JP2022500078A5 - - Google Patents

Info

Publication number
JP2022500078A5
JP2022500078A5 JP2021538170A JP2021538170A JP2022500078A5 JP 2022500078 A5 JP2022500078 A5 JP 2022500078A5 JP 2021538170 A JP2021538170 A JP 2021538170A JP 2021538170 A JP2021538170 A JP 2021538170A JP 2022500078 A5 JP2022500078 A5 JP 2022500078A5
Authority
JP
Japan
Prior art keywords
peptide
pharmaceutical composition
seq
composition according
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021538170A
Other languages
English (en)
Japanese (ja)
Other versions
JP7496826B2 (ja
JP2022500078A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/050332 external-priority patent/WO2020055812A1/en
Publication of JP2022500078A publication Critical patent/JP2022500078A/ja
Publication of JP2022500078A5 publication Critical patent/JP2022500078A5/ja
Priority to JP2024031305A priority Critical patent/JP7737492B2/ja
Application granted granted Critical
Publication of JP7496826B2 publication Critical patent/JP7496826B2/ja
Priority to JP2025142971A priority patent/JP2025184877A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021538170A 2018-09-10 2019-09-10 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用 Active JP7496826B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024031305A JP7737492B2 (ja) 2018-09-10 2024-03-01 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用
JP2025142971A JP2025184877A (ja) 2018-09-10 2025-08-29 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728997P 2018-09-10 2018-09-10
US62/728,997 2018-09-10
PCT/US2019/050332 WO2020055812A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024031305A Division JP7737492B2 (ja) 2018-09-10 2024-03-01 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用

Publications (3)

Publication Number Publication Date
JP2022500078A JP2022500078A (ja) 2022-01-04
JP2022500078A5 true JP2022500078A5 (https=) 2022-09-06
JP7496826B2 JP7496826B2 (ja) 2024-06-07

Family

ID=69778115

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021538170A Active JP7496826B2 (ja) 2018-09-10 2019-09-10 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用
JP2024031305A Active JP7737492B2 (ja) 2018-09-10 2024-03-01 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用
JP2025142971A Pending JP2025184877A (ja) 2018-09-10 2025-08-29 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024031305A Active JP7737492B2 (ja) 2018-09-10 2024-03-01 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用
JP2025142971A Pending JP2025184877A (ja) 2018-09-10 2025-08-29 Cav-1タンパク質の修飾ペプチドフラグメント及び線維症の治療におけるその使用

Country Status (8)

Country Link
US (4) US11905336B2 (https=)
EP (1) EP3849580A4 (https=)
JP (3) JP7496826B2 (https=)
CN (2) CN121159628A (https=)
AU (2) AU2019339260B2 (https=)
BR (1) BR112021004404A2 (https=)
CA (1) CA3111563A1 (https=)
WO (1) WO2020055812A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110201144B (zh) 2013-03-15 2024-01-02 得克萨斯州大学系统董事会 用Nutlin-3a和肽抑制肺纤维化
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND THEIR USE IN THE TREATMENT OF FIBROSIS
US20220160814A1 (en) * 2019-03-11 2022-05-26 Lung Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US20230159608A1 (en) * 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
US20230226149A1 (en) * 2020-06-19 2023-07-20 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
EP4297768A4 (en) 2021-02-25 2025-01-15 Lung Therapeutics, LLC Biomarkers for the treatment of interstitial lung disease
WO2022266410A1 (en) * 2021-06-17 2022-12-22 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
JP2024539242A (ja) * 2021-10-22 2024-10-28 ラング セラピューティクス,エルエルシー 慢性腎疾患の治療のための改変カベオリン-1ペプチド
CN119661656A (zh) * 2024-11-20 2025-03-21 华中科技大学同济医学院附属梨园医院 一种靶向拮抗pCAV1的多肽及其应用

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021387A (en) 1975-11-19 1977-05-03 President And Fellows Of Harvard College Eosinophilotactic tetrapeptides
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
IT1190891B (it) 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
US4816449A (en) 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
US4613676A (en) 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
ZA846192B (en) 1984-08-09 1986-03-26 Merck Patent Gmbh Immunotherapeutic polypeptide agents
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
DK53291D0 (da) 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US6540154B1 (en) 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US6629646B1 (en) 1991-04-24 2003-10-07 Aerogen, Inc. Droplet ejector with oscillating tapered aperture
US5277175A (en) 1991-07-12 1994-01-11 Riggs John H Continuous flow nebulizer apparatus and method, having means maintaining a constant-level reservoir
GB9120005D0 (en) 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US5355872B1 (en) 1992-03-04 1998-10-20 John H Riggs Low flow rate nebulizer apparatus and method of nebulization
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5329028A (en) 1992-08-05 1994-07-12 Genentech, Inc. Carbohydrate-directed cross-linking reagents
HUT71860A (en) 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
JP3401005B2 (ja) 1992-12-11 2003-04-28 ユニバーシティ オブ フロリダ 有害生物の防除のための材料および方法
US5559209A (en) 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
JPH11512299A (ja) 1995-09-06 1999-10-26 ライダー,スチーブン,エル. 可変酸素濃度高流量噴霧器
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
US6017735A (en) 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US20030113271A1 (en) 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
IT1291122B1 (it) 1997-03-28 1998-12-29 Sar Spa Micropompa per la nebulizzazione di fluidi con valvola dosatrice perfezionata
US6096707A (en) 1997-07-11 2000-08-01 Biotie Therapies Ltd. Integrin binding peptide and use thereof
US6044841A (en) 1997-08-29 2000-04-04 1263152 Ontario Inc. Breath actuated nebulizer with valve assembly having a relief piston
US6041776A (en) 1998-05-14 2000-03-28 Briggs, Iii; Stephen W. Medical nebulization device
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
SE9900369D0 (sv) 1999-02-04 1999-02-04 Siemens Elema Ab Ultrasonic nebuliser
US6328030B1 (en) 1999-03-12 2001-12-11 Daniel E. Kidwell Nebulizer for ventilation system
EP1076091A1 (en) * 1999-08-09 2001-02-14 Universite Catholique De Louvain Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds
WO2002009798A1 (en) 2000-08-02 2002-02-07 Research Development Foundation Jet nebulizer assembly for home administration of drugs in aerosols
US20020077283A1 (en) 2000-09-08 2002-06-20 Sessa William C. Caveolin peptides and their use as therapeutics
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
GB0119852D0 (en) 2001-08-15 2001-10-10 Univ York Baculovirus
US7360536B2 (en) 2002-01-07 2008-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
WO2003059424A1 (en) 2002-01-15 2003-07-24 Aerogen, Inc. Methods and systems for operating an aerosol generator
WO2003086278A2 (en) 2002-04-05 2003-10-23 Board Of Regents, The University Of Texas System Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
EP1501479A1 (en) 2002-05-07 2005-02-02 Nektar Therapeutics Capsules for dry powder inhalers and methods of making and using same
US20040175384A1 (en) 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US20070207158A1 (en) 2003-06-17 2007-09-06 Harrison Roger G Conjugate for the specific targeting of anticancer agents to tumor cells or tumor vasculature and production thereof
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
EP1734938B1 (en) 2004-03-26 2012-06-20 Universita' Degli Studi Di Parma Insulin highly respirable microparticles
PT1765397E (pt) 2004-05-25 2013-02-04 Tactic Pharma Llc Anticorpos inibidores que se ligam ao complexo ativador plasminogénico do tipo uroquinasa (upa) e seu receptor (upar)
EP1896662B1 (en) 2005-05-25 2014-07-23 AeroGen, Inc. Vibration systems and methods
TWI299993B (en) 2005-12-15 2008-08-21 Dev Center Biotechnology Aqueous inhalation pharmaceutical composition
US8058227B2 (en) 2006-10-03 2011-11-15 Medical University Of South Carolina Method of treating fibrosis in a subject in need thereof comprising administering a composition comprising a CSD
JP2010506860A (ja) * 2006-10-19 2010-03-04 アンジオケム,インコーポレーテッド P−糖タンパク質機能を刺激するための化合物およびその使用
US20090068258A1 (en) 2007-08-28 2009-03-12 Lisanti Michael P Caveolin-mimetic peptide for prevention and treatment of pulmonary hypertension and right ventricular hypertrophy
EP2220115A2 (en) 2007-12-13 2010-08-25 Glaxo Group Limited Polypeptides, antibody variable domains & antagonists
WO2009111625A2 (en) * 2008-03-05 2009-09-11 Board Of Regents, The University Of Texas System Peptide inhibition of lung epithelial apoptosis and pulmonary fibrosis
US20110171193A1 (en) 2008-06-12 2011-07-14 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating pulmonary hypertension
SG193209A1 (en) 2008-09-10 2013-09-30 Genentech Inc Methods for inhibiting ocular angiogenesis
EP2349314B1 (en) 2008-10-21 2013-02-27 Baxter International Inc. Lyophilized recombinant vwf formulations
GB2466121B (en) 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
SG176053A1 (en) 2009-05-15 2011-12-29 Intermune Inc Methods of treating hiv patients with anti-fibrotics
KR20120110090A (ko) 2009-09-28 2012-10-09 에프. 호프만-라 로슈 리미티드 C형 간염 바이러스 복제의 신규한 마크로시클릭 저해제
DK2533761T3 (da) 2010-02-11 2019-06-24 Ablynx Nv Fremgangsmåder og sammensætninger til fremstilling af aerosoler
WO2012061828A2 (en) * 2010-11-05 2012-05-10 The Regents Of The University Of California Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord
CN107099581B (zh) 2012-03-27 2021-07-13 弗·哈夫曼-拉罗切有限公司 预测、诊断和治疗特发性肺纤维化的方法
WO2013184482A1 (en) 2012-06-04 2013-12-12 Yale University Method of treating and preventing ocular angiogenesis
US10441536B2 (en) 2013-03-13 2019-10-15 Actavis Group Ptc Ehf Micronized colistimethane sodium pharmaceutical compositions
CN110201144B (zh) 2013-03-15 2024-01-02 得克萨斯州大学系统董事会 用Nutlin-3a和肽抑制肺纤维化
CN104274827B (zh) 2013-07-01 2020-07-14 上海贺普药业股份有限公司 贺普拉肽的制剂
PE20160789A1 (es) 2013-11-04 2016-08-17 Univ Texas Composiciones y metodos para admistracion de una enzima a las vias respiratorias de un sujeto
WO2015080943A1 (en) 2013-11-26 2015-06-04 Yale University Novel cell-penetrating compositions and methods using same
WO2015080980A2 (en) * 2013-11-26 2015-06-04 E&B Technologies Llc Treatment of autoimmune and/or inflammatory disease using novel caveolin modulators
EP4056194A1 (en) 2015-02-27 2022-09-14 Board of Regents, The University of Texas System Polypeptide therapeutics and uses thereof
CN107216394B (zh) * 2017-06-21 2020-10-09 江南大学 一种小窝蛋白-1脚手架区融合多肽的制备方法及其应用
US20190224243A1 (en) 2018-01-25 2019-07-25 Musc Foundation For Research Development Enhancement of the Beneficial Effects of Mesenchymal Stem Cell Treatment by the Caveolin-1 Scaffolding Domain Peptide and Subdomains
US12280088B2 (en) 2018-09-10 2025-04-22 Board Of Regents, The University Of Texas System Dry powder formulation of caveolin-1 peptides and methods of use thereof
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND THEIR USE IN THE TREATMENT OF FIBROSIS
US20240082342A1 (en) 2018-11-21 2024-03-14 Board Of Regents, The University Of Texas System Peptide therapeutics for increasing lung cell viability
WO2020106922A1 (en) 2018-11-21 2020-05-28 Board Of Regents, The University Of Texas System Peptide therapeutics for acute and chronic airway and alveolar diseases
US20220160814A1 (en) 2019-03-11 2022-05-26 Lung Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US12097222B2 (en) 2019-06-06 2024-09-24 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
CN111671886B (zh) 2020-03-05 2022-11-15 上海甘翼生物医药科技有限公司 一种预防高危易感人群感染冠状病毒或发生冠状病毒感染疾病的药物组合及其用途
US20230159608A1 (en) 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
US20230226149A1 (en) 2020-06-19 2023-07-20 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
EP4297768A4 (en) 2021-02-25 2025-01-15 Lung Therapeutics, LLC Biomarkers for the treatment of interstitial lung disease
US12449810B2 (en) 2021-03-01 2025-10-21 The Boeing Company Autonomous maneuver generation to mate connectors
WO2022266410A1 (en) 2021-06-17 2022-12-22 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
JP2024539242A (ja) 2021-10-22 2024-10-28 ラング セラピューティクス,エルエルシー 慢性腎疾患の治療のための改変カベオリン-1ペプチド

Similar Documents

Publication Publication Date Title
JP2022500078A5 (https=)
US9359405B2 (en) Antagonists of the interleukin-1 receptor
US12162915B2 (en) Cell penetrating peptides that inhibit IRF5 nuclear localization
JP2014533235A5 (https=)
CN103200955A (zh) 包含肽和病毒神经氨酸酶抑制剂的组合物
TW201521759A (zh) 具有溶栓、抗栓和自由基清除三重活性的化合物,其製備方法、組合物和應用
CN111690071A (zh) 一种具有靶向穿膜性的抗肿瘤多肽
CN114409733B (zh) 靶向抑制mlkl乙酰化的多肽和/或其衍生物及其用途
TWI496579B (zh) 類鋅手指胜肽、其表現質體、及包含其之醫藥組成物之用途
CN114644687A (zh) 一种可拮抗rbm25蛋白rna结合活性的多肽rbip-21及其应用
CN110511285B (zh) 一种重组融合多肽及其应用
JP7824885B2 (ja) 表皮水疱症の治療で使用するためのホーミングペプチド誘導デコリン複合体
CN101671390A (zh) 人干扰素α衍生物及其聚乙二醇化修饰物的制备和用途
CN113980144B (zh) 一种多肽类似物及其应用
CN114364691B (zh) 作为纤维化基质积累的抑制剂的肽
KR102702011B1 (ko) 폐내 염증의 완화
CN110366422A (zh) 包含其中细胞穿透肽与ctctla4肽融合的融合蛋白作为活性成分的用于预防或治疗炎性呼吸系统疾病的药物组合物
US20200268839A1 (en) Composition for treating pulmonary fibrosis and emphysema and therapeutic method using the same
JP2016519110A5 (https=)
CN116813703A (zh) 靶向竞争性抑制ccl1结合自分泌运动因子受体amfr的多肽和/或其衍生物及应用
JP2025500508A5 (https=)
CN118451094A (zh) 抗病毒肽及其使用方法
CN116253776A (zh) 靶向抑制trib3的多肽及其用途
Class et al. Patent application title: Antagonists of the Interleukin-1 Receptor Inventors: Vladimir Berezin (Copenhagen N, DK) Vladimir Berezin (Copenhagen N, DK) Elisabeth Bock (Charlottenlund, DK) Assignees: SERODUS ASA
NZ615710B2 (en) Antagonists of the interleukin- 1 receptor