JP2020536082A5 - - Google Patents
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- Publication number
- JP2020536082A5 JP2020536082A5 JP2020518661A JP2020518661A JP2020536082A5 JP 2020536082 A5 JP2020536082 A5 JP 2020536082A5 JP 2020518661 A JP2020518661 A JP 2020518661A JP 2020518661 A JP2020518661 A JP 2020518661A JP 2020536082 A5 JP2020536082 A5 JP 2020536082A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- alkylene
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 241000588914 Enterobacter Species 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 4
- 241000607720 Serratia Species 0.000 claims 4
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims 2
- 241000588722 Escherichia Species 0.000 claims 2
- 241000588748 Klebsiella Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 2
- 229960003324 clavulanic acid Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229960005256 sulbactam Drugs 0.000 claims 2
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims 2
- 229960003865 tazobactam Drugs 0.000 claims 2
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- NDCUAPJVLWFHHB-UHNVWZDZSA-N avibactam Chemical compound C1N2[C@H](C(N)=O)CC[C@@]1([H])N(OS(O)(=O)=O)C2=O NDCUAPJVLWFHHB-UHNVWZDZSA-N 0.000 claims 1
- 229960002379 avibactam Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566779P | 2017-10-02 | 2017-10-02 | |
| US62/566,779 | 2017-10-02 | ||
| PCT/US2018/053039 WO2019070492A1 (en) | 2017-10-02 | 2018-09-27 | CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536082A JP2020536082A (ja) | 2020-12-10 |
| JP2020536082A5 true JP2020536082A5 (https=) | 2021-05-13 |
| JP7252948B2 JP7252948B2 (ja) | 2023-04-05 |
Family
ID=65994576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020518661A Active JP7252948B2 (ja) | 2017-10-02 | 2018-09-27 | 細菌感染症を治療するためのクロマンモノバクタム化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11433055B2 (https=) |
| EP (1) | EP3691639B1 (https=) |
| JP (1) | JP7252948B2 (https=) |
| KR (1) | KR102425959B1 (https=) |
| CN (2) | CN111201021B (https=) |
| AU (1) | AU2018345523B2 (https=) |
| CA (1) | CA3076022C (https=) |
| CL (1) | CL2020000860A1 (https=) |
| CO (1) | CO2020004087A2 (https=) |
| CR (1) | CR20200148A (https=) |
| DO (1) | DOP2020000058A (https=) |
| EA (1) | EA202090604A1 (https=) |
| ES (1) | ES2968467T3 (https=) |
| GE (2) | GEP20227406B (https=) |
| IL (1) | IL273306B (https=) |
| JO (1) | JOP20200130B1 (https=) |
| MA (1) | MA50629A (https=) |
| MX (1) | MX2020003581A (https=) |
| NI (1) | NI202000023A (https=) |
| PE (1) | PE20201256A1 (https=) |
| PH (1) | PH12020550107A1 (https=) |
| SA (1) | SA520411571B1 (https=) |
| SG (1) | SG11202002575UA (https=) |
| UA (1) | UA126000C2 (https=) |
| WO (1) | WO2019070492A1 (https=) |
| ZA (1) | ZA202001721B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156697B (zh) * | 2019-05-30 | 2022-05-06 | 常州沃腾化工科技有限公司 | 一种1,2-二甲基-1,4,5,6-四氢嘧啶的合成方法 |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| SMT202500271T1 (it) | 2020-07-02 | 2025-09-12 | Incyte Corp | Composti di urea triciclici come inibitori di v617f di jak2 |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| WO2022120048A1 (en) * | 2020-12-03 | 2022-06-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Hdac inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| AU2021473165B2 (en) * | 2021-11-09 | 2025-05-22 | Guangzhou HC New Drug Research Co., Ltd. | PHARMACEUTICAL COMPOSITION CONTAINING β-LACTAM COMPOUND AND USE THEREOF |
| CR20240212A (es) * | 2021-11-18 | 2024-07-01 | Merck Sharp & Dohme Llc | Compuestos monobactámicos de cromano amidina para tratar las infecciones bacterianas |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| CN119173514A (zh) | 2022-03-17 | 2024-12-20 | 因赛特公司 | 作为jak2 v617f抑制剂的三环脲化合物 |
| WO2024019916A2 (en) * | 2022-07-18 | 2024-01-25 | Merck Sharp & Dohme Llc | Chromane amidine monobactam compounds for the treatment of bacterial infections |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684722A (en) | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| WO2007065288A2 (en) | 2005-12-07 | 2007-06-14 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| EP1938822A1 (en) * | 2006-12-21 | 2008-07-02 | Novartis AG | Combination therapy for the treatment of airways disease |
| BR112013008765B8 (pt) | 2010-10-11 | 2023-05-02 | Biogen Idec Int Neuroscience Gmbh | Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa |
| AU2011336209B2 (en) | 2010-11-29 | 2015-03-19 | Pfizer Inc. | Monobactams |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| PL2857039T3 (pl) | 2012-05-31 | 2020-05-18 | Osaka City University | Środek terapeutyczny lub środek profilaktyczny na otępienie |
| US20140275007A1 (en) | 2013-03-14 | 2014-09-18 | Rempex Pharmaceuticals, Inc. | Oxamazin antibiotics |
| US20160326157A1 (en) | 2014-01-06 | 2016-11-10 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| AP2016009374A0 (en) | 2014-03-24 | 2016-08-31 | Novartis Ag | Monobactam organic compounds for the treatment of bacterial infections |
| TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗－ｔａｕ抗體 |
| DK3212189T3 (da) * | 2014-10-31 | 2020-10-26 | Abbvie Overseas Sarl | Substituerede chromaner og fremgangsmåde til anvendelse deraf |
| FR3031423B1 (fr) * | 2015-01-06 | 2018-11-30 | Centre National De La Recherche Scientifique | Procede et dispositif de conversion de courant et vehicule comportant un tel dispositif |
| CA3008006C (en) * | 2015-12-15 | 2024-04-09 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| KR102408800B1 (ko) * | 2016-03-07 | 2022-06-13 | 머크 샤프 앤드 돔 코포레이션 | 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 |
-
2018
- 2018-09-27 AU AU2018345523A patent/AU2018345523B2/en active Active
- 2018-09-27 ES ES18864229T patent/ES2968467T3/es active Active
- 2018-09-27 WO PCT/US2018/053039 patent/WO2019070492A1/en not_active Ceased
- 2018-09-27 GE GEAP201815303A patent/GEP20227406B/en unknown
- 2018-09-27 CR CR20200148A patent/CR20200148A/es unknown
- 2018-09-27 SG SG11202002575UA patent/SG11202002575UA/en unknown
- 2018-09-27 EP EP18864229.2A patent/EP3691639B1/en active Active
- 2018-09-27 PE PE2020000692A patent/PE20201256A1/es unknown
- 2018-09-27 MX MX2020003581A patent/MX2020003581A/es unknown
- 2018-09-27 US US16/651,456 patent/US11433055B2/en active Active
- 2018-09-27 EA EA202090604A patent/EA202090604A1/ru unknown
- 2018-09-27 GE GEAP202215303A patent/GEAP202215303A/en unknown
- 2018-09-27 MA MA050629A patent/MA50629A/fr unknown
- 2018-09-27 CA CA3076022A patent/CA3076022C/en active Active
- 2018-09-27 JP JP2020518661A patent/JP7252948B2/ja active Active
- 2018-09-27 CN CN201880064269.2A patent/CN111201021B/zh active Active
- 2018-09-27 KR KR1020207012234A patent/KR102425959B1/ko active Active
- 2018-09-27 CN CN202410563311.2A patent/CN118496221A/zh active Pending
- 2018-09-27 UA UAA202002037A patent/UA126000C2/uk unknown
-
2020
- 2020-03-15 IL IL273306A patent/IL273306B/en unknown
- 2020-03-16 DO DO2020000058A patent/DOP2020000058A/es unknown
- 2020-03-18 ZA ZA2020/01721A patent/ZA202001721B/en unknown
- 2020-03-19 SA SA520411571A patent/SA520411571B1/ar unknown
- 2020-03-20 PH PH12020550107A patent/PH12020550107A1/en unknown
- 2020-03-24 NI NI202000023A patent/NI202000023A/es unknown
- 2020-03-31 CL CL2020000860A patent/CL2020000860A1/es unknown
- 2020-03-31 CO CONC2020/0004087A patent/CO2020004087A2/es unknown
- 2020-05-28 JO JOJO/P/2020/0130A patent/JOP20200130B1/ar active
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