JP2023052051A5 - - Google Patents
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- JP2023052051A5 JP2023052051A5 JP2022206177A JP2022206177A JP2023052051A5 JP 2023052051 A5 JP2023052051 A5 JP 2023052051A5 JP 2022206177 A JP2022206177 A JP 2022206177A JP 2022206177 A JP2022206177 A JP 2022206177A JP 2023052051 A5 JP2023052051 A5 JP 2023052051A5
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- Prior art keywords
- cell
- composition
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- delivery system
- functional domains
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 241001545398 Listeria weihenstephanensis Species 0.000 claims 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 102000015619 APOBEC Deaminases Human genes 0.000 claims 2
- 108010024100 APOBEC Deaminases Proteins 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 2
- 241000210552 Carnobacterium gallinarum DSM 4847 Species 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 229930010555 Inosine Natural products 0.000 claims 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 2
- 241000448224 Lachnospiraceae bacterium MA2020 Species 0.000 claims 2
- 241000412895 Lachnospiraceae bacterium NK4A179 Species 0.000 claims 2
- 241000029603 Leptotrichia shahii Species 0.000 claims 2
- 241000778057 Leptotrichia wadei F0279 Species 0.000 claims 2
- 241000186807 Listeria seeligeri Species 0.000 claims 2
- 241001112727 Listeriaceae Species 0.000 claims 2
- 208000009869 Neu-Laxova syndrome Diseases 0.000 claims 2
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 2
- 241000007215 Paludibacter propionicigenes WB4 Species 0.000 claims 2
- 241000191023 Rhodobacter capsulatus Species 0.000 claims 2
- 241000730265 Rhodobacter capsulatus R121 Species 0.000 claims 2
- 241000433126 Rhodobacter capsulatus SB 1003 Species 0.000 claims 2
- 241000274840 [Clostridium] aminophilum DSM 10710 Species 0.000 claims 2
- 229960005305 adenosine Drugs 0.000 claims 2
- 229940104302 cytosine Drugs 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 229960003786 inosine Drugs 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 229940035893 uracil Drugs 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023098872A JP2023134453A (ja) | 2016-06-17 | 2023-06-16 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| JP2025087622A JP2025138635A (ja) | 2016-06-17 | 2025-05-27 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351662P | 2016-06-17 | 2016-06-17 | |
| US201662351803P | 2016-06-17 | 2016-06-17 | |
| US62/351,662 | 2016-06-17 | ||
| US62/351,803 | 2016-06-17 | ||
| US201662376377P | 2016-08-17 | 2016-08-17 | |
| US62/376,377 | 2016-08-17 | ||
| US201662410366P | 2016-10-19 | 2016-10-19 | |
| US62/410,366 | 2016-10-19 | ||
| US201662432240P | 2016-12-09 | 2016-12-09 | |
| US62/432,240 | 2016-12-09 | ||
| US201762471792P | 2017-03-15 | 2017-03-15 | |
| US62/471,792 | 2017-03-15 | ||
| US201762484786P | 2017-04-12 | 2017-04-12 | |
| US62/484,786 | 2017-04-12 | ||
| JP2018566199A JP7267013B2 (ja) | 2016-06-17 | 2017-06-19 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| PCT/US2017/038154 WO2017219027A1 (en) | 2016-06-17 | 2017-06-19 | Type vi crispr orthologs and systems |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566199A Division JP7267013B2 (ja) | 2016-06-17 | 2017-06-19 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023098872A Division JP2023134453A (ja) | 2016-06-17 | 2023-06-16 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023052051A JP2023052051A (ja) | 2023-04-11 |
| JP2023052051A5 true JP2023052051A5 (https=) | 2023-06-27 |
Family
ID=59295312
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566199A Active JP7267013B2 (ja) | 2016-06-17 | 2017-06-19 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| JP2022206177A Pending JP2023052051A (ja) | 2016-06-17 | 2022-12-23 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| JP2023098872A Pending JP2023134453A (ja) | 2016-06-17 | 2023-06-16 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| JP2025087622A Pending JP2025138635A (ja) | 2016-06-17 | 2025-05-27 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566199A Active JP7267013B2 (ja) | 2016-06-17 | 2017-06-19 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023098872A Pending JP2023134453A (ja) | 2016-06-17 | 2023-06-16 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
| JP2025087622A Pending JP2025138635A (ja) | 2016-06-17 | 2025-05-27 | Ｖｉ型ｃｒｉｓｐｒオルソログ及び系 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11788083B2 (https=) |
| EP (1) | EP3455357A1 (https=) |
| JP (4) | JP7267013B2 (https=) |
| KR (2) | KR20230156150A (https=) |
| CN (1) | CN109642231A (https=) |
| AU (4) | AU2017283713B2 (https=) |
| BR (1) | BR112018076190A2 (https=) |
| CA (1) | CA3028158A1 (https=) |
| WO (1) | WO2017219027A1 (https=) |
Families Citing this family (172)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| CA2839702C (en) | 2011-06-23 | 2021-04-20 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| CA3208970A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| CN108026526B (zh) | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CA3005968A1 (en) | 2015-11-23 | 2017-06-01 | The Regents Of The University Of California | Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9 |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| US12595478B2 (en) * | 2016-06-29 | 2026-04-07 | The Broad Institute, Inc. | Crispr-Cas systems having destabilization domain |
| CN109790527A (zh) | 2016-07-26 | 2019-05-21 | 通用医疗公司 | 普氏菌属和弗朗西斯氏菌属的CRISPR1(Cpf1)的变体 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| BR112019006388A2 (pt) | 2016-09-30 | 2019-06-25 | Univ California | enzimas modificadoras de ácido nucleico guiadas por rna e métodos de uso das mesmas |
| MX2019003674A (es) | 2016-09-30 | 2021-01-08 | Univ California | Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| CN110506128A (zh) | 2016-12-09 | 2019-11-26 | 博德研究所 | 基于crispr效应系统的诊断 |
| US12404514B2 (en) | 2016-12-09 | 2025-09-02 | The Broad Institute, Inc. | CRISPR-systems for modifying a trait of interest in a plant |
| EP3555297A1 (en) | 2016-12-19 | 2019-10-23 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP7229923B2 (ja) | 2017-01-06 | 2023-02-28 | エディタス・メディシン、インコーポレイテッド | ヌクレアーゼ切断を評価する方法 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| US11021740B2 (en) | 2017-03-15 | 2021-06-01 | The Broad Institute, Inc. | Devices for CRISPR effector system based diagnostics |
| US11174515B2 (en) | 2017-03-15 | 2021-11-16 | The Broad Institute, Inc. | CRISPR effector system based diagnostics |
| JP2020511141A (ja) * | 2017-03-15 | 2020-04-16 | ザ・ブロード・インスティテュート・インコーポレイテッド | 新規Ｃａｓ１３ｂオルソログＣＲＩＳＰＲ酵素及び系 |
| US11104937B2 (en) | 2017-03-15 | 2021-08-31 | The Broad Institute, Inc. | CRISPR effector system based diagnostics |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11963966B2 (en) | 2017-03-31 | 2024-04-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
| US11618928B2 (en) | 2017-04-12 | 2023-04-04 | The Broad Institute, Inc. | CRISPR effector system based diagnostics for malaria detection |
| US12590288B2 (en) | 2017-04-12 | 2026-03-31 | The Broad Institute, Inc. | Method of treating an inflammatory disease by administering an agent which binds a surface receptor on a tuft cell that induces an ILC class 2 inflammatory response |
| AU2018251801B2 (en) | 2017-04-12 | 2024-11-07 | Massachusetts Institute Of Technology | Novel type VI CRISPR orthologs and systems |
| US11591589B2 (en) | 2017-04-21 | 2023-02-28 | The General Hospital Corporation | Variants of Cpf1 (Cas12a) with altered PAM specificity |
| US11499151B2 (en) | 2017-04-28 | 2022-11-15 | Editas Medicine, Inc. | Methods and systems for analyzing guide RNA molecules |
| WO2018208998A1 (en) | 2017-05-10 | 2018-11-15 | The Regents Of The University Of California | Directed editing of cellular rna via nuclear delivery of crispr/cas9 |
| EP3622092A4 (en) | 2017-05-11 | 2021-06-23 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| MX2019014640A (es) | 2017-06-09 | 2020-10-05 | Editas Medicine Inc | Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas. |
| WO2018232195A1 (en) | 2017-06-14 | 2018-12-20 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| WO2019005886A1 (en) * | 2017-06-26 | 2019-01-03 | The Broad Institute, Inc. | CRISPR / CAS-CYTIDINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED EDITING OF NUCLEIC ACIDS |
| US10392616B2 (en) | 2017-06-30 | 2019-08-27 | Arbor Biotechnologies, Inc. | CRISPR RNA targeting enzymes and systems and uses thereof |
| US12415000B2 (en) | 2017-07-07 | 2025-09-16 | The Broad Institute, Inc. | CRISPR system based antiviral therapy |
| US12049643B2 (en) | 2017-07-14 | 2024-07-30 | The Broad Institute, Inc. | Methods and compositions for modulating cytotoxic lymphocyte activity |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| US12105089B2 (en) | 2017-07-17 | 2024-10-01 | The Broad Institute, Inc. | Cell atlas of the healthy and ulcerative colitis human colon |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CN111630162A (zh) * | 2017-10-04 | 2020-09-04 | 博德研究所 | 基于crispr效应系统的诊断 |
| WO2019071048A1 (en) | 2017-10-04 | 2019-04-11 | The Broad Institute, Inc. | SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US20200332272A1 (en) * | 2017-10-23 | 2020-10-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| WO2019094955A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas |
| WO2019113506A1 (en) | 2017-12-07 | 2019-06-13 | The Broad Institute, Inc. | Methods and compositions for multiplexing single cell and single nuclei sequencing |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CA3086550A1 (en) * | 2017-12-22 | 2019-06-27 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
| EP3728576A4 (en) * | 2017-12-22 | 2021-11-24 | The Broad Institute, Inc. | CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF RNA BASES |
| AU2019213047B2 (en) * | 2018-01-29 | 2025-07-24 | Massachusetts Institute Of Technology | CRISPR effector system based diagnostics |
| CN108559738A (zh) * | 2018-02-12 | 2018-09-21 | 南昌大学 | 一种植物rna修饰和编辑的系统及方法 |
| WO2019178428A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna and rna targeting enzymes and systems |
| WO2019178427A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| JP7113395B2 (ja) * | 2018-03-30 | 2022-08-05 | 株式会社クロバーナ | 核酸構築物、医薬組成物、抗がん剤、抗ウイルス剤及び抗菌剤 |
| CN108796036B (zh) * | 2018-04-03 | 2021-11-19 | 交弘生物科技(上海)有限公司 | 基于原核Argonaute蛋白的核酸检测方法及其应用 |
| JP7399876B2 (ja) * | 2018-04-16 | 2023-12-18 | ジョージア テック リサーチ コーポレーション | 病態治療のためのＲＮＡエディターのｍＲＮＡ駆動型発現 |
| CA3097857A1 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Fusion proteins and fusion ribonucleic acids for tracking and manipulating cellular rna |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| CN108546718B (zh) * | 2018-05-16 | 2021-07-09 | 康春生 | crRNA介导的CRISPR/Cas13a基因编辑系统在肿瘤细胞中的应用 |
| WO2019222555A1 (en) | 2018-05-16 | 2019-11-21 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| CN110527697B (zh) * | 2018-05-23 | 2023-07-07 | 中国科学院分子植物科学卓越创新中心 | 基于CRISPR-Cas13a的RNA定点编辑技术 |
| US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| US20190390193A1 (en) * | 2018-06-23 | 2019-12-26 | John Lawrence Mee | Reversible method for sustainable human cognitive enhancement |
| EP3814519A1 (en) | 2018-06-26 | 2021-05-05 | The Broad Institute, Inc. | Crispr/cas and transposase based amplification compositions, systems and methods |
| AU2019291827A1 (en) | 2018-06-26 | 2020-12-24 | Massachusetts Institute Of Technology | Crispr double nickase based amplification compositions, systems, and methods |
| WO2020006036A1 (en) | 2018-06-26 | 2020-01-02 | Massachusetts Institute Of Technology | Crispr effector system based amplification methods, systems, and diagnostics |
| WO2020000454A1 (zh) * | 2018-06-29 | 2020-01-02 | 深圳市博奥康生物科技有限公司 | 一种表达LwCas13a基因的质粒、构建方法及其应用 |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CA3110800A1 (en) | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| CN112469832A (zh) * | 2018-07-23 | 2021-03-09 | 德克萨斯大学系统董事会 | 蛋白质上的翻译后修饰的单分子测序鉴别 |
| JP6915820B2 (ja) * | 2018-07-25 | 2021-08-04 | 国立研究開発法人産業技術総合研究所 | 植物における標的ｄｎａのメチル化を抑制する方法 |
| SG11202102068TA (en) * | 2018-07-31 | 2021-03-30 | Broad Inst Inc | Novel crispr enzymes and systems |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| US12421507B2 (en) | 2018-08-20 | 2025-09-23 | The Broad Institute, Inc. | Methods and compositions for optochemical control of CRISPR-CAS9 |
| US20220010333A1 (en) * | 2018-09-06 | 2022-01-13 | The Regents Of The University Of California | Rna and dna base editing via engineered adar recruitment |
| CA3117476A1 (en) | 2018-10-05 | 2020-04-09 | Board Of Regents, The University Of Texas System | Solid-phase n-terminal peptide capture and release |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| EP3650553B1 (en) * | 2018-11-07 | 2023-07-12 | Siemens Healthcare GmbH | Method for detection of specific nucleic acids |
| US12402610B2 (en) | 2018-11-09 | 2025-09-02 | The Broad Institute, Inc. | Methods and compositions for modulating innate lymphoid cell pathogenic effectors |
| AU2019380590A1 (en) | 2018-11-14 | 2021-07-01 | Massachusetts Institute Of Technology | Multiplexing highly evolving viral variants with Sherlock detection method |
| MX2021005701A (es) | 2018-11-14 | 2021-09-23 | Broad Inst Inc | Sistema crispr a base de sistemas y métodos de diagnóstico de gotas. |
| US20220282275A1 (en) * | 2018-11-15 | 2022-09-08 | The Broad Institute, Inc. | G-to-t base editors and uses thereof |
| CA3120432A1 (en) * | 2018-11-15 | 2020-05-22 | China Agricultural University | Crispr-cas12j enzyme and system |
| US20250043366A1 (en) | 2018-12-13 | 2025-02-06 | The Broad Institute, Inc. | Tiled assays using crispr-cas based detection |
| EP3931313A2 (en) | 2019-01-04 | 2022-01-05 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| AU2020208346B2 (en) * | 2019-01-14 | 2026-01-29 | University Of Rochester | Targeted nuclear RNA cleavage and polyadenylation with CRISPR-cas |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| US20220154258A1 (en) | 2019-03-14 | 2022-05-19 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
| US12534714B2 (en) | 2019-03-18 | 2026-01-27 | The Broad Institute, Inc. | Type VII CRISPR proteins and systems |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| AU2020248911B2 (en) * | 2019-03-26 | 2022-12-15 | Edigene Inc. | Method for identifying functional elements |
| CN109913502A (zh) * | 2019-04-16 | 2019-06-21 | 和元生物技术（上海）股份有限公司 | 一种Cas9-gRNA表达系统及其应用 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| JP2022532789A (ja) * | 2019-05-22 | 2022-07-19 | シトロジーン インコーポレイテッド | 微生物の迅速な識別装置および方法 |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| WO2021011493A1 (en) * | 2019-07-12 | 2021-01-21 | Duke University | 3' utr crispr-dcas 13 engineering system and methods of using same |
| WO2021011649A2 (en) * | 2019-07-15 | 2021-01-21 | National University Of Singapore | Methods and compositions for gene specific demethylation and activation |
| CN110819652A (zh) * | 2019-08-21 | 2020-02-21 | 山东金城生物药业有限公司 | 一种谷氨酸棒杆菌同时基因敲除及基因表达抑制的双功能系统及应用 |
| US20220333208A1 (en) | 2019-09-03 | 2022-10-20 | The Broad Institute, Inc. | Crispr effector system based multiplex cancer diagnostics |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| CN115175996A (zh) * | 2019-09-20 | 2022-10-11 | 博德研究所 | 新颖vi型crispr酶和系统 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
| AU2020395113A1 (en) | 2019-12-02 | 2022-06-09 | Shape Therapeutics Inc. | Therapeutic editing |
| WO2021146641A1 (en) | 2020-01-17 | 2021-07-22 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| JP2023513211A (ja) * | 2020-02-07 | 2023-03-30 | ユニバーシティ オブ ロチェスター | タンパク質合成を増強するためのＣＲＩＳＰＲ－Ｃａｓ１３による標的ＲＮＡ翻訳 |
| CN111337666B (zh) * | 2020-02-12 | 2021-04-02 | 山东大学 | I-motif重组介导的FRET探针及其原位成像癌细胞表面蛋白质同源二聚化的应用 |
| WO2021169980A1 (en) * | 2020-02-25 | 2021-09-02 | Shanghaitech University | Compositions and methods for detecting nucleic acid-protein interactions |
| CN115315519A (zh) * | 2020-02-28 | 2022-11-08 | 辉大(上海)生物科技有限公司 | VI-E型和VI-F型CRISPR-Cas系统及其用途 |
| WO2021188734A1 (en) | 2020-03-17 | 2021-09-23 | The Broad Institute, Inc. | Crispr system high throughput diagnostic systems and methods |
| US11453907B2 (en) | 2020-03-23 | 2022-09-27 | The Broad Institute, Inc. | Crispr effector system based coronavirus diagnostics |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| JP7419168B2 (ja) * | 2020-06-10 | 2024-01-22 | 株式会社東芝 | 改変型ｐｉｇｇｙＢａｃトランスポゼースのポリペプチド、それをコードするポリヌクレオチド、導入キャリア、キット、細胞のゲノムに目的配列を組込む方法及び細胞製造方法 |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2022188039A1 (en) | 2021-03-09 | 2022-09-15 | Huigene Therapeutics Co., Ltd. | Engineered crispr/cas13 system and uses thereof |
| CN118109438A (zh) * | 2020-09-30 | 2024-05-31 | 辉大(上海)生物科技有限公司 | 工程化的CRISPR/Cas13系统及其用途 |
| WO2022068912A1 (en) | 2020-09-30 | 2022-04-07 | Huigene Therapeutics Co., Ltd. | Engineered crispr/cas13 system and uses thereof |
| EP4229202A4 (en) * | 2020-10-13 | 2025-10-01 | Brigham & Womens Hospital Inc | COMPOSITIONS AND METHODS TARGETING CIRC2082 FOR THE TREATMENT OF CANCER |
| EP4240853A2 (en) * | 2020-11-03 | 2023-09-13 | Science Solutions LLC | Novel class 2 crispr-cas rna-guided endonucleases |
| CN112430586B (zh) * | 2020-11-16 | 2021-09-07 | 珠海舒桐医疗科技有限公司 | 一种VI-B型CRISPR/Cas13基因编辑系统及其应用 |
| WO2022136370A1 (en) * | 2020-12-22 | 2022-06-30 | Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Application of crispr/cas13 for therapy of rna virus and/or bacterium induced diseases |
| CN116802287A (zh) * | 2021-01-05 | 2023-09-22 | 学校法人川崎学园 | 包括人类在内的生物体细胞中的转录产物、转染rna及其纯化复合物的工具 |
| US20220325298A1 (en) * | 2021-04-12 | 2022-10-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Crispr epigenetic therapeutics for pain management |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| EP4347818A2 (en) | 2021-06-01 | 2024-04-10 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| US20230058054A1 (en) * | 2021-06-29 | 2023-02-23 | Huigene Therapeutics Co., Ltd. | Crispr/cas system and uses thereof |
| EP4141112B1 (en) * | 2021-07-08 | 2025-06-11 | Korea Advanced Institute of Science and Technology | Rna expression regulation or editing method through activity control of cas13 protein |
| WO2023283622A1 (en) | 2021-07-08 | 2023-01-12 | Montana State University | Crispr-based programmable rna editing |
| WO2023004391A2 (en) | 2021-07-21 | 2023-01-26 | Montana State University | Nucleic acid detection using type iii crispr complex |
| EP4215612A1 (en) * | 2022-01-20 | 2023-07-26 | Sartorius Stedim Cellca GmbH | Genome editing with crispr/cas nucleases comprising collateral activity |
| CN115712847B (zh) * | 2022-11-21 | 2026-03-17 | 长江水利委员会长江科学院 | 一种基于强震监测数据的高拱坝模态参数自动识别方法 |
| WO2024112957A1 (en) | 2022-11-23 | 2024-05-30 | Amber Bio Inc. | Gene-modifying endonucleases |
| US12435357B2 (en) | 2022-12-22 | 2025-10-07 | Kanso Diagnostics Ltd. | Diagnostic device for detecting a target nucleic acid molecule in a biological sample |
| KR20250151430A (ko) | 2023-02-15 | 2025-10-21 | 아버 바이오테크놀로지스, 인크. | 스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법 |
| WO2024226832A1 (en) * | 2023-04-25 | 2024-10-31 | Orgenesis Inc. | Ribonucleases for treating viral infections |
| WO2025006545A2 (en) * | 2023-06-27 | 2025-01-02 | The Regents Of The University Of California | Nuclease effector bound type-vi crispr enzymes |
| WO2025096250A1 (en) * | 2023-10-30 | 2025-05-08 | Cz Biohub Sf, Llc | Manipulating spatial rna localization |
| KR102891058B1 (ko) * | 2023-11-22 | 2025-11-26 | 한국화학연구원 | 피부 자극성 평가용 형광 리포터가 도입된 인간 피부 세포 시스템 |
| KR102877367B1 (ko) * | 2023-11-22 | 2025-10-29 | 한국화학연구원 | 흡입독성 평가용 형광 리포터가 도입된 인간 폐 세포 시스템 |
| KR102877375B1 (ko) * | 2023-11-22 | 2025-10-30 | 한국화학연구원 | 세포질 상분리 현상 실시간 모니터링용 형광 표지인자가 도입된 인간 전분화능 줄기세포 모델 기반 독성 평가 시스템 |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| CN120775820A (zh) * | 2024-04-07 | 2025-10-14 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体 |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
Family Cites Families (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| ATE137807T1 (de) * | 1988-12-05 | 1996-05-15 | Salk Inst For Biological Studi | Systeme für amplifikation/nachweis von nukleinsäuren |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| GB9114259D0 (en) | 1991-07-02 | 1991-08-21 | Ici Plc | Plant derived enzyme and dna sequences |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| JP2952041B2 (ja) | 1992-07-27 | 1999-09-20 | パイオニア ハイ−ブレッド インターナショナル，インコーポレイテッド | 培養ダイズ細胞のａｇｒｏｂａｃｔｅｒｉｕｍ媒介形質転換の改良法 |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| WO1994026877A1 (en) | 1993-05-17 | 1994-11-24 | The Regents Of The University Of California | Ribozyme gene therapy for hiv infection and aids |
| US5789156A (en) | 1993-06-14 | 1998-08-04 | Basf Ag | Tetracycline-regulated transcriptional inhibitors |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| AU698739B2 (en) | 1995-06-06 | 1998-11-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5846946A (en) | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
| GB9907461D0 (en) | 1999-03-31 | 1999-05-26 | King S College London | Neurite regeneration |
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| EP1025217B1 (en) | 1997-10-24 | 2006-10-04 | Invitrogen Corporation | Recombinational cloning using nucleic acids having recombination sites |
| US6750059B1 (en) | 1998-07-16 | 2004-06-15 | Whatman, Inc. | Archiving of vectors |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7868149B2 (en) | 1999-07-20 | 2011-01-11 | Monsanto Technology Llc | Plant genome sequence and uses thereof |
| US6603061B1 (en) | 1999-07-29 | 2003-08-05 | Monsanto Company | Agrobacterium-mediated plant transformation method |
| JP2004521606A (ja) * | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Ｒｎａの検出法 |
| GB0024550D0 (https=) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
| US7776321B2 (en) | 2001-09-26 | 2010-08-17 | Mayo Foundation For Medical Education And Research | Mutable vaccines |
| GB0125216D0 (en) | 2001-10-19 | 2001-12-12 | Univ Strathclyde | Dendrimers for use in targeted delivery |
| US20090100536A1 (en) | 2001-12-04 | 2009-04-16 | Monsanto Company | Transgenic plants with enhanced agronomic traits |
| CN1620508A (zh) | 2001-12-21 | 2005-05-25 | 牛津生物医学（英国）有限公司 | 转基因生物 |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| GB0220467D0 (en) | 2002-09-03 | 2002-10-09 | Oxford Biomedica Ltd | Composition |
| EP1558724A4 (en) | 2002-11-01 | 2006-08-02 | New England Biolabs Inc | ORGANIC RNA SCREENING AND ITS USE IN INTERRUPTING GENE TRANSMISSION IN THE ENVIRONMENT |
| CA2532228C (en) | 2003-07-16 | 2017-02-14 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| GB0325379D0 (en) | 2003-10-30 | 2003-12-03 | Oxford Biomedica Ltd | Vectors |
| CA2569664C (en) | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| JP4764426B2 (ja) | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
| AU2005274948B2 (en) | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| GB0422877D0 (en) | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
| WO2007048046A2 (en) | 2005-10-20 | 2007-04-26 | Protiva Biotherapeutics, Inc. | Sirna silencing of filovirus gene expression |
| US8044019B2 (en) | 2005-10-28 | 2011-10-25 | Mitsubishi Tanabe Pharma Corporation | Cell penetrating peptide |
| CN101346393B (zh) | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| US7915399B2 (en) | 2006-06-09 | 2011-03-29 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| JP2008078613A (ja) | 2006-08-24 | 2008-04-03 | Rohm Co Ltd | 窒化物半導体の製造方法及び窒化物半導体素子 |
| US20100099858A1 (en) | 2006-09-28 | 2010-04-22 | Mirkin Chad A | Maximizing Oligonucleotide Loading on Gold Nanoparticle |
| WO2008064289A2 (en) | 2006-11-21 | 2008-05-29 | The Samuel Roberts Noble Foundation, Inc. | Biofuel production methods and compositions |
| WO2008149176A1 (en) | 2007-06-06 | 2008-12-11 | Cellectis | Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof |
| US8404658B2 (en) | 2007-12-31 | 2013-03-26 | Nanocor Therapeutics, Inc. | RNA interference for the treatment of heart failure |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2009147368A1 (en) | 2008-06-04 | 2009-12-10 | Medical Research Council | Peptides |
| BRPI0910198A2 (pt) | 2008-06-30 | 2016-01-12 | Silenseed Ltd | composição para administração a partir de um sítio local de um agente baseado em nucleotídeos e método para tratar um sujeito sofrendo de uma doença requerendo tratamento local com um agente baseado em nucleotídeo. |
| US20110117189A1 (en) | 2008-07-08 | 2011-05-19 | S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. | Ophthalmic compositions for treating pathologies of the posterior segment of the eye |
| EP3269395A1 (en) | 2008-11-07 | 2018-01-17 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| GB2465749B (en) | 2008-11-25 | 2013-05-08 | Algentech Sas | Plant cell transformation method |
| WO2010096488A1 (en) | 2009-02-17 | 2010-08-26 | The Regents Of The University Of California | Method of reducing acetylation in plants to improve biofuel production |
| WO2011000107A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| EP2449106B1 (en) | 2009-07-01 | 2015-04-08 | Protiva Biotherapeutics Inc. | Compositions and methods for silencing apolipoprotein b |
| US20110027239A1 (en) | 2009-07-29 | 2011-02-03 | Tissue Genesis, Inc. | Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer |
| US8927807B2 (en) | 2009-09-03 | 2015-01-06 | The Regents Of The University Of California | Nitrate-responsive promoter |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| US20120003201A1 (en) | 2010-04-21 | 2012-01-05 | Nicholas Susanne B | Vault agents for chronic kidney disease |
| US9567573B2 (en) | 2010-04-26 | 2017-02-14 | Sangamo Biosciences, Inc. | Genome editing of a Rosa locus using nucleases |
| US8372951B2 (en) | 2010-05-14 | 2013-02-12 | National Tsing Hua University | Cell penetrating peptides for intracellular delivery |
| WO2011148194A1 (en) | 2010-05-28 | 2011-12-01 | Oxford Biomedica (Uk) Ltd | Delivery of lentiviral vectors to the brain |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| EP2691443B1 (en) | 2011-03-28 | 2021-02-17 | Massachusetts Institute of Technology | Conjugated lipomers and uses thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US20120295960A1 (en) | 2011-05-20 | 2012-11-22 | Oxford Biomedica (Uk) Ltd. | Treatment regimen for parkinson's disease |
| US9603949B2 (en) | 2011-09-01 | 2017-03-28 | University Of Iowa Research Foundation | Oligonucleotide-based probes for detection of bacterial nucleases |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US20130185823A1 (en) | 2012-01-16 | 2013-07-18 | Academia Sinica | Mesoporous silica nanoparticle-mediated delivery of dna into arabidopsis root |
| AU2013266968B2 (en) * | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| AU2013293270B2 (en) | 2012-07-25 | 2018-08-16 | Massachusetts Institute Of Technology | Inducible DNA binding proteins and genome perturbation tools and applications thereof |
| US8614194B1 (en) | 2012-07-25 | 2013-12-24 | Kaohsiung Medical University | Anionic cell penetrating peptide and its use for intracellular delivery |
| AU2013335451C1 (en) * | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| IL239344B2 (en) * | 2012-12-12 | 2024-06-01 | Broad Inst Inc | Systems engineering, methods and optimal guiding components for sequence manipulation |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| WO2014093709A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| WO2014204723A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions |
| RU2716420C2 (ru) | 2013-06-17 | 2020-03-11 | Те Брод Инститьют Инк. | Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени |
| CN105492611A (zh) | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
| WO2014204724A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| CN105683379A (zh) | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| MX374532B (es) | 2013-06-17 | 2025-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos. |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| WO2015065964A1 (en) | 2013-10-28 | 2015-05-07 | The Broad Institute Inc. | Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof |
| US20150165054A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3470089A1 (en) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| EP3835419A1 (en) * | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| US10513711B2 (en) * | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
| JP6823593B2 (ja) * | 2014-11-06 | 2021-02-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | Ｒｎａ誘導型エンドヌクレアーゼの細胞へのペプチド媒介輸送 |
| JP6814155B2 (ja) * | 2014-12-12 | 2021-01-13 | ジュー，ジェイムズ | 対象とする細胞を選択的に除去する方法及び組成物 |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| AU2016279077A1 (en) * | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| CN116814590A (zh) * | 2015-10-22 | 2023-09-29 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| EP3390624A4 (en) * | 2015-12-18 | 2019-07-10 | The Regents of The University of California | Modified site-directed modifying polypeptides and methods of use thereof |
| IL299616A (en) * | 2016-01-08 | 2023-03-01 | Univ California | Conditionally active heterodimeric polypeptides and methods of using them |
| US11427837B2 (en) * | 2016-01-12 | 2022-08-30 | The Regents Of The University Of California | Compositions and methods for enhanced genome editing |
| WO2017136335A1 (en) * | 2016-02-01 | 2017-08-10 | The Regents Of The University Of California | Self-inactivating endonuclease-encoding nucleic acids and methods of using the same |
| WO2017139505A2 (en) * | 2016-02-11 | 2017-08-17 | The Regents Of The University Of California | Methods and compositions for modifying a mutant dystrophin gene in a cell's genome |
| US20180112234A9 (en) * | 2016-03-14 | 2018-04-26 | Intellia Therapeutics, Inc. | Methods and compositions for gene editing |
| LT3436077T (lt) * | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| WO2017173092A1 (en) * | 2016-03-31 | 2017-10-05 | The Regents Of The University Of California | Methods for genome editing in zygotes |
| WO2017189336A1 (en) * | 2016-04-25 | 2017-11-02 | The Regents Of The University Of California | Methods and compositions for genomic editing |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CN110506128A (zh) * | 2016-12-09 | 2019-11-26 | 博德研究所 | 基于crispr效应系统的诊断 |
| US11021740B2 (en) * | 2017-03-15 | 2021-06-01 | The Broad Institute, Inc. | Devices for CRISPR effector system based diagnostics |
| US11174515B2 (en) * | 2017-03-15 | 2021-11-16 | The Broad Institute, Inc. | CRISPR effector system based diagnostics |
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2017
- 2017-06-19 CN CN201780050351.5A patent/CN109642231A/zh active Pending
- 2017-06-19 WO PCT/US2017/038154 patent/WO2017219027A1/en not_active Ceased
- 2017-06-19 KR KR1020237037115A patent/KR20230156150A/ko active Pending
- 2017-06-19 BR BR112018076190A patent/BR112018076190A2/pt not_active Application Discontinuation
- 2017-06-19 KR KR1020197001527A patent/KR20190019168A/ko not_active Ceased
- 2017-06-19 AU AU2017283713A patent/AU2017283713B2/en active Active
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