JP2022502431A - スルホマレイミドに基づくリンカーおよび対応する複合体 - Google Patents

スルホマレイミドに基づくリンカーおよび対応する複合体 Download PDF

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JP2022502431A
JP2022502431A JP2021517292A JP2021517292A JP2022502431A JP 2022502431 A JP2022502431 A JP 2022502431A JP 2021517292 A JP2021517292 A JP 2021517292A JP 2021517292 A JP2021517292 A JP 2021517292A JP 2022502431 A JP2022502431 A JP 2022502431A
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seq
antibody
group
alkyl
linker
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JP2022502431A5 (https=
JPWO2020065408A5 (https=
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ミシェル、ペレス
フレデリク、マリオン
ジャン−フランソワ、アウー
シリル、ドレフュス
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ピエール、ファーブル、メディカマン
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Publication of JP2022502431A5 publication Critical patent/JP2022502431A5/ja
Publication of JPWO2020065408A5 publication Critical patent/JPWO2020065408A5/ja
Priority to JP2024106489A priority Critical patent/JP7830555B2/ja
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
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  • Epidemiology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Genetics & Genomics (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2021517292A 2018-09-27 2019-09-27 スルホマレイミドに基づくリンカーおよび対応する複合体 Pending JP2022502431A (ja)

Priority Applications (1)

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JP2024106489A JP7830555B2 (ja) 2018-09-27 2024-07-01 スルホマレイミドに基づくリンカーおよび対応する複合体

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Application Number Priority Date Filing Date Title
EP18306270 2018-09-27
EP18306270.2 2018-09-27
PCT/IB2019/001114 WO2020065408A1 (en) 2018-09-27 2019-09-27 Sulfomaleimide-based linkers and corresponding conjugates

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JP2024106489A Division JP7830555B2 (ja) 2018-09-27 2024-07-01 スルホマレイミドに基づくリンカーおよび対応する複合体

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