JP2023504003A5 - - Google Patents
Info
- Publication number
- JP2023504003A5 JP2023504003A5 JP2022530820A JP2022530820A JP2023504003A5 JP 2023504003 A5 JP2023504003 A5 JP 2023504003A5 JP 2022530820 A JP2022530820 A JP 2022530820A JP 2022530820 A JP2022530820 A JP 2022530820A JP 2023504003 A5 JP2023504003 A5 JP 2023504003A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- region
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025061637A JP2025118616A (ja) | 2019-11-25 | 2025-04-03 | 抗ｐｄ－１－抗ｖｅｇｆａ二重特異性抗体、その医薬組成物および使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911164156 | 2019-11-25 | ||
| CN201911164156.2 | 2019-11-25 | ||
| PCT/CN2020/131447 WO2021104302A1 (zh) | 2019-11-25 | 2020-11-25 | 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025061637A Division JP2025118616A (ja) | 2019-11-25 | 2025-04-03 | 抗ｐｄ－１－抗ｖｅｇｆａ二重特異性抗体、その医薬組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504003A JP2023504003A (ja) | 2023-02-01 |
| JP2023504003A5 true JP2023504003A5 (https=) | 2023-12-04 |
| JP7662635B2 JP7662635B2 (ja) | 2025-04-15 |
Family
ID=75923361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022530820A Active JP7662635B2 (ja) | 2019-11-25 | 2020-11-25 | 抗ｐｄ－１－抗ｖｅｇｆａ二重特異性抗体、その医薬組成物および使用 |
| JP2025061637A Pending JP2025118616A (ja) | 2019-11-25 | 2025-04-03 | 抗ｐｄ－１－抗ｖｅｇｆａ二重特異性抗体、その医薬組成物および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025061637A Pending JP2025118616A (ja) | 2019-11-25 | 2025-04-03 | 抗ｐｄ－１－抗ｖｅｇｆａ二重特異性抗体、その医薬組成物および使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230027029A1 (https=) |
| EP (1) | EP4067387B1 (https=) |
| JP (2) | JP7662635B2 (https=) |
| KR (1) | KR20220104033A (https=) |
| CN (1) | CN112830972A (https=) |
| AU (1) | AU2020390967A1 (https=) |
| BR (1) | BR112022010069A2 (https=) |
| CA (1) | CA3162748A1 (https=) |
| DK (1) | DK4067387T3 (https=) |
| FI (1) | FI4067387T3 (https=) |
| IL (1) | IL293241A (https=) |
| MX (1) | MX2022006330A (https=) |
| PH (1) | PH12022551278A1 (https=) |
| WO (1) | WO2021104302A1 (https=) |
| ZA (1) | ZA202206885B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109053895B (zh) | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| EP4190819A4 (en) * | 2021-03-12 | 2024-08-14 | Akeso Biopharma, Inc. | PHARMACEUTICAL COMBINATION CONTAINING BISPECIFIC ANTI-PD-1-ANTI-VEGFA ANTIBODY, AND USE THEREOF |
| CN115192718A (zh) * | 2021-04-14 | 2022-10-18 | 中山康方生物医药有限公司 | 抗cd47的单克隆抗体及其用途 |
| JP2024536881A (ja) * | 2021-09-29 | 2024-10-08 | 中山康方生物医▲藥▼有限公司 | 抗ｌａｇ３抗体、医薬組成物、及び使用 |
| CN115558029B (zh) * | 2021-10-22 | 2024-01-30 | 立凌生物制药(苏州)有限公司 | 靶向pd-1的双特异性抗体、及其制备和应用 |
| CN114181310B (zh) * | 2022-02-14 | 2022-07-05 | 中山康方生物医药有限公司 | 抗tigit抗体、其药物组合物及用途 |
| CN116731188B (zh) * | 2022-03-02 | 2025-02-14 | 三优生物医药(上海)有限公司 | 抗pd-l1和vegf双特异性抗体及其应用 |
| CN114736303A (zh) * | 2022-03-17 | 2022-07-12 | 英诺湖医药(杭州)有限公司 | 抗pd-l1和4-1bb的双功能抗体及其医药用途 |
| KR20250026284A (ko) | 2022-06-22 | 2025-02-25 | 아케소 바이오파마, 인크. | 약학 조성물 및 이의 용도 |
| CA3208447A1 (en) * | 2022-09-09 | 2024-03-09 | Akeso Biopharma, Inc. | Therapeutic combination and use thereof |
| CN117679505A (zh) | 2022-09-09 | 2024-03-12 | 中山康方生物医药有限公司 | 药物组合及用途 |
| PE20252392A1 (es) * | 2022-12-12 | 2025-10-10 | Lanova Medicines Ltd | Anticuerpos biespecificos que se dirigen a pd1 y vegf |
| KR20250133728A (ko) | 2023-01-06 | 2025-09-08 | 라센 테라퓨틱스, 인코포레이티드 | 항-il-18bp 항체 |
| CN118620082A (zh) * | 2023-03-10 | 2024-09-10 | 南京维立志博生物科技有限公司 | 靶向vegf途径和pd-1的双特异性抗原结合蛋白、其组合物和用途 |
| WO2025056056A1 (zh) * | 2023-09-14 | 2025-03-20 | 中山康方生物医药有限公司 | 药物组合及用途 |
| WO2025157267A1 (zh) * | 2024-01-25 | 2025-07-31 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双特异性抗体的医药用途 |
| CN120025456B (zh) * | 2024-03-13 | 2025-11-07 | 寻济生物科技（北京）有限公司 | 一种抗vegfa融合构建体及其制备方法和应用 |
| WO2025201450A1 (zh) * | 2024-03-27 | 2025-10-02 | 康方汇科(上海)生物有限公司 | 药物组合及用途 |
| WO2026051964A1 (en) | 2024-09-04 | 2026-03-12 | Akeso Biopharma Co., Ltd. | Antibody that binds vegfa and pd-1 and uses thereof to treat cancers |
| WO2026067461A1 (en) * | 2024-09-25 | 2026-04-02 | Adaptocue, Llc | Multispecific antibody protein and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| ES2533266T5 (es) * | 2007-10-30 | 2018-04-18 | Genentech, Inc. | Purificación de anticuerpos mediante cromatografía de intercambio catiónico |
| CA2785907A1 (en) * | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Ron binding constructs and methods of use thereof |
| JP6180663B2 (ja) * | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| CN105175545B (zh) * | 2015-10-20 | 2019-01-25 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd-1双功能抗体及其应用 |
| KR20250057128A (ko) * | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US11421028B2 (en) * | 2016-02-06 | 2022-08-23 | Epimab Biotherapeutics, Inc. | Fabs-in-tandem immunoglobulin and uses thereof |
| RU2693661C2 (ru) * | 2016-03-04 | 2019-07-03 | Сычуань Келунь-Байотек Байофармасьютикал Ко., Лтд. | Антитело против pdl-1, его фармацевтическая композиция и применение |
| CN109862910A (zh) * | 2016-08-03 | 2019-06-07 | 小利兰·斯坦福大学托管委员会 | 破坏巨噬细胞上的Fc受体接合增强抗SIRPα抗体疗法的功效 |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| TW201837467A (zh) * | 2017-03-01 | 2018-10-16 | 美商建南德克公司 | 用於癌症之診斷及治療方法 |
| JP2020514370A (ja) * | 2017-03-17 | 2020-05-21 | キュアバック アーゲー | 組合せ抗癌療法のためのｒｎａワクチン及び免疫チェックポイント阻害剤 |
| CN106939050B (zh) * | 2017-03-27 | 2019-05-10 | 顺昊细胞生物技术（天津）股份有限公司 | 抗pd1和cd19双特异性抗体及其应用 |
| TW201902514A (zh) * | 2017-06-05 | 2019-01-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｐｄ－１抗體與ｖｅｇｆ配體或ｖｅｇｆ受體抑制劑聯合在製備治療腫瘤的藥物中的用途 |
| AU2018394939B2 (en) * | 2017-12-29 | 2022-02-24 | Ap Biosciences, Inc. | Monospecific and bispecific proteins with immune checkpoint regulation for cancer therapy |
| CA3090878A1 (en) * | 2018-02-11 | 2019-08-15 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-pd-1/anti-vegf natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof |
| CN109053895B (zh) * | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| CN110563849B (zh) * | 2019-08-09 | 2022-09-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd1双特异性抗体 |
| CN110498857B (zh) * | 2019-08-09 | 2022-09-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd1双特异性抗体 |
| CN110960543A (zh) * | 2019-12-10 | 2020-04-07 | 安徽瀚海博兴生物技术有限公司 | 一种联合抗vegf-抗pd1双特异性抗体用于制备抗癌药物 |
-
2020
- 2020-11-25 PH PH1/2022/551278A patent/PH12022551278A1/en unknown
- 2020-11-25 US US17/779,425 patent/US20230027029A1/en active Pending
- 2020-11-25 BR BR112022010069A patent/BR112022010069A2/pt unknown
- 2020-11-25 AU AU2020390967A patent/AU2020390967A1/en active Pending
- 2020-11-25 WO PCT/CN2020/131447 patent/WO2021104302A1/zh not_active Ceased
- 2020-11-25 FI FIEP20892544.6T patent/FI4067387T3/fi active
- 2020-11-25 IL IL293241A patent/IL293241A/en unknown
- 2020-11-25 JP JP2022530820A patent/JP7662635B2/ja active Active
- 2020-11-25 EP EP20892544.6A patent/EP4067387B1/en active Active
- 2020-11-25 CN CN202011341655.7A patent/CN112830972A/zh active Pending
- 2020-11-25 KR KR1020227021354A patent/KR20220104033A/ko active Pending
- 2020-11-25 MX MX2022006330A patent/MX2022006330A/es unknown
- 2020-11-25 DK DK20892544.6T patent/DK4067387T3/da active
- 2020-11-25 CA CA3162748A patent/CA3162748A1/en active Pending
-
2022
- 2022-06-21 ZA ZA2022/06885A patent/ZA202206885B/en unknown
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2025
- 2025-04-03 JP JP2025061637A patent/JP2025118616A/ja active Pending