|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
EP0435911B1
(en)
|
1988-09-23 |
1996-03-13 |
Cetus Oncology Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
ES2091684T3
(es)
|
1992-11-13 |
1996-11-01 |
Idec Pharma Corp |
Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
PT971946E
(pt)
|
1997-01-21 |
2006-11-30 |
Gen Hospital Corp |
Selecção de proteínas utilizando fusões arn-proteína
|
|
EP0985039B1
(en)
*
|
1997-06-12 |
2008-02-20 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
PT1137941E
(pt)
|
1998-12-10 |
2009-10-15 |
Brystol Myers Squibb Company |
Esqueletos de proteínas para compostos miméticos de anticorpos e outras proteínas de ligação
|
|
US7115396B2
(en)
*
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
JP4118462B2
(ja)
|
1999-07-19 |
2008-07-16 |
株式会社リコー |
携帯電子機器
|
|
EP1074563A1
(en)
|
1999-08-02 |
2001-02-07 |
F. Hoffmann-La Roche Ag |
Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
JP2003528632A
(ja)
|
2000-03-31 |
2003-09-30 |
インスティティ・パスツール |
血管内皮成長因子(vegf)−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法
|
|
US6545853B1
(en)
|
2000-07-10 |
2003-04-08 |
Hughes Electronics Corporation |
Alternate grounding method
|
|
AU1325102A
(en)
|
2000-10-16 |
2002-04-29 |
Phylos Inc |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6989452B2
(en)
|
2001-05-31 |
2006-01-24 |
Medarex, Inc. |
Disulfide prodrugs and linkers and stabilizers useful therefor
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
CN102584997A
(zh)
|
2002-11-08 |
2012-07-18 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子-α的单结构域抗体及其用途
|
|
EP2281577B1
(en)
|
2003-05-14 |
2016-11-16 |
ImmunoGen, Inc. |
Drug conjugate composition
|
|
NZ583292A
(en)
|
2003-11-06 |
2012-03-30 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
SI1729795T1
(sl)
|
2004-02-09 |
2016-04-29 |
Human Genome Sciences, Inc. |
Albuminski fuzijski proteini
|
|
AU2005216251B2
(en)
|
2004-02-23 |
2011-03-10 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
US7778814B2
(en)
|
2004-03-30 |
2010-08-17 |
Siemens Aktiengesellschaft |
Method and device for simulating an automation system
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
MXPA06013413A
(es)
|
2004-05-19 |
2007-01-23 |
Medarex Inc |
Enlazadores quimicos y conjugados de los mismos.
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
JP5290756B2
(ja)
|
2005-09-26 |
2013-09-18 |
メダレックス インコーポレイテッド |
抗体−薬剤コンジュゲート及びその使用
|
|
WO2007038868A2
(en)
|
2005-10-03 |
2007-04-12 |
The University Of British Columbia |
Novel enediyne compound and uses thereof
|
|
EP1940789B1
(en)
|
2005-10-26 |
2011-11-23 |
Medarex, Inc. |
Methods and compounds for preparing cc-1065 analogs
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
PE20080316A1
(es)
|
2006-05-25 |
2008-04-10 |
Bristol Myers Squibb Co |
Compuestos de aziridinil-epotilona
|
|
AR062448A1
(es)
|
2006-05-25 |
2008-11-12 |
Endocyte Inc |
Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
JP2010519310A
(ja)
|
2007-02-21 |
2010-06-03 |
メダレックス インコーポレイテッド |
単一のアミノ酸を有する化学リンカーおよびその複合体
|
|
EP2217274A1
(en)
*
|
2007-11-28 |
2010-08-18 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
AU2008345424A1
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
MX2010011957A
(es)
|
2008-05-02 |
2011-03-04 |
Novartis Ag Star |
Moleculas de union basadas en fibronectina mejoradas y usos de las mismas.
|
|
EP2799448A1
(en)
*
|
2008-05-22 |
2014-11-05 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
PL2949670T3
(pl)
|
2009-12-10 |
2019-07-31 |
F. Hoffmann-La Roche Ag |
Przeciwciała wiążące się preferencyjnie z zewnątrzkomórkową domeną 4 ludzkiego CSF-1R i ich zastosowanie
|
|
BR112012019881A2
(pt)
|
2010-02-18 |
2017-06-27 |
Bristol Myers Squibb Co |
proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23
|
|
US9169323B2
(en)
|
2010-03-05 |
2015-10-27 |
Hoffmann-La Roche Inc. |
Antibodies against human CSF-1R
|
|
US9221910B2
(en)
|
2010-03-05 |
2015-12-29 |
Hoffmann-La Roche Inc. |
Antibodies against human CSF-1R
|
|
JP5969458B2
(ja)
|
2010-04-09 |
2016-08-17 |
アルブミディクス アクティーゼルスカブ |
アルブミン誘導体及び変異体
|
|
EP3424949A1
(en)
*
|
2010-04-13 |
2019-01-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind pcsk9
|
|
AU2011240620A1
(en)
*
|
2010-04-13 |
2012-10-18 |
Medimmune, Llc |
Fibronectin type III domain-based multimeric scaffolds
|
|
CN102971329B
(zh)
|
2010-04-15 |
2016-06-29 |
麦迪穆有限责任公司 |
用于治疗增殖性疾病的吡咯并苯并二氮杂卓
|
|
NZ602932A
(en)
|
2010-04-15 |
2014-08-29 |
Seattle Genetics Inc |
Targeted pyrrolobenzodiazapine conjugates
|
|
AU2011248083B2
(en)
|
2010-05-04 |
2015-09-10 |
Five Prime Therapeutics, Inc. |
Antibodies that bind CSF1R
|
|
AU2011283646B2
(en)
|
2010-07-30 |
2015-07-09 |
Novartis Ag |
Fibronectin cradle molecules and libraries thereof
|
|
WO2012059486A1
(en)
|
2010-11-01 |
2012-05-10 |
Novozymes Biopharma Dk A/S |
Albumin variants
|
|
DK2640740T3
(en)
*
|
2010-11-15 |
2017-06-26 |
Pieris Pharmaceuticals Gmbh |
MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3)
|
|
MX365235B
(es)
*
|
2010-11-30 |
2019-05-28 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno.
|
|
US8852599B2
(en)
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
CN103987718A
(zh)
|
2011-09-20 |
2014-08-13 |
斯皮罗根有限公司 |
作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
|
|
CA2853889A1
(en)
|
2011-12-15 |
2013-06-20 |
F. Hoffmann-La Roche Ag |
Antibodies against human csf-1r and uses thereof
|
|
BR112014018961A8
(pt)
|
2012-02-06 |
2017-07-11 |
Genentech Inc |
Anticorpo isolado, anticorpo biespecífico, fragmento, ácido nucleico isolado, vetor, célula hospedeira, método de produção de anticorpos, composição farmacêutica, uso do anticorpo, método de tratamento, método de inibição e artigo industrializado
|
|
TW201336851A
(zh)
|
2012-02-13 |
2013-09-16 |
必治妥美雅史谷比公司 |
烯二炔化合物,其共軛物及彼等之用途與方法
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
HK1208233A1
(en)
|
2012-05-11 |
2016-02-26 |
戊瑞治疗有限公司 |
Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
|
|
EP2890398A4
(en)
|
2012-08-31 |
2016-03-09 |
Five Prime Therapeutics Inc |
METHODS OF TREATING DISEASES WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR RECEIVER 1 (CSF1R)
|
|
LT3835310T
(lt)
*
|
2012-09-13 |
2024-04-25 |
Bristol-Myers Squibb Company |
Fibronektino pagrindo karkaso domeno baltymai, kurie rišasi prie miostatino
|
|
SI2956173T1
(sl)
|
2013-02-14 |
2017-06-30 |
Bristol-Myers Squibb Company |
Spojine tubulizina, postopki pridobivanja in uporaba
|
|
US9433689B2
(en)
|
2013-03-12 |
2016-09-06 |
The Board Of Trustees Of The Leland Stanford Junio |
Probes and methods of imaging non-Hodgkins lymphoma
|
|
US20160000946A1
(en)
*
|
2013-03-14 |
2016-01-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Radiolabeled anti-glypican-3 immunoconjugates for immuno-pet imaging of hepatocellular carcinoma
|
|
CN105899515B
(zh)
*
|
2013-08-14 |
2020-01-14 |
威廉马歇莱思大学 |
uncialamycin的衍生物、合成方法及其作为抗肿瘤剂的用途
|
|
EP3647322B1
(en)
*
|
2014-03-20 |
2021-10-20 |
Bristol-Myers Squibb Company |
Stabilized fibronectin based scaffold molecules
|
|
ES2809125T3
(es)
|
2015-09-23 |
2021-03-03 |
Bristol Myers Squibb Co |
Moléculas de armazón a base de fibronectina de unión a glipicano-3
|