JP2021535177A5 - - Google Patents
Info
- Publication number
- JP2021535177A5 JP2021535177A5 JP2021512257A JP2021512257A JP2021535177A5 JP 2021535177 A5 JP2021535177 A5 JP 2021535177A5 JP 2021512257 A JP2021512257 A JP 2021512257A JP 2021512257 A JP2021512257 A JP 2021512257A JP 2021535177 A5 JP2021535177 A5 JP 2021535177A5
- Authority
- JP
- Japan
- Prior art keywords
- lung
- disease
- transplant rejection
- pharmaceutically acceptable
- chronic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022141182A JP2022172299A (ja) | 2018-09-04 | 2022-09-06 | Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726562P | 2018-09-04 | 2018-09-04 | |
| US62/726,562 | 2018-09-04 | ||
| PCT/US2019/049276 WO2020051105A1 (en) | 2018-09-04 | 2019-09-03 | Dimethyl amino azetidine amides as jak inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022141182A Division JP2022172299A (ja) | 2018-09-04 | 2022-09-06 | Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535177A JP2021535177A (ja) | 2021-12-16 |
| JP2021535177A5 true JP2021535177A5 (https=) | 2022-08-18 |
| JP7324836B2 JP7324836B2 (ja) | 2023-08-10 |
Family
ID=67982186
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512257A Active JP7324836B2 (ja) | 2018-09-04 | 2019-09-03 | Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド |
| JP2022141182A Pending JP2022172299A (ja) | 2018-09-04 | 2022-09-06 | Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022141182A Pending JP2022172299A (ja) | 2018-09-04 | 2022-09-06 | Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US10947229B2 (https=) |
| EP (1) | EP3837258B1 (https=) |
| JP (2) | JP7324836B2 (https=) |
| KR (1) | KR102826491B1 (https=) |
| CN (1) | CN112739697B (https=) |
| AR (1) | AR116115A1 (https=) |
| AU (1) | AU2019336167B2 (https=) |
| BR (1) | BR112021004052A2 (https=) |
| CL (1) | CL2021000514A1 (https=) |
| CO (1) | CO2021002977A2 (https=) |
| DK (1) | DK3837258T3 (https=) |
| EA (1) | EA202190681A1 (https=) |
| ES (1) | ES2982858T3 (https=) |
| FI (1) | FI3837258T3 (https=) |
| HR (1) | HRP20241002T1 (https=) |
| HU (1) | HUE068058T2 (https=) |
| IL (1) | IL281146B2 (https=) |
| LT (1) | LT3837258T (https=) |
| MA (1) | MA53229A (https=) |
| MX (1) | MX2021002521A (https=) |
| PH (1) | PH12021550368A1 (https=) |
| PL (1) | PL3837258T3 (https=) |
| PT (1) | PT3837258T (https=) |
| SG (1) | SG11202101734RA (https=) |
| SI (1) | SI3837258T1 (https=) |
| TW (1) | TWI791886B (https=) |
| WO (1) | WO2020051105A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA123633C2 (uk) | 2015-11-03 | 2021-05-05 | Тереванс Байофарма Ар Енд Ді Айпі, Елелсі | Сполуки інгібітору jak-кінази для лікування респіраторного захворювання |
| WO2018165392A1 (en) | 2017-03-09 | 2018-09-13 | Theravance Biopharma R&D Ip, Llc | Jak inhibitors containing a 4-membered heterocyclic amide |
| JP2021535176A (ja) | 2018-09-04 | 2021-12-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｊａｋ阻害剤およびその中間体を調製するためのプロセス |
| FI3837258T3 (fi) * | 2018-09-04 | 2024-05-27 | Theravance Biopharma R&D Ip Llc | Dimetyyliaminoatsetidiiniamideja jak-estäjinä |
| UA127328C2 (uk) | 2018-09-04 | 2023-07-19 | Тереванс Байофарма Ар Енд Ді Айпі, Елелсі | 5-7-членні гетероциклічні аміди як інгібітори jak |
| TW202144343A (zh) * | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
| CN115803023A (zh) * | 2020-05-08 | 2023-03-14 | 施万生物制药研发Ip有限责任公司 | 发用奈珠西替尼治疗感染冠状病毒的患者的方法 |
| WO2022271604A1 (en) | 2021-06-21 | 2022-12-29 | Theravance Biopharma R&D Ip, Llc | Method of treating a patient infected with a coronavirus and having a baseline level of crp below 150 mg/l |
| EP4359402B1 (en) * | 2021-06-25 | 2026-03-11 | Theravance Biopharma R&D IP, LLC | Imidazolo indazole compounds as jak inhibitors |
| KR20230092805A (ko) * | 2021-12-17 | 2023-06-26 | 주식회사 대웅제약 | (2R, 3S)-2-(3-(4,5-디클로로-1H-벤조[d]이미다졸-1-일)프로필)피페리딘-3-올의 신규한 산부가염 및 결정형 |
| US20250288561A1 (en) | 2022-05-05 | 2025-09-18 | Theravance Biopharma R&D Ip, Llc | Nezulcitinib for delivery by nebulized oral inhalation |
| WO2023230236A1 (en) | 2022-05-26 | 2023-11-30 | Theravance Biopharma R&D Ip, Llc | Process for preparing jak inhibitors and intermediates thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| EP1648455A4 (en) | 2003-07-23 | 2009-03-04 | Exelixis Inc | MODULATORS OF ALK PROTEIN (ANAPLASTIC LYMPHOMA KINASE) AND METHODS OF USE |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| JP2010111624A (ja) | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ｔｔｋ阻害作用を有するインダゾール誘導体 |
| WO2010114971A1 (en) | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| LT3001903T (lt) | 2009-12-21 | 2018-01-10 | Samumed, Llc | 1h-pirazolo[3,4-b]piridinai ir jų terapinis panaudojimas |
| US8575336B2 (en) * | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| SI3077395T1 (en) | 2013-12-05 | 2018-03-30 | Pfizer Inc. | Pyrrolo(2,3-d)pyrimidinyl, pyrrolo(2,3-b)pyrazinyl and pyrrolo(2,3-d)pyridinyl acrylamides |
| KR20170002623A (ko) | 2014-05-14 | 2017-01-06 | 화이자 인코포레이티드 | 피라졸로피리딘 및 피라졸로피리미딘 |
| WO2016026078A1 (en) | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
| KR101663277B1 (ko) | 2015-03-30 | 2016-10-06 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물 |
| DK3371185T3 (da) | 2015-11-03 | 2020-11-30 | Topivert Pharma Ltd | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer |
| WO2017077283A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| UA123633C2 (uk) * | 2015-11-03 | 2021-05-05 | Тереванс Байофарма Ар Енд Ді Айпі, Елелсі | Сполуки інгібітору jak-кінази для лікування респіраторного захворювання |
| WO2018165392A1 (en) | 2017-03-09 | 2018-09-13 | Theravance Biopharma R&D Ip, Llc | Jak inhibitors containing a 4-membered heterocyclic amide |
| US20180258546A1 (en) | 2017-03-09 | 2018-09-13 | Lam Research Corporation | Electroplating apparatus and methods utilizing independent control of impinging electrolyte |
| KR20200003121A (ko) | 2017-05-01 | 2020-01-08 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | Jak 저해제 화합물의 결정형 |
| WO2018204233A1 (en) | 2017-05-01 | 2018-11-08 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a jak inhibitor compound |
| AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
| CN112566713A (zh) | 2018-07-20 | 2021-03-26 | 波里费拉公司 | 具有再循环回路的渗透模块 |
| UA127328C2 (uk) | 2018-09-04 | 2023-07-19 | Тереванс Байофарма Ар Енд Ді Айпі, Елелсі | 5-7-членні гетероциклічні аміди як інгібітори jak |
| FI3837258T3 (fi) | 2018-09-04 | 2024-05-27 | Theravance Biopharma R&D Ip Llc | Dimetyyliaminoatsetidiiniamideja jak-estäjinä |
| JP2021535176A (ja) | 2018-09-04 | 2021-12-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｊａｋ阻害剤およびその中間体を調製するためのプロセス |
| KR20210084512A (ko) | 2018-10-29 | 2021-07-07 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | Jak 억제제로서 2-아자비시클로 헥산 화합물 |
| HUE067145T2 (hu) | 2019-02-25 | 2024-10-28 | Henan Medinno Pharmaceutical Tech Co Ltd | JAK inhibitor vegyület és alkalmazása |
| WO2020181034A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
| CN112279848A (zh) | 2019-07-25 | 2021-01-29 | 四川海思科制药有限公司 | 一种泛JAKs抑制剂及其用途 |
| TW202144343A (zh) * | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
| CN115803023A (zh) | 2020-05-08 | 2023-03-14 | 施万生物制药研发Ip有限责任公司 | 发用奈珠西替尼治疗感染冠状病毒的患者的方法 |
| WO2022178215A1 (en) | 2021-02-19 | 2022-08-25 | Theravance Biopharma R&D Ip, Llc | Amino amide tetrahydro imidazo pyridines as jak inhibitors |
| WO2022204473A1 (en) | 2021-03-26 | 2022-09-29 | Theravance Biopharma R&D Ip, Llc | Crystalline form of a dihydrochloride salt of a jak inhibitor compound |
| WO2022271604A1 (en) * | 2021-06-21 | 2022-12-29 | Theravance Biopharma R&D Ip, Llc | Method of treating a patient infected with a coronavirus and having a baseline level of crp below 150 mg/l |
-
2019
- 2019-09-03 FI FIEP19769674.3T patent/FI3837258T3/fi active
- 2019-09-03 EA EA202190681A patent/EA202190681A1/ru unknown
- 2019-09-03 SG SG11202101734RA patent/SG11202101734RA/en unknown
- 2019-09-03 DK DK19769674.3T patent/DK3837258T3/da active
- 2019-09-03 CN CN201980057577.7A patent/CN112739697B/zh active Active
- 2019-09-03 AU AU2019336167A patent/AU2019336167B2/en active Active
- 2019-09-03 HR HRP20241002TT patent/HRP20241002T1/hr unknown
- 2019-09-03 MX MX2021002521A patent/MX2021002521A/es unknown
- 2019-09-03 PT PT197696743T patent/PT3837258T/pt unknown
- 2019-09-03 HU HUE19769674A patent/HUE068058T2/hu unknown
- 2019-09-03 EP EP19769674.3A patent/EP3837258B1/en active Active
- 2019-09-03 LT LTEPPCT/US2019/049276T patent/LT3837258T/lt unknown
- 2019-09-03 AR ARP190102520A patent/AR116115A1/es not_active Application Discontinuation
- 2019-09-03 PH PH1/2021/550368A patent/PH12021550368A1/en unknown
- 2019-09-03 BR BR112021004052-8A patent/BR112021004052A2/pt unknown
- 2019-09-03 MA MA053229A patent/MA53229A/fr unknown
- 2019-09-03 SI SI201930791T patent/SI3837258T1/sl unknown
- 2019-09-03 TW TW108131679A patent/TWI791886B/zh active
- 2019-09-03 KR KR1020217009936A patent/KR102826491B1/ko active Active
- 2019-09-03 PL PL19769674.3T patent/PL3837258T3/pl unknown
- 2019-09-03 IL IL281146A patent/IL281146B2/en unknown
- 2019-09-03 WO PCT/US2019/049276 patent/WO2020051105A1/en not_active Ceased
- 2019-09-03 ES ES19769674T patent/ES2982858T3/es active Active
- 2019-09-03 US US16/559,077 patent/US10947229B2/en active Active
- 2019-09-03 JP JP2021512257A patent/JP7324836B2/ja active Active
-
2021
- 2021-02-04 US US17/248,717 patent/US11634419B2/en active Active
- 2021-03-02 CL CL2021000514A patent/CL2021000514A1/es unknown
- 2021-03-04 CO CONC2021/0002977A patent/CO2021002977A2/es unknown
-
2022
- 2022-09-06 JP JP2022141182A patent/JP2022172299A/ja active Pending
-
2023
- 2023-03-09 US US18/181,138 patent/US20230322774A1/en not_active Abandoned
-
2024
- 2024-05-31 US US18/680,940 patent/US12398135B2/en active Active
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