JP2022521413A - Ｓｙｋ阻害剤としての縮合ピラジンの固体形態 - Google Patents

Ｓｙｋ阻害剤としての縮合ピラジンの固体形態 Download PDF

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JP2022521413A
JP2022521413A JP2021549463A JP2021549463A JP2022521413A JP 2022521413 A JP2022521413 A JP 2022521413A JP 2021549463 A JP2021549463 A JP 2021549463A JP 2021549463 A JP2021549463 A JP 2021549463A JP 2022521413 A JP2022521413 A JP 2022521413A
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compound
ray powder
substantially shown
crystal
curve
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JP2022521413A5 (enExample
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パトリシア アンドレス，
ピーター チー‐チュ ファン，
ピエール ギグア，
チアジェン ライ，
クレイグ スチュワート，
ジン テン，
ドゥオン ディー． トラン，
イヴァ トラントチェバ，
ブライアン ヤルマック，
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クロノス バイオ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021549463A 2019-02-22 2020-02-20 Ｓｙｋ阻害剤としての縮合ピラジンの固体形態 Pending JP2022521413A (ja)

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US201962809337P 2019-02-22 2019-02-22
US62/809,337 2019-02-22
PCT/US2020/019071 WO2020172431A1 (en) 2019-02-22 2020-02-20 Solid forms of condensed pyrazines as syk inhibitors

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JP2022521413A true JP2022521413A (ja) 2022-04-07
JP2022521413A5 JP2022521413A5 (enExample) 2023-02-28

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US (3) US11339168B2 (enExample)
EP (1) EP3927708A1 (enExample)
JP (1) JP2022521413A (enExample)
KR (1) KR20210131372A (enExample)
CN (1) CN113950479A (enExample)
AU (1) AU2020225455A1 (enExample)
CA (1) CA3130848A1 (enExample)
MX (1) MX2021010131A (enExample)
TW (1) TW202045510A (enExample)
WO (1) WO2020172431A1 (enExample)
ZA (1) ZA202106014B (enExample)

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TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US20240285621A1 (en) 2020-09-23 2024-08-29 Nerviano Medical Sciences S.R.L. Pyrazolyl-pyrimidine derivatives as kinase inhibitors
CN112939983A (zh) * 2021-02-01 2021-06-11 暨明医药科技（苏州）有限公司 一种SYK激酶抑制剂Lanraplenib的合成方法
EP4646412A1 (en) * 2022-12-09 2025-11-12 Kronos Bio, Inc. Crystalline forms of lanraplenib and methods of making and using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515729A (ja) * 2009-12-23 2013-05-09 武田薬品工業株式会社 Ｓｙｋ阻害剤としての縮合複素芳香族ピロリジノン
JP2017501229A (ja) * 2013-12-23 2017-01-12 ギリアード サイエンシーズ， インコーポレイテッド Ｓｙｋ阻害剤

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