TWI791886B - 作為jak抑制劑之二甲基胺基氮雜環丁烷醯胺 - Google Patents

作為jak抑制劑之二甲基胺基氮雜環丁烷醯胺 Download PDF

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Publication number
TWI791886B
TWI791886B TW108131679A TW108131679A TWI791886B TW I791886 B TWI791886 B TW I791886B TW 108131679 A TW108131679 A TW 108131679A TW 108131679 A TW108131679 A TW 108131679A TW I791886 B TWI791886 B TW I791886B
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Taiwan
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compound
pharmaceutically acceptable
acceptable salt
lung
disease
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TW108131679A
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Chinese (zh)
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TW202024073A (zh
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丹尼爾 D 羅恩
卡梅朗 史密斯
柯賓 湯普森
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美商施萬生物製藥研發 Ip有限責任公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW108131679A 2018-09-04 2019-09-03 作為jak抑制劑之二甲基胺基氮雜環丁烷醯胺 TWI791886B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726562P 2018-09-04 2018-09-04
US62/726,562 2018-09-04

Publications (2)

Publication Number Publication Date
TW202024073A TW202024073A (zh) 2020-07-01
TWI791886B true TWI791886B (zh) 2023-02-11

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TW108131679A TWI791886B (zh) 2018-09-04 2019-09-03 作為jak抑制劑之二甲基胺基氮雜環丁烷醯胺

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US (4) US10947229B2 (https=)
EP (1) EP3837258B1 (https=)
JP (2) JP7324836B2 (https=)
KR (1) KR102826491B1 (https=)
CN (1) CN112739697B (https=)
AR (1) AR116115A1 (https=)
AU (1) AU2019336167B2 (https=)
BR (1) BR112021004052A2 (https=)
CL (1) CL2021000514A1 (https=)
CO (1) CO2021002977A2 (https=)
DK (1) DK3837258T3 (https=)
EA (1) EA202190681A1 (https=)
ES (1) ES2982858T3 (https=)
FI (1) FI3837258T3 (https=)
HR (1) HRP20241002T1 (https=)
HU (1) HUE068058T2 (https=)
IL (1) IL281146B2 (https=)
LT (1) LT3837258T (https=)
MA (1) MA53229A (https=)
MX (1) MX2021002521A (https=)
PH (1) PH12021550368A1 (https=)
PL (1) PL3837258T3 (https=)
PT (1) PT3837258T (https=)
SG (1) SG11202101734RA (https=)
SI (1) SI3837258T1 (https=)
TW (1) TWI791886B (https=)
WO (1) WO2020051105A1 (https=)

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WO2021226637A1 (en) * 2020-05-08 2021-11-11 Theravance Biopharma R&D Ip, Llc Method of treating a patient infected with a coronavirus with nezulcitinib
US20230021647A1 (en) * 2021-06-21 2023-01-26 Theravance Biopharma R&D Ip, Llc Method of treating a patient infected with a coronavirus and having a baseline level of crp below 150 mg/l
TW202317550A (zh) 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
JP7644873B2 (ja) * 2021-12-17 2025-03-12 デウン ファーマシューティカル カンパニー リミテッド (2R,3S)-2-(3-(4,5-ジクロロ-1H-ベンゾ[d]イミダゾール-1-イル)プロピル)ピペリジン-3-オールの新規な酸付加塩および結晶形
US20250288561A1 (en) 2022-05-05 2025-09-18 Theravance Biopharma R&D Ip, Llc Nezulcitinib for delivery by nebulized oral inhalation
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TW202144343A (zh) * 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
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HRP20241002T1 (hr) 2024-10-25
EP3837258B1 (en) 2024-04-24
IL281146B1 (en) 2023-08-01
MX2021002521A (es) 2021-04-28
CN112739697A (zh) 2021-04-30
US20210155620A1 (en) 2021-05-27
MA53229A (fr) 2022-05-11
AU2019336167A1 (en) 2021-03-11
JP7324836B2 (ja) 2023-08-10
US12398135B2 (en) 2025-08-26
WO2020051105A1 (en) 2020-03-12
CL2021000514A1 (es) 2021-07-23
LT3837258T (lt) 2024-05-27
PT3837258T (pt) 2024-06-20
IL281146A (en) 2021-04-29
BR112021004052A2 (pt) 2021-05-25
AR116115A1 (es) 2021-03-31
SI3837258T1 (sl) 2024-09-30
US10947229B2 (en) 2021-03-16
ES2982858T3 (es) 2024-10-17
US11634419B2 (en) 2023-04-25
AU2019336167B2 (en) 2024-08-29
SG11202101734RA (en) 2021-03-30
CO2021002977A2 (es) 2021-05-31
EA202190681A1 (ru) 2021-05-28
US20250034131A1 (en) 2025-01-30
US20200071323A1 (en) 2020-03-05
TW202024073A (zh) 2020-07-01
JP2021535177A (ja) 2021-12-16
IL281146B2 (en) 2023-12-01
PH12021550368A1 (en) 2022-03-28
HUE068058T2 (hu) 2024-12-28
PL3837258T3 (pl) 2024-09-16
DK3837258T3 (da) 2024-07-22
EP3837258A1 (en) 2021-06-23
FI3837258T3 (fi) 2024-05-27
JP2022172299A (ja) 2022-11-15
CN112739697B (zh) 2023-10-20
KR20210056381A (ko) 2021-05-18
US20230322774A1 (en) 2023-10-12
KR102826491B1 (ko) 2025-06-27

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