JP2022115876A5 - - Google Patents
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- Publication number
- JP2022115876A5 JP2022115876A5 JP2022070213A JP2022070213A JP2022115876A5 JP 2022115876 A5 JP2022115876 A5 JP 2022115876A5 JP 2022070213 A JP2022070213 A JP 2022070213A JP 2022070213 A JP2022070213 A JP 2022070213A JP 2022115876 A5 JP2022115876 A5 JP 2022115876A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cancer
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037865 fusion proteins Human genes 0.000 claims 26
- 108020001507 fusion proteins Proteins 0.000 claims 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 108700004922 F42A Proteins 0.000 claims 5
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 5
- 102220596838 Non-structural maintenance of chromosomes element 1 homolog_R38A_mutation Human genes 0.000 claims 5
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 5
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000013636 protein dimer Substances 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 102220505697 Palmitoyl-protein thioesterase 1_Y45F_mutation Human genes 0.000 claims 2
- 102220610852 Thialysine N-epsilon-acetyltransferase_L72G_mutation Human genes 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000009608 Papillomavirus Infections Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 208000021145 human papilloma virus infection Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2018-0110698 | 2018-09-17 | ||
| KR20180110698 | 2018-09-17 | ||
| KR10-2019-0001867 | 2019-01-07 | ||
| KR20190001867 | 2019-01-07 | ||
| US201962832013P | 2019-04-10 | 2019-04-10 | |
| US62/832,013 | 2019-04-10 | ||
| KR20190053436 | 2019-05-08 | ||
| KR10-2019-0053436 | 2019-05-08 | ||
| JP2020562067A JP7085644B2 (ja) | 2018-09-17 | 2019-09-16 | Ｉｌ－２タンパク質およびｃｄ８０タンパク質を含む融合タンパク質およびその使用 |
| PCT/KR2019/011928 WO2020060122A1 (ko) | 2018-09-17 | 2019-09-16 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020562067A Division JP7085644B2 (ja) | 2018-09-17 | 2019-09-16 | Ｉｌ－２タンパク質およびｃｄ８０タンパク質を含む融合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022115876A JP2022115876A (ja) | 2022-08-09 |
| JP2022115876A5 true JP2022115876A5 (enExample) | 2022-09-20 |
| JP7569820B2 JP7569820B2 (ja) | 2024-10-18 |
Family
ID=69887592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020562067A Active JP7085644B2 (ja) | 2018-09-17 | 2019-09-16 | Ｉｌ－２タンパク質およびｃｄ８０タンパク質を含む融合タンパク質およびその使用 |
| JP2022070213A Active JP7569820B2 (ja) | 2018-09-17 | 2022-04-21 | Ｉｌ－２タンパク質およびｃｄ８０タンパク質を含む融合タンパク質およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020562067A Active JP7085644B2 (ja) | 2018-09-17 | 2019-09-16 | Ｉｌ－２タンパク質およびｃｄ８０タンパク質を含む融合タンパク質およびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US11492384B2 (enExample) |
| EP (2) | EP4403635A3 (enExample) |
| JP (2) | JP7085644B2 (enExample) |
| KR (2) | KR102201086B1 (enExample) |
| CN (2) | CN118725141A (enExample) |
| AU (1) | AU2019343850B2 (enExample) |
| CA (1) | CA3086486A1 (enExample) |
| CL (1) | CL2020001872A1 (enExample) |
| DK (1) | DK3715367T3 (enExample) |
| ES (1) | ES2985387T3 (enExample) |
| FI (1) | FI3715367T3 (enExample) |
| HU (1) | HUE068059T2 (enExample) |
| IL (1) | IL275592B (enExample) |
| MX (1) | MX2020007072A (enExample) |
| PE (1) | PE20201418A1 (enExample) |
| PH (1) | PH12020551026A1 (enExample) |
| PL (1) | PL3715367T3 (enExample) |
| PT (1) | PT3715367T (enExample) |
| SG (1) | SG11202005873QA (enExample) |
| TW (2) | TWI824258B (enExample) |
| WO (1) | WO2020060122A1 (enExample) |
| ZA (1) | ZA202003645B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018076260A2 (pt) * | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US11492384B2 (en) * | 2018-09-17 | 2022-11-08 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
| JP7381750B2 (ja) * | 2019-11-20 | 2023-11-15 | ジーアイ・セル・インコーポレイテッド | ナチュラルキラー細胞培養用組成物及びこれを用いたナチュラルキラー細胞の製造方法 |
| US20230015408A1 (en) * | 2019-11-20 | 2023-01-19 | Gi Cell, Inc. | Medium composition for culturing t cells and method for culturing t cells using same |
| US20230014358A1 (en) * | 2019-11-27 | 2023-01-19 | Gi Cell, Inc. | Composition for anticancer treatment, comprising nk cells and fusion protein which comprises il-2 protein and cd80 protein |
| CN114746544A (zh) * | 2019-11-27 | 2022-07-12 | 吉爱希公司 | 用于治疗癌症的、包含含有il-2蛋白和cd80蛋白的融合蛋白与自然杀手细胞的药物组合物 |
| EP4140495A4 (en) | 2020-03-18 | 2024-05-01 | GI Innovation, Inc. | Pharmaceutical composition for cancer treatment comprising fusion protein including il-2 protein and cd80 protein and anticancer drug |
| KR102604984B1 (ko) | 2020-03-18 | 2023-11-23 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 제제 |
| US20230139890A1 (en) * | 2020-03-18 | 2023-05-04 | Gi Innovation, Inc. | Fusion protein comprising il-2 protein and cd80 protein fragment or variant thereof, and uses thereof |
| PE20221759A1 (es) * | 2020-03-31 | 2022-11-11 | Hanmi Pharm Ind Co Ltd | Nuevos analogos de il-2 inmunoestimuladores |
| US20230235011A1 (en) * | 2020-05-25 | 2023-07-27 | Beijing Beyond Biotechnology Co., Ltd | Fc-cd80 fusion protein and conjugates thereof and their uses |
| KR102373965B1 (ko) * | 2020-06-05 | 2022-03-15 | (주)지아이이노베이션 | Ｉｌ-２ 단백질 및 ｃｄ８０ 단백질을 포함하는 융합단백질을 포함하는 방사선 치료 증진용 약학적 조성물 |
| KR102313505B1 (ko) * | 2020-06-30 | 2021-10-18 | (주)지아이이노베이션 | 항-lag-3 항체 및 il-2를 포함하는 융합단백질 및 이의 용도 |
| AR122863A1 (es) * | 2020-07-02 | 2022-10-12 | Inhibrx Inc | Polipéptidos que comprenden polipéptidos con il-2 modificada y usos de los mismos |
| WO2022045849A1 (ko) * | 2020-08-31 | 2022-03-03 | 주식회사 지아이셀 | Il15 단백질, il15 수용체 알파 단백질, fc 도메인 및 il2 단백질을 포함하는 융합단백질 및 이의 용도 |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| AU2021397206A1 (en) * | 2020-12-08 | 2023-07-27 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-egfr chimeric antigen receptors |
| AU2022232951B2 (en) * | 2021-03-10 | 2025-06-26 | Immunowake Inc. | Immunomodulatory molecules and uses thereof |
| WO2022057696A2 (zh) * | 2021-09-08 | 2022-03-24 | 中南大学湘雅医院 | 一种重组蛋白的编码序列、重组蛋白及其单克隆抗体的制备方法 |
| WO2023234743A1 (ko) * | 2022-06-03 | 2023-12-07 | (주)지아이이노베이션 | 항-tigit 항체를 포함하는 이중 특이적 항체 및 이의 용도 |
| EP4545562A4 (en) * | 2022-06-22 | 2025-10-01 | Gi Innovation Inc | FUSION PROTEIN COMPRISING AN ANTI-CD73 ANTIBODY AND IL-2, AND USE THEREOF |
| WO2024063546A1 (ko) | 2022-09-20 | 2024-03-28 | 주식회사 지아이바이옴 | 락토바실러스 플란타룸 균주의 병용 요법 및 이를 이용한 암 치료 방법 |
| CN119997963A (zh) * | 2022-09-20 | 2025-05-13 | 南韩商Gi生物群系公司 | 植物乳杆菌菌株的联合疗法及利用该菌株的癌症治疗方法 |
| CN115850436A (zh) * | 2022-10-14 | 2023-03-28 | 海徕科(北京)生物技术有限公司 | 白介素2突变体及其应用 |
| WO2025063755A1 (ko) * | 2023-09-20 | 2025-03-27 | 주식회사 에스엘바이젠 | 항암 dna 백신 및 면역반응-증진용 융합단백질을 포함하는 신규 암 치료제 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71275A0 (en) * | 1983-03-21 | 1984-06-29 | Sparamedica Ag | Human interleukin-2-and its preparation |
| CN86104525A (zh) * | 1985-07-31 | 1987-02-25 | 武田药品工业株式会社 | 人类白细胞介素-2的分析方法和试剂 |
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| GB9810999D0 (en) | 1998-05-21 | 1998-07-22 | Goken Joop | Materials and methods relating to the expression of genes |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| WO2003015697A2 (en) | 2001-08-13 | 2003-02-27 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| CU23229A1 (es) | 2002-05-10 | 2007-09-26 | Ct Ingenieria Genetica Biotech | ANTAGONISTA QUIMéRICO ANTH1 |
| AU2005227263A1 (en) * | 2004-03-05 | 2005-10-06 | Novartis Vaccines And Diagnostics, Inc. | In vitro test system for predicting patient tolerability of therapeutic agents |
| EP2402754B2 (en) * | 2006-03-06 | 2023-07-26 | Amunix Operating Inc. | Unstructured recombinant polymers and uses thereof |
| CA2656700A1 (en) | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
| BRPI0815416A2 (pt) * | 2007-08-15 | 2014-10-21 | Amunix Inc | Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos |
| CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| LT3075745T (lt) | 2011-02-10 | 2018-11-26 | Roche Glycart Ag | Mutavę interleukino-2 polipeptidai |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US8956619B2 (en) * | 2011-10-25 | 2015-02-17 | University Of Maryland, Baltimore County | Soluble CD80 as a therapeutic to reverse immune supression in cancer patients |
| MX368665B (es) | 2013-03-15 | 2019-10-10 | Abbvie Biotherapeutics Inc | Variantes de fc. |
| AU2015308527C1 (en) * | 2014-08-29 | 2021-07-15 | F. Hoffmann-La Roche Ag | Combination therapy of tumor-targeted IL-2 variant immunocytokines and antibodies against human PD-L1 |
| MA43163A (fr) * | 2015-11-02 | 2018-09-12 | Five Prime Therapeutics Inc | Polypeptides à domaine extracellulaire cd80 et leur utilisation dans le traitement du cancer |
| KR20240115933A (ko) * | 2016-05-04 | 2024-07-26 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| BR112018076260A2 (pt) * | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| PT3606946T (pt) * | 2017-04-03 | 2022-10-17 | Hoffmann La Roche | Imunoconjugados de um anticorpo anti-pd-1 com uma il-2 mutante ou com il-15 |
| US11492384B2 (en) * | 2018-09-17 | 2022-11-08 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
-
2019
- 2019-09-16 US US16/959,312 patent/US11492384B2/en active Active
- 2019-09-16 CA CA3086486A patent/CA3086486A1/en active Pending
- 2019-09-16 MX MX2020007072A patent/MX2020007072A/es unknown
- 2019-09-16 SG SG11202005873QA patent/SG11202005873QA/en unknown
- 2019-09-16 AU AU2019343850A patent/AU2019343850B2/en active Active
- 2019-09-16 ES ES19862449T patent/ES2985387T3/es active Active
- 2019-09-16 CN CN202410942368.3A patent/CN118725141A/zh active Pending
- 2019-09-16 EP EP24175556.0A patent/EP4403635A3/en active Pending
- 2019-09-16 DK DK19862449.6T patent/DK3715367T3/da active
- 2019-09-16 CN CN201980025699.8A patent/CN111971295B/zh active Active
- 2019-09-16 PE PE2020000980A patent/PE20201418A1/es unknown
- 2019-09-16 PL PL19862449.6T patent/PL3715367T3/pl unknown
- 2019-09-16 JP JP2020562067A patent/JP7085644B2/ja active Active
- 2019-09-16 WO PCT/KR2019/011928 patent/WO2020060122A1/ko not_active Ceased
- 2019-09-16 FI FIEP19862449.6T patent/FI3715367T3/fi active
- 2019-09-16 EP EP19862449.6A patent/EP3715367B1/en active Active
- 2019-09-16 HU HUE19862449A patent/HUE068059T2/hu unknown
- 2019-09-16 KR KR1020190113659A patent/KR102201086B1/ko active Active
- 2019-09-16 PT PT198624496T patent/PT3715367T/pt unknown
- 2019-09-17 TW TW110122590A patent/TWI824258B/zh active
- 2019-09-17 TW TW108133398A patent/TWI755630B/zh active
-
2020
- 2020-06-17 ZA ZA2020/03645A patent/ZA202003645B/en unknown
- 2020-06-22 IL IL275592A patent/IL275592B/en unknown
- 2020-06-30 PH PH12020551026A patent/PH12020551026A1/en unknown
- 2020-07-14 CL CL2020001872A patent/CL2020001872A1/es unknown
-
2021
- 2021-01-05 KR KR1020210000775A patent/KR102558191B1/ko active Active
-
2022
- 2022-04-21 JP JP2022070213A patent/JP7569820B2/ja active Active
- 2022-08-01 US US17/878,664 patent/US12291555B2/en active Active
- 2022-08-01 US US17/878,703 patent/US12286464B2/en active Active
-
2025
- 2025-04-01 US US19/097,579 patent/US20250230212A1/en active Pending
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