AU2019339260B2 - Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis - Google Patents

Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis Download PDF

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Publication number
AU2019339260B2
AU2019339260B2 AU2019339260A AU2019339260A AU2019339260B2 AU 2019339260 B2 AU2019339260 B2 AU 2019339260B2 AU 2019339260 A AU2019339260 A AU 2019339260A AU 2019339260 A AU2019339260 A AU 2019339260A AU 2019339260 B2 AU2019339260 B2 AU 2019339260B2
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peptide
administration
lung
amino acid
aaegkasfttftvtkgsaa
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AU2019339260A1 (en
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Dale Christensen
John J. Koleng
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Rein Therapeutics Inc
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Rein Therapeutics Inc
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Assigned to REIN THERAPEUTICS, INC. reassignment REIN THERAPEUTICS, INC. Request for Assignment Assignors: LUNG THERAPEUTICS, LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2019339260A 2018-09-10 2019-09-10 Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis Active AU2019339260B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025234225A AU2025234225A1 (en) 2018-09-10 2025-09-19 Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728997P 2018-09-10 2018-09-10
US62/728,997 2018-09-10
PCT/US2019/050332 WO2020055812A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Related Child Applications (1)

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AU2025234225A Division AU2025234225A1 (en) 2018-09-10 2025-09-19 Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis

Publications (2)

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AU2019339260A1 AU2019339260A1 (en) 2021-03-25
AU2019339260B2 true AU2019339260B2 (en) 2025-06-26

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AU2019339260A Active AU2019339260B2 (en) 2018-09-10 2019-09-10 Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis
AU2025234225A Pending AU2025234225A1 (en) 2018-09-10 2025-09-19 Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis

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Country Status (8)

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US (4) US11905336B2 (https=)
EP (1) EP3849580A4 (https=)
JP (3) JP7496826B2 (https=)
CN (2) CN121159628A (https=)
AU (2) AU2019339260B2 (https=)
BR (1) BR112021004404A2 (https=)
CA (1) CA3111563A1 (https=)
WO (1) WO2020055812A1 (https=)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
CN110201144B (zh) 2013-03-15 2024-01-02 得克萨斯州大学系统董事会 用Nutlin-3a和肽抑制肺纤维化
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND THEIR USE IN THE TREATMENT OF FIBROSIS
US20220160814A1 (en) * 2019-03-11 2022-05-26 Lung Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US20230159608A1 (en) * 2020-04-21 2023-05-25 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
US20230226149A1 (en) * 2020-06-19 2023-07-20 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of pathogen-induced lung injury
EP4297768A4 (en) 2021-02-25 2025-01-15 Lung Therapeutics, LLC Biomarkers for the treatment of interstitial lung disease
WO2022266410A1 (en) * 2021-06-17 2022-12-22 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
JP2024539242A (ja) * 2021-10-22 2024-10-28 ラング セラピューティクス，エルエルシー 慢性腎疾患の治療のための改変カベオリン－１ペプチド
CN119661656A (zh) * 2024-11-20 2025-03-21 华中科技大学同济医学院附属梨园医院 一种靶向拮抗pCAV1的多肽及其应用

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CA3111563A1 (en) 2020-03-19
US20260062444A1 (en) 2026-03-05
CN112739367A (zh) 2021-04-30
AU2025234225A1 (en) 2025-10-09
AU2019339260A1 (en) 2021-03-25
US20230212223A1 (en) 2023-07-06
JP7737492B2 (ja) 2025-09-10
US20240018186A1 (en) 2024-01-18
JP2025184877A (ja) 2025-12-18
EP3849580A4 (en) 2022-06-15
KR20210084453A (ko) 2021-07-07
EP3849580A1 (en) 2021-07-21
US20210347820A1 (en) 2021-11-11
BR112021004404A2 (pt) 2021-08-03
US11905336B2 (en) 2024-02-20
WO2020055812A1 (en) 2020-03-19
US11787838B2 (en) 2023-10-17
JP7496826B2 (ja) 2024-06-07
JP2022500078A (ja) 2022-01-04
CN112739367B (zh) 2025-06-06
CN121159628A (zh) 2025-12-19
US12497431B2 (en) 2025-12-16
JP2024071397A (ja) 2024-05-24

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