JP2022554169A5 - - Google Patents
Info
- Publication number
- JP2022554169A5 JP2022554169A5 JP2022523904A JP2022523904A JP2022554169A5 JP 2022554169 A5 JP2022554169 A5 JP 2022554169A5 JP 2022523904 A JP2022523904 A JP 2022523904A JP 2022523904 A JP2022523904 A JP 2022523904A JP 2022554169 A5 JP2022554169 A5 JP 2022554169A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- trifluoroethyl
- pyrrolidine
- methylphenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962925596P | 2019-10-24 | 2019-10-24 | |
| US62/925,596 | 2019-10-24 | ||
| US202063044898P | 2020-06-26 | 2020-06-26 | |
| US63/044,898 | 2020-06-26 | ||
| PCT/US2020/057132 WO2021081375A1 (en) | 2019-10-24 | 2020-10-23 | Inhibitors of raf kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022554169A JP2022554169A (ja) | 2022-12-28 |
| JP2022554169A5 true JP2022554169A5 (https=) | 2023-10-30 |
| JP7626910B2 JP7626910B2 (ja) | 2025-02-05 |
Family
ID=75619376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523904A Active JP7626910B2 (ja) | 2019-10-24 | 2020-10-23 | Ｒａｆキナーゼの阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11098031B1 (https=) |
| EP (1) | EP4048259A4 (https=) |
| JP (1) | JP7626910B2 (https=) |
| KR (1) | KR20220104702A (https=) |
| CN (1) | CN114845711B (https=) |
| AU (1) | AU2020371727B2 (https=) |
| BR (1) | BR112022007612A2 (https=) |
| CA (1) | CA3158530A1 (https=) |
| CL (1) | CL2022000998A1 (https=) |
| CO (1) | CO2022006712A2 (https=) |
| IL (1) | IL292424B1 (https=) |
| MX (1) | MX2022004937A (https=) |
| PH (1) | PH12022550976A1 (https=) |
| TW (1) | TWI899110B (https=) |
| WO (1) | WO2021081375A1 (https=) |
| ZA (1) | ZA202204284B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202106684A (zh) | 2019-05-03 | 2021-02-16 | 美商奇奈特生物製藥公司 | Raf激酶抑制劑 |
| JP7626910B2 (ja) | 2019-10-24 | 2025-02-05 | ピエール ファーブル メディカモン | Ｒａｆキナーゼの阻害剤 |
| JP7214925B2 (ja) * | 2019-12-06 | 2023-01-30 | メッドシャイン ディスカバリー インコーポレイテッド | Ｐａｎ－ＲＡＦキナーゼ阻害剤としてのビアリール化合物 |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| WO2022060996A1 (en) * | 2020-09-18 | 2022-03-24 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| WO2022081469A1 (en) | 2020-10-12 | 2022-04-21 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| BR112023021913A2 (pt) * | 2021-04-23 | 2024-01-16 | Kinnate Biopharma Inc | Tratamento de câncer com inibidor de raf |
| EP4326255A4 (en) * | 2021-04-23 | 2025-03-12 | Pierre Fabre Medicament | Solid state forms of (s)-n-(3-(2-(((r)-1-hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and salts thereof |
| EP4373806A4 (en) * | 2021-07-19 | 2025-06-18 | Pierre Fabre Medicament | Preparation method of 3- (2, 2, 2-trifluoroethyl) pyrrolidine hydrochloride |
| WO2023061492A1 (zh) * | 2021-10-14 | 2023-04-20 | 华领医药技术（上海）有限公司 | 2-氧代-3-氮杂双环[3.1.0]己烷衍生物 |
| WO2023070053A1 (en) * | 2021-10-21 | 2023-04-27 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| CA3240192A1 (en) * | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| EP4472968A1 (en) * | 2022-02-03 | 2024-12-11 | Pierre Fabre Medicament | Inhibitors of raf kinases |
| EP4486722A4 (en) * | 2022-03-02 | 2026-03-25 | Nico Therapeutics Inc | COMPOUNDS, COMPOSITIONS AND PROCESSES |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
| US20070244120A1 (en) | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
| GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| EA018551B1 (ru) | 2008-02-22 | 2013-08-30 | Айрм Ллк | ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ c-KIT И PDGFR |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| JP2012514044A (ja) | 2008-12-30 | 2012-06-21 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｒａｆキナーゼ阻害剤として有用なヘテロアリール化合物 |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| SI3366293T1 (sl) | 2012-06-07 | 2020-08-31 | Deciphera Pharmaceuticals, Llc | Dihidronafthiridini in sorodne spojine uporabne kot kinazni inhibitorji za zdravljenje proliferativnih bolezni |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| EP3191467B1 (en) | 2014-09-12 | 2020-10-21 | Novartis AG | Compounds and compositions as kinase inhibitors |
| CN107074828B (zh) * | 2014-09-12 | 2020-05-19 | 诺华股份有限公司 | 用作raf激酶抑制剂的化合物和组合物 |
| CA3026876A1 (en) | 2016-06-10 | 2017-12-14 | Novartis Ag | Therapeutic uses of a c-raf inhibitor |
| AU2017329090B9 (en) | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
| WO2020168172A1 (en) | 2019-02-15 | 2020-08-20 | Zamboni Chem Solutions Inc. | Conjugate compounds for the degradation of raf |
| WO2020198058A1 (en) * | 2019-03-22 | 2020-10-01 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| TW202106684A (zh) | 2019-05-03 | 2021-02-16 | 美商奇奈特生物製藥公司 | Raf激酶抑制劑 |
| JP7626910B2 (ja) | 2019-10-24 | 2025-02-05 | ピエール ファーブル メディカモン | Ｒａｆキナーゼの阻害剤 |
| WO2022060996A1 (en) | 2020-09-18 | 2022-03-24 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| WO2022081469A1 (en) | 2020-10-12 | 2022-04-21 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| BR112023021913A2 (pt) | 2021-04-23 | 2024-01-16 | Kinnate Biopharma Inc | Tratamento de câncer com inibidor de raf |
| EP4326255A4 (en) | 2021-04-23 | 2025-03-12 | Pierre Fabre Medicament | Solid state forms of (s)-n-(3-(2-(((r)-1-hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and salts thereof |
-
2020
- 2020-10-23 JP JP2022523904A patent/JP7626910B2/ja active Active
- 2020-10-23 BR BR112022007612A patent/BR112022007612A2/pt unknown
- 2020-10-23 PH PH1/2022/550976A patent/PH12022550976A1/en unknown
- 2020-10-23 TW TW109136965A patent/TWI899110B/zh active
- 2020-10-23 US US17/079,152 patent/US11098031B1/en active Active
- 2020-10-23 IL IL292424A patent/IL292424B1/en unknown
- 2020-10-23 EP EP20878472.8A patent/EP4048259A4/en active Pending
- 2020-10-23 AU AU2020371727A patent/AU2020371727B2/en active Active
- 2020-10-23 CA CA3158530A patent/CA3158530A1/en active Pending
- 2020-10-23 MX MX2022004937A patent/MX2022004937A/es unknown
- 2020-10-23 KR KR1020227016515A patent/KR20220104702A/ko active Pending
- 2020-10-23 CN CN202080090257.4A patent/CN114845711B/zh active Active
- 2020-10-23 WO PCT/US2020/057132 patent/WO2021081375A1/en not_active Ceased
-
2021
- 2021-03-25 US US17/213,036 patent/US12312336B2/en active Active
-
2022
- 2022-04-14 ZA ZA2022/04284A patent/ZA202204284B/en unknown
- 2022-04-21 CL CL2022000998A patent/CL2022000998A1/es unknown
- 2022-05-20 CO CONC2022/0006712A patent/CO2022006712A2/es unknown
-
2025
- 2025-04-18 US US19/183,462 patent/US20260055084A1/en active Pending
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