JP2022502362A5 - - Google Patents

Info

Publication number
JP2022502362A5
JP2022502362A5 JP2021514980A JP2021514980A JP2022502362A5 JP 2022502362 A5 JP2022502362 A5 JP 2022502362A5 JP 2021514980 A JP2021514980 A JP 2021514980A JP 2021514980 A JP2021514980 A JP 2021514980A JP 2022502362 A5 JP2022502362 A5 JP 2022502362A5
Authority
JP
Japan
Prior art keywords
phenyl
ethynyl
hydroxy
propyl
amino
Prior art date
Application number
JP2021514980A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020061375A5 (https=
JP7495395B2 (ja
JP2022502362A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/052021 external-priority patent/WO2020061375A1/en
Publication of JP2022502362A publication Critical patent/JP2022502362A/ja
Publication of JPWO2020061375A5 publication Critical patent/JPWO2020061375A5/ja
Publication of JP2022502362A5 publication Critical patent/JP2022502362A5/ja
Application granted granted Critical
Publication of JP7495395B2 publication Critical patent/JP7495395B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021514980A 2018-09-20 2019-09-19 抗菌性化合物 Active JP7495395B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862734173P 2018-09-20 2018-09-20
US62/734,173 2018-09-20
US201862767313P 2018-11-14 2018-11-14
US62/767,313 2018-11-14
PCT/US2019/052021 WO2020061375A1 (en) 2018-09-20 2019-09-19 Antibacterial compounds

Publications (4)

Publication Number Publication Date
JP2022502362A JP2022502362A (ja) 2022-01-11
JPWO2020061375A5 JPWO2020061375A5 (https=) 2022-09-27
JP2022502362A5 true JP2022502362A5 (https=) 2022-09-27
JP7495395B2 JP7495395B2 (ja) 2024-06-04

Family

ID=69887856

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021514980A Active JP7495395B2 (ja) 2018-09-20 2019-09-19 抗菌性化合物

Country Status (12)

Country Link
US (3) US11407740B2 (https=)
EP (1) EP3853210A4 (https=)
JP (1) JP7495395B2 (https=)
CN (1) CN113166077B (https=)
AU (1) AU2019345150A1 (https=)
BR (1) BR112021005044A2 (https=)
CA (1) CA3113226A1 (https=)
IL (1) IL281614B2 (https=)
MX (1) MX2021003084A (https=)
SG (1) SG11202102712WA (https=)
TW (1) TWI900469B (https=)
WO (1) WO2020061375A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017083431A2 (en) 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
EP3621962A4 (en) 2017-05-10 2020-12-09 Forge Therapeutics, Inc. ANTIBACTERIAL COMPOUNDS
IL281614B2 (en) 2018-09-20 2024-12-01 Blacksmith Medicines Inc Antibacterial compounds
JP2023501528A (ja) 2019-11-14 2023-01-18 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の改善された合成
WO2021195258A1 (en) * 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor, formulations, and uses thereof
WO2021195260A1 (en) * 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
WO2023011573A1 (zh) * 2021-08-05 2023-02-09 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途
JP7700363B2 (ja) * 2021-08-05 2025-06-30 浙江海正薬業股▲ふん▼有限公司 芳香族アセチレン系誘導体及びその製造方法と用途
JP2024536864A (ja) * 2021-09-28 2024-10-08 ブラックスミス メディシンズ,インク. Lpxc阻害剤およびその使用
TW202417432A (zh) * 2022-08-10 2024-05-01 美商布萊克史密斯醫藥公司 抗菌化合物

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
US5543534A (en) 1994-12-29 1996-08-06 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6699849B1 (en) 1998-02-23 2004-03-02 Cyclops, Ehf. Cyclodextrin complexes of benzodiazepines
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20050009101A1 (en) 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
BR0211750A (pt) 2001-08-10 2004-10-13 Shionogi & Co Agente antiviral
WO2003048152A2 (en) 2001-12-05 2003-06-12 Tularik Inc. Inflammation modulators
MXPA04007428A (es) 2002-02-01 2004-10-11 Pfizer Prod Inc Formas de dosificacion de liberacion inmediata que contienen dispersiones de farmaco solido.
CA2851462A1 (en) * 2003-01-08 2004-07-29 University Of Washington Antibacterial agents
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
WO2005110399A2 (en) 2004-04-29 2005-11-24 The Regents Of The University Of California Zinc-binding groups for metalloprotein inhibitors
EP1755586A2 (en) 2004-04-29 2007-02-28 The Regents of the University of California Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors
EP2057127B1 (en) 2006-08-31 2012-01-11 Schering Corporation Hydantoin derivatives useful as antibacterial agents
EP2089365A1 (en) 2006-10-05 2009-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derived metalloprotease inhibitors
JP5539864B2 (ja) 2007-06-12 2014-07-02 アカオゲン,インコーポレーテッド 抗菌剤
US8871728B2 (en) * 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
WO2010059838A2 (en) 2008-11-20 2010-05-27 Decode Genetics Ehf Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects
IT1392249B1 (it) 2008-11-28 2012-02-22 Univ Degli Studi Urbino Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
WO2012151567A1 (en) 2011-05-05 2012-11-08 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for preventing and treating influenza
WO2012177635A1 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US9394260B2 (en) 2012-04-03 2016-07-19 Bristol-Myers Squibb Company Pyrimidinone carboxamide inhibitors of endothelial lipase
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
KR20150039832A (ko) * 2012-08-06 2015-04-13 사피라 파르마슈티칼즈 게엠베하 디하이드록시피리미딘 탄산 유도체 및 바이러스성 질환의 치료, 개선 또는 예방에서의 이의 용도
EP2948450A4 (en) 2013-01-28 2016-11-09 Viamet Pharmaceuticals Inc METALLOENZYMINHIBITORVERBINDUNGEN
WO2014160649A1 (en) * 2013-03-29 2014-10-02 Novartis Ag Hydroxamic acid derivatives as lpxc inhibitors for the treatment of bacterial infections
CA2921427A1 (en) * 2013-08-16 2015-02-19 Duke University Substituted hydroxamic acid compounds
WO2015085238A1 (en) 2013-12-05 2015-06-11 The Regents Of The University Of California, A California Corporation Inhibitors of lpxc
WO2015099107A1 (ja) 2013-12-26 2015-07-02 塩野義製薬株式会社 含窒素6員環誘導体およびそれらを含有する医薬組成物
RU2017112319A (ru) 2014-09-12 2018-10-12 Тояма Кемикал Ко., Лтд. Новая фармацевтическая композиция, содержащая производное гидроксамовой кислоты или его соль
HRP20192009T1 (hr) 2014-12-16 2020-02-07 Novartis Ag Spojevi izoksazol hidroksamske kiseline kao inhibitori lpxc-a
CN105777464B (zh) 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
EP3374355A4 (en) 2015-11-09 2019-04-17 Forge Therapeutics, Inc. COMPOUNDS BASED ON PYRONE AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS
WO2017083431A2 (en) 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
US10889556B2 (en) 2016-03-08 2021-01-12 The Regents Of The University Of California Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
EP3558939A1 (en) * 2016-12-23 2019-10-30 Intervet International B.V. Compounds useful for treating a mannheimia haemolytica or histophilus somni infection
CN110248950A (zh) 2017-01-31 2019-09-17 富士胶片富山化学株式会社 作为异羟肟酸的前体药的化合物或其盐、冷冻干燥制剂、LpxC抑制剂及抗菌剂
EP3621962A4 (en) 2017-05-10 2020-12-09 Forge Therapeutics, Inc. ANTIBACTERIAL COMPOUNDS
EP3621961A4 (en) 2017-05-10 2020-09-09 Forge Therapeutics, Inc. Antibacterial compounds
TW201906819A (zh) 2017-05-25 2019-02-16 日商大正製藥股份有限公司 新穎之咪唑衍生物
WO2019086452A1 (en) * 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
WO2019154412A1 (zh) 2018-02-10 2019-08-15 山东亨利医药科技有限责任公司 作为抗菌素的化合物
IL281614B2 (en) 2018-09-20 2024-12-01 Blacksmith Medicines Inc Antibacterial compounds
WO2020102572A1 (en) 2018-11-14 2020-05-22 Forge Therapeutics, Inc. Antibacterial compounds
WO2021195258A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor, formulations, and uses thereof
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
WO2022086920A1 (en) 2020-10-20 2022-04-28 Blacksmith Medicines, Inc. Glutaminyl-peptide cyclotransferase like (qpctl) protein inhibitors and uses thereof
AR124841A1 (es) * 2021-02-11 2023-05-10 Forge Therapeutics Inc Compuestos antibacterianos
US20240150298A1 (en) 2021-02-11 2024-05-09 Blacksmith Medicines, Inc. Antibacterial compounds
JP2024536864A (ja) * 2021-09-28 2024-10-08 ブラックスミス メディシンズ,インク. Lpxc阻害剤およびその使用
WO2024036170A1 (en) 2022-08-10 2024-02-15 Blacksmith Medicines, Inc. Antibacterial compounds
TW202417432A (zh) 2022-08-10 2024-05-01 美商布萊克史密斯醫藥公司 抗菌化合物

Similar Documents

Publication Publication Date Title
JP2022502362A5 (https=)
JP2021515033A5 (https=)
JP2025186368A5 (https=)
RU2013150349A (ru) 5-замещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов васе, содержащие их композиции и их применение
JP2021524484A5 (https=)
RU2017135520A (ru) Бициклические производные хиназолинона
RU2009125916A (ru) Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения
HRP20211918T1 (hr) Triazol n-vezane karbamoil cikloheksil kiseline kao lpa antagonisti
IL264982B (en) Hetero(aryl)cyclopropylamine compounds as lsd1 inhibitors
RU2014124950A (ru) Производные 2-фениламинопиримидина в качестве модуляторов богатой лейцином повторной киназы 2 (lrrk2) для лечения болезни паркинсона
JP2015533782A (ja) スルファモイル−アリールアミド及びb型肝炎の治療のための薬剤としてのその使用
JP2022501429A5 (https=)
HRP20160112T1 (hr) HETEROARIL SUPSTITUIRANI PIROLO[2,3-b]PIRIDINI I PIROLO[2,3-b]PIRIMIDINI KAO INHIBITORI JANUS KINAZE
RU2012122805A (ru) Производные ациламино-замещенной циклической карбоновой кислоты и их применение в качестве фармацевтических препаратов
RU2007101236A (ru) Новые гидантоиновые производные для лечения обструктивных заболеваний дыхательных путей
RU2012125372A (ru) Производные пиразола в качестве ингибиторов 11-бета-hsd1
JP2013531070A5 (https=)
RU2006101541A (ru) Производные пиперазина и способ их применения
JP2021515004A5 (https=)
RU2019136279A (ru) C5 -Анилинохиназолиновые соединения и их использование в лечении рака
CA2803055A1 (en) Heteroaryl compounds and compositions as protein kinase inhibitors
JP2013530957A5 (https=)
JP2018512408A5 (https=)
JP2022511209A5 (https=)
JPWO2020061375A5 (https=)