JP2018527360A5 - - Google Patents

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Publication number
JP2018527360A5
JP2018527360A5 JP2018512334A JP2018512334A JP2018527360A5 JP 2018527360 A5 JP2018527360 A5 JP 2018527360A5 JP 2018512334 A JP2018512334 A JP 2018512334A JP 2018512334 A JP2018512334 A JP 2018512334A JP 2018527360 A5 JP2018527360 A5 JP 2018527360A5
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JP
Japan
Prior art keywords
moiety
compound according
protein
compound
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018512334A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018527360A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/052829 external-priority patent/WO2017053391A1/en
Publication of JP2018527360A publication Critical patent/JP2018527360A/ja
Publication of JP2018527360A5 publication Critical patent/JP2018527360A5/ja
Pending legal-status Critical Current

Links

JP2018512334A 2015-09-22 2016-09-21 修飾された細胞毒とその治療的使用 Pending JP2018527360A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222059P 2015-09-22 2015-09-22
US62/222,059 2015-09-22
PCT/US2016/052829 WO2017053391A1 (en) 2015-09-22 2016-09-21 Modified cytotoxins and their therapeutic use

Publications (2)

Publication Number Publication Date
JP2018527360A JP2018527360A (ja) 2018-09-20
JP2018527360A5 true JP2018527360A5 (enExample) 2019-10-31

Family

ID=58276138

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018512334A Pending JP2018527360A (ja) 2015-09-22 2016-09-21 修飾された細胞毒とその治療的使用

Country Status (14)

Country Link
US (3) US10023581B2 (enExample)
EP (1) EP3353159A4 (enExample)
JP (1) JP2018527360A (enExample)
KR (1) KR20180045001A (enExample)
CN (1) CN108368075A (enExample)
AU (1) AU2016326392B2 (enExample)
CA (1) CA2998528A1 (enExample)
HK (1) HK1254461A1 (enExample)
IL (1) IL257932A (enExample)
MX (1) MX380314B (enExample)
MY (1) MY193776A (enExample)
RU (1) RU2721949C2 (enExample)
WO (1) WO2017053391A1 (enExample)
ZA (1) ZA201801482B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY193776A (en) * 2015-09-22 2022-10-27 Univ California Modified cytotoxins and their therapeutics use
US10286079B2 (en) 2015-09-22 2019-05-14 The Regents Of The University Of California Modified cytotoxins and their therapeutic use
CA3057292A1 (en) * 2017-03-22 2018-09-27 The Regents Of The University Of California Modified oligonucleotides and therapeutic uses thereof
US20220273607A1 (en) * 2019-07-09 2022-09-01 Northwestern University Methods of using modified cytotoxins to treat cancer
IT202100025172A1 (it) * 2021-09-30 2023-03-30 Indena Spa Processo per la preparazione di derivati tassanici
KR20250057244A (ko) 2023-10-20 2025-04-29 (주)블루엔씨 고정밀 3d 프린팅 기반 금형 제작 방법 및 장치

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411984A (en) 1992-10-16 1995-05-02 Virginia Tech Intellectual Properties, Inc. Water soluble analogs and prodrugs of taxol
GB2278843A (en) * 1993-06-07 1994-12-14 British Tech Group Anti-cancer compounds
US5534499A (en) 1994-05-19 1996-07-09 The University Of British Columbia Lipophilic drug derivatives for use in liposomes
AU735205B2 (en) 1997-05-16 2001-07-05 Commonwealth Scientific And Industrial Research Organisation Vaccine and assay
US5981564A (en) * 1998-07-01 1999-11-09 Universite Laval Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
AU2002953095A0 (en) * 2002-11-29 2002-12-19 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
NO319551B1 (no) 2003-07-04 2005-08-29 Thia Medica As Proteinmateriale fra enkeltceller
GB0321613D0 (en) 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1670515A2 (en) 2003-09-19 2006-06-21 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
RU2340616C2 (ru) * 2003-10-29 2008-12-10 Сонус Фармасьютикалз, Инк. Токоферол-модифицированные терапевтические лекарственные соединения
GB0412181D0 (en) * 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
EP1804838A2 (en) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
ES2484796T3 (es) 2005-03-18 2014-08-12 Novo Nordisk A/S Compuestos de GLP-1 extendidos
WO2007075825A2 (en) * 2005-12-20 2007-07-05 Sonus Pharmaceuticals, Inc. Lipophilic anticancer drug compounds
BRPI0907754A2 (pt) 2008-02-08 2015-07-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos terapêuticos
CA2721153C (en) * 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
WO2010107487A2 (en) 2009-03-18 2010-09-23 Wu Nian Lipid-drug conjugates for drug delivery
CA2756397A1 (en) 2009-04-02 2010-10-07 Shire Llc Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof
WO2011085000A2 (en) 2010-01-06 2011-07-14 The University Of North Carolina At Chapel Hill Fatty acid derivatives and analogs of drugs
RU2012134974A (ru) 2010-01-22 2014-02-27 Ново Нордиск Хелс Кеа Аг Стабилизированное соединение гормона роста
PL2525834T3 (pl) 2010-01-22 2020-10-19 Novo Nordisk Health Care Ag Hormony wzrostu o przedłużonej skuteczności in-vivo
ES2582590T3 (es) 2010-02-16 2016-09-13 Novo Nordisk A/S Método de purificación
CN103002891B (zh) * 2010-05-10 2016-10-26 加利福尼亚大学董事会 比例计量型组合药物递送
EP2392324A1 (en) * 2010-06-01 2011-12-07 Societe De Coordination De Recherches Therapeutiques Rhenium complexes and their pharmaceutical use
BR112013007442A2 (pt) 2010-09-28 2019-09-24 Amylin Pharmaceuticals Llc polipeptídeos construídos tendo duração de ação realçada
MX349054B (es) 2010-09-28 2017-07-07 Aegerion Pharmaceuticals Inc Leptinas altamente solubles.
WO2012048204A2 (en) * 2010-10-08 2012-04-12 Virginia Commonwealth University Prodrugs utilizing a transporter directed uptake mechanism
EP2723452A2 (en) 2011-06-22 2014-04-30 Vyome Biosciences Pvt Ltd Conjugate-based antifungal and antibacterial prodrugs
JP6006309B2 (ja) 2011-07-08 2016-10-12 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド
DK2729160T3 (da) 2011-07-08 2019-07-01 Aegerion Pharmaceuticals Inc Manipulerede polypeptider, der har forbedret virkningstid og reduceret immunogenicitet
KR101435261B1 (ko) * 2012-07-23 2014-09-02 아주대학교산학협력단 항암제-링커-알부민 결합체, 이의 제조방법 및 상기 결합체를 포함하는 약물 전달용 조성물
WO2014078895A1 (en) * 2012-11-21 2014-05-30 The University Of Sydney Omega-3 analogues
WO2014121033A1 (en) * 2013-02-04 2014-08-07 Fl Therapeutics Llc Soluble complexes of drug analogs and albumin
US20160115192A1 (en) * 2013-06-10 2016-04-28 Cedars-Sinai Medical Center Antioxidant, anti-inflammatory and anticancer derivatives of triptolide and nanospheres thereof
WO2015081891A1 (en) 2013-12-06 2015-06-11 Baikang (Suzhou) Co., Ltd Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
CN107708702A (zh) * 2014-11-17 2018-02-16 塞勒克塔生物科学有限公司 磷脂醚类似物作为靶向癌症的药物载体
CN104478813A (zh) * 2014-12-20 2015-04-01 苏州博源医疗科技有限公司 5-氟尿嘧啶衍生物、5-氟尿嘧啶免疫原及其抗体与5-氟尿嘧啶检测试剂盒
US10286079B2 (en) * 2015-09-22 2019-05-14 The Regents Of The University Of California Modified cytotoxins and their therapeutic use
MY193776A (en) * 2015-09-22 2022-10-27 Univ California Modified cytotoxins and their therapeutics use
US20200048198A1 (en) * 2017-03-22 2020-02-13 The Regents Of The University Of California Modified histone deacetylase inhibitors and uses thereof
US20210137874A1 (en) * 2017-03-22 2021-05-13 The Regents Of The University Of California Modified platinum compounds and therapeutic uses thereof
US20210137957A1 (en) * 2017-03-22 2021-05-13 The Regents Of The University Of California Modified anthracycline compounds and their therapeutic use
AU2018258345A1 (en) * 2017-04-27 2019-10-17 The Regents Of The University Of California Modified mri contrast agents and uses thereof

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