JP2021534815A5 - - Google Patents
Info
- Publication number
- JP2021534815A5 JP2021534815A5 JP2021531201A JP2021531201A JP2021534815A5 JP 2021534815 A5 JP2021534815 A5 JP 2021534815A5 JP 2021531201 A JP2021531201 A JP 2021531201A JP 2021531201 A JP2021531201 A JP 2021531201A JP 2021534815 A5 JP2021534815 A5 JP 2021534815A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- human
- car according
- cells
- intracellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024099001A JP2024123133A (ja) | 2018-08-10 | 2024-06-19 | Tnfr2ドメインを含む新規car構築物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862717234P | 2018-08-10 | 2018-08-10 | |
| US62/717,234 | 2018-08-10 | ||
| PCT/IB2019/000907 WO2020030979A2 (en) | 2018-08-10 | 2019-08-09 | New car constructs comprising tnfr2 domains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024099001A Division JP2024123133A (ja) | 2018-08-10 | 2024-06-19 | Tnfr2ドメインを含む新規car構築物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021534815A JP2021534815A (ja) | 2021-12-16 |
| JP2021534815A5 true JP2021534815A5 (https=) | 2022-08-17 |
Family
ID=68470557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531201A Pending JP2021534815A (ja) | 2018-08-10 | 2019-08-09 | Tnfr2ドメインを含む新規car構築物 |
| JP2024099001A Pending JP2024123133A (ja) | 2018-08-10 | 2024-06-19 | Tnfr2ドメインを含む新規car構築物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024099001A Pending JP2024123133A (ja) | 2018-08-10 | 2024-06-19 | Tnfr2ドメインを含む新規car構築物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210292389A1 (https=) |
| EP (1) | EP3833446A2 (https=) |
| JP (2) | JP2021534815A (https=) |
| KR (1) | KR20210046006A (https=) |
| CN (1) | CN112888481A (https=) |
| AU (1) | AU2019318135A1 (https=) |
| BR (1) | BR112021002579A2 (https=) |
| CA (1) | CA3109253A1 (https=) |
| IL (1) | IL280697A (https=) |
| MX (1) | MX2021001592A (https=) |
| SG (1) | SG11202101415UA (https=) |
| WO (1) | WO2020030979A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| EP3808766A1 (en) * | 2019-10-15 | 2021-04-21 | Sangamo Therapeutics France | Chimeric antigen receptor specific for interleukin-23 receptor |
| WO2021183795A1 (en) * | 2020-03-11 | 2021-09-16 | Poseida Therapeutics, Inc. | Chimeric stimulatory receptors and methods of use in t cell activation and differentiation |
| CN113528449A (zh) * | 2020-04-20 | 2021-10-22 | 浙江瑞加美生物科技有限公司 | 一种制备通用型人源化car19-dnt细胞的技术及其应用 |
| JP7825834B2 (ja) * | 2021-01-20 | 2026-03-09 | ソウル ナショナル ユニバーシティ アールアンドディビー ファウンデーション | 抗c4dキメラ抗原受容体調節性t細胞およびその使用 |
| JP2024526201A (ja) * | 2021-06-25 | 2024-07-17 | サンガモ セラピューティクス,インコーポレイテッド | Il-23rに特異的な抗原結合体及びその使用 |
| EP4376859A4 (en) * | 2021-07-29 | 2025-07-30 | Sonoma Biotherapeutics Inc | SYNOVIAL EXTRACELLULAR MATRIX-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR TARGETING REGULATORY T CELLS TO TREAT AUTOIMMUNE DISEASES |
| US20240382525A1 (en) * | 2021-10-26 | 2024-11-21 | Gavish-Galilee Bio Applications Ltd. | Cd4+ and/or cd8+ cell populations comprising icars for use in treatment therapies |
| CN114262689A (zh) * | 2021-12-17 | 2022-04-01 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种快速检测cd19/cd20-car-t细胞活性的方法 |
| EP4479143A1 (en) * | 2022-02-18 | 2024-12-25 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
| WO2025006795A1 (en) * | 2023-06-30 | 2025-01-02 | Board Of Regents, The University Of Texas System | Tsyn-seq: a t cell synapse-based tumor antigen identification platform |
| WO2025170881A1 (en) * | 2024-02-06 | 2025-08-14 | The Board Of Trustees Of The University Of Illinois | Methods and kits for reducing the risk of allograft rejection |
| WO2025250847A1 (en) * | 2024-05-29 | 2025-12-04 | The Texas A&M University System | Compositions containing hsp60-specific regulatory t cells and methods of treatment using the same |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| KR20030032922A (ko) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| ES2298745T3 (es) | 2003-04-24 | 2008-05-16 | Fondazione Centro San Raffaele Del Monte Tabor | Promotores bidireccionales de sintesis y utilizacion de los mismos. |
| WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| GB0603081D0 (en) | 2006-02-15 | 2006-03-29 | Dynal Biotech Asa Oslo | Method |
| EP2126054B1 (en) | 2007-01-31 | 2016-07-06 | Yeda Research And Development Company Limited | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| AU2011281062B2 (en) | 2010-07-21 | 2015-01-22 | Board Of Regents, The University Of Texas System | Methods and compositions for modification of a HLA locus |
| CA2832540C (en) | 2011-04-08 | 2020-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| ES2918501T3 (es) * | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| ES2857226T3 (es) * | 2014-03-15 | 2021-09-28 | Novartis Ag | Receptor de antígeno quimérico regulable |
| US20170335281A1 (en) * | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| AU2015301460B2 (en) * | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
| WO2016184570A1 (en) | 2015-05-18 | 2016-11-24 | Numab Ag | Novel treatment methods based on multifunctional molecules |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| CA3019650C (en) * | 2016-04-01 | 2023-07-25 | Kite Pharma, Inc. | Chimeric receptors and methods of use thereof |
| JP7100028B2 (ja) * | 2016-10-20 | 2022-07-12 | セルジーン コーポレイション | セレブロン系のヘテロ二量体化可能なキメラ抗原受容体 |
| WO2018106993A1 (en) * | 2016-12-09 | 2018-06-14 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Tlr9-binding chimeric antigen receptors |
| CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| US11827705B2 (en) | 2017-03-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Methods to protect transplanted tissue from rejection |
| SG11202002520UA (en) | 2017-09-19 | 2020-04-29 | Univ British Columbia | Anti-hla-a2 antibodies and methods of using the same |
-
2019
- 2019-08-09 KR KR1020217006566A patent/KR20210046006A/ko not_active Ceased
- 2019-08-09 MX MX2021001592A patent/MX2021001592A/es unknown
- 2019-08-09 BR BR112021002579-0A patent/BR112021002579A2/pt not_active IP Right Cessation
- 2019-08-09 CN CN201980066796.1A patent/CN112888481A/zh active Pending
- 2019-08-09 JP JP2021531201A patent/JP2021534815A/ja active Pending
- 2019-08-09 WO PCT/IB2019/000907 patent/WO2020030979A2/en not_active Ceased
- 2019-08-09 US US17/267,410 patent/US20210292389A1/en not_active Abandoned
- 2019-08-09 CA CA3109253A patent/CA3109253A1/en active Pending
- 2019-08-09 SG SG11202101415UA patent/SG11202101415UA/en unknown
- 2019-08-09 AU AU2019318135A patent/AU2019318135A1/en not_active Abandoned
- 2019-08-09 EP EP19798705.0A patent/EP3833446A2/en not_active Withdrawn
-
2021
- 2021-02-07 IL IL280697A patent/IL280697A/en unknown
-
2024
- 2024-06-19 JP JP2024099001A patent/JP2024123133A/ja active Pending
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