UY31215A1 - Compuestos de morfolino pirimidina, procesos para su preparacion, composiciones farmacéuticas conteniéndolos y su uso en terapia. - Google Patents
Compuestos de morfolino pirimidina, procesos para su preparacion, composiciones farmacéuticas conteniéndolos y su uso en terapia.Info
- Publication number
- UY31215A1 UY31215A1 UY31215A UY31215A UY31215A1 UY 31215 A1 UY31215 A1 UY 31215A1 UY 31215 A UY31215 A UY 31215A UY 31215 A UY31215 A UY 31215A UY 31215 A1 UY31215 A1 UY 31215A1
- Authority
- UY
- Uruguay
- Prior art keywords
- therapy
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de formula (I) o una sal farmacéuticamente aceptable del mismo, procesos para su preparacion, composiciones farmacéuticas que los contienen y su uso en terapia, por ejemplo en el tratamiento de una enfermedad proliferativa tal como el cáncer y particularmente en una enfermedad mediada por una mTOR y7/o una o más enzimas PI3K.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94856607P | 2007-07-09 | 2007-07-09 | |
US3029708P | 2008-02-21 | 2008-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31215A1 true UY31215A1 (es) | 2009-03-02 |
Family
ID=40010883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31215A UY31215A1 (es) | 2007-07-09 | 2008-07-09 | Compuestos de morfolino pirimidina, procesos para su preparacion, composiciones farmacéuticas conteniéndolos y su uso en terapia. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20090018134A1 (es) |
EP (1) | EP2074118A2 (es) |
JP (1) | JP2010533158A (es) |
KR (1) | KR20100031639A (es) |
CN (1) | CN101801962A (es) |
AR (1) | AR067478A1 (es) |
AU (1) | AU2008273889B2 (es) |
BR (1) | BRPI0814818A2 (es) |
CA (1) | CA2692945A1 (es) |
CL (1) | CL2008002006A1 (es) |
CO (1) | CO6390066A2 (es) |
CR (1) | CR11201A (es) |
DO (1) | DOP2010000011A (es) |
EA (1) | EA201000092A1 (es) |
NI (1) | NI201000004A (es) |
PE (1) | PE20090773A1 (es) |
TW (1) | TW200904813A (es) |
UY (1) | UY31215A1 (es) |
WO (1) | WO2009007748A2 (es) |
ZA (1) | ZA201000106B (es) |
Families Citing this family (81)
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EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
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TW201028410A (en) | 2008-12-22 | 2010-08-01 | Astrazeneca Ab | Chemical compounds 610 |
WO2010103094A1 (en) | 2009-03-13 | 2010-09-16 | Cellzome Limited | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
US8946204B2 (en) | 2009-05-07 | 2015-02-03 | Gruenenthal Gmbh | Substituted phenylureas and phenylamides as vanilloid receptor ligands |
EP2427435B1 (en) | 2009-05-07 | 2017-06-14 | Medifron DBT Inc. | Substituted phenylureas and phenylamides as vanilloid receptor ligands |
JP5680639B2 (ja) | 2009-07-02 | 2015-03-04 | サノフイ | 新規6−モルホリン−4−イル−ピリミジン−4−(3h)−オン誘導体、およびakt(pkb)リン酸化阻害剤としてのこの医薬調製物 |
ES2464125T3 (es) | 2009-07-02 | 2014-05-30 | Sanofi | Nuevos derivados de (6-oxo-1,6-dihidro-pirimidin-2-il)-amida, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
KR20120115237A (ko) | 2009-10-30 | 2012-10-17 | 어리어드 파마슈티칼스, 인코포레이티드 | 암 치료 방법 및 조성물 |
CA2788678C (en) | 2010-02-03 | 2019-02-26 | Signal Pharmaceuticals, Llc | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
WO2011107585A1 (en) | 2010-03-04 | 2011-09-09 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
RU2013114932A (ru) * | 2010-09-03 | 2014-10-10 | Пирамал Энтерпрайзис Лимитед | Гетероциклические соединения в качестве ингибиторов dgat1 |
WO2012058671A1 (en) | 2010-10-31 | 2012-05-03 | Endo Pharmaceuticals Inc. | Substituted quinazoline and pyrido-pyrimidine derivatives |
EP2658844B1 (fr) | 2010-12-28 | 2016-10-26 | Sanofi | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
JP2014510122A (ja) | 2011-04-04 | 2014-04-24 | セルゾーム リミテッド | mTOR阻害剤としてのジヒドロピロロピリミジン誘導体 |
CA2843887A1 (en) | 2011-08-03 | 2013-02-07 | Signal Pharmaceuticals, Llc | Identification of gene expression profile as a predictive biomarker for lkb1 status |
CA2849189A1 (en) | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
CU24269B1 (es) | 2011-09-27 | 2017-08-08 | Novartis Ag | 3- pirimidin- 4-il- oxazolidin- 2- onas inhibidores de la idh mutante |
BR112014008241A2 (pt) | 2011-10-07 | 2017-04-18 | Cellzome Ltd | composto, composição farmacêutica, métodos para tratar, controlar, retardar ou prevenir doenças e distúrbios, e para preparar um composto, e, uso de um composto |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
RU2014149145A (ru) | 2012-05-23 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Композиции и способы получения и применения эндодермальных клеток и гепатоцитов |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
MX355945B (es) | 2013-03-14 | 2018-05-07 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
BR112015026238A8 (pt) | 2013-04-17 | 2019-12-24 | Signal Pharm Llc | composto dihidropirazino-pirazina, composição farmacêutica que o compreende, uso do composto, métodos para inibir ou medir a fosforilação e para inibir a atividade da proteína quinase, bem como kit |
MX2015014590A (es) | 2013-04-17 | 2016-03-03 | Signal Pharm Llc | Tratamiento de cancer con dihidropirazino-pirazinas. |
BR112015026257B1 (pt) | 2013-04-17 | 2022-12-20 | Signal Pharmaceuticals, Llc | Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit |
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WO2023098882A1 (en) * | 2021-12-02 | 2023-06-08 | Beigene, Ltd. | Methods of synthesis of chiral 3, 5-disubstituted morpholine compounds and intermediates useful therein |
Family Cites Families (9)
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DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
PT1335906E (pt) * | 2000-11-10 | 2007-01-31 | Hoffmann La Roche | Derivados de pirimidina e a sua utilização como ligantes de receptores do neuropéptido y |
BRPI0508310A (pt) * | 2004-03-02 | 2007-07-24 | Hoffmann La Roche | derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina e compostos relacionados como ligandos do receptor gaba, para o tratamento de ansiedade, depressão e epilepsia |
US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2007027855A2 (en) * | 2005-09-01 | 2007-03-08 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
GB0520657D0 (en) * | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
KR101435231B1 (ko) * | 2006-08-24 | 2014-10-02 | 아스트라제네카 아베 | 증식성 질환의 치료에 유용한 모르폴리노 피리미딘 유도체 |
JP2010533159A (ja) * | 2007-07-09 | 2010-10-21 | アストラゼネカ アクチボラグ | 化合物947 |
KR20100042280A (ko) * | 2007-07-09 | 2010-04-23 | 아스트라제네카 아베 | Mtor 키나제 및/또는 pi3k와 연관된 질환에 사용되는 모르폴리노 피리미딘 유도체 |
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2008
- 2008-07-08 EA EA201000092A patent/EA201000092A1/ru unknown
- 2008-07-08 BR BRPI0814818A patent/BRPI0814818A2/pt not_active IP Right Cessation
- 2008-07-08 EP EP08776181A patent/EP2074118A2/en not_active Withdrawn
- 2008-07-08 AR ARP080102944A patent/AR067478A1/es unknown
- 2008-07-08 CN CN200880106248A patent/CN101801962A/zh active Pending
- 2008-07-08 AU AU2008273889A patent/AU2008273889B2/en not_active Expired - Fee Related
- 2008-07-08 JP JP2010515600A patent/JP2010533158A/ja active Pending
- 2008-07-08 CA CA 2692945 patent/CA2692945A1/en not_active Abandoned
- 2008-07-08 KR KR1020107002969A patent/KR20100031639A/ko not_active Application Discontinuation
- 2008-07-08 WO PCT/GB2008/050546 patent/WO2009007748A2/en active Application Filing
- 2008-07-09 TW TW097125962A patent/TW200904813A/zh unknown
- 2008-07-09 US US12/170,128 patent/US20090018134A1/en not_active Abandoned
- 2008-07-09 UY UY31215A patent/UY31215A1/es unknown
- 2008-07-09 PE PE2008001149A patent/PE20090773A1/es not_active Application Discontinuation
- 2008-07-09 CL CL2008002006A patent/CL2008002006A1/es unknown
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2010
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- 2010-01-08 DO DO2010000011A patent/DOP2010000011A/es unknown
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US20090018134A1 (en) | 2009-01-15 |
EP2074118A2 (en) | 2009-07-01 |
CN101801962A (zh) | 2010-08-11 |
TW200904813A (en) | 2009-02-01 |
EA201000092A1 (ru) | 2010-06-30 |
JP2010533158A (ja) | 2010-10-21 |
CR11201A (es) | 2010-06-17 |
NI201000004A (es) | 2010-10-12 |
ZA201000106B (en) | 2011-06-29 |
WO2009007748A3 (en) | 2009-04-23 |
CL2008002006A1 (es) | 2009-06-26 |
BRPI0814818A2 (pt) | 2019-09-10 |
AR067478A1 (es) | 2009-10-14 |
AU2008273889A1 (en) | 2009-01-15 |
CO6390066A2 (es) | 2012-02-29 |
DOP2010000011A (es) | 2010-03-31 |
PE20090773A1 (es) | 2009-07-23 |
WO2009007748A2 (en) | 2009-01-15 |
KR20100031639A (ko) | 2010-03-23 |
CA2692945A1 (en) | 2009-01-15 |
AU2008273889B2 (en) | 2012-03-08 |
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