JP2022500042A - 抗ｈｉｖ抗体１０−１０７４バリアント - Google Patents

抗ｈｉｖ抗体１０−１０７４バリアント Download PDF

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Publication number
JP2022500042A
JP2022500042A JP2021513989A JP2021513989A JP2022500042A JP 2022500042 A JP2022500042 A JP 2022500042A JP 2021513989 A JP2021513989 A JP 2021513989A JP 2021513989 A JP2021513989 A JP 2021513989A JP 2022500042 A JP2022500042 A JP 2022500042A
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JP
Japan
Prior art keywords
lmdv
hiv
antibody
antigen
heavy chain
Prior art date
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Pending
Application number
JP2021513989A
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English (en)
Japanese (ja)
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JP2022500042A5 (enExample
Inventor
ヌッセンツウェイグ，ミケル
ケッチャム，ランダール，アール．
シスカ，クリスティーヌ，シー．
ギレスピー，アリソン，ジェイ．
クラーク，ルチリオ，エイチ．
ケルウィン，ブルース，エー．
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Rockefeller University
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Rockefeller University
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Application filed by Rockefeller University filed Critical Rockefeller University
Publication of JP2022500042A publication Critical patent/JP2022500042A/ja
Publication of JP2022500042A5 publication Critical patent/JP2022500042A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021513989A 2018-09-14 2019-09-12 抗ｈｉｖ抗体１０−１０７４バリアント Pending JP2022500042A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862731356P 2018-09-14 2018-09-14
US62/731,356 2018-09-14
PCT/US2019/050823 WO2020056145A1 (en) 2018-09-14 2019-09-12 Anti-hiv antibody 10-1074 variants

Publications (2)

Publication Number Publication Date
JP2022500042A true JP2022500042A (ja) 2022-01-04
JP2022500042A5 JP2022500042A5 (enExample) 2022-09-16

Family

ID=69778483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021513989A Pending JP2022500042A (ja) 2018-09-14 2019-09-12 抗ｈｉｖ抗体１０−１０７４バリアント

Country Status (8)

Country Link
US (2) US12441782B2 (enExample)
EP (1) EP3849612A4 (enExample)
JP (1) JP2022500042A (enExample)
KR (1) KR102938690B1 (enExample)
CN (2) CN113271974B (enExample)
AU (1) AU2019338454B9 (enExample)
CA (1) CA3112486A1 (enExample)
WO (1) WO2020056145A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025527677A (ja) * 2022-08-26 2025-08-22 ギリアード サイエンシーズ， インコーポレイテッド 広域中和抗体のための投与及びスケジューリングレジメン

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI762925B (zh) 2019-05-21 2022-05-01 美商基利科學股份有限公司 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法
JP7518286B2 (ja) 2020-08-25 2024-07-17 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを標的とする多重特異性抗原結合分子及び使用方法
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
CN116437958A (zh) 2020-11-11 2023-07-14 吉利德科学公司 鉴定对采用gp120 CD4结合位点导向的抗体的疗法敏感的HIV患者的方法
WO2023154761A2 (en) * 2022-02-08 2023-08-17 The Wistar Institute Of Anatomy And Biology Modified primary immune cells for induction or enhancement of immunotherapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516527A (ja) * 2011-05-17 2014-07-17 ザ ロックフェラー ユニバーシティー ヒト免疫不全ウイルスを無毒化する抗体、およびその使用方法。
JP2015534982A (ja) * 2012-10-18 2015-12-07 ザ ロックフェラー ユニバーシティー 広域中和抗ｈｉｖ抗体
WO2016014484A1 (en) * 2014-07-21 2016-01-28 The Rockefeller University Combination of broadly neutralizing hiv antibodies and viral inducers
WO2018125813A1 (en) * 2016-12-27 2018-07-05 The Rockefeller University Broadly neutralizing anti-hiv-1 antibodies and methods of use thereof

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GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
FI903489A7 (fi) 1988-11-11 1990-07-10 Medical Res Council Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516527A (ja) * 2011-05-17 2014-07-17 ザ ロックフェラー ユニバーシティー ヒト免疫不全ウイルスを無毒化する抗体、およびその使用方法。
JP2015534982A (ja) * 2012-10-18 2015-12-07 ザ ロックフェラー ユニバーシティー 広域中和抗ｈｉｖ抗体
WO2016014484A1 (en) * 2014-07-21 2016-01-28 The Rockefeller University Combination of broadly neutralizing hiv antibodies and viral inducers
WO2018125813A1 (en) * 2016-12-27 2018-07-05 The Rockefeller University Broadly neutralizing anti-hiv-1 antibodies and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025527677A (ja) * 2022-08-26 2025-08-22 ギリアード サイエンシーズ， インコーポレイテッド 広域中和抗体のための投与及びスケジューリングレジメン

Also Published As

Publication number Publication date
KR20210060548A (ko) 2021-05-26
AU2019338454B9 (en) 2026-06-11
EP3849612A4 (en) 2022-07-06
KR102938690B1 (ko) 2026-03-13
US20220119504A1 (en) 2022-04-21
WO2020056145A1 (en) 2020-03-19
US12441782B2 (en) 2025-10-14
CN113271974B (zh) 2025-09-09
AU2019338454A1 (en) 2021-04-08
CN113271974A (zh) 2021-08-17
CA3112486A1 (en) 2020-03-19
CN121021680A (zh) 2025-11-28
EP3849612A1 (en) 2021-07-21
AU2019338454B2 (en) 2026-05-21
US20260049122A1 (en) 2026-02-19

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