MX2023008865A - Pirrolopirimidina y pirazolopirimidina sustituidas como degradadores de tirosina cinasa de bruton (btk). - Google Patents
Pirrolopirimidina y pirazolopirimidina sustituidas como degradadores de tirosina cinasa de bruton (btk).Info
- Publication number
- MX2023008865A MX2023008865A MX2023008865A MX2023008865A MX2023008865A MX 2023008865 A MX2023008865 A MX 2023008865A MX 2023008865 A MX2023008865 A MX 2023008865A MX 2023008865 A MX2023008865 A MX 2023008865A MX 2023008865 A MX2023008865 A MX 2023008865A
- Authority
- MX
- Mexico
- Prior art keywords
- btk
- bruton
- tyrosine kinase
- degraders
- pyrazolopyrimidine
- Prior art date
Links
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title abstract 4
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title abstract 4
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
- 239000001064 degrader Substances 0.000 title 1
- 150000004944 pyrrolopyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción se relaciona con compuestos novedosos que degradan tirosina cinasa de Bruton (BTK), composiciones farmacéuticas que contienen esos compuestos y su uso en la prevención y tratamiento de condiciones moduladas por la BTK.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163145126P | 2021-02-03 | 2021-02-03 | |
| PCT/US2022/014830 WO2022169798A2 (en) | 2021-02-03 | 2022-02-02 | Substituted pyrrolopyrimidine and pyrazolopyrimidine as bruton's tyrosine kinase (btk) degraders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023008865A true MX2023008865A (es) | 2023-08-31 |
Family
ID=80447078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023008865A MX2023008865A (es) | 2021-02-03 | 2022-02-02 | Pirrolopirimidina y pirazolopirimidina sustituidas como degradadores de tirosina cinasa de bruton (btk). |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11530222B2 (es) |
| EP (1) | EP4039688B1 (es) |
| JP (1) | JP2024505558A (es) |
| KR (1) | KR20230142539A (es) |
| CN (1) | CN117042769A (es) |
| CA (1) | CA3209082A1 (es) |
| MX (1) | MX2023008865A (es) |
| WO (1) | WO2022169798A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122481A2 (en) * | 2021-12-20 | 2023-06-29 | Sigma-Aldrich Co. Llc | Chemical linkers |
| WO2024169871A1 (zh) * | 2023-02-17 | 2024-08-22 | 江苏威凯尔医药科技有限公司 | Btk抑制剂及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114946A (en) | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| US4818541A (en) | 1987-08-19 | 1989-04-04 | Schering Corporation | Transdermal delivery of enantiomers of phenylpropanolamine |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| AU2016322063A1 (en) * | 2015-09-16 | 2018-04-12 | Loxo Oncology, Inc. | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer |
| EP3481831B1 (en) * | 2016-07-07 | 2023-09-06 | Daewoong Pharmaceutical Co., Ltd. | 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same |
| US11020398B2 (en) * | 2016-08-24 | 2021-06-01 | Arqule, Inc. | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| US11028088B2 (en) * | 2018-03-10 | 2021-06-08 | Yale University | Modulators of BTK proteolysis and methods of use |
| WO2020023851A1 (en) * | 2018-07-26 | 2020-01-30 | Yale University | Bifunctional substitued pyrimidines as modulators of fak proteolyse |
| WO2020252397A1 (en) * | 2019-06-12 | 2020-12-17 | Baylor College Of Medicine | Small molecule proteolysis-targeting chimeras and methods of use thereof |
| CN112812100B (zh) * | 2019-11-18 | 2022-04-05 | 四川海思科制药有限公司 | 一种具有降解btk激酶的化合物及其制备方法和药学上的应用 |
| CN112979656A (zh) * | 2019-12-12 | 2021-06-18 | 上海美志医药科技有限公司 | 一类靶向降解btk蛋白的化合物 |
-
2022
- 2022-02-02 EP EP22154786.2A patent/EP4039688B1/en active Active
- 2022-02-02 US US17/591,051 patent/US11530222B2/en active Active
- 2022-02-02 MX MX2023008865A patent/MX2023008865A/es unknown
- 2022-02-02 JP JP2023546433A patent/JP2024505558A/ja active Pending
- 2022-02-02 KR KR1020237029298A patent/KR20230142539A/ko unknown
- 2022-02-02 CA CA3209082A patent/CA3209082A1/en active Pending
- 2022-02-02 US US18/263,656 patent/US20240132502A1/en active Pending
- 2022-02-02 WO PCT/US2022/014830 patent/WO2022169798A2/en active Application Filing
- 2022-02-02 CN CN202280022626.5A patent/CN117042769A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3209082A1 (en) | 2022-08-11 |
| WO2022169798A3 (en) | 2022-09-22 |
| US20240132502A1 (en) | 2024-04-25 |
| WO2022169798A2 (en) | 2022-08-11 |
| JP2024505558A (ja) | 2024-02-06 |
| US11530222B2 (en) | 2022-12-20 |
| US20220259207A1 (en) | 2022-08-18 |
| EP4039688A3 (en) | 2022-11-23 |
| EP4039688B1 (en) | 2024-10-09 |
| EP4039688A2 (en) | 2022-08-10 |
| KR20230142539A (ko) | 2023-10-11 |
| CN117042769A (zh) | 2023-11-10 |
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