JP2024505558A5 - - Google Patents
Info
- Publication number
- JP2024505558A5 JP2024505558A5 JP2023546433A JP2023546433A JP2024505558A5 JP 2024505558 A5 JP2024505558 A5 JP 2024505558A5 JP 2023546433 A JP2023546433 A JP 2023546433A JP 2023546433 A JP2023546433 A JP 2023546433A JP 2024505558 A5 JP2024505558 A5 JP 2024505558A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- pyrimidine
- piperazine
- piperidine
- dioxopiperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163145126P | 2021-02-03 | 2021-02-03 | |
| US63/145,126 | 2021-02-03 | ||
| PCT/US2022/014830 WO2022169798A2 (en) | 2021-02-03 | 2022-02-02 | Substituted pyrrolopyrimidine and pyrazolopyrimidine as bruton's tyrosine kinase (btk) degraders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024505558A JP2024505558A (ja) | 2024-02-06 |
| JP2024505558A5 true JP2024505558A5 (https=) | 2025-02-10 |
Family
ID=80447078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023546433A Pending JP2024505558A (ja) | 2021-02-03 | 2022-02-02 | ブルトン型チロシンキナーゼ（ｂｔｋ）分解剤としての置換ピロロピリミジンおよびピラゾロピリミジン |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20240132502A1 (https=) |
| EP (2) | EP4501327A3 (https=) |
| JP (1) | JP2024505558A (https=) |
| KR (1) | KR20230142539A (https=) |
| CN (1) | CN117042769A (https=) |
| CA (1) | CA3209082A1 (https=) |
| DK (1) | DK4039688T3 (https=) |
| ES (1) | ES3010513T3 (https=) |
| FI (1) | FI4039688T3 (https=) |
| MX (1) | MX2023008865A (https=) |
| WO (1) | WO2022169798A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202317099A (zh) * | 2020-09-10 | 2023-05-01 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN118434717A (zh) * | 2021-12-20 | 2024-08-02 | 西格马-奥尔德里奇有限责任公司 | 化学接头 |
| WO2024169871A1 (zh) * | 2023-02-17 | 2024-08-22 | 江苏威凯尔医药科技有限公司 | Btk抑制剂及其用途 |
| WO2024244888A1 (zh) * | 2023-05-26 | 2024-12-05 | 广东弘烨医药科技有限公司 | 9元杂芳基化合物、含其的药物组合物及其制备方法和应用 |
| AU2024298923A1 (en) | 2023-07-25 | 2026-01-22 | Monte Rosa Therapeutics Ag | Substituted piperidinediones for targeted protein degradation |
| CN120535526A (zh) * | 2024-02-26 | 2025-08-26 | 中国药科大学 | 直接结合蛋白酶体的非泛素依赖型蛋白水解靶向嵌合体NuTAC及其应用 |
| WO2026040951A1 (zh) * | 2024-08-19 | 2026-02-26 | 深圳市塔吉瑞生物医药股份有限公司 | 靶向btk蛋白降解靶向嵌合体类化合物及其组合物及用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114946A (en) | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| US4818541A (en) | 1987-08-19 | 1989-04-04 | Schering Corporation | Transdermal delivery of enantiomers of phenylpropanolamine |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| CN106146511A (zh) * | 2015-04-03 | 2016-11-23 | 安润医药科技（苏州）有限公司 | 吡唑并嘧啶衍生物、制备方法、药物组合物及用途 |
| JP7337502B2 (ja) * | 2015-09-16 | 2023-09-04 | ロクソ オンコロジー， インコーポレイテッド | がんの治療のためのｂｔｋ阻害剤としてのピラゾロピリミジン誘導体 |
| ES2965081T3 (es) * | 2016-07-07 | 2024-04-11 | Daewoong Pharmaceutical Co Ltd | Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados |
| TW201811795A (zh) * | 2016-08-24 | 2018-04-01 | 美商亞闊股份有限公司 | 胺基－吡咯并嘧啶酮化合物及其用途 |
| EP3765026A4 (en) * | 2018-03-10 | 2021-12-22 | Yale University | BTK PROTEOLYSIS MODULATORS AND METHODS FOR USE |
| WO2020023851A1 (en) * | 2018-07-26 | 2020-01-30 | Yale University | Bifunctional substitued pyrimidines as modulators of fak proteolyse |
| CN113544130B (zh) * | 2019-05-31 | 2024-01-09 | 西藏海思科制药有限公司 | 一种btk抑制剂环衍生物及其制备方法和药学上的应用 |
| WO2020252397A1 (en) * | 2019-06-12 | 2020-12-17 | Baylor College Of Medicine | Small molecule proteolysis-targeting chimeras and methods of use thereof |
| CN112812100B (zh) * | 2019-11-18 | 2022-04-05 | 四川海思科制药有限公司 | 一种具有降解btk激酶的化合物及其制备方法和药学上的应用 |
| CN112979656A (zh) * | 2019-12-12 | 2021-06-18 | 上海美志医药科技有限公司 | 一类靶向降解btk蛋白的化合物 |
-
2022
- 2022-02-02 EP EP24204895.7A patent/EP4501327A3/en active Pending
- 2022-02-02 CA CA3209082A patent/CA3209082A1/en active Pending
- 2022-02-02 MX MX2023008865A patent/MX2023008865A/es unknown
- 2022-02-02 EP EP22154786.2A patent/EP4039688B1/en active Active
- 2022-02-02 US US18/263,656 patent/US20240132502A1/en active Pending
- 2022-02-02 FI FIEP22154786.2T patent/FI4039688T3/fi active
- 2022-02-02 WO PCT/US2022/014830 patent/WO2022169798A2/en not_active Ceased
- 2022-02-02 US US17/591,051 patent/US11530222B2/en active Active
- 2022-02-02 ES ES22154786T patent/ES3010513T3/es active Active
- 2022-02-02 KR KR1020237029298A patent/KR20230142539A/ko active Pending
- 2022-02-02 JP JP2023546433A patent/JP2024505558A/ja active Pending
- 2022-02-02 CN CN202280022626.5A patent/CN117042769A/zh active Pending
- 2022-02-02 DK DK22154786.2T patent/DK4039688T3/da active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024505558A5 (https=) | ||
| AU2020333251B2 (en) | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors | |
| JP7755488B2 (ja) | 統合的ストレス経路の調節剤としての置換シクロアルキル | |
| JP7273172B2 (ja) | Ｈｐｋ１阻害活性を有する置換６－アザベンゾイミダゾール化合物 | |
| TWI737635B (zh) | 作為mdm2－p53抑制劑之新穎螺﹝3h－吲哚－3，2´－吡咯啶﹞－2（1h）－酮化合物及其衍生物 | |
| JP2024009851A (ja) | Ｐｄ－１／ｐｄ－ｌ１阻害剤 | |
| JP2023504147A (ja) | ユビキチンプロテオソーム経路を介したｂｔｋの分解のための二官能性化合物 | |
| JP6585158B2 (ja) | ヤヌスキナーゼの阻害に有用なピロロ［２，３−ｄ］ピリミジン誘導体 | |
| AU2019257450A1 (en) | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are JAK inhibitors | |
| JP6636539B2 (ja) | 変形性関節症の治療のためのａｄａｍｔｓ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体 | |
| JP2017520607A5 (https=) | ||
| JP2022517189A (ja) | 癌疾患の処置のためのエンドリボヌクレアーゼのイノシトール要求酵素ｉ（ｉｒｅｉアルファ）の阻害剤としてのピリド－ピリミジノン化合物及びプテリジノン化合物 | |
| CA3031063A1 (en) | Benzo-quinolizin-2oxo carboxylic acid derivatives for the treatment of hbv infection | |
| JP2022536540A (ja) | アミノピリミジンアミドオートファジー阻害剤およびその使用方法 | |
| AU2017286654A1 (en) | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | |
| TW201701879A (zh) | Ｉｒａｋ４抑制劑組合 | |
| ES2655971T9 (es) | Compuestos de aminopirimidinilo como inhibidores de JAK | |
| CN108430993A (zh) | Tank-结合激酶抑制剂化合物 | |
| TW201840549A (zh) | 2-雜芳基-3-氧代-2,3-二氫噠嗪-4-甲醯胺 | |
| AU2018233402A1 (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders | |
| JP2019112433A (ja) | ４−アザインドール誘導体 | |
| TWI831829B (zh) | 苯氧基-吡啶基-嘧啶化合物及使用方法 | |
| AU2016335086B2 (en) | Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors | |
| JP2018535927A (ja) | 抗がん活性を有するｍｄｍ２−ｐ５３相互作用のイソインドリノン阻害剤 | |
| WO2023049886A1 (en) | Imidazopyridazine il-17 inhibitor compounds |