JP2023002701A5 - - Google Patents
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- Publication number
- JP2023002701A5 JP2023002701A5 JP2022168473A JP2022168473A JP2023002701A5 JP 2023002701 A5 JP2023002701 A5 JP 2023002701A5 JP 2022168473 A JP2022168473 A JP 2022168473A JP 2022168473 A JP2022168473 A JP 2022168473A JP 2023002701 A5 JP2023002701 A5 JP 2023002701A5
- Authority
- JP
- Japan
- Prior art keywords
- angioedema
- therapeutic agent
- atom
- prophylactic
- preventive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000028185 Angioedema Diseases 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 230000000069 prophylactic effect Effects 0.000 claims 8
- 230000003449 preventive effect Effects 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000004431 deuterium atom Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052805 deuterium Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 1
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 206010019860 Hereditary angioedema Diseases 0.000 claims 1
- -1 OH Chemical group 0.000 claims 1
- 208000005707 acquired angioedema Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- WCYWZMWISLQXQU-FIBGUPNXSA-N trideuteriomethane Chemical group [2H][C]([2H])[2H] WCYWZMWISLQXQU-FIBGUPNXSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17203675.8 | 2017-11-24 | ||
| EP17203675 | 2017-11-24 | ||
| JP2020545875A JP7164619B2 (ja) | 2017-11-24 | 2018-11-23 | 新規ブラジキニンｂ２受容体アンタゴニスト |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545875A Division JP7164619B2 (ja) | 2017-11-24 | 2018-11-23 | 新規ブラジキニンｂ２受容体アンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023002701A JP2023002701A (ja) | 2023-01-10 |
| JP2023002701A5 true JP2023002701A5 (https=) | 2023-03-29 |
Family
ID=60473364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545875A Active JP7164619B2 (ja) | 2017-11-24 | 2018-11-23 | 新規ブラジキニンｂ２受容体アンタゴニスト |
| JP2022168473A Pending JP2023002701A (ja) | 2017-11-24 | 2022-10-20 | 新規ブラジキニンｂ２受容体アンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545875A Active JP7164619B2 (ja) | 2017-11-24 | 2018-11-23 | 新規ブラジキニンｂ２受容体アンタゴニスト |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10836748B2 (https=) |
| EP (2) | EP3713928B1 (https=) |
| JP (2) | JP7164619B2 (https=) |
| KR (1) | KR102413321B1 (https=) |
| CN (1) | CN111433196B (https=) |
| AR (1) | AR113839A1 (https=) |
| AU (1) | AU2018371186B2 (https=) |
| CA (1) | CA3082948A1 (https=) |
| CY (1) | CY1125348T1 (https=) |
| DK (1) | DK3713928T3 (https=) |
| EA (1) | EA202091256A1 (https=) |
| ES (1) | ES2908409T3 (https=) |
| HR (1) | HRP20220429T1 (https=) |
| HU (1) | HUE058217T2 (https=) |
| IL (1) | IL274883B2 (https=) |
| LT (1) | LT3713928T (https=) |
| MA (1) | MA50804B1 (https=) |
| MX (1) | MX2020005287A (https=) |
| PH (1) | PH12020550683A1 (https=) |
| PL (1) | PL3713928T3 (https=) |
| PT (1) | PT3713928T (https=) |
| RS (1) | RS63087B1 (https=) |
| SG (1) | SG11202004653TA (https=) |
| SI (1) | SI3713928T1 (https=) |
| SM (1) | SMT202200154T1 (https=) |
| TW (1) | TWI768156B (https=) |
| UY (1) | UY37981A (https=) |
| WO (1) | WO2019101906A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019101906A1 (en) | 2017-11-24 | 2019-05-31 | Pharvaris B.V. | Novel bradykinin b2 receptor antagonists |
| UY38706A (es) * | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| UY38707A (es) | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Nuevos antagonistas cíclicos del receptor b2 de bradiquinina |
| KR20230107269A (ko) * | 2020-11-12 | 2023-07-14 | 파르바리스 게엠베하 | 혈관부종의 예방 및 치료 |
| EP4380929A1 (en) | 2021-08-05 | 2024-06-12 | Pharvaris GmbH | Solid form of a bradykinin b2-receptor antagonist |
| RS65427B1 (sr) * | 2021-08-05 | 2024-05-31 | Pharvaris Gmbh | Kompozicija na bazi lipida za oralnu primenu antagonista receptora bradikinina b2 |
| EP4499100A1 (en) | 2022-03-25 | 2025-02-05 | Pharvaris GmbH | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物 |
| IL315699A (en) | 2022-03-25 | 2024-11-01 | Pharvaris Gmbh | A solid composition comprising dissolved bradykinin B2 receptor antagonists |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| EP0807105B1 (en) | 1994-10-27 | 2004-06-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists |
| FR2737892B1 (fr) | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
| GB9602029D0 (en) | 1996-02-01 | 1996-04-03 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| DE19609827A1 (de) | 1996-03-13 | 1997-09-18 | Hoechst Ag | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
| DE19610784A1 (de) | 1996-03-19 | 1997-09-25 | Hoechst Ag | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19612067A1 (de) | 1996-03-27 | 1997-10-02 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
| AUPN952696A0 (en) | 1996-04-29 | 1996-05-23 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| DE19712960A1 (de) | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| WO1999064039A1 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Bradykinin antagonists |
| CA2347001A1 (en) | 1998-10-21 | 2000-04-27 | Fujisawa Pharmaceutical Co., Ltd. | Vitreous form of known bradykinin antagonist |
| FR2790260B1 (fr) | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| GB9913079D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| WO2001056995A1 (en) | 2000-01-18 | 2001-08-09 | Nuerogen Corporation | Substituted imidazoles as selective modulators of bradykinin b2 receptors |
| CA2364178C (en) | 2000-12-05 | 2006-01-10 | Yasuhiro Katsu | N-benzenesulfonyl l-proline compounds as bradykinin antagonists |
| WO2003087090A2 (en) | 2002-04-10 | 2003-10-23 | Ortho-Mcneil Pharmaceutical,Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
| ITMI20021247A1 (it) | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| ITMI20041963A1 (it) | 2004-10-15 | 2005-01-15 | Luso Farmaco Inst | "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" |
| EP1741444A1 (en) | 2005-07-05 | 2007-01-10 | Jerini AG | Kinin antagonists for treating bladder dysfunction |
| TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽ｂ２受體調節劑 |
| AR073304A1 (es) * | 2008-09-22 | 2010-10-28 | Jerini Ag | Moduladores del receptor de bradiquinina b2 de molecula pequena |
| CA2904052A1 (en) | 2013-03-14 | 2014-10-02 | Shire Human Genetic Therapies, Inc. | Methods of treating b2-bradykinin receptor mediated angioedema |
| WO2019101906A1 (en) | 2017-11-24 | 2019-05-31 | Pharvaris B.V. | Novel bradykinin b2 receptor antagonists |
-
2018
- 2018-11-23 WO PCT/EP2018/082338 patent/WO2019101906A1/en not_active Ceased
- 2018-11-23 MX MX2020005287A patent/MX2020005287A/es unknown
- 2018-11-23 TW TW107141872A patent/TWI768156B/zh active
- 2018-11-23 HR HRP20220429TT patent/HRP20220429T1/hr unknown
- 2018-11-23 KR KR1020207017972A patent/KR102413321B1/ko active Active
- 2018-11-23 PT PT188189922T patent/PT3713928T/pt unknown
- 2018-11-23 JP JP2020545875A patent/JP7164619B2/ja active Active
- 2018-11-23 SG SG11202004653TA patent/SG11202004653TA/en unknown
- 2018-11-23 LT LTEPPCT/EP2018/082338T patent/LT3713928T/lt unknown
- 2018-11-23 SM SM20220154T patent/SMT202200154T1/it unknown
- 2018-11-23 AU AU2018371186A patent/AU2018371186B2/en active Active
- 2018-11-23 ES ES18818992T patent/ES2908409T3/es active Active
- 2018-11-23 AR ARP180103444A patent/AR113839A1/es unknown
- 2018-11-23 CN CN201880076162.XA patent/CN111433196B/zh active Active
- 2018-11-23 EP EP18818992.2A patent/EP3713928B1/en active Active
- 2018-11-23 EA EA202091256A patent/EA202091256A1/ru unknown
- 2018-11-23 HU HUE18818992A patent/HUE058217T2/hu unknown
- 2018-11-23 UY UY0001037981A patent/UY37981A/es active IP Right Grant
- 2018-11-23 EP EP21213719.4A patent/EP3998259A1/en active Pending
- 2018-11-23 IL IL274883A patent/IL274883B2/en unknown
- 2018-11-23 RS RS20220335A patent/RS63087B1/sr unknown
- 2018-11-23 MA MA50804A patent/MA50804B1/fr unknown
- 2018-11-23 DK DK18818992.2T patent/DK3713928T3/da active
- 2018-11-23 CA CA3082948A patent/CA3082948A1/en active Pending
- 2018-11-23 SI SI201830628T patent/SI3713928T1/sl unknown
- 2018-11-23 PL PL18818992T patent/PL3713928T3/pl unknown
-
2020
- 2020-04-28 US US16/861,131 patent/US10836748B2/en active Active
- 2020-05-21 PH PH12020550683A patent/PH12020550683A1/en unknown
- 2020-09-25 US US17/033,347 patent/US11261173B2/en active Active
-
2022
- 2022-01-18 US US17/578,161 patent/US11820756B2/en active Active
- 2022-04-11 CY CY20221100272T patent/CY1125348T1/el unknown
- 2022-10-20 JP JP2022168473A patent/JP2023002701A/ja active Pending
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