JP2023052201A5 - - Google Patents
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- JP2023052201A5 JP2023052201A5 JP2023000295A JP2023000295A JP2023052201A5 JP 2023052201 A5 JP2023052201 A5 JP 2023052201A5 JP 2023000295 A JP2023000295 A JP 2023000295A JP 2023000295 A JP2023000295 A JP 2023000295A JP 2023052201 A5 JP2023052201 A5 JP 2023052201A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235896P | 2015-10-01 | 2015-10-01 | |
| US62/235,896 | 2015-10-01 | ||
| JP2018516828A JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| PCT/US2016/054691 WO2017059207A1 (en) | 2015-10-01 | 2016-09-30 | Methods and reagents for analyzing protein-protein interfaces |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Division JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023052201A JP2023052201A (ja) | 2023-04-11 |
| JP2023052201A5 true JP2023052201A5 (https=) | 2023-06-14 |
| JP7812813B2 JP7812813B2 (ja) | 2026-02-10 |
Family
ID=58427956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2023000295A Active JP7812813B2 (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9989535B2 (https=) |
| EP (2) | EP4242304A3 (https=) |
| JP (2) | JP7411326B2 (https=) |
| AU (3) | AU2016329064B2 (https=) |
| CA (1) | CA3000822A1 (https=) |
| WO (1) | WO2017059207A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| EP4242304A3 (en) | 2015-10-01 | 2024-02-07 | Revolution Medicines, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| MX380313B (es) | 2016-02-04 | 2025-03-12 | Univ Johns Hopkins | Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos. |
| US11708391B2 (en) | 2016-02-04 | 2023-07-25 | The Johns Hopkins University | Rapaglutins, novel inhibitors of GLUT and use thereof |
| US11066416B2 (en) * | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| CN109641062A (zh) | 2016-04-12 | 2019-04-16 | 华普卓威生物公司 | 用于产生化合物的组合物和方法 |
| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| IL269779B2 (en) * | 2017-04-05 | 2026-04-01 | Revolution Medicines Inc | Methods and reagents for the analysis of protein-protein interfaces |
| CA3058953A1 (en) * | 2017-04-05 | 2018-10-11 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
| CA3074690A1 (en) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | Shp2 inhibitor compositions and methods for treating cancer |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| JP7361693B2 (ja) | 2017-12-15 | 2023-10-16 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての多環式化合物 |
| CA3090417A1 (en) * | 2018-02-23 | 2019-08-29 | Dana-Farber Cancer Institute, Inc. | Small molecules for inducing selective protein degradation and uses thereof |
| AU2020377925A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
| IL322454A (en) | 2019-11-04 | 2025-09-01 | Revolution Medicines Inc | ras inhibitors |
| US20250388598A1 (en) * | 2019-11-04 | 2025-12-25 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| JP2023501942A (ja) * | 2019-11-08 | 2023-01-20 | ナノテンパー・テクノロジーズ・ゲーエムベーハー | 溶液中の粒子の特徴付け |
| CN111118046B (zh) * | 2020-01-16 | 2022-02-22 | 中国人民解放军军事科学院军事医学研究院 | 一种能够调控MSCs成脂肪分化能力的基因及其衍生产品 |
| GB202007106D0 (en) * | 2020-05-14 | 2020-07-01 | Ucl Business Plc | Cyclosporine analogues |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| KR20240017811A (ko) | 2021-05-05 | 2024-02-08 | 레볼루션 메디슨즈, 인크. | 암의 치료를 위한 ras 억제제 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN119661684B (zh) * | 2024-10-21 | 2025-11-25 | 山东大学 | 一种高抗炎活性的脂联素突变体及其制备方法与应用 |
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| EP0290762B1 (en) | 1984-10-04 | 1993-05-12 | Sandoz Ag | Cyclosporins |
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| CA2014590C (en) | 1989-04-15 | 1999-12-14 | Mitsuo Masaki | Novel peptides, and antidementia agents containing the same |
| US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
| ATE138807T1 (de) | 1992-03-27 | 1996-06-15 | American Home Prod | 29-demethoxyrapamycin zur induktion der immunosuppression |
| CA2171629A1 (en) | 1993-09-20 | 1995-03-30 | Chaitan Khosla | Recombinant production of novel polyketides |
| IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
| GB9410142D0 (en) | 1994-05-20 | 1994-07-06 | Univ Warwick | Carbapenems |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| US6124453A (en) * | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| SE9603465D0 (sv) | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
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| US6153383A (en) | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
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| MXPA01003376A (es) | 1998-10-02 | 2002-11-07 | Kosan Biosciences Inc | Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas. |
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| GB9927191D0 (en) | 1999-11-17 | 2000-01-12 | Angeletti P Ist Richerche Bio | Methods and means for regulation of gene expression |
| US7220552B1 (en) * | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| EP1230353A4 (en) | 1999-11-19 | 2002-11-06 | Univ Leland Stanford Junior | BIFUNCTIONAL MOLECULES AND THEIR USE IN THE DESTRUCTION OF PROTEIN-PROTEIN INTERACTIONS |
| KR20020025959A (ko) * | 2000-05-23 | 2002-04-04 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 및 이의 용도 |
| US7176037B2 (en) | 2000-07-13 | 2007-02-13 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
| WO2003014311A2 (en) | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Methods for altering polyketide synthase genes |
| US6809077B2 (en) * | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
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| WO2004041279A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Gamma-aminoamide modulators of chemokine receptor activity |
| US7012065B2 (en) * | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
| CA2643826A1 (en) * | 2006-02-27 | 2008-06-12 | Paul A. Wender | Compositions and methods for transport of molecules with enhanced release properties across biological barriers |
| US20070203168A1 (en) | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same |
| US7601852B2 (en) | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
| GB0805363D0 (en) | 2008-03-20 | 2008-04-30 | Sinvent As | Novel NRPS-PKS gene cluster and its manipulation and utility |
| WO2010031185A1 (en) | 2008-09-19 | 2010-03-25 | Protox Therapeutics Inc. | Treating cancer stem cells using targeted cargo proteins |
| CN102224242B (zh) | 2008-09-24 | 2014-09-24 | 中国科学院上海有机化学研究所 | 新基因簇 |
| KR20110111321A (ko) | 2009-01-30 | 2011-10-10 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체 |
| AU2010273220B2 (en) | 2009-07-13 | 2015-10-15 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| US8664186B2 (en) | 2009-07-24 | 2014-03-04 | Universite De Lorraine | Stambomycin and derivatives, their production and their uses as drugs |
| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| WO2011049157A1 (ja) | 2009-10-22 | 2011-04-28 | ペプチドリーム株式会社 | ペプチド翻訳合成におけるrapidディスプレイ法 |
| US9250237B2 (en) | 2010-11-30 | 2016-02-02 | The Johns Hopkins University | Hybrid cyclic libraries and screens thereof |
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| PL2710018T3 (pl) | 2011-05-19 | 2022-04-04 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Związki makrocykliczne jako inhibitory kinaz białkowych |
| WO2012174489A2 (en) | 2011-06-15 | 2012-12-20 | The Ohio State University | Small molecule composite surfaces as inhibitors of protein-protein interactions |
| DE102011111991A1 (de) * | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
| EP2763975B1 (en) * | 2011-10-05 | 2016-04-06 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| ES2781523T3 (es) | 2012-07-12 | 2020-09-02 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de unión celular con agentes citotóxicos |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| EP2806274A1 (en) | 2013-05-24 | 2014-11-26 | AIT Austrian Institute of Technology GmbH | Lung cancer diagnostic method and means |
| US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
| WO2015132784A1 (en) | 2014-03-03 | 2015-09-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method and device for detection of pseudomonas aeruginosa |
| TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| EP3277704A1 (en) * | 2015-03-31 | 2018-02-07 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
| EP4242304A3 (en) | 2015-10-01 | 2024-02-07 | Revolution Medicines, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| US11479797B2 (en) | 2016-10-28 | 2022-10-25 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
-
2016
- 2016-09-30 EP EP23172763.7A patent/EP4242304A3/en active Pending
- 2016-09-30 US US15/282,430 patent/US9989535B2/en active Active
- 2016-09-30 CA CA3000822A patent/CA3000822A1/en active Pending
- 2016-09-30 WO PCT/US2016/054691 patent/WO2017059207A1/en not_active Ceased
- 2016-09-30 AU AU2016329064A patent/AU2016329064B2/en active Active
- 2016-09-30 EP EP16852685.3A patent/EP3355930A4/en not_active Withdrawn
- 2016-09-30 JP JP2018516828A patent/JP7411326B2/ja active Active
-
2018
- 2018-05-09 US US15/974,921 patent/US10948495B2/en active Active
- 2018-05-09 US US15/974,923 patent/US10466249B2/en active Active
-
2021
- 2021-01-28 US US17/161,505 patent/US20210405060A1/en not_active Abandoned
-
2023
- 2023-01-04 JP JP2023000295A patent/JP7812813B2/ja active Active
-
2024
- 2024-01-17 AU AU2024200321A patent/AU2024200321A1/en not_active Abandoned
- 2024-03-01 US US18/593,086 patent/US20250085291A1/en active Pending
-
2026
- 2026-02-20 AU AU2026201288A patent/AU2026201288A1/en active Pending
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