BR112021002579A2 - novas construções de car compreendendo os domínios de tnfr2 - Google Patents

novas construções de car compreendendo os domínios de tnfr2 Download PDF

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Publication number
BR112021002579A2
BR112021002579A2 BR112021002579-0A BR112021002579A BR112021002579A2 BR 112021002579 A2 BR112021002579 A2 BR 112021002579A2 BR 112021002579 A BR112021002579 A BR 112021002579A BR 112021002579 A2 BR112021002579 A2 BR 112021002579A2
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Brazil
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domain
seq
cells
car
fragment
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BR112021002579-0A
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English (en)
Portuguese (pt)
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Tobias Abel
David Fenard
Julie Gertner-Dardenne
François Meyer
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Sangamo Therapeutics France
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0634—Cells from the blood or the immune system
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BR112021002579-0A 2018-08-10 2019-08-09 novas construções de car compreendendo os domínios de tnfr2 BR112021002579A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862717234P 2018-08-10 2018-08-10
US62/717,234 2018-08-10
PCT/IB2019/000907 WO2020030979A2 (en) 2018-08-10 2019-08-09 New car constructs comprising tnfr2 domains

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BR112021002579A2 true BR112021002579A2 (pt) 2021-05-11

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BR112021002579-0A BR112021002579A2 (pt) 2018-08-10 2019-08-09 novas construções de car compreendendo os domínios de tnfr2

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US (1) US20210292389A1 (https=)
EP (1) EP3833446A2 (https=)
JP (2) JP2021534815A (https=)
KR (1) KR20210046006A (https=)
CN (1) CN112888481A (https=)
AU (1) AU2019318135A1 (https=)
BR (1) BR112021002579A2 (https=)
CA (1) CA3109253A1 (https=)
IL (1) IL280697A (https=)
MX (1) MX2021001592A (https=)
SG (1) SG11202101415UA (https=)
WO (1) WO2020030979A2 (https=)

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EP3808766A1 (en) * 2019-10-15 2021-04-21 Sangamo Therapeutics France Chimeric antigen receptor specific for interleukin-23 receptor
WO2021183795A1 (en) * 2020-03-11 2021-09-16 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
CN113528449A (zh) * 2020-04-20 2021-10-22 浙江瑞加美生物科技有限公司 一种制备通用型人源化car19-dnt细胞的技术及其应用
JP7825834B2 (ja) * 2021-01-20 2026-03-09 ソウル ナショナル ユニバーシティ アールアンドディビー ファウンデーション 抗ｃ４ｄキメラ抗原受容体調節性ｔ細胞およびその使用
JP2024526201A (ja) * 2021-06-25 2024-07-17 サンガモ セラピューティクス，インコーポレイテッド Ｉｌ－２３ｒに特異的な抗原結合体及びその使用
EP4376859A4 (en) * 2021-07-29 2025-07-30 Sonoma Biotherapeutics Inc SYNOVIAL EXTRACELLULAR MATRIX-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR TARGETING REGULATORY T CELLS TO TREAT AUTOIMMUNE DISEASES
US20240382525A1 (en) * 2021-10-26 2024-11-21 Gavish-Galilee Bio Applications Ltd. Cd4+ and/or cd8+ cell populations comprising icars for use in treatment therapies
CN114262689A (zh) * 2021-12-17 2022-04-01 上海纳米技术及应用国家工程研究中心有限公司 一种快速检测cd19/cd20-car-t细胞活性的方法
EP4479143A1 (en) * 2022-02-18 2024-12-25 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
WO2025006795A1 (en) * 2023-06-30 2025-01-02 Board Of Regents, The University Of Texas System Tsyn-seq: a t cell synapse-based tumor antigen identification platform
WO2025170881A1 (en) * 2024-02-06 2025-08-14 The Board Of Trustees Of The University Of Illinois Methods and kits for reducing the risk of allograft rejection
WO2025250847A1 (en) * 2024-05-29 2025-12-04 The Texas A&M University System Compositions containing hsp60-specific regulatory t cells and methods of treatment using the same

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CN112888481A (zh) 2021-06-01
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