JP2022023100A5 - - Google Patents

Download PDF

Info

Publication number
JP2022023100A5
JP2022023100A5 JP2021164668A JP2021164668A JP2022023100A5 JP 2022023100 A5 JP2022023100 A5 JP 2022023100A5 JP 2021164668 A JP2021164668 A JP 2021164668A JP 2021164668 A JP2021164668 A JP 2021164668A JP 2022023100 A5 JP2022023100 A5 JP 2022023100A5
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
detectable label
attachment
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021164668A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022023100A (ja
JP7244601B2 (ja
Filing date
Publication date
Priority claimed from JP2017527209A external-priority patent/JP6674951B2/ja
Application filed filed Critical
Publication of JP2022023100A publication Critical patent/JP2022023100A/ja
Publication of JP2022023100A5 publication Critical patent/JP2022023100A5/ja
Priority to JP2023036774A priority Critical patent/JP7569404B2/ja
Application granted granted Critical
Publication of JP7244601B2 publication Critical patent/JP7244601B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021164668A 2014-11-21 2021-10-06 酵素不要及び増幅不要の配列決定 Active JP7244601B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023036774A JP7569404B2 (ja) 2014-11-21 2023-03-09 酵素不要及び増幅不要の配列決定

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462082883P 2014-11-21 2014-11-21
US62/082,883 2014-11-21
JP2017527209A JP6674951B2 (ja) 2014-11-21 2015-11-19 酵素不要及び増幅不要の配列決定
JP2020040296A JP6959378B2 (ja) 2014-11-21 2020-03-09 酵素不要及び増幅不要の配列決定

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020040296A Division JP6959378B2 (ja) 2014-11-21 2020-03-09 酵素不要及び増幅不要の配列決定

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023036774A Division JP7569404B2 (ja) 2014-11-21 2023-03-09 酵素不要及び増幅不要の配列決定

Publications (3)

Publication Number Publication Date
JP2022023100A JP2022023100A (ja) 2022-02-07
JP2022023100A5 true JP2022023100A5 (enExample) 2022-08-04
JP7244601B2 JP7244601B2 (ja) 2023-03-22

Family

ID=54705918

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017527209A Active JP6674951B2 (ja) 2014-11-21 2015-11-19 酵素不要及び増幅不要の配列決定
JP2020040296A Active JP6959378B2 (ja) 2014-11-21 2020-03-09 酵素不要及び増幅不要の配列決定
JP2021164668A Active JP7244601B2 (ja) 2014-11-21 2021-10-06 酵素不要及び増幅不要の配列決定
JP2023036774A Active JP7569404B2 (ja) 2014-11-21 2023-03-09 酵素不要及び増幅不要の配列決定

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2017527209A Active JP6674951B2 (ja) 2014-11-21 2015-11-19 酵素不要及び増幅不要の配列決定
JP2020040296A Active JP6959378B2 (ja) 2014-11-21 2020-03-09 酵素不要及び増幅不要の配列決定

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023036774A Active JP7569404B2 (ja) 2014-11-21 2023-03-09 酵素不要及び増幅不要の配列決定

Country Status (10)

Country Link
US (4) US20160194701A1 (enExample)
EP (4) EP3221469B1 (enExample)
JP (4) JP6674951B2 (enExample)
KR (4) KR102298387B1 (enExample)
CN (2) CN113403373B (enExample)
AU (3) AU2015349870B2 (enExample)
CA (1) CA2968376C (enExample)
ES (2) ES2910099T3 (enExample)
SG (1) SG11201704098VA (enExample)
WO (1) WO2016081740A1 (enExample)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014531908A (ja) * 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
EP4249605B1 (en) 2011-12-22 2024-08-28 President And Fellows Of Harvard College Methods for analyte detection
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
EP2971184B1 (en) 2013-03-12 2019-04-17 President and Fellows of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
EP3003392B1 (en) 2013-06-04 2019-10-23 President and Fellows of Harvard College Rna-guideded transcriptional regulation
LT3013983T (lt) 2013-06-25 2023-05-10 Prognosys Biosciences, Inc. Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP4273263A3 (en) 2014-07-30 2024-01-31 President and Fellows of Harvard College Systems and methods for determining nucleic acids
SG11201707515SA (en) 2015-04-10 2017-10-30 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3325650B1 (en) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
SG10202107055SA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
JP6882282B2 (ja) 2015-11-03 2021-06-02 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元核酸含有マトリックスの立体撮像のための方法と装置
EP3449016B1 (en) 2016-04-25 2025-07-23 President and Fellows of Harvard College Hybridization chain reaction methods for in situ molecular detection
EP4324929B1 (en) * 2016-05-16 2025-09-17 Bruker Spatial Biology, Inc. Methods for detecting target nucleic acids in a sample
EP3472359B1 (en) 2016-06-21 2022-03-16 10X Genomics, Inc. Nucleic acid sequencing
JP7239465B2 (ja) 2016-08-31 2023-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光in situ配列決定による検出のための核酸配列ライブラリの作製法
WO2018045186A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
JP7033602B2 (ja) * 2017-01-27 2022-03-10 エフ.ホフマン-ラ ロシュ アーゲー ロングレンジ配列決定のためのバーコードを付けられたdna
US11788123B2 (en) 2017-05-26 2023-10-17 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
WO2019069371A1 (ja) * 2017-10-03 2019-04-11 株式会社ニコン 検体中の検出対象の検出方法、検出キット及び流体デバイス
CN120210336A (zh) 2017-10-06 2025-06-27 10X基因组学有限公司 Rna模板化连接
CN110079592B (zh) * 2018-01-26 2021-02-12 厦门艾德生物医药科技股份有限公司 用于检测基因突变和已知、未知基因融合类型的高通量测序靶向捕获目标区域的探针和方法
CN119753098A (zh) 2018-02-12 2025-04-04 布鲁克空间生物学公司 生物分子探针以及检测基因和蛋白表达的方法
EP3765063A4 (en) 2018-03-15 2021-12-15 Twinstrand Biosciences, Inc. METHODS AND REAGENTS FOR THE ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING AND OTHER APPLICATIONS OF NUCLEIC ACID MATERIAL
KR102893736B1 (ko) 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
EP3836967A4 (en) 2018-07-30 2022-06-15 ReadCoor, LLC METHODS AND SYSTEMS FOR SAMPLE PROCESSING OR ANALYSIS
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
WO2020123742A1 (en) 2018-12-13 2020-06-18 President And Fellows Of Harvard College Amplification methods and systems for merfish and other applications
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020240025A1 (en) 2019-05-31 2020-12-03 Cartana Ab Method of detecting target nucleic acid molecules
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
US20230059203A1 (en) * 2019-12-19 2023-02-23 Akoya Biosciences, Inc. RNA Detection
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
CN121022991A (zh) 2019-12-23 2025-11-28 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
CN115038794A (zh) 2019-12-23 2022-09-09 10X基因组学有限公司 在基于分区的测定中使用固定生物样品的组合物和方法
CA3161593A1 (en) * 2019-12-30 2021-07-08 President And Fellows Of Harvard College Genome-scale imaging of the 3d organization and transcriptional activity of chromatin
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
CN115485391A (zh) 2020-02-17 2022-12-16 10X基因组学有限公司 染色质相互作用的原位分析
EP4107285B1 (en) 2020-02-21 2024-10-09 10X Genomics, Inc. Methods and compositions for integrated in situ spatial assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
US20230265491A1 (en) * 2020-05-04 2023-08-24 10X Genomics, Inc. Spatial transcriptomic transfer modes
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
ES2989052T3 (es) 2020-05-22 2024-11-25 10X Genomics Inc Medición espacio-temporal simultánea de la expresión génica y la actividad celular
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
ES2981265T3 (es) 2020-06-08 2024-10-08 10X Genomics Inc Métodos para determinar un margen quirúrgico y métodos de uso del mismo
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
EP4168575A1 (en) 2020-06-18 2023-04-26 Resolve BioSciences GmbH Multiplex method for detecting different analytes in a sample
EP4172362B1 (en) 2020-06-25 2024-09-18 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
EP4428246B1 (en) 2021-04-14 2025-12-24 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
WO2022236054A1 (en) 2021-05-06 2022-11-10 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4582555A3 (en) 2021-06-03 2025-10-22 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
CA3224093A1 (en) 2021-07-30 2023-02-02 Jorge Ivan Hernandez Neuta Methods and compositions for synchronizing reactions in situ
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
EP4326898B1 (en) 2021-08-16 2024-07-31 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
ES3011462T3 (en) 2021-09-01 2025-04-07 10X Genomics Inc Methods for blocking a capture probe on a spatial array
EP4419707A1 (en) 2021-11-10 2024-08-28 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
CN118974836A (zh) 2022-03-08 2024-11-15 10X基因组学有限公司 将光学拥挤最小化的原位代码设计方法
AU2023243205A1 (en) 2022-04-01 2024-09-19 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
JP2025516589A (ja) 2022-05-11 2025-05-30 10エックス ジェノミクス インコーポレイテッド インサイチュー配列決定のための組成物及び方法
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
CN119677873A (zh) 2022-08-16 2025-03-21 10X基因组学有限公司 Ap50聚合酶及其用途
WO2024196728A2 (en) 2023-03-17 2024-09-26 Nanostring Technologies, Inc. Nucleic acid probes for combined sequencing and spatial analysis
WO2024196764A2 (en) 2023-03-17 2024-09-26 Nanostring Technologies, Inc. Assay for recombinase accessible chromatin and related compositions and methods
WO2025029831A1 (en) 2023-07-31 2025-02-06 10X Genomics, Inc. Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5091519A (en) 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5066580A (en) 1988-08-31 1991-11-19 Becton Dickinson And Company Xanthene dyes that emit to the red of fluorescein
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6426513B1 (en) 1998-09-18 2002-07-30 Massachusetts Institute Of Technology Water-soluble thiol-capped nanocrystals
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
ATE307901T1 (de) * 1999-04-08 2005-11-15 Gen Probe Inc Amplifikation und sequenzierung von primer-paaren und deren verwendung
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6576291B2 (en) 2000-12-08 2003-06-10 Massachusetts Institute Of Technology Preparation of nanocrystallites
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
ATE556845T1 (de) 2001-07-20 2012-05-15 Life Technologies Corp Lumineszierende nanopartikel und ihre herstellung
JP4283578B2 (ja) * 2003-03-31 2009-06-24 学校法人片柳学園 不一致増幅物質を含むプローブ核酸を用いる標的配列の検出方法、プローブ核酸および標的配列検出用アッセイキット
CA2580070A1 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
JP4839051B2 (ja) * 2004-10-08 2011-12-14 シスメックス株式会社 核酸プローブを用いる被検物質の検出方法
US20090299640A1 (en) 2005-11-23 2009-12-03 University Of Utah Research Foundation Methods and Compositions Involving Intrinsic Genes
AU2006330830B2 (en) 2005-12-23 2013-01-10 Bruker Spatial Biology, Inc. Nanoreporters and methods of manufacturing and use thereof
EP1963500B1 (en) 2005-12-23 2013-02-13 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
EP2495337A1 (en) * 2006-02-24 2012-09-05 Callida Genomics, Inc. High throughput genome sequencing on DNA arrays
ES2620398T3 (es) 2006-05-22 2017-06-28 Nanostring Technologies, Inc. Sistemas y métodos para analizar nanoindicadores
US7745129B1 (en) * 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
US8415102B2 (en) 2007-04-10 2013-04-09 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
US9631239B2 (en) 2008-05-30 2017-04-25 University Of Utah Research Foundation Method of classifying a breast cancer instrinsic subtype
US8519115B2 (en) 2008-08-14 2013-08-27 Nanostring Technologies, Inc. Stable nanoreporters
JP5985390B2 (ja) * 2009-04-02 2016-09-06 フリューダイム・コーポレイション 標的核酸にバーコードを付加するためのマルチプライマー増幅方法
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
JP5914362B2 (ja) 2010-02-11 2016-05-11 ナノストリング テクノロジーズ, インコーポレイテッド 低分子rna分子の検出のための組成物および方法
US20110229888A1 (en) 2010-03-16 2011-09-22 Hengen Paul N Compositions and Methods for the Detection of Genomic Features
EP2685988A4 (en) 2011-03-15 2014-08-20 Univ North Carolina Methods of treating breast cancer with anthracycline therapy
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
CN108342453A (zh) * 2011-05-09 2018-07-31 富鲁达公司 基于探针的核酸检测
AU2012272763B2 (en) 2011-06-24 2016-11-03 Nanostring Technologies, Inc. Multivariate diagnostic assays and methods for using same
JP2014531908A (ja) * 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
AU2012345789B2 (en) 2011-11-30 2018-02-15 British Columbia Cancer Agency Branch Methods of treating breast cancer with taxane therapy
US10385392B2 (en) * 2011-12-30 2019-08-20 Abbott Molecular Inc. Nucleic acid hybridization probes
IN2014MN02418A (enExample) 2012-05-22 2015-08-14 Nanostring Technologies Inc
JP2015530072A (ja) 2012-06-29 2015-10-15 ナノストリング テクノロジーズ,インコーポレイティド ゲムシタビン療法による乳癌の治療方法
WO2014075067A1 (en) 2012-11-12 2014-05-15 Nanostring Technologies, Inc. Methods to predict breast cancer outcome
US10415080B2 (en) * 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
KR102893736B1 (ko) * 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법

Similar Documents

Publication Publication Date Title
JP2022023100A5 (enExample)
JP2017535269A5 (enExample)
AU2022271472B2 (en) Enzyme- and amplification-free sequencing
CN101851652B (zh) 基于微阵列芯片的通用多重聚合酶链式反应的实现方法
US7914989B2 (en) Capture moieties for nucleic acids and uses thereof
US9957550B2 (en) Attenuators
IL152727A (en) Single copy genomic hybridization probes and method of generating same
US20160251712A1 (en) Sequential Sequencing
JP2015511819A5 (enExample)
WO2015014962A1 (en) Sequence capture method using specialized capture probes (heatseq)
JP2022502343A (ja) 肝癌によく見られた複数の変異を同時に検出するctDNAライブラリーの構築及びシークエンシングデータの分析の方法
RU2001114072A (ru) Диагностический анализ
JP2020516232A5 (enExample)
JPWO2019222178A5 (enExample)
Böhme et al. Detection of food spoilage and pathogenic bacteria based on ligation detection reaction coupled to flow‐through hybridization on membranes
CN110592260B (zh) 硬粒小麦成株抗叶锈病位点的竞争性等位基因特异聚合酶链式反应标记及其应用
WO1992005280A1 (en) Identification of organisms
WO2015071552A1 (en) Multi-unit probes with high specificity and a method of designing the same
CN108291254B (zh) 用于检测单核苷酸多态性的试剂盒和方法
WO2007095055A2 (en) Methods and compositions for detecting viral nucleic acid in a cell
JP7589951B2 (ja) プローブ誘導ヘテロ二重鎖の移動度アッセイ
US20080058218A1 (en) Arrays of compound probes and methods using the same
KR101898258B1 (ko) 프로브 및 융해패턴 분석을 이용한 염기서열 동일성 판별방법
JP2008534011A (ja) ユニーク配列ハイブリダイゼーションプローブ(usp)
EP4455307A1 (en) Ex-situ sequencing of rca product generated in-situ