7662644B2 JP 2022537022 A JP2022537022 A JP 2022537022A JP 2022537022 A JP2022537022 A JP 2022537022A JP 7662644 B2 JP7662644 B2 JP 7662644B2
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Prior art keywords
benzo
methoxy
ethane
imidazole
diyl
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Japanese (ja)
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JP2023506899A (ja
JP2023506899A5 (https=
Inventor
ベンジャミン ジョゼフ モロー，
ジョナサン グラント ヒューバート，
ポール アンソニー スタップル，
ミシェル アン カメリーノ，
マシュー ロイド デニス，
アンソニー ニコラス クッズーペ，
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シーティーエックスティー・ピーティーワイ・リミテッド
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Priority claimed from GBGB1918761.6A external-priority patent/GB201918761D0/en
Priority claimed from GBGB2009944.6A external-priority patent/GB202009944D0/en
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Publication of JP2023506899A publication Critical patent/JP2023506899A/ja
Publication of JP2023506899A5 publication Critical patent/JP2023506899A5/ja
Priority to JP2025005355A priority Critical patent/JP2025061311A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022537022A 2019-12-18 2020-12-18 化合物 Active JP7662644B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025005355A JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1918761.6 2019-12-18
GBGB1918761.6A GB201918761D0 (en) 2019-12-18 2019-12-18 Compounds
GBGB2009944.6A GB202009944D0 (en) 2020-06-30 2020-06-30 Compounds
GB2009944.6 2020-06-30
PCT/AU2020/051394 WO2021119753A1 (en) 2019-12-18 2020-12-18 Compounds

Related Child Applications (1)

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JP2025005355A Division JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

Publications (3)

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JP2023506899A JP2023506899A (ja) 2023-02-20
JP2023506899A5 JP2023506899A5 (https=) 2023-12-12
JP7662644B2 true JP7662644B2 (ja) 2025-04-15

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JP2025005355A Pending JP2025061311A (ja) 2019-12-18 2025-01-15 化合物

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Country Status (8)

Country Link
US (1) US12415785B2 (https=)
EP (1) EP4077318B1 (https=)
JP (2) JP7662644B2 (https=)
CN (1) CN114981265B (https=)
AU (1) AU2020409429A1 (https=)
CA (1) CA3164751A1 (https=)
ES (1) ES3056923T3 (https=)
WO (1) WO2021119753A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022266711A1 (en) * 2021-06-23 2022-12-29 Aculeus Therapeutics Pty Ltd Substituted amidobenzimidazole dimers as sting modulators
CN113603661B (zh) * 2021-08-11 2024-04-09 沈阳药科大学 (s)-5-氟-3-甲基异苯并呋喃-3-酮的合成方法
CN114349662A (zh) * 2022-01-20 2022-04-15 杭州裕普润生物科技有限公司 一种溴化苄的制备方法
CN114671747B (zh) * 2022-04-08 2024-10-29 浙江永太科技股份有限公司 一种4-氯-2-氟苯甲醛的合成方法
EP4615962A1 (en) * 2022-11-09 2025-09-17 Kathleen E. Clarence-Smith Pharmaceutical combination for the treatment of multiple myeloma, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma
WO2024174863A1 (zh) * 2023-02-22 2024-08-29 深圳众格生物科技有限公司 Sting激动剂及其制备方法和医药用途

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US12415785B2 (en) 2025-09-16
US20230062932A1 (en) 2023-03-02
EP4077318A4 (en) 2023-11-22
CN114981265B (zh) 2025-01-03
JP2023506899A (ja) 2023-02-20
EP4077318B1 (en) 2025-10-15
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