JP2022521746A5 - - Google Patents

Info

Publication number
JP2022521746A5
JP2022521746A5 JP2021549312A JP2021549312A JP2022521746A5 JP 2022521746 A5 JP2022521746 A5 JP 2022521746A5 JP 2021549312 A JP2021549312 A JP 2021549312A JP 2021549312 A JP2021549312 A JP 2021549312A JP 2022521746 A5 JP2022521746 A5 JP 2022521746A5
Authority
JP
Japan
Prior art keywords
thio
piperidine
dione
oxoisoindorin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021549312A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022521746A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2020/076578 external-priority patent/WO2020173426A1/zh
Publication of JP2022521746A publication Critical patent/JP2022521746A/ja
Priority to JP2023199850A priority Critical patent/JP2024023405A/ja
Publication of JP2022521746A5 publication Critical patent/JP2022521746A5/ja
Pending legal-status Critical Current

Links

JP2021549312A 2019-02-25 2020-02-25 グルタルイミド骨格に基づく硫黄含有化合物及びその応用 Pending JP2022521746A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023199850A JP2024023405A (ja) 2019-02-25 2023-11-27 グルタルイミド骨格に基づく硫黄含有化合物及びその応用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910138460 2019-02-25
CN201910138460.3 2019-02-25
PCT/CN2020/076578 WO2020173426A1 (zh) 2019-02-25 2020-02-25 基于戊二酰亚胺骨架的含硫化合物及其应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023199850A Division JP2024023405A (ja) 2019-02-25 2023-11-27 グルタルイミド骨格に基づく硫黄含有化合物及びその応用

Publications (2)

Publication Number Publication Date
JP2022521746A JP2022521746A (ja) 2022-04-12
JP2022521746A5 true JP2022521746A5 (https=) 2025-12-22

Family

ID=72201479

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021549312A Pending JP2022521746A (ja) 2019-02-25 2020-02-25 グルタルイミド骨格に基づく硫黄含有化合物及びその応用
JP2023199850A Pending JP2024023405A (ja) 2019-02-25 2023-11-27 グルタルイミド骨格に基づく硫黄含有化合物及びその応用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023199850A Pending JP2024023405A (ja) 2019-02-25 2023-11-27 グルタルイミド骨格に基づく硫黄含有化合物及びその応用

Country Status (7)

Country Link
US (1) US12582641B2 (https=)
EP (1) EP3932922A4 (https=)
JP (2) JP2022521746A (https=)
KR (1) KR102746993B1 (https=)
CN (1) CN111606883B (https=)
AU (1) AU2020228803B2 (https=)
WO (1) WO2020173426A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018068906A2 (pt) 2016-03-16 2019-01-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo
WO2019196812A1 (zh) * 2018-04-09 2019-10-17 上海科技大学 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
CN112512589A (zh) * 2018-07-11 2021-03-16 H·李·莫菲特癌症中心研究有限公司 二聚体免疫调节化合物对抗基于cereblon的机制
CN111606883B (zh) 2019-02-25 2023-05-09 上海科技大学 基于戊二酰亚胺骨架的含硫化合物及其应用
CN111747924B (zh) * 2019-03-29 2023-11-10 华东师范大学 一类来那度胺/泊马度胺类似物及其应用
WO2021023233A1 (zh) 2019-08-05 2021-02-11 上海科技大学 Egfr蛋白降解剂及其抗肿瘤应用
AU2021226514B2 (en) * 2020-02-25 2023-10-19 Shanghaitech University Glutarimide skeleton-based compounds and application thereof
CN114456173B (zh) * 2020-11-10 2023-09-19 江苏恒瑞医药股份有限公司 稠环基取代的环己二酰亚胺类衍生物、其制备方法及其在医药上的应用
WO2023025136A1 (zh) * 2021-08-27 2023-03-02 杭州格博生物医药有限公司 异吲哚啉酮化合物及其用途
CN118019736A (zh) * 2022-09-08 2024-05-10 标新生物医药科技(上海)有限公司 基于cereblon蛋白设计的分子胶化合物及其应用
WO2024064358A1 (en) * 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN116284195B (zh) * 2023-02-08 2025-07-01 湖南欧亚药业有限公司 一种氟维司群的制备方法
CN117551057B (zh) * 2023-03-24 2026-04-10 浙江海正药业股份有限公司 苯并环类衍生物及其制备方法和用途
EP4722207A1 (en) * 2023-06-01 2026-04-08 Gluetacs Therapeutics (Shanghai) Co., Ltd. Oxoisoindolinyl-substituted tetrahydropyrimidinedione derivative and use thereof
WO2025016351A1 (zh) * 2023-07-14 2025-01-23 标新生物医药科技(上海)有限公司 基于硫代的戊二酰亚胺基异吲哚啉酮骨架的化合物及其应用
CN120787222A (zh) * 2024-02-04 2025-10-14 标新生物医药科技(上海)有限公司 基于取代的异吲哚啉酮新颖骨架化合物、含有其的双功能蛋白降解剂及它们的应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0739379B2 (ja) 1988-12-28 1995-05-01 クリンゲ・ファルマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トランス‐1,1,2‐トリフェニル―ブト‐1‐エン誘導体の製造方法
PL1633724T3 (pl) 2003-03-12 2011-10-31 Kudos Pharm Ltd Pochodne ftalazynonu
US7973057B2 (en) 2003-09-17 2011-07-05 The United States Of America As Represented By The Department Of Health And Human Services Thalidomide analogs
PT1794163E (pt) 2004-09-22 2010-03-01 Pfizer Método para a preparação de inibidores de poli(adpribose)- polimerases
JP4611444B2 (ja) 2007-01-10 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ(adp−リボース)ポリメラーゼ(parp)阻害剤としてのアミド置換インダゾール
MX2009010082A (es) 2007-03-20 2009-10-19 Celgene Corp Derivados y composiciones que comprenden isoindolina 4'-o-sustituida y metodos para utilizar la misma.
TWI389893B (zh) 2007-07-06 2013-03-21 Astellas Pharma Inc 二(芳胺基)芳基化合物
ES2424977T3 (es) 2007-08-08 2013-10-10 Glaxosmithkline Intellectual Property Development Limited Derivados de 2-[(2-{fenilamino}-1H-pirrolo[2,3-D]pirimidin-4-il)amino]benzamida como inhibidores de IGF-1R para el tratamiento del cáncer
MX353308B (es) 2008-05-21 2018-01-08 Ariad Pharma Inc Derivados fosforosos como inhibidores de cinasa.
ES2575084T3 (es) 2009-06-10 2016-06-24 Chugai Seiyaku Kabushiki Kaisha Compuesto tetracíclico
PL3202460T3 (pl) 2010-02-11 2019-12-31 Celgene Corporation Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
UY33539A (es) 2010-08-02 2012-02-29 Astrazeneca Ab Compuestos químicos alk
PL2625176T3 (pl) 2010-10-08 2017-08-31 Xcovery Holding Company Llc Podstawione związki 6-amino-pirydazyn-3-ylo-karboksyamidu jako modulatory kinazy białkowej
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
CN103396397A (zh) 2013-08-14 2013-11-20 中国人民解放军军事医学科学院毒物药物研究所 来那度胺衍生物及其作为药物的用途
CN103787802B (zh) * 2014-02-11 2015-08-19 华东师范大学 一类芳基烷基硫醚化合物及其合成方法
RU2738833C9 (ru) 2014-04-14 2022-02-28 Арвинас, Оперэйшнз, Инк. Имидные модуляторы протеолиза и способы их применения
US20160022642A1 (en) 2014-07-25 2016-01-28 Yale University Compounds Useful for Promoting Protein Degradation and Methods Using Same
AU2015305449B2 (en) * 2014-08-22 2021-05-06 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
NZ731789A (en) 2014-10-30 2019-04-26 Kangpu Biopharmaceuticals Ltd Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
CA2988414C (en) 2015-06-04 2023-09-26 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
BR112018008918A8 (pt) 2015-11-02 2019-02-26 Univ Yale compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos
WO2017117474A1 (en) 2015-12-30 2017-07-06 Dana-Farber Cancer Institute, Inc. Bifunctional compounds for her3 degradation and methods of use
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
SG11201808728QA (en) 2016-04-06 2018-11-29 Univ Michigan Regents Mdm2 protein degraders
EP3445765A4 (en) 2016-04-22 2019-09-18 Dana Farber Cancer Institute, Inc. DECREASE OF CYCLINE-DEPENDENT KINASE 4/6 (CDK4 / 6) BY CONJUGATION OF CDK4 / 6 INHIBITORS WITH E3-LIGASE LIGANDS AND METHODS OF USE
AU2017254713C1 (en) 2016-04-22 2021-04-29 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for degradation of EGFR and methods of use
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
CN106432104A (zh) 2016-05-16 2017-02-22 大连医科大学 金刚烷基喹唑啉化合物、组合物及其用途
CA3036834A1 (en) 2016-09-13 2018-03-22 The Regents Of The University Of Michigan Fused 1,4-oxazepines as bet protein degraders
CA3036841A1 (en) 2016-09-13 2018-03-22 The Regents Of The University Of Michigan Fused 1,4-diazepines as bet protein degraders
CN110506039A (zh) 2016-10-11 2019-11-26 阿尔维纳斯股份有限公司 用于雄激素受体靶向降解的化合物和方法
MX2019005007A (es) 2016-11-01 2019-07-18 Arvinas Inc Protac dirigidos a la proteína tau y métodos asociados de uso.
CA3042294A1 (en) 2016-11-22 2018-05-31 Dana-Farber Cancer Institute, Inc. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
BR112019011200B1 (pt) 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
JP2020505327A (ja) 2016-12-23 2020-02-20 アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. Egfrタンパク質分解標的化キメラ分子およびその関連する使用方法
KR20250117470A (ko) 2016-12-23 2025-08-04 아비나스 오퍼레이션스, 인코포레이티드 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
BR112019015312A2 (pt) 2017-01-26 2020-03-10 Arvinas Operations, Inc. Moduladores da proteólise pelo receptor de estrogênio e métodos de uso associados
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
AU2018351050B2 (en) 2017-10-18 2025-09-18 Novartis Ag Compositions and methods for selective protein degradation
CA3085645C (en) 2017-12-13 2024-01-16 Shanghaitech University Alk protein degraders and their use in cancer therapy
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019195609A2 (en) 2018-04-04 2019-10-10 Arvinas Operations, Inc. Modulators of proteolysis and associated methods of use
WO2019196812A1 (zh) * 2018-04-09 2019-10-17 上海科技大学 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
AU2019294835B2 (en) 2018-06-29 2025-04-17 Dana-Farber Cancer Institute, Inc. Ligands to cereblon (CRBN)
AU2019348094B2 (en) 2018-09-30 2022-12-22 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Isoindoline compound, preparation method, pharmaceutical composition and use thereof
WO2020114482A1 (zh) 2018-12-06 2020-06-11 中国科学院上海药物研究所 一类异吲哚啉类化合物、其制备方法、药物组合物及其应用
CN111606883B (zh) 2019-02-25 2023-05-09 上海科技大学 基于戊二酰亚胺骨架的含硫化合物及其应用
CN109928956B (zh) 2019-02-27 2020-10-13 杭州偶联医药科技有限公司 一种靶向泛素化降解egfr蛋白的化合物及其药物组合物和应用
WO2020198435A1 (en) 2019-03-26 2020-10-01 The Regents Of The University Of Michigan Small molecule degraders of stat3
CN110204532B (zh) 2019-05-15 2022-03-08 浙江工业大学 一种靶向egfr蛋白降解的化合物及其制备方法和应用
WO2021023233A1 (zh) * 2019-08-05 2021-02-11 上海科技大学 Egfr蛋白降解剂及其抗肿瘤应用
CN110512980B (zh) 2019-09-27 2024-08-30 苏州光格科技股份有限公司 一种防火门自动控制装置
WO2021113557A1 (en) 2019-12-04 2021-06-10 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
EP3835298B1 (en) 2019-12-12 2024-06-26 Accutar Biotechnology Inc. Novel chroman derivatives having estrogen receptor degradation activity and uses thereof
AU2021226514B2 (en) * 2020-02-25 2023-10-19 Shanghaitech University Glutarimide skeleton-based compounds and application thereof
CN113582980B (zh) * 2020-04-30 2023-11-24 上海科技大学 基于杂环和戊二酰亚胺骨架的化合物及其应用

Similar Documents

Publication Publication Date Title
JP2022521746A5 (https=)
US12344595B2 (en) 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors
US11878975B2 (en) Substituted indole compounds useful as TLR inhibitors
EP3288558B1 (en) Combinations of inhibitors of irak4 with inhibitors of btk
EP2101759B1 (en) Methods of using mek inhibitors
JP2025508703A5 (https=)
JP2022020003A5 (https=)
JP2019512505A5 (https=)
RU2472509C2 (ru) Способ лечения артрита
IL295799A (en) Trophomyosin receptor kinase (trk) degradation compounds and methods of use
CA2515343A1 (en) Antiparasitic terpene alkaloids
JP2021524484A5 (https=)
WO2018057973A4 (en) Compounds and methods for ido and tdo modulation, and indications therefor
US20080182845A1 (en) Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
TWI780061B (zh) 吲哚啉酮化合物之用途
BR112020021552A2 (pt) Compostos de 4-aminoisoindolina-1,3-diona substituídos, suas composições e métodos de tratamento com os mesmos
AU2018233402A1 (en) Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders
JP2011524363A5 (https=)
RU2008144584A (ru) 4,5-дигидро-[1,2,4]триазоло[4,3-f]птеридины в качестве ингибиторов протеинкиназы plk1 для лечения пролиферативных заболеваний
JP2009541223A5 (https=)
RU2014110623A (ru) Пирролопиразиновые ингибиторы киназы
RU2348628C2 (ru) Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
CN114555589B (zh) 用于抑制ezh2的化合物和组合物
JPWO2021060453A5 (https=)
JP2024505558A5 (https=)