JP2022521746A - グルタルイミド骨格に基づく硫黄含有化合物及びその応用 - Google Patents

グルタルイミド骨格に基づく硫黄含有化合物及びその応用 Download PDF

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JP2022521746A
JP2022521746A JP2021549312A JP2021549312A JP2022521746A JP 2022521746 A JP2022521746 A JP 2022521746A JP 2021549312 A JP2021549312 A JP 2021549312A JP 2021549312 A JP2021549312 A JP 2021549312A JP 2022521746 A JP2022521746 A JP 2022521746A
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thio
piperidine
dione
oxoisoindoline
amino
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JP2022521746A5 (https=
JPWO2020173426A5 (https=
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小宝 楊
標 姜
星 仇
寧 孫
仁紅 孫
林義 劉
超偉 任
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ShanghaiTech University
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ShanghaiTech University
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
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JP2021549312A 2019-02-25 2020-02-25 グルタルイミド骨格に基づく硫黄含有化合物及びその応用 Pending JP2022521746A (ja)

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PCT/CN2020/076578 WO2020173426A1 (zh) 2019-02-25 2020-02-25 基于戊二酰亚胺骨架的含硫化合物及其应用

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JP2023525951A (ja) * 2020-02-25 2023-06-20 シャンハイテック ユニバーシティ グルタルイミド骨格に基づく化合物及びその使用
US12564638B2 (en) 2019-08-05 2026-03-03 Shanghaitech University EGFR protein degradant and anti-tumor application thereof
US12582641B2 (en) 2019-02-25 2026-03-24 Shanghaitech University Sulfur-containing compound based on glutarimide skeleton and application thereof

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CN110357889B (zh) * 2018-04-09 2022-03-15 上海科技大学 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
BR112021000395A2 (pt) 2018-07-11 2021-04-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Compostos imunomoduladores diméricos contra mecanismos baseados em cereblon
CN111747924B (zh) * 2019-03-29 2023-11-10 华东师范大学 一类来那度胺/泊马度胺类似物及其应用
CN114456173B (zh) * 2020-11-10 2023-09-19 江苏恒瑞医药股份有限公司 稠环基取代的环己二酰亚胺类衍生物、其制备方法及其在医药上的应用
WO2023025136A1 (zh) * 2021-08-27 2023-03-02 杭州格博生物医药有限公司 异吲哚啉酮化合物及其用途
CN118019736A (zh) * 2022-09-08 2024-05-10 标新生物医药科技(上海)有限公司 基于cereblon蛋白设计的分子胶化合物及其应用
WO2024064358A1 (en) * 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN116284195B (zh) * 2023-02-08 2025-07-01 湖南欧亚药业有限公司 一种氟维司群的制备方法
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