WO2018074862A3 - Tha를 유효성분으로 포함하는 유방암 치료용 약학적 조성물 - Google Patents

Tha를 유효성분으로 포함하는 유방암 치료용 약학적 조성물 Download PDF

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WO2018074862A3
WO2018074862A3 PCT/KR2017/011595 KR2017011595W WO2018074862A3 WO 2018074862 A3 WO2018074862 A3 WO 2018074862A3 KR 2017011595 W KR2017011595 W KR 2017011595W WO 2018074862 A3 WO2018074862 A3 WO 2018074862A3
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breast cancer
tha
active ingredient
pharmaceutical composition
treating breast
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PCT/KR2017/011595
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English (en)
French (fr)
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WO2018074862A2 (ko
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강건욱
오광석
김용철
정성백
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한국유나이티드제약 주식회사
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Priority to US16/343,494 priority Critical patent/US11793772B2/en
Priority to JP2019521019A priority patent/JP6883101B2/ja
Publication of WO2018074862A2 publication Critical patent/WO2018074862A2/ko
Publication of WO2018074862A3 publication Critical patent/WO2018074862A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A23V2250/2112—Curcumin, turmeric

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 THA (2,4,6-trihydroxyacetophenone)를 유효성분으로 포함하는 유방암 예방, 개선, 또는 치료용 조성물에 관한 것으로서, 보다 구체적으로 본 발명의 조성물은 Plk1 (Polo-like kinase 1)의 활성을 억제함으로써 유방암 치료에 우수한 효과를 나타내므로, 유방암에 대한 예방, 개선, 및 치료 용도로 이용할 수 있을 것으로 기대된다.
PCT/KR2017/011595 2016-10-21 2017-10-19 Tha를 유효성분으로 포함하는 유방암 치료용 약학적 조성물 WO2018074862A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16/343,494 US11793772B2 (en) 2016-10-21 2017-10-19 Pharmaceutical composition comprising THA as active ingredient for treating breast cancer
JP2019521019A JP6883101B2 (ja) 2016-10-21 2017-10-19 Ｔｈａを有効成分として含む乳癌治療用薬学的組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0137599 2016-10-21
KR1020160137599A KR101819509B1 (ko) 2016-10-21 2016-10-21 Tha를 유효성분으로 포함하는 유방암 또는 호르몬 저항성 유방암 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2018074862A2 WO2018074862A2 (ko) 2018-04-26
WO2018074862A3 true WO2018074862A3 (ko) 2018-08-09

Family

ID=61025834

Family Applications (1)

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PCT/KR2017/011595 WO2018074862A2 (ko) 2016-10-21 2017-10-19 Tha를 유효성분으로 포함하는 유방암 치료용 약학적 조성물

Country Status (4)

Country Link
US (1) US11793772B2 (ko)
JP (1) JP6883101B2 (ko)
KR (1) KR101819509B1 (ko)
WO (1) WO2018074862A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102404681B1 (ko) 2018-01-10 2022-06-07 한국유나이티드제약 주식회사 Tha를 유효성분으로 포함하는 전립선암 치료용 약학적 조성물
KR102076263B1 (ko) 2019-09-20 2020-02-11 서울대학교산학협력단 셀레노사마필린 a를 유효성분으로 포함하는 유방암 예방 및 치료용 조성물
CN113633740B (zh) * 2021-08-23 2022-10-04 湖南中医药大学 用于治疗乳腺结节的中药组合物、中药制剂和中药制品

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060074108A1 (en) * 2004-10-04 2006-04-06 Bioderm Research Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101494280B1 (ko) 2012-12-28 2015-02-23 한국화학연구원 콜치신 유도체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물
KR102001957B1 (ko) 2013-02-25 2019-07-19 한국화학연구원 8-하이드록시-7-아이오도-5-퀴놀린설폰산 또는 1-(2,4,6-트리하이드록시페닐)프로판-1-온을 유효성분으로 포함하는 암 치료 또는 예방용 약학적 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060074108A1 (en) * 2004-10-04 2006-04-06 Bioderm Research Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHO, M.-Y. ET AL.: "Geranyl Derivative of Phloroacetophenone Induces Cancer Cell -specific Apoptosis through Bax-mediated Mitochondrial Pathway in MCF-7 Human Breast Cancer Cells", BIOLOGICAL AND PHARMACEUTICAL BULLETI N, vol. 35, no. 1, 2012, pages 98 - 104, XP055535531 *
CHO, M.-Y.: "Apoptosis-inducing Activity of Synthetic Polyphenol Compound, 3-geranyl-2,4,6-trihydroxyacetophenone, in MCF-7 and Adriamycin-resistant MCF-7 Breast Cancer Cells", THESIS, 2009 *
FERREIRA, E. A. ET AL.: "The 2',4',6'-trihydroxyacetophenone Isolated from Myrcia Multiflora Has Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption", PLANTA MEDICA, vol. 77, no. 14, 2011, pages 1569 - 1574, XP055535535 *
REZK, B. M. ET AL.: "The Antioxidant Activity of Phloretin: the Disclosure of a New Antioxidant Pharmacophore in Flavonoids", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 295, no. 1, 2002, pages 9 - 13, XP055535541 *

Also Published As

Publication number Publication date
WO2018074862A2 (ko) 2018-04-26
JP6883101B2 (ja) 2021-06-09
KR101819509B1 (ko) 2018-01-17
US11793772B2 (en) 2023-10-24
US20190262281A1 (en) 2019-08-29
JP2019535666A (ja) 2019-12-12

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