KR102858995B1 - 설포말레이미드계 링커 및 상응하는 컨쥬게이트 - Google Patents

설포말레이미드계 링커 및 상응하는 컨쥬게이트

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Publication number
KR102858995B1
KR102858995B1 KR1020217012389A KR20217012389A KR102858995B1 KR 102858995 B1 KR102858995 B1 KR 102858995B1 KR 1020217012389 A KR1020217012389 A KR 1020217012389A KR 20217012389 A KR20217012389 A KR 20217012389A KR 102858995 B1 KR102858995 B1 KR 102858995B1
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residue
alkyl
independently
chemical formula
antibody
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KR20210065991A (ko
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미쉘 쁘르
프레데릭 마리옹
쟝-프랑끄와 아오
씨리으 드르이퓌
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피에르 파브르 메디카먼트
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020217012389A 2018-09-27 2019-09-27 설포말레이미드계 링커 및 상응하는 컨쥬게이트 Active KR102858995B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18306270 2018-09-27
EP18306270.2 2018-09-27
PCT/IB2019/001114 WO2020065408A1 (en) 2018-09-27 2019-09-27 Sulfomaleimide-based linkers and corresponding conjugates

Publications (2)

Publication Number Publication Date
KR20210065991A KR20210065991A (ko) 2021-06-04
KR102858995B1 true KR102858995B1 (ko) 2025-09-11

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