JP2023134735A5 - - Google Patents
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- Publication number
- JP2023134735A5 JP2023134735A5 JP2023117421A JP2023117421A JP2023134735A5 JP 2023134735 A5 JP2023134735 A5 JP 2023134735A5 JP 2023117421 A JP2023117421 A JP 2023117421A JP 2023117421 A JP2023117421 A JP 2023117421A JP 2023134735 A5 JP2023134735 A5 JP 2023134735A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- amino acid
- acid sequence
- scfv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000040430 polynucleotide Human genes 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004039 Caspase-9 Human genes 0.000 claims 1
- 108090000566 Caspase-9 Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762536934P | 2017-07-25 | 2017-07-25 | |
| US62/536,934 | 2017-07-25 | ||
| JP2020503988A JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
| PCT/US2018/043779 WO2019023396A1 (en) | 2017-07-25 | 2018-07-25 | ENHANCED CHIMERIC ANTIGENIC RECEPTORS AND USES THEREOF |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Division JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023134735A JP2023134735A (ja) | 2023-09-27 |
| JP2023134735A5 true JP2023134735A5 (https=) | 2024-05-20 |
Family
ID=65040821
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Withdrawn JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
| JP2023117421A Pending JP2023134735A (ja) | 2017-07-25 | 2023-07-19 | 強化されたキメラ抗原受容体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Withdrawn JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240336699A1 (https=) |
| EP (2) | EP4582146A3 (https=) |
| JP (2) | JP2020530989A (https=) |
| KR (1) | KR20200032174A (https=) |
| CN (2) | CN111432823A (https=) |
| AU (1) | AU2018306307B2 (https=) |
| CA (1) | CA3070998A1 (https=) |
| TW (1) | TW201908335A (https=) |
| WO (1) | WO2019023396A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2021032783A1 (en) | 2019-08-21 | 2021-02-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Methods for detecting, quantifying and monitoring immune-cell mediated cytotoxicity of cell populations comprising immune cells and/or stem cells |
| NL2023924B1 (nl) * | 2019-10-01 | 2021-06-01 | Lely Patent Nv | Meetsysteem voor levensmiddelen |
| WO2021225532A1 (en) * | 2020-05-08 | 2021-11-11 | Mahidol University | A chimeric antigen receptor and modified cells carrying the receptor |
| KR102297396B1 (ko) * | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| CN116981685A (zh) * | 2020-12-03 | 2023-10-31 | 世纪治疗股份有限公司 | 基因工程化细胞及其用途 |
| CN113980134B (zh) | 2020-12-11 | 2022-05-31 | 广州百暨基因科技有限公司 | 抗cll1抗体及其应用 |
| CN113234169B (zh) * | 2020-12-11 | 2022-11-01 | 广州百暨基因科技有限公司 | 靶向cll1嵌合抗原受体及其应用 |
| US20240226294A9 (en) * | 2021-02-15 | 2024-07-11 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Customized chimeric antigen receptor polypeptides |
| MX2023011927A (es) | 2021-04-07 | 2023-10-23 | Century Therapeutics Inc | Composiciones y metodos para la generacion de linfocitos t gamma-delta a partir de celulas madre pluripotentes inducidas. |
| US20220333074A1 (en) | 2021-04-07 | 2022-10-20 | Century Therapeutics, Inc. | Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells |
| CA3210702A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Gene transfer vectors and methods of engineering cells |
| KR20240007911A (ko) * | 2021-04-14 | 2024-01-17 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Cd5-양성 암을 표적화하기 위한 키메라 항원 수용체 |
| TWI863006B (zh) * | 2021-10-18 | 2024-11-21 | 美商凱特製藥公司 | 用於嵌合抗原受體之信號傳導域 |
| WO2023129937A1 (en) | 2021-12-29 | 2023-07-06 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof |
| WO2023240212A2 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof |
| CA3257650A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Immunoeffector cells derived from genetically modified, multipotential stem cells with membrane IL-12 and their uses |
| WO2024102838A1 (en) | 2022-11-09 | 2024-05-16 | Century Therapeutics, Inc. | Engineered interleukin-7 receptors and uses thereof |
| KR20250143301A (ko) | 2022-11-10 | 2025-10-01 | 센츄리 쎄라퓨틱스 인코포레이티드 | 항-넥틴4 키메라 항원 수용체를 갖는 유전자 조작 세포 및 이의 용도 |
| CN121152880A (zh) * | 2023-05-25 | 2025-12-16 | 南京传奇生物科技有限公司 | 嵌合抗原受体及其用途 |
| WO2025101938A2 (en) | 2023-11-10 | 2025-05-15 | Century Therapeutics, Inc. | Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof |
| WO2025106626A1 (en) | 2023-11-15 | 2025-05-22 | Century Therapeutics, Inc. | Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof |
| WO2025207798A1 (en) | 2024-03-26 | 2025-10-02 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof |
| WO2025207795A1 (en) | 2024-03-26 | 2025-10-02 | Juno Therapeutics, Inc. | Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| EP1291360A1 (en) * | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| EP2216342B1 (en) | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anti-CD19 antibodies |
| DK2496698T3 (en) * | 2009-11-03 | 2019-04-15 | Hope City | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION |
| KR102437522B1 (ko) * | 2012-05-25 | 2022-08-26 | 셀렉티스 | 면역요법을 위한 동종이형 및 면역억제제 저항성인 ｔ 세포의 조작 방법 |
| AU2013327136A1 (en) | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| DK2958943T3 (da) * | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| WO2015017214A1 (en) * | 2013-07-29 | 2015-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
| KR20160145802A (ko) * | 2014-04-23 | 2016-12-20 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법 |
| AU2015343013B2 (en) * | 2014-11-05 | 2020-07-16 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| ES2869972T3 (es) * | 2015-01-26 | 2021-10-26 | Cellectis | Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas |
| EP3286225B1 (en) * | 2015-04-23 | 2020-07-01 | Baylor College of Medicine | Cd5 chimeric antigen receptor for adoptive t cell therapy |
| CN108884140B (zh) * | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| WO2017112877A1 (en) * | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
-
2018
- 2018-07-25 CN CN201880058794.3A patent/CN111432823A/zh active Pending
- 2018-07-25 CA CA3070998A patent/CA3070998A1/en active Pending
- 2018-07-25 KR KR1020207005375A patent/KR20200032174A/ko not_active Ceased
- 2018-07-25 WO PCT/US2018/043779 patent/WO2019023396A1/en not_active Ceased
- 2018-07-25 TW TW107125720A patent/TW201908335A/zh unknown
- 2018-07-25 EP EP25169707.4A patent/EP4582146A3/en active Pending
- 2018-07-25 CN CN202410061631.8A patent/CN118206655A/zh active Pending
- 2018-07-25 JP JP2020503988A patent/JP2020530989A/ja not_active Withdrawn
- 2018-07-25 EP EP18838056.2A patent/EP3658163A4/en not_active Withdrawn
- 2018-07-25 AU AU2018306307A patent/AU2018306307B2/en active Active
-
2023
- 2023-07-19 JP JP2023117421A patent/JP2023134735A/ja active Pending
-
2024
- 2024-06-21 US US18/750,233 patent/US20240336699A1/en active Pending
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