JP2023134735A5 - - Google Patents
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- JP2023134735A5 JP2023134735A5 JP2023117421A JP2023117421A JP2023134735A5 JP 2023134735 A5 JP2023134735 A5 JP 2023134735A5 JP 2023117421 A JP2023117421 A JP 2023117421A JP 2023117421 A JP2023117421 A JP 2023117421A JP 2023134735 A5 JP2023134735 A5 JP 2023134735A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- amino acid
- acid sequence
- scfv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000040430 polynucleotide Human genes 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004039 Caspase-9 Human genes 0.000 claims 1
- 108090000566 Caspase-9 Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762536934P | 2017-07-25 | 2017-07-25 | |
| US62/536,934 | 2017-07-25 | ||
| PCT/US2018/043779 WO2019023396A1 (en) | 2017-07-25 | 2018-07-25 | ENHANCED CHIMERIC ANTIGENIC RECEPTORS AND USES THEREOF |
| JP2020503988A JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Division JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023134735A JP2023134735A (ja) | 2023-09-27 |
| JP2023134735A5 true JP2023134735A5 (https=) | 2024-05-20 |
Family
ID=65040821
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Withdrawn JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
| JP2023117421A Pending JP2023134735A (ja) | 2017-07-25 | 2023-07-19 | 強化されたキメラ抗原受容体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503988A Withdrawn JP2020530989A (ja) | 2017-07-25 | 2018-07-25 | 強化されたキメラ抗原受容体およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240336699A1 (https=) |
| EP (2) | EP4582146A3 (https=) |
| JP (2) | JP2020530989A (https=) |
| KR (1) | KR20200032174A (https=) |
| CN (2) | CN111432823A (https=) |
| AU (1) | AU2018306307B2 (https=) |
| CA (1) | CA3070998A1 (https=) |
| TW (1) | TW201908335A (https=) |
| WO (1) | WO2019023396A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| EP4018198A1 (en) | 2019-08-21 | 2022-06-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Methods for detecting, quantifying and monitoring immune-cell mediated cytotoxicity of cell populations comprising immune cells and/or stem cells |
| NL2023924B1 (nl) * | 2019-10-01 | 2021-06-01 | Lely Patent Nv | Meetsysteem voor levensmiddelen |
| CN115461361B (zh) * | 2020-05-08 | 2025-03-14 | 玛希敦大学 | 嵌合抗原受体和携带该受体的经修饰的细胞 |
| KR102297396B1 (ko) * | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| CN116981685A (zh) * | 2020-12-03 | 2023-10-31 | 世纪治疗股份有限公司 | 基因工程化细胞及其用途 |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN113234169B (zh) * | 2020-12-11 | 2022-11-01 | 广州百暨基因科技有限公司 | 靶向cll1嵌合抗原受体及其应用 |
| CN113045658B (zh) | 2020-12-11 | 2021-12-24 | 广州百暨基因科技有限公司 | 抗cll1抗体及其应用 |
| WO2022174172A1 (en) * | 2021-02-15 | 2022-08-18 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Customized chimeric antigen receptor polypeptides |
| WO2022216624A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells |
| JP2024514522A (ja) | 2021-04-07 | 2024-04-02 | センチュリー セラピューティクス，インコーポレイテッド | 遺伝子導入ベクターおよび細胞を操作する方法 |
| BR112023018844A2 (pt) | 2021-04-07 | 2023-10-10 | Century Therapeutics Inc | Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas |
| CA3216557A1 (en) * | 2021-04-14 | 2022-10-20 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors to target cd5-positive cancers |
| WO2023069936A1 (en) * | 2021-10-18 | 2023-04-27 | Kite Pharma, Inc. | Signaling domains for chimeric antigen receptors |
| AU2022423987A1 (en) | 2021-12-29 | 2024-07-11 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof |
| US20250090582A1 (en) | 2022-06-08 | 2025-03-20 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof |
| CN119698467A (zh) | 2022-06-08 | 2025-03-25 | 世纪治疗股份有限公司 | 衍生自遗传工程化以具有膜结合的il12的诱导多能干细胞的免疫效应细胞及其用途 |
| WO2024102838A1 (en) | 2022-11-09 | 2024-05-16 | Century Therapeutics, Inc. | Engineered interleukin-7 receptors and uses thereof |
| AU2023375625A1 (en) | 2022-11-10 | 2025-05-15 | Century Therapeutics, Inc. | Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof |
| EP4720302A1 (en) * | 2023-05-25 | 2026-04-08 | Legend Biotech Ireland Limited | Chimeric antigen receptors and uses thereof |
| WO2025101938A2 (en) | 2023-11-10 | 2025-05-15 | Century Therapeutics, Inc. | Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof |
| WO2025106626A1 (en) | 2023-11-15 | 2025-05-22 | Century Therapeutics, Inc. | Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof |
| WO2025207798A1 (en) | 2024-03-26 | 2025-10-02 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof |
| WO2025207795A1 (en) | 2024-03-26 | 2025-10-02 | Juno Therapeutics, Inc. | Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| EP0571613B1 (en) * | 1991-12-13 | 2003-09-17 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| CA2534639C (en) | 2003-07-31 | 2013-07-30 | Immunomedics, Inc. | Anti-cd19 antibodies |
| TR201904484T4 (tr) * | 2009-11-03 | 2019-05-21 | Hope City | Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt). |
| BR112014029417B1 (pt) * | 2012-05-25 | 2023-03-07 | Cellectis | Método ex vivo para a preparação de células t para imunoterapia |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| JP6647868B2 (ja) * | 2013-02-20 | 2020-02-14 | ノバルティス アーゲー | ヒト化抗ＥＧＦＲｖＩＩＩキメラ抗原受容体を用いたがんの処置 |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| EP3925618A1 (en) * | 2013-07-29 | 2021-12-22 | 2seventy bio, Inc. | Multipartite signaling proteins and uses thereof |
| CA2945388A1 (en) * | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| US20170333480A1 (en) * | 2014-11-05 | 2017-11-23 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| BR112017013981A2 (pt) * | 2015-01-26 | 2018-01-02 | Cellectis | receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer |
| US10786549B2 (en) * | 2015-04-23 | 2020-09-29 | Baylor College Of Medicine | CD5 chimeric antigen receptor for adoptive T cell therapy |
| EP4212547A1 (en) * | 2015-12-03 | 2023-07-19 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| WO2017112877A1 (en) * | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
-
2018
- 2018-07-25 CA CA3070998A patent/CA3070998A1/en active Pending
- 2018-07-25 TW TW107125720A patent/TW201908335A/zh unknown
- 2018-07-25 CN CN201880058794.3A patent/CN111432823A/zh active Pending
- 2018-07-25 EP EP25169707.4A patent/EP4582146A3/en active Pending
- 2018-07-25 CN CN202410061631.8A patent/CN118206655A/zh active Pending
- 2018-07-25 EP EP18838056.2A patent/EP3658163A4/en not_active Withdrawn
- 2018-07-25 AU AU2018306307A patent/AU2018306307B2/en active Active
- 2018-07-25 WO PCT/US2018/043779 patent/WO2019023396A1/en not_active Ceased
- 2018-07-25 KR KR1020207005375A patent/KR20200032174A/ko not_active Ceased
- 2018-07-25 JP JP2020503988A patent/JP2020530989A/ja not_active Withdrawn
-
2023
- 2023-07-19 JP JP2023117421A patent/JP2023134735A/ja active Pending
-
2024
- 2024-06-21 US US18/750,233 patent/US20240336699A1/en active Pending