KR20210131372A - Syk 억제제로서의 축합된 피라진의 고체 형태 - Google Patents

Syk 억제제로서의 축합된 피라진의 고체 형태 Download PDF

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KR20210131372A
KR20210131372A KR1020217029790A KR20217029790A KR20210131372A KR 20210131372 A KR20210131372 A KR 20210131372A KR 1020217029790 A KR1020217029790 A KR 1020217029790A KR 20217029790 A KR20217029790 A KR 20217029790A KR 20210131372 A KR20210131372 A KR 20210131372A
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compound
ray powder
sesqui
powder diffractogram
mono
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Korean (ko)
Inventor
파트리샤 안드레스
피터 씨. 펑
피에르 지게어
치아젠 라이
크레이그 스튜어트
징 텅
두옹 디. 트란
이바 트란체바
브라이언 야르무치
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크로노스 바이오, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217029790A 2019-02-22 2020-02-20 Syk 억제제로서의 축합된 피라진의 고체 형태 Ceased KR20210131372A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962809337P 2019-02-22 2019-02-22
US62/809,337 2019-02-22
PCT/US2020/019071 WO2020172431A1 (en) 2019-02-22 2020-02-20 Solid forms of condensed pyrazines as syk inhibitors

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KR20210131372A true KR20210131372A (ko) 2021-11-02

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KR1020217029790A Ceased KR20210131372A (ko) 2019-02-22 2020-02-20 Syk 억제제로서의 축합된 피라진의 고체 형태

Country Status (11)

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US (3) US11339168B2 (enExample)
EP (1) EP3927708A1 (enExample)
JP (1) JP2022521413A (enExample)
KR (1) KR20210131372A (enExample)
CN (1) CN113950479A (enExample)
AU (1) AU2020225455A1 (enExample)
CA (1) CA3130848A1 (enExample)
MX (1) MX2021010131A (enExample)
TW (1) TW202045510A (enExample)
WO (1) WO2020172431A1 (enExample)
ZA (1) ZA202106014B (enExample)

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Publication number Priority date Publication date Assignee Title
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
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CN112939983A (zh) * 2021-02-01 2021-06-11 暨明医药科技（苏州）有限公司 一种SYK激酶抑制剂Lanraplenib的合成方法
EP4646412A1 (en) * 2022-12-09 2025-11-12 Kronos Bio, Inc. Crystalline forms of lanraplenib and methods of making and using the same

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