JP2022502431A5 - - Google Patents
Info
- Publication number
- JP2022502431A5 JP2022502431A5 JP2021517292A JP2021517292A JP2022502431A5 JP 2022502431 A5 JP2022502431 A5 JP 2022502431A5 JP 2021517292 A JP2021517292 A JP 2021517292A JP 2021517292 A JP2021517292 A JP 2021517292A JP 2022502431 A5 JP2022502431 A5 JP 2022502431A5
- Authority
- JP
- Japan
- Prior art keywords
- integer
- formula
- alkyl
- ch2ch2o
- cycloalkanediyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024106489A JP7830555B2 (ja) | 2018-09-27 | 2024-07-01 | スルホマレイミドに基づくリンカーおよび対応する複合体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306270.2 | 2018-09-27 | ||
| EP18306270 | 2018-09-27 | ||
| PCT/IB2019/001114 WO2020065408A1 (en) | 2018-09-27 | 2019-09-27 | Sulfomaleimide-based linkers and corresponding conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024106489A Division JP7830555B2 (ja) | 2018-09-27 | 2024-07-01 | スルホマレイミドに基づくリンカーおよび対応する複合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022502431A JP2022502431A (ja) | 2022-01-11 |
| JP2022502431A5 true JP2022502431A5 (https=) | 2022-10-11 |
Family
ID=63857832
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517292A Pending JP2022502431A (ja) | 2018-09-27 | 2019-09-27 | スルホマレイミドに基づくリンカーおよび対応する複合体 |
| JP2024106489A Active JP7830555B2 (ja) | 2018-09-27 | 2024-07-01 | スルホマレイミドに基づくリンカーおよび対応する複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024106489A Active JP7830555B2 (ja) | 2018-09-27 | 2024-07-01 | スルホマレイミドに基づくリンカーおよび対応する複合体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12011485B2 (https=) |
| EP (1) | EP3856258B1 (https=) |
| JP (2) | JP2022502431A (https=) |
| KR (1) | KR102858995B1 (https=) |
| CN (1) | CN113453724B (https=) |
| AU (1) | AU2019350536B2 (https=) |
| BR (1) | BR112021005655A2 (https=) |
| CA (1) | CA3113378C (https=) |
| MX (1) | MX2021003295A (https=) |
| WO (1) | WO2020065408A1 (https=) |
| ZA (1) | ZA202101990B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201908886D0 (en) * | 2019-06-20 | 2019-08-07 | Almac Discovery Ltd | Anthracycline derivatives |
| WO2024008102A1 (en) * | 2022-07-05 | 2024-01-11 | Wuxi Xdc (Shanghai) Co., Ltd. | Linker for conjugation |
| WO2024235120A1 (zh) * | 2023-05-12 | 2024-11-21 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和用途 |
| CN119751374A (zh) * | 2024-12-09 | 2025-04-04 | 中国科学院水生生物研究所 | 高抑菌活性、低生态毒性的异噻唑啉酮类化合物及其制备方法和应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4127687A (en) * | 1976-07-19 | 1978-11-28 | Rohm And Haas Company | Prevention of fouling of marine structures such as boat hulls |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| JPH04248881A (ja) | 1991-01-25 | 1992-09-04 | Mitsubishi Kasei Corp | 顔料分散型水性記録液 |
| JPH04261476A (ja) | 1991-02-15 | 1992-09-17 | Mitsubishi Kasei Corp | インクジェットプリンター用クリーニング液 |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| TW258789B (https=) | 1992-09-28 | 1995-10-01 | Rohm & Haas | |
| KR20070110327A (ko) * | 2005-03-08 | 2007-11-16 | 미쓰비시 가가꾸 가부시키가이샤 | 이방성 색소 필름용 조성물, 이방성 색소 필름 및 편광소자 |
| JP2007025635A (ja) * | 2005-06-17 | 2007-02-01 | Fujitsu Hitachi Plasma Display Ltd | プラズマディスプレイ装置及びその処理方法 |
| US20060293374A1 (en) | 2005-06-24 | 2006-12-28 | Beers Scott A | Substituted isothiazolones |
| CN101397280A (zh) | 2008-11-04 | 2009-04-01 | 东华大学 | 反应性异噻唑啉酮类抗菌整理剂的制备方法 |
| DE102012213321A1 (de) * | 2012-07-30 | 2014-01-30 | Robert Bosch Gmbh | Verfahren und Vorrichtung zum Betreiben eines Fahrzeugs |
| FR3005051A1 (fr) | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| US9840533B2 (en) | 2013-04-29 | 2017-12-12 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| US10781259B2 (en) * | 2013-06-06 | 2020-09-22 | Magenta Therapeutics, Inc. | Modified antibodies and related compounds, compositions, and methods of use |
| CN106456602B (zh) | 2014-03-27 | 2020-11-24 | 范德比尔特大学 | 取代的吲哚mcl-1抑制剂 |
| HRP20190888T8 (hr) | 2014-04-25 | 2019-10-04 | Pierre Fabre Médicament | Konjugat antitijela za igf-1r i lijeka i njegova upotreba u liječenju karcinoma |
| HUE047952T2 (hu) | 2014-04-25 | 2020-05-28 | Pf Medicament | Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra |
| DK3134438T3 (da) | 2014-04-25 | 2020-12-07 | Pf Medicament | IGF-1R-antistof og anvendelse heraf som adresseringsvehikel til behandling af cancer |
| CN104230916B (zh) * | 2014-09-30 | 2020-04-28 | 上海化学试剂研究所有限公司 | 一种异噻唑啉酮类化合物及其制备方法和应用 |
| EP3209334A2 (en) * | 2014-10-20 | 2017-08-30 | Igenica Biotherapeutics, Inc. | Novel antibody-drug conjugates and related compounds, compositions, and methods of use |
| EP3546473B1 (en) | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| CA2989269C (en) * | 2015-06-15 | 2020-09-22 | Robert Yongxin Zhao | Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule |
| WO2017051254A1 (en) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-egfr antibody drug conjugates |
| US20180369268A1 (en) | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| US11129910B2 (en) * | 2016-02-04 | 2021-09-28 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
| PE20210255A1 (es) | 2016-12-01 | 2021-02-10 | Takeda Pharmaceuticals Co | Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon) |
-
2019
- 2019-09-27 EP EP19813935.4A patent/EP3856258B1/en active Active
- 2019-09-27 WO PCT/IB2019/001114 patent/WO2020065408A1/en not_active Ceased
- 2019-09-27 BR BR112021005655-6A patent/BR112021005655A2/pt unknown
- 2019-09-27 CA CA3113378A patent/CA3113378C/en active Active
- 2019-09-27 US US17/280,800 patent/US12011485B2/en active Active
- 2019-09-27 AU AU2019350536A patent/AU2019350536B2/en active Active
- 2019-09-27 MX MX2021003295A patent/MX2021003295A/es unknown
- 2019-09-27 CN CN201980077950.5A patent/CN113453724B/zh active Active
- 2019-09-27 KR KR1020217012389A patent/KR102858995B1/ko active Active
- 2019-09-27 JP JP2021517292A patent/JP2022502431A/ja active Pending
-
2021
- 2021-03-24 ZA ZA2021/01990A patent/ZA202101990B/en unknown
-
2024
- 2024-03-29 US US18/622,613 patent/US20240350657A1/en active Pending
- 2024-07-01 JP JP2024106489A patent/JP7830555B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020202853B2 (en) | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics | |
| JP2022502431A5 (https=) | ||
| JP7244987B2 (ja) | 多剤抗体薬物コンジュゲート | |
| JP2023512036A5 (https=) | ||
| RU2019105549A (ru) | Гидрофильные саморазрушающиеся линкеры и их конъюгаты | |
| AU2018368520B2 (en) | Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of Cathepsin B | |
| JP2023520930A (ja) | 電荷多様性リンカー | |
| JP2022525704A5 (https=) | ||
| CN111542344A (zh) | 包含单分子量聚肌氨酸的配体-药物-缀合物 | |
| JP2015524796A5 (ja) | 細胞毒性剤と細胞結合受容体との共役体 | |
| EA037203B1 (ru) | Конъюгаты антитело-лекарственное средство с самостабилизирующимися линкерами | |
| JP2017528418A5 (https=) | ||
| RU2017101662A (ru) | Конъюгаты антитела против фолатного рецептора альфа (fra) c лекарственным средством и способы их применения | |
| JP7830555B2 (ja) | スルホマレイミドに基づくリンカーおよび対応する複合体 | |
| JP2020519610A5 (https=) | ||
| JP2024528719A (ja) | コンジュゲート化試薬及びそのコンジュゲート | |
| CN118119409A (zh) | 癌的治疗和/或预防用药物组合物 | |
| JP2024520853A5 (https=) | ||
| RU2021110933A (ru) | Линкеры на основе сульфомалеимида и соответствующие конъюгаты | |
| RU2815199C2 (ru) | Линкеры на основе сульфомалеимида и соответствующие конъюгаты | |
| Johannes et al. | Protease-sensitive Linkers | |
| WO2026051926A1 (zh) | 一种基于依喜替康的抗体-药物偶联物及其制备方法和用途 | |
| WO2025206033A1 (ja) | ｕＰＡＲ結合性ＨＬＨペプチド、ペプチド－薬物複合体および組成物 | |
| JP2025508819A5 (https=) | ||
| EA046139B1 (ru) | Конъюгаты лиганда-лекарственного средства в качестве субстратов для селективного расщепления под действием экзопептидазной активности катепсина b |