JP2022540200A5 - - Google Patents

Info

Publication number
JP2022540200A5
JP2022540200A5 JP2022501162A JP2022501162A JP2022540200A5 JP 2022540200 A5 JP2022540200 A5 JP 2022540200A5 JP 2022501162 A JP2022501162 A JP 2022501162A JP 2022501162 A JP2022501162 A JP 2022501162A JP 2022540200 A5 JP2022540200 A5 JP 2022540200A5
Authority
JP
Japan
Prior art keywords
alkyl
cycloalkyl
haloalkyl
alkenil
alkinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022501162A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022540200A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/041506 external-priority patent/WO2021007477A1/en
Publication of JP2022540200A publication Critical patent/JP2022540200A/ja
Publication of JP2022540200A5 publication Critical patent/JP2022540200A5/ja
Pending legal-status Critical Current

Links

JP2022501162A 2019-07-11 2020-07-10 Lrrk2阻害剤としてのインダゾールおよびアザインダゾール Pending JP2022540200A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962872891P 2019-07-11 2019-07-11
US62/872,891 2019-07-11
US201962937979P 2019-11-20 2019-11-20
US62/937,979 2019-11-20
PCT/US2020/041506 WO2021007477A1 (en) 2019-07-11 2020-07-10 Indazoles and azaindazoles as lrrk2 inhibitors

Publications (2)

Publication Number Publication Date
JP2022540200A JP2022540200A (ja) 2022-09-14
JP2022540200A5 true JP2022540200A5 (https=) 2023-07-19

Family

ID=71787214

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022501162A Pending JP2022540200A (ja) 2019-07-11 2020-07-10 Lrrk2阻害剤としてのインダゾールおよびアザインダゾール

Country Status (12)

Country Link
US (2) US11427558B1 (https=)
EP (1) EP3997081A1 (https=)
JP (1) JP2022540200A (https=)
KR (1) KR20220045954A (https=)
CN (1) CN114450274A (https=)
AU (1) AU2020311940A1 (https=)
BR (1) BR112022000325A2 (https=)
CA (1) CA3145305A1 (https=)
IL (1) IL288903A (https=)
MX (1) MX2021015996A (https=)
TW (1) TW202116754A (https=)
WO (1) WO2021007477A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114072387B (zh) * 2019-11-06 2024-03-08 暨南大学 吲唑类化合物及其药用组合物和应用
US12435084B2 (en) 2020-04-09 2025-10-07 Eli Lilly And Company Indazole derivatives as inhibitors of SARM1
WO2022155419A1 (en) * 2021-01-15 2022-07-21 ESCAPE Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
WO2022271840A1 (en) * 2021-06-22 2022-12-29 The Board Of Trustees Of The Leland Stanford Junior University Selective indazole lrrk2 inhibitors and methods for use thereof
WO2025000053A1 (en) * 2023-06-28 2025-01-02 Psylo Pty Ltd Compounds
CN117186066B (zh) * 2023-09-08 2025-07-22 中国药科大学 吲唑类alk5抑制剂及其制备方法与用途

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3917662B2 (ja) 1996-02-14 2007-05-23 日立化成工業株式会社 非複屈折性光学用樹脂組成物及びこれを用いた光学用素子
EA002113B1 (ru) 1996-09-04 2001-12-24 Пфайзер Инк. Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно)
US6258822B1 (en) * 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
US6133290A (en) 1998-07-31 2000-10-17 Eli Lilly And Company 5-HT1F agonists
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US20020147198A1 (en) 2001-01-12 2002-10-10 Guoqing Chen Substituted arylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
WO2004078746A2 (en) 2003-02-28 2004-09-16 Bayer Pharmaceuticals Corporation 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatrory disorders
TWI422583B (zh) 2003-03-07 2014-01-11 參天製藥股份有限公司 具有以4-吡啶烷硫基為取代基之新穎化合物
EP2385041B1 (en) 2003-05-01 2013-09-18 Bristol-Myers Squibb Company Pyrazole-amine compounds useful as kinase inhibitors
EP1628661A2 (en) 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
JP2007519753A (ja) 2004-01-30 2007-07-19 スミスクライン ビーチャム コーポレーション 化合物
DE102004028862A1 (de) 2004-06-15 2005-12-29 Merck Patent Gmbh 3-Aminoindazole
WO2006032851A1 (en) 2004-09-20 2006-03-30 Biolipox Ab Pyrazole compounds useful in the treatment of inflammation
DE102004051277A1 (de) 2004-10-21 2006-04-27 Merck Patent Gmbh Heterocyclische Carbonylverbindungen
WO2006053227A2 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
TW200628463A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp Heteroaryl compounds
ATE451363T1 (de) 2005-01-26 2009-12-15 Schering Corp 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs
US20060223849A1 (en) 2005-03-14 2006-10-05 Mjalli Adnan M Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
DE102005014089A1 (de) 2005-03-22 2006-09-28 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US7553964B2 (en) 2005-06-03 2009-06-30 Abbott Laboratories Cyclobutyl amine derivatives
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
US7816535B2 (en) 2006-01-25 2010-10-19 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
CN101379060B (zh) 2006-02-10 2012-05-23 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
US8658801B2 (en) 2006-02-16 2014-02-25 Syngenta Crop Protection, Llc Pesticides containing a bicyclic bisamide structure
AU2007227210A1 (en) 2006-03-20 2007-09-27 Synta Pharmaceuticals Corp. Benzoimidazolyl-parazine compounds for inflammation and immune-related uses
AU2007230911A1 (en) 2006-03-23 2007-10-04 Synta Pharmaceuticals Corp. Benzimidazolyl-pyridine compounds for inflammation and immune-related uses
US20080280891A1 (en) 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
AR063311A1 (es) 2006-10-18 2009-01-21 Novartis Ag Compuestos organicos
US7960567B2 (en) 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
GB0716414D0 (en) 2007-08-22 2007-10-03 Syngenta Participations Ag Novel insecticides
WO2009035951A2 (en) 2007-09-11 2009-03-19 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
US8324219B2 (en) 2007-09-20 2012-12-04 Synta Pharmaceuticals Corp. Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
WO2009038784A1 (en) 2007-09-21 2009-03-26 Amgen Inc. Triazole fused heteroaryl compounds as p38 kinase inhibitors
DE102007047735A1 (de) 2007-10-05 2009-04-09 Merck Patent Gmbh Thiazolderivate
WO2009061730A2 (en) 2007-11-05 2009-05-14 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid
EP2215094B1 (en) 2007-11-15 2016-01-27 YM BioSciences Australia Pty Ltd N-containing heterocyclic compounds
WO2009073788A1 (en) 2007-12-07 2009-06-11 Firestone Leigh H Compositions and methods for treating menopausal females
WO2009112445A1 (en) 2008-03-10 2009-09-17 Novartis Ag Method of increasing cellular phosphatidyl choline by dgat1 inhibition
CA2722704A1 (en) 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Cyclylamine derivatives as calcium channel blockers
NZ603525A (en) 2008-06-27 2015-02-27 Celgene Avilomics Res Inc Pyrimidine based compound and uses thereof
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010029300A1 (en) 2008-09-12 2010-03-18 Biolipox Ab Bis aromatic compounds for use in the treatment of inflammation
MX2011010218A (es) 2009-04-02 2011-10-10 Merck Patent Gmbh Inhibidores de autotaxina.
RU2012116124A (ru) 2009-09-21 2013-10-27 Вандербилт Юниверсити О-БЕНЗИЛ НИКОТИНАМИДНЫЕ АНАЛОГИ КАК ПОЗИТИВНЫЕ АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ mGluR5
US20120202814A1 (en) 2009-10-02 2012-08-09 Università Degli Studi Di Siena Compounds with ddx3 inhibitory activity and uses thereof
WO2011123937A1 (en) 2010-04-06 2011-10-13 University Health Network Kinase inhibitors and method of treating cancer with same
US8822447B2 (en) 2010-04-22 2014-09-02 Janssen Pharmaceutica Nv Indazole compounds useful as ketohexokinase inhibitors
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
JP6112486B2 (ja) 2010-04-27 2017-04-12 カルシメディカ,インク. 細胞内カルシウムを調節する化合物
US20130053382A1 (en) 2010-04-30 2013-02-28 Sunil Paliwal Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1)
EP2609089A1 (en) 2010-08-27 2013-07-03 Universität des Saarlandes Selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
PL2616444T3 (pl) 2010-09-14 2016-04-29 Inst Biochemii I Biofizyki Pan Związki będące modulatorami zmutowanego białka CFTR oraz ich zastosowanie w leczeniu chorób związanych z zaburzeniami w funkcjonowaniu białka CFTR
NO2638031T3 (https=) * 2010-11-10 2018-03-10
US8791112B2 (en) 2011-03-30 2014-07-29 Arrien Pharmaceuticals Llc Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
BR112013025142A2 (pt) 2011-04-01 2019-09-24 Univ Utah Res Found análogos de 3-(1h-benzo{d}imidazol-2-il)-1h-indazol substituído como inibidores da cinase pdk1
RU2637936C2 (ru) 2011-05-23 2017-12-08 Элан Фармасьютикалз, Инк. Ингибиторы активности киназы lrrk2
KR20140095513A (ko) 2011-11-01 2014-08-01 에프. 호프만-라 로슈 아게 이미다조피리다진 화합물
HK1203412A1 (en) 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2013106432A1 (en) 2012-01-09 2013-07-18 X-Rx, Inc. Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof
KR20160046693A (ko) 2012-04-02 2016-04-29 싸이토키네틱스, 인코포레이티드 횡격막 기능을 향상시키는 방법들
US8962322B2 (en) 2012-12-03 2015-02-24 City Of Hope Enhancers of induced pluripotent stem cell reprogramming
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
WO2014134774A1 (en) 2013-03-04 2014-09-12 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
WO2014150981A1 (en) 2013-03-15 2014-09-25 Elan Pharmaceuticals, Llc Inhibitors of lrrk2 kinase activity
US10005720B2 (en) 2013-04-05 2018-06-26 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
CN105228983A (zh) 2013-05-30 2016-01-06 普莱希科公司 用于激酶调节的化合物及其适应症
EP3004098B1 (en) 2013-06-06 2017-08-09 Chiesi Farmaceutici S.p.A. Kinase inhibitors
KR20160023676A (ko) 2013-06-21 2016-03-03 에프. 호프만-라 로슈 아게 RORc 조절제로서 아릴 설탐 유도체
CA2919783C (en) 2013-08-02 2018-02-06 Pfizer Inc. Heterobicycloaryl rorc2 inhibitors and methods of use thereof
US9718818B2 (en) 2013-08-22 2017-08-01 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
EP3082805B1 (en) 2013-12-20 2020-02-05 Institute for Drug Discovery, LLC Substituted amino triazoles, and methods using same
EP3190889B1 (en) 2014-09-03 2021-11-17 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
US20160113931A1 (en) 2014-10-24 2016-04-28 University Of Macau Method of treating and/or preventing neurodegenerative diseases
CA2968299A1 (en) 2014-11-18 2016-05-26 Rutgers, The State University Of New Jersey Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
EP3270694A4 (en) 2015-02-17 2018-09-05 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP3265445B1 (en) 2015-03-06 2021-05-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
KR20180030201A (ko) * 2015-07-23 2018-03-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화합물
CA2995094A1 (en) 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
EP3350158A4 (en) 2015-09-16 2019-05-08 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2017049409A1 (en) 2015-09-25 2017-03-30 The Centre For Drug Research And Development Compositions for promoting readthrough of premature termination codons, and methods of using the same
JP2019513700A (ja) 2016-03-16 2019-05-30 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺有害生物剤及び植物保護剤としてのn−(シアノベンジル)−6−(シクロプロピル−カルボニルアミノ)−4−(フェニル)−ピリジン−2−カルボキサミド誘導体及び関連する化合物
CN108884068B (zh) 2016-03-24 2021-02-26 特殊治疗有限公司 作为dub抑制剂的1-氰基-吡咯烷衍生物
WO2017201585A1 (en) * 2016-05-26 2017-11-30 Genea Ip Holdings Pty Ltd Modulators of dux4 for regulation of muscle function
TWI800498B (zh) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
BR112019015252A2 (pt) 2017-01-25 2020-04-14 Glaxosmithkline Ip Dev Ltd compostos
CN110225910A (zh) 2017-01-25 2019-09-10 葛兰素史密斯克莱知识产权发展有限公司 化合物
CA3050152A1 (en) 2017-01-25 2018-08-02 Glaxosmithkline Intellectual Property Development Limited Compounds
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
US11021471B2 (en) 2017-05-10 2021-06-01 Forge Therapeutics, Inc. Antibacterial compounds
CN107176932B (zh) 2017-05-26 2020-06-05 中国药科大学 苯并恶嗪酮衍生物及其制备方法和用途
WO2019002624A1 (de) 2017-06-30 2019-01-03 Kleuser, Burkhard Mittel zur therapie entzündlicher darmerkrankungen
US11427573B2 (en) 2017-08-16 2022-08-30 Vanderbilt University Indazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11174248B2 (en) 2017-10-11 2021-11-16 Merck Sharp & Dohme Corp. Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
WO2019074809A1 (en) 2017-10-11 2019-04-18 Merck Sharp & Dohme Corp. INDAZOLYL-SPIRO [2.2] PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
SG11202003807RA (en) 2017-11-03 2020-05-28 Univ Montreal Compounds and use thereof in the expansion of stem cells and/or progenitor cells
US20210261553A1 (en) 2018-05-15 2021-08-26 E-Scape Bio, Inc. Fused tetrazoles as lrrk2 inhibitors
WO2020092136A1 (en) 2018-10-31 2020-05-07 Merck Sharp & Dohme Corp. N-heteroaryl indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
US20220204473A1 (en) 2018-12-25 2022-06-30 Shanghai Meiyue Biotech Development Co., Ltd. Compound as irak inhibitor
US20220162192A1 (en) 2019-03-21 2022-05-26 ESCAPE Bio, Inc. Indazoles as lrrk2 inhibitors
CN112566905B (zh) 2019-05-10 2024-07-30 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物,其制法与医药上的用途
WO2020247298A2 (en) 2019-06-06 2020-12-10 Merck Sharp & Dohme Corp. 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
WO2021050688A1 (en) 2019-09-10 2021-03-18 X-Chem, Inc. Compounds and uses thereof
CN114072387B (zh) 2019-11-06 2024-03-08 暨南大学 吲唑类化合物及其药用组合物和应用
CA3181786A1 (en) 2020-05-01 2021-11-04 The Regents Of The University Of California Inhibitors of alpha 2 beta 1 integrin and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2022540200A5 (https=)
RU2012126989A (ru) 2-амино-5,5-дифтор-5,6-дигидро-4н-оксазины в качестве ингибиторов васе 1 и(или) васе 2
US8901156B2 (en) Compounds and methods
IL274816B2 (en) Sulfone pyridine alkyl amide-substituted heteroaryl compounds
RU2016102137A (ru) Первичные карбоксамиды в качестве ингибиторов bik
JP2020536116A5 (https=)
JP2016523911A5 (https=)
JP2015517580A5 (https=)
JP2021504443A5 (https=)
CA2630269A1 (en) Inhibitors of diacyglycerol acyltransferase (dgat)
JP2015514794A5 (https=)
HRP20110520T1 (hr) Acilaminopirazoli kao inhibitori fgfr
JP2009525285A5 (https=)
RU2015132181A (ru) Фтор-[1,3]-оксазины в качестве ингибиторов васе1
JP2010533158A5 (https=)
ME01308B (me) Jedinjenja biaril etra uree
IL273705B2 (en) Benzothiazole compounds and methods of using them for the treatment of neurodegenerative diseases
RU2014152625A (ru) Конденсированные с гетероарилкетонами азадекалины - модуляторы глюкокортикоидных рецепторов
JP2018521119A5 (https=)
HRP20170112T1 (hr) Supstituirani spojevi piridin-2-karboksamida kao kinazni inhibitori signalne regulacije apoptoze
JP2017508766A5 (https=)
JP2010540462A5 (https=)
JP2017512794A5 (https=)
HRP20171991T1 (hr) Derivati pirolidin karbonske kiseline kao agonisti g-protein spojenog receptora (gpr43), farmaceutski pripravak i postupci za primjenu u liječenju poremećaja metabolizma
JP2014513122A5 (https=)