CN111432823A - 增强的嵌合抗原受体及其用途 - Google Patents

增强的嵌合抗原受体及其用途 Download PDF

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CN111432823A
CN111432823A CN201880058794.3A CN201880058794A CN111432823A CN 111432823 A CN111432823 A CN 111432823A CN 201880058794 A CN201880058794 A CN 201880058794A CN 111432823 A CN111432823 A CN 111432823A
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car
cell
seq
cells
amino acid
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S·O·安格
E·刘
P·施帕
K·雷兹瓦尼
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University of Texas System
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University of Texas System
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CN201880058794.3A 2017-07-25 2018-07-25 增强的嵌合抗原受体及其用途 Pending CN111432823A (zh)

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US201762536934P 2017-07-25 2017-07-25
US62/536,934 2017-07-25
PCT/US2018/043779 WO2019023396A1 (en) 2017-07-25 2018-07-25 ENHANCED CHIMERIC ANTIGENIC RECEPTORS AND USES THEREOF

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022120942A1 (zh) * 2020-12-11 2022-06-16 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
WO2024240243A1 (en) * 2023-05-25 2024-11-28 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors and uses thereof
US12358990B2 (en) 2020-12-11 2025-07-15 Guangzhou Bio-Gene Technology Co., Ltd Anti-CLL1 antibody and use thereof

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3883955A1 (en) * 2018-11-19 2021-09-29 Board of Regents, The University of Texas System A modular, polycistronic vector for car and tcr transduction
EP4018198A1 (en) 2019-08-21 2022-06-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Methods for detecting, quantifying and monitoring immune-cell mediated cytotoxicity of cell populations comprising immune cells and/or stem cells
NL2023924B1 (nl) * 2019-10-01 2021-06-01 Lely Patent Nv Meetsysteem voor levensmiddelen
CN115461361B (zh) * 2020-05-08 2025-03-14 玛希敦大学 嵌合抗原受体和携带该受体的经修饰的细胞
KR102297396B1 (ko) * 2020-07-29 2021-09-06 (주)티카로스 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포
CN116981685A (zh) * 2020-12-03 2023-10-31 世纪治疗股份有限公司 基因工程化细胞及其用途
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2022174172A1 (en) * 2021-02-15 2022-08-18 H. Lee Moffitt Cancer Center And Research Institute Inc. Customized chimeric antigen receptor polypeptides
WO2022216624A1 (en) 2021-04-07 2022-10-13 Century Therapeutics, Inc. Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells
JP2024514522A (ja) 2021-04-07 2024-04-02 センチュリー セラピューティクス，インコーポレイテッド 遺伝子導入ベクターおよび細胞を操作する方法
BR112023018844A2 (pt) 2021-04-07 2023-10-10 Century Therapeutics Inc Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas
CA3216557A1 (en) * 2021-04-14 2022-10-20 Board Of Regents, The University Of Texas System Chimeric antigen receptors to target cd5-positive cancers
WO2023069936A1 (en) * 2021-10-18 2023-04-27 Kite Pharma, Inc. Signaling domains for chimeric antigen receptors
AU2022423987A1 (en) 2021-12-29 2024-07-11 Century Therapeutics, Inc. Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
US20250090582A1 (en) 2022-06-08 2025-03-20 Century Therapeutics, Inc. Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
CN119698467A (zh) 2022-06-08 2025-03-25 世纪治疗股份有限公司 衍生自遗传工程化以具有膜结合的il12的诱导多能干细胞的免疫效应细胞及其用途
WO2024102838A1 (en) 2022-11-09 2024-05-16 Century Therapeutics, Inc. Engineered interleukin-7 receptors and uses thereof
AU2023375625A1 (en) 2022-11-10 2025-05-15 Century Therapeutics, Inc. Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof
WO2025101938A2 (en) 2023-11-10 2025-05-15 Century Therapeutics, Inc. Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof
WO2025106626A1 (en) 2023-11-15 2025-05-22 Century Therapeutics, Inc. Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof
WO2025207798A1 (en) 2024-03-26 2025-10-02 Century Therapeutics, Inc. Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof
WO2025207795A1 (en) 2024-03-26 2025-10-02 Juno Therapeutics, Inc. Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160145337A1 (en) * 2012-05-25 2016-05-26 Cellectis Cd19 specific chimeric antigen receptor and uses thereof
US20170008963A1 (en) * 2013-02-20 2017-01-12 Jennifer Brogdon TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR
US20170152480A1 (en) * 2009-11-03 2017-06-01 City Of Hope Truncated Epiderimal Growth Factor Receptor (EGFRt) for Transduced T Cell Selection
WO2017096329A1 (en) * 2015-12-03 2017-06-08 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
EP0571613B1 (en) * 1991-12-13 2003-09-17 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
CA2534639C (en) 2003-07-31 2013-07-30 Immunomedics, Inc. Anti-cd19 antibodies
MX370148B (es) 2012-10-02 2019-12-03 Memorial Sloan Kettering Cancer Center Composiciones y su uso para inmunoterapia.
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
EP3925618A1 (en) * 2013-07-29 2021-12-22 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
CA2945388A1 (en) * 2014-04-23 2015-10-29 Board Of Regents, The University Of Texas System Chimeric antigen receptors (car) for use in therapy and methods for making the same
US20170333480A1 (en) * 2014-11-05 2017-11-23 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
BR112017013981A2 (pt) * 2015-01-26 2018-01-02 Cellectis receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer
US10786549B2 (en) * 2015-04-23 2020-09-29 Baylor College Of Medicine CD5 chimeric antigen receptor for adoptive T cell therapy
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170152480A1 (en) * 2009-11-03 2017-06-01 City Of Hope Truncated Epiderimal Growth Factor Receptor (EGFRt) for Transduced T Cell Selection
US20160145337A1 (en) * 2012-05-25 2016-05-26 Cellectis Cd19 specific chimeric antigen receptor and uses thereof
US20170008963A1 (en) * 2013-02-20 2017-01-12 Jennifer Brogdon TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR
WO2017096329A1 (en) * 2015-12-03 2017-06-08 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GIANPIETRO DOTTI等: "Design and development of therapies using chimeric antigen receptor-expressing T cells", 《IMMUNOLOGICAL REVIEWS》, vol. 257, pages 1, XP055552726, DOI: 10.1111/imr.12131 *
XIULI WANG等: "A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells", 《BLOOD》, vol. 118, no. 5, pages 1257 - 1258 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022120942A1 (zh) * 2020-12-11 2022-06-16 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
KR20220084040A (ko) 2020-12-11 2022-06-21 광저우 바이오-진 테크놀로지 컴퍼니 리미티드 Cll1을 표적으로 하는 키메라 항원 수용체 및 그의 응용
GB2606869A (en) * 2020-12-11 2022-11-23 Guangzhou Bio Gene Tech Co Ltd CLL1-Targeting chimeric antigen receptor and application thereof
AU2020480789B2 (en) * 2020-12-11 2025-03-27 Guangzhou Bio-Gene Technology Co., Ltd CLL1-targeting chimeric antigen receptor and application thereof
US12358990B2 (en) 2020-12-11 2025-07-15 Guangzhou Bio-Gene Technology Co., Ltd Anti-CLL1 antibody and use thereof
US12508312B2 (en) 2020-12-11 2025-12-30 Guangzhou Bio-Gene Technology Co., Ltd Chimeric antigen receptor targeting CLL1 and use thereof
WO2024240243A1 (en) * 2023-05-25 2024-11-28 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors and uses thereof

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