|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
DE3169595D1
(en)
|
1980-11-10 |
1985-05-02 |
Gersonde Klaus |
Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
|
|
EP0088046B1
(de)
|
1982-02-17 |
1987-12-09 |
Ciba-Geigy Ag |
Lipide in wässriger Phase
|
|
EP0143949B1
(en)
|
1983-11-01 |
1988-10-12 |
TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION |
Pharmaceutical composition containing urokinase
|
|
JPH07509133A
(ja)
|
1992-07-17 |
1995-10-12 |
リボザイム・ファーマシューティカルズ・インコーポレイテッド |
動物疾患の処置のための方法および剤
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US6447796B1
(en)
|
1994-05-16 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Sustained release hydrophobic bioactive PLGA microspheres
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
ES2356342T3
(es)
|
1998-01-05 |
2011-04-07 |
The University Of Washington |
Mejora de transporte utilizando agentes de alteración de membrana.
|
|
WO2000053722A2
(en)
|
1999-03-10 |
2000-09-14 |
Phogen Limited |
Delivery of nucleic acids and proteins to cells
|
|
AU767394C
(en)
|
1999-12-29 |
2005-04-21 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
|
US20020130430A1
(en)
|
2000-12-29 |
2002-09-19 |
Castor Trevor Percival |
Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
|
|
WO2002087541A1
(en)
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
|
US7141540B2
(en)
|
2001-11-30 |
2006-11-28 |
Genta Salus Llc |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
|
|
BR122019027966B8
(pt)
|
2002-05-02 |
2021-07-27 |
Wyeth Corp |
conjugado monomérico de derivado de caliqueamicina/anti-corpo anti-cd22 e uso dos mesmos
|
|
ES2369542T3
(es)
|
2002-07-31 |
2011-12-01 |
Seattle Genetics, Inc. |
Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
|
|
ES2367430T3
(es)
|
2002-12-23 |
2011-11-03 |
Wyeth Llc |
Anticuerpos contra pd-1 y sus usos.
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
EA014640B1
(ru)
|
2003-07-21 |
2010-12-30 |
Иммьюноджен, Инк. |
Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения
|
|
NZ551180A
(en)
|
2004-06-01 |
2009-10-30 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
WO2006135436A2
(en)
|
2004-10-22 |
2006-12-21 |
University Of Florida Research Foundation, Inc. |
Inhibition of gene expression and therapeutic uses thereof
|
|
JP5238936B2
(ja)
|
2005-03-25 |
2013-07-17 |
ジーアイティーアール,インク. |
Gitr結合分子およびその使用
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
HUE035853T2
(en)
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
PT2170959E
(pt)
|
2007-06-18 |
2014-01-07 |
Merck Sharp & Dohme |
Anticorpos para o receptor humano de morte programada pd-1
|
|
PT2175884T
(pt)
|
2007-07-12 |
2016-09-21 |
Gitr Inc |
Terapias de combinação empregando moléculas de ligação a gitr
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
KR101559599B1
(ko)
|
2007-11-26 |
2015-10-12 |
바이엘 인텔렉쳐 프로퍼티 게엠베하 |
항-메소텔린 항체 및 이의 용도
|
|
WO2009073620A2
(en)
|
2007-11-30 |
2009-06-11 |
Newlink Genetics |
Ido inhibitors
|
|
US9446146B2
(en)
|
2007-12-26 |
2016-09-20 |
Biotest Ag |
Methods and agents for improving targeting of CD138 expressing tumor cells
|
|
AU2008353145B2
(en)
|
2008-01-03 |
2013-09-12 |
Universite D' Aix-Marseille |
Bitherapy and tritherapy used for treating an HIV-positive patient
|
|
ES2588194T3
(es)
|
2008-04-11 |
2016-10-31 |
Seattle Genetics, Inc. |
Detección y tratamiento de cáncer pancreático, de ovario y otros cánceres
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
MX356367B
(es)
|
2008-12-09 |
2018-05-25 |
Genentech Inc |
Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
|
|
IN2015DN02826A
(enExample)
|
2009-09-03 |
2015-09-11 |
Merck Sharp & Dohme |
|
|
EP2493862B1
(en)
|
2009-10-28 |
2016-10-05 |
Newlink Genetics Corporation |
Imidazole derivatives as ido inhibitors
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
DK2510010T3
(en)
|
2009-12-10 |
2015-12-14 |
Hoffmann La Roche |
Antibodies that bind to human CSF1R extracellular domain 4 and their use
|
|
DK2542256T3
(da)
|
2010-03-04 |
2019-08-26 |
Macrogenics Inc |
Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
|
|
RU2617971C2
(ru)
|
2010-03-05 |
2017-04-28 |
Ф.Хоффманн-Ля Рош Аг |
Антитела против csf-1r человека и их применение
|
|
CN102918061B
(zh)
|
2010-03-05 |
2016-06-08 |
霍夫曼-拉罗奇有限公司 |
针对人csf-1r的抗体及其用途
|
|
EP3943154A1
(en)
|
2010-05-04 |
2022-01-26 |
Five Prime Therapeutics, Inc. |
Antibodies that bind csf1r
|
|
NZ729044A
(en)
|
2010-09-09 |
2020-07-31 |
Pfizer |
4-1bb binding molecules
|
|
EP3842074A1
(en)
|
2010-09-29 |
2021-06-30 |
Philogen S.p.A. |
Protein-drug conjugates
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
NO2694640T3
(enExample)
|
2011-04-15 |
2018-03-17 |
|
|
|
CA2833636A1
(en)
|
2011-04-20 |
2012-10-26 |
Amplimmune, Inc. |
Antibodies and other molecules that bind b7-h1 and pd-1
|
|
AU2012340174A1
(en)
|
2011-11-16 |
2014-05-29 |
Amgen Inc. |
Methods of treating epidermal growth factor deletion mutant VIII related disorders
|
|
BR112014012819B1
(pt)
|
2011-11-28 |
2022-08-16 |
Merck Patent Gmbh |
Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
|
|
MX356337B
(es)
|
2011-12-15 |
2018-05-23 |
Hoffmann La Roche |
Anticuerpos contra csf-1r humano y sus usos.
|
|
MX2014008961A
(es)
|
2012-02-06 |
2014-10-14 |
Genentech Inc |
Composiciones y metodos para utilizar inhibidores de csf1r.
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
KR20150018533A
(ko)
|
2012-05-11 |
2015-02-23 |
파이브 프라임 테라퓨틱스, 인크. |
콜로니 자극 인자 1 수용체(csf1r)에 결속하는 항체들에 의한 질병 상태의 치료 방법
|
|
AR091649A1
(es)
|
2012-07-02 |
2015-02-18 |
Bristol Myers Squibb Co |
Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
|
|
US9682143B2
(en)
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
CN107759690A
(zh)
|
2012-08-31 |
2018-03-06 |
戊瑞治疗有限公司 |
用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
|
|
EP2988786A4
(en)
|
2013-04-22 |
2016-12-21 |
Avelas Biosciences Inc |
COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE
|
|
EP2801370A1
(en)
*
|
2013-05-07 |
2014-11-12 |
Fundació Privada Institut d'Investigació Oncològica de Vall Hebron |
Methods and compositions for the treatment of cancer
|
|
PT3057585T
(pt)
|
2013-10-15 |
2020-10-21 |
Seagen Inc |
Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
|
|
EP3084003A4
(en)
|
2013-12-17 |
2017-07-19 |
Merck Sharp & Dohme Corp. |
Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
|
|
EP3125943B1
(en)
|
2014-04-04 |
2026-04-22 |
Merck Sharp & Dohme LLC |
Phosphate based linkers for intracellular delivery of drug conjugates
|
|
SG11201701565PA
(en)
|
2014-09-03 |
2017-03-30 |
Immunogen Inc |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
US20190085404A1
(en)
|
2016-03-04 |
2019-03-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of identifying and treating immune checkpoint inhibitor-responsive neoplasms and cells, transgenic animals and kits for use therein
|
|
EP3269734A1
(en)
*
|
2016-07-15 |
2018-01-17 |
Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron |
Methods and compositions for the treatment of cancer
|
|
EP3630189A4
(en)
|
2017-05-24 |
2021-06-23 |
The Board of Regents of The University of Texas System |
LINKER FOR ANTIBODY MEDICINAL CONJUGATES
|
|
US20210087238A1
(en)
|
2017-07-28 |
2021-03-25 |
Phylogica Limited |
Cell penetrating peptides and related compositions and methods
|