CN112739721A - 一种单域抗体及包含抗体结构的嵌合抗原受体 - Google Patents
一种单域抗体及包含抗体结构的嵌合抗原受体 Download PDFInfo
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Abstract
一种靶向BCMA的抗原结合蛋白，尤其涉及一种包含该抗原结合蛋白的嵌合抗原受体，及其应用。该嵌合抗原受体包含靶向BCMA的胞外域、跨膜域和胞内结构域。该嵌合抗原受体在以BCMA作为靶点的CAR‑T疗法中对肿瘤细胞具有良好的杀伤效果。
Description
PCT国内申请，说明书已公开。
Claims (41)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019109188235 | 2019-09-26 | ||
| CN201910918823 | 2019-09-26 | ||
| PCT/CN2020/117540 WO2021057866A1 (zh) | 2019-09-26 | 2020-09-24 | 一种单域抗体及包含抗体结构的嵌合抗原受体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112739721A true CN112739721A (zh) | 2021-04-30 |
| CN112739721B CN112739721B (zh) | 2023-01-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080002988.9A Active CN112739721B (zh) | 2019-09-26 | 2020-09-24 | 一种单域抗体及包含抗体结构的嵌合抗原受体 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112739721B (zh) |
| WO (1) | WO2021057866A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022116952A1 (zh) * | 2020-12-01 | 2022-06-09 | 苏州克睿基因生物科技有限公司 | 靶向cd70的抗原结合蛋白及其应用 |
| CN116396389A (zh) * | 2023-05-05 | 2023-07-07 | 成都优赛诺生物科技有限公司 | 一种靶向bcma的单域抗体、嵌合抗原受体及其应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11970548B2 (en) * | 2021-08-27 | 2024-04-30 | Innovative Cellular Therapeutics Holdings, Ltd. | Nanobody target GCC and uses in chimeric antigen receptor cell therapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105384825A (zh) * | 2015-08-11 | 2016-03-09 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| CN110041433A (zh) * | 2019-04-26 | 2019-07-23 | 上海科棋药业科技有限公司 | 一种靶向bcma的嵌合抗原受体及其应用 |
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| CN110041433A (zh) * | 2019-04-26 | 2019-07-23 | 上海科棋药业科技有限公司 | 一种靶向bcma的嵌合抗原受体及其应用 |
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| WO2022116952A1 (zh) * | 2020-12-01 | 2022-06-09 | 苏州克睿基因生物科技有限公司 | 靶向cd70的抗原结合蛋白及其应用 |
| CN116396389A (zh) * | 2023-05-05 | 2023-07-07 | 成都优赛诺生物科技有限公司 | 一种靶向bcma的单域抗体、嵌合抗原受体及其应用 |
| CN116396389B (zh) * | 2023-05-05 | 2024-01-23 | 成都优赛诺生物科技有限公司 | 一种靶向bcma的单域抗体、嵌合抗原受体及其应用 |
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