JP2022500042A5 - - Google Patents
Info
- Publication number
- JP2022500042A5 JP2022500042A5 JP2021513989A JP2021513989A JP2022500042A5 JP 2022500042 A5 JP2022500042 A5 JP 2022500042A5 JP 2021513989 A JP2021513989 A JP 2021513989A JP 2021513989 A JP2021513989 A JP 2021513989A JP 2022500042 A5 JP2022500042 A5 JP 2022500042A5
- Authority
- JP
- Japan
- Prior art keywords
- lmdv
- antigen
- heavy chain
- substitution
- binding moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862731356P | 2018-09-14 | 2018-09-14 | |
| US62/731,356 | 2018-09-14 | ||
| PCT/US2019/050823 WO2020056145A1 (en) | 2018-09-14 | 2019-09-12 | Anti-hiv antibody 10-1074 variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022500042A JP2022500042A (ja) | 2022-01-04 |
| JP2022500042A5 true JP2022500042A5 (enExample) | 2022-09-16 |
Family
ID=69778483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513989A Pending JP2022500042A (ja) | 2018-09-14 | 2019-09-12 | 抗ｈｉｖ抗体１０−１０７４バリアント |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12441782B2 (enExample) |
| EP (1) | EP3849612A4 (enExample) |
| JP (1) | JP2022500042A (enExample) |
| KR (1) | KR102938690B1 (enExample) |
| CN (2) | CN113271974B (enExample) |
| AU (1) | AU2019338454B9 (enExample) |
| CA (1) | CA3112486A1 (enExample) |
| WO (1) | WO2020056145A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI762925B (zh) | 2019-05-21 | 2022-05-01 | 美商基利科學股份有限公司 | 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法 |
| JP7518286B2 (ja) | 2020-08-25 | 2024-07-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを標的とする多重特異性抗原結合分子及び使用方法 |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| CN116437958A (zh) | 2020-11-11 | 2023-07-14 | 吉利德科学公司 | 鉴定对采用gp120 CD4结合位点导向的抗体的疗法敏感的HIV患者的方法 |
| WO2023154761A2 (en) * | 2022-02-08 | 2023-08-17 | The Wistar Institute Of Anatomy And Biology | Modified primary immune cells for induction or enhancement of immunotherapy |
| CN119768183A (zh) * | 2022-08-26 | 2025-04-04 | 吉利德科学公司 | 用于广泛中和抗体的给药和安排方案 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US81A (en) | 1836-11-15 | Erawijjg | ||
| US6593A (en) | 1849-07-17 | Cutting | ||
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| AU4289496A (en) | 1994-12-02 | 1996-06-19 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| CA3201524C (en) * | 2010-08-31 | 2026-01-13 | International Aids Vaccine Initiative | Human immunodeficiency virus (hiv)-neutralizing antibodies |
| CN112225798B (zh) * | 2011-05-17 | 2023-07-18 | 洛克菲勒大学 | 人类免疫缺陷病毒中和抗体及其使用方法 |
| US9879068B2 (en) * | 2012-06-21 | 2018-01-30 | California Institute Of Technology | Antibodies targeting HIV escape mutants |
| PT2908912T (pt) * | 2012-10-18 | 2020-09-04 | Univ Rockefeller | Anticorpos anti-hiv amplamente neutralizantes |
| US10676521B2 (en) * | 2014-07-21 | 2020-06-09 | The Rockefeller University | Combination of broadly neutralizing HIV antibodies and viral inducers |
| BR112019013468A8 (pt) * | 2016-12-27 | 2022-11-22 | Univ Rockefeller | Anticorpos anti-hiv-1 amplamente neutralizante e métodos de uso dos mesmos |
| WO2020086782A1 (en) | 2018-10-24 | 2020-04-30 | The Wistar Institute Of Anatomy And Biology | Dna antibody constructs for use against hiv |
-
2019
- 2019-09-12 US US17/275,310 patent/US12441782B2/en active Active
- 2019-09-12 AU AU2019338454A patent/AU2019338454B9/en active Active
- 2019-09-12 KR KR1020217011145A patent/KR102938690B1/ko active Active
- 2019-09-12 CA CA3112486A patent/CA3112486A1/en active Pending
- 2019-09-12 WO PCT/US2019/050823 patent/WO2020056145A1/en not_active Ceased
- 2019-09-12 JP JP2021513989A patent/JP2022500042A/ja active Pending
- 2019-09-12 EP EP19859927.6A patent/EP3849612A4/en active Pending
- 2019-09-12 CN CN201980074145.7A patent/CN113271974B/zh active Active
- 2019-09-12 CN CN202511190725.6A patent/CN121021680A/zh active Pending
-
2025
- 2025-08-13 US US19/298,749 patent/US20260049122A1/en active Pending
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