JP2022000444A5 - - Google Patents
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- Publication number
- JP2022000444A5 JP2022000444A5 JP2021152371A JP2021152371A JP2022000444A5 JP 2022000444 A5 JP2022000444 A5 JP 2022000444A5 JP 2021152371 A JP2021152371 A JP 2021152371A JP 2021152371 A JP2021152371 A JP 2021152371A JP 2022000444 A5 JP2022000444 A5 JP 2022000444A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pseudo
- alkenyl
- solid phase
- single bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000006239 protecting group Chemical group 0.000 claims 28
- 239000007790 solid phase Substances 0.000 claims 22
- 239000002777 nucleoside Substances 0.000 claims 19
- 108091034117 Oligonucleotide Proteins 0.000 claims 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 15
- 125000000262 haloalkenyl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 8
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 6
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003835 nucleoside group Chemical group 0.000 claims 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023079618A JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015224617 | 2015-11-17 | ||
| JP2015224617 | 2015-11-17 | ||
| JP2017551927A JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Division JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023079618A Division JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022000444A JP2022000444A (ja) | 2022-01-04 |
| JP2022000444A5 true JP2022000444A5 (enExample) | 2022-11-29 |
Family
ID=58718980
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Active JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
| JP2021152371A Pending JP2022000444A (ja) | 2015-11-17 | 2021-09-17 | オリゴヌクレオチドの製造方法 |
| JP2023079618A Active JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Active JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023079618A Active JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11548910B2 (enExample) |
| EP (1) | EP3378869A4 (enExample) |
| JP (3) | JP6950529B2 (enExample) |
| CN (1) | CN108350018A (enExample) |
| TW (1) | TWI729028B (enExample) |
| WO (1) | WO2017086397A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017086397A1 (ja) * | 2015-11-17 | 2017-05-26 | 日産化学工業株式会社 | オリゴヌクレオチドの製造方法 |
| CN108473526B (zh) | 2015-12-16 | 2022-08-09 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| US11174279B2 (en) * | 2016-06-21 | 2021-11-16 | National Institute Of Advanced Industrial Science And Technology | Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used |
| JP7306263B2 (ja) * | 2017-05-02 | 2023-07-11 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| JP7140111B2 (ja) * | 2017-05-16 | 2022-09-21 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| EP3733680A4 (en) * | 2017-12-27 | 2021-12-29 | KNC Laboratories Co., Ltd | Production of highly fat-soluble phosphoramidite |
| CN108586449A (zh) * | 2018-06-08 | 2018-09-28 | 山东阳谷华泰化工股份有限公司 | 一种n-（2-巯基苯并噻唑）邻苯二甲酰亚胺及其制备方法和应用 |
| JP7296636B2 (ja) * | 2018-07-20 | 2023-06-23 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| JP6770553B2 (ja) * | 2018-07-20 | 2020-10-14 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| JP7567483B2 (ja) | 2019-02-15 | 2024-10-16 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| CN113631564B (zh) * | 2019-03-28 | 2025-02-25 | 味之素株式会社 | 具有硫代磷酸酯化部位的寡核苷酸的制造方法 |
| US12559516B2 (en) | 2019-05-21 | 2026-02-24 | Natias Inc. | Multi-fluorous blockmer for oligonucleotide synthesis, and oligonucleotide synthesis method using the same |
| US20230406878A1 (en) * | 2020-11-11 | 2023-12-21 | Biogen Ma Inc. | Oligonucleotides, reagents, and preparation thereof |
| US20240300993A1 (en) * | 2021-07-06 | 2024-09-12 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| JP7220439B1 (ja) | 2022-03-14 | 2023-02-10 | 国立大学法人東北大学 | キメラ分子の製造方法 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| EP4678626A1 (en) | 2023-03-06 | 2026-01-14 | Spera Pharma, Inc. | Long-chain alkenyloxy-substituted benzoyl derivative and oligonucleotide synthesis method using same |
| WO2024228396A1 (ja) | 2023-05-01 | 2024-11-07 | 株式会社ナティアス | オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成 |
| JP7433684B1 (ja) | 2023-05-24 | 2024-02-20 | 塩野フィネス株式会社 | 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法 |
| WO2025082632A1 (en) | 2023-10-16 | 2025-04-24 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3707529A (en) | 1970-09-04 | 1972-12-26 | Du Pont | Elastomeric vinylidene fluoride polymers with 55-95 percent non-ionic end groups |
| US3860722A (en) | 1972-09-22 | 1975-01-14 | Richardson Merrell Inc | Hypolipidemic agents |
| JPS60174797A (ja) * | 1984-02-21 | 1985-09-09 | Funai Corp | Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤 |
| CA2234159A1 (en) | 1995-10-19 | 1997-04-24 | Alecia Settle | Method for solution phase synthesis of oligonucleotides |
| EP1289911A2 (en) | 2000-06-13 | 2003-03-12 | Proligo LLC | Universal solid supports for solid phase oligosynthesis and methods for their preparation and use |
| JP3947483B2 (ja) * | 2003-02-28 | 2007-07-18 | 財団法人野口研究所 | ジアミド型ゲル化剤 |
| JP2006523237A (ja) * | 2003-04-03 | 2006-10-12 | セマフォア ファーマシューティカルズ， インコーポレイテッド | Ｐｉ−３キナーゼインヒビタープロドラッグ |
| JP4616175B2 (ja) * | 2003-09-02 | 2011-01-19 | 株式会社キラルジェン | ５’−ホスフィチル化モノマーおよびｈ−ホスホネートオリゴヌクレオチド誘導体の製造方法 |
| JP5548852B2 (ja) * | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| CN102139203B (zh) | 2011-01-14 | 2013-01-23 | 河北师范大学 | 一种选择性凝胶化苯胺(或取代苯胺)的有机小分子凝胶剂及其应用 |
| DK2711370T3 (en) * | 2011-05-17 | 2018-02-26 | Ajinomoto Kk | PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES |
| EP2816053B1 (en) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| US9284344B2 (en) | 2012-05-30 | 2016-03-15 | Hokkaido System Science Co., Ltd. | Oligonucleotide synthesis method using highly dispersible liquid-phase support |
| US9303056B2 (en) | 2012-07-25 | 2016-04-05 | Kochi University | Monomer for synthesis of RNA, method for producing same, and method for producing RNA |
| US10214555B2 (en) | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| CN113717239B (zh) | 2015-01-21 | 2024-12-24 | 味之素株式会社 | 沉淀促进剂以及使用其的沉淀方法 |
| WO2017086397A1 (ja) * | 2015-11-17 | 2017-05-26 | 日産化学工業株式会社 | オリゴヌクレオチドの製造方法 |
| CN108473526B (zh) * | 2015-12-16 | 2022-08-09 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
-
2016
- 2016-11-17 WO PCT/JP2016/084150 patent/WO2017086397A1/ja not_active Ceased
- 2016-11-17 EP EP16866398.7A patent/EP3378869A4/en not_active Withdrawn
- 2016-11-17 CN CN201680064758.9A patent/CN108350018A/zh active Pending
- 2016-11-17 JP JP2017551927A patent/JP6950529B2/ja active Active
- 2016-11-17 US US15/776,709 patent/US11548910B2/en active Active
- 2016-11-17 TW TW105137671A patent/TWI729028B/zh not_active IP Right Cessation
-
2021
- 2021-09-17 JP JP2021152371A patent/JP2022000444A/ja active Pending
-
2023
- 2023-05-12 JP JP2023079618A patent/JP7531018B2/ja active Active
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