JP2018537483A5 - - Google Patents
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- Publication number
- JP2018537483A5 JP2018537483A5 JP2018530835A JP2018530835A JP2018537483A5 JP 2018537483 A5 JP2018537483 A5 JP 2018537483A5 JP 2018530835 A JP2018530835 A JP 2018530835A JP 2018530835 A JP2018530835 A JP 2018530835A JP 2018537483 A5 JP2018537483 A5 JP 2018537483A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- independently
- cycloalkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 20
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 125000002950 monocyclic group Chemical group 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000006413 ring segment Chemical group 0.000 claims 7
- 208000035143 Bacterial infection Diseases 0.000 claims 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 4
- 125000003831 tetrazolyl group Chemical group 0.000 claims 4
- 229940123930 Lactamase inhibitor Drugs 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims 2
- NDCUAPJVLWFHHB-UHNVWZDZSA-N avibactam Chemical compound C1N2[C@H](C(N)=O)CC[C@@]1([H])N(OS(O)(=O)=O)C2=O NDCUAPJVLWFHHB-UHNVWZDZSA-N 0.000 claims 2
- 229960002379 avibactam Drugs 0.000 claims 2
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 2
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 2
- 229960003324 clavulanic acid Drugs 0.000 claims 2
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
- 235000019000 fluorine Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- -1 oxadiazolonyl Chemical group 0.000 claims 2
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims 2
- 229960005256 sulbactam Drugs 0.000 claims 2
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000147019 Enterobacter sp. Species 0.000 claims 1
- 241000488157 Escherichia sp. Species 0.000 claims 1
- 241000588754 Klebsiella sp. Species 0.000 claims 1
- 241001169527 Morganella sp. (in: Fungi) Species 0.000 claims 1
- 241000589774 Pseudomonas sp. Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 **OC(C(*)(C#I)ON=C(C(N[C@@](C(*)(*)N1OS(O)(=O)=O)C1=O)=O)C1=NC(N)=S*1)*=* Chemical compound **OC(C(*)(C#I)ON=C(C(N[C@@](C(*)(*)N1OS(O)(=O)=O)C1=O)=O)C1=NC(N)=S*1)*=* 0.000 description 10
- BLHTXORQJNCSII-UHFFFAOYSA-N Cc1c[n](C)cn1 Chemical compound Cc1c[n](C)cn1 BLHTXORQJNCSII-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562267855P | 2015-12-15 | 2015-12-15 | |
| US62/267,855 | 2015-12-15 | ||
| PCT/US2016/066064 WO2017106064A1 (en) | 2015-12-15 | 2016-12-12 | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537483A JP2018537483A (ja) | 2018-12-20 |
| JP2018537483A5 true JP2018537483A5 (https=) | 2020-01-16 |
| JP7184646B2 JP7184646B2 (ja) | 2022-12-06 |
Family
ID=59057420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530835A Active JP7184646B2 (ja) | 2015-12-15 | 2016-12-12 | ビアリールモノバクタム化合物および細菌感染治療のためのそれの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20180339983A1 (https=) |
| EP (2) | EP3978472B1 (https=) |
| JP (1) | JP7184646B2 (https=) |
| KR (1) | KR20180093925A (https=) |
| CN (1) | CN108368040B (https=) |
| AU (1) | AU2016371600B2 (https=) |
| CA (1) | CA3008006C (https=) |
| MA (1) | MA44083A (https=) |
| MX (1) | MX385731B (https=) |
| RU (1) | RU2746129C2 (https=) |
| WO (1) | WO2017106064A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2985784T3 (es) | 2011-11-18 | 2024-11-07 | Regeneron Pharma | Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares |
| MX389242B (es) | 2015-06-15 | 2025-03-20 | Nmd Pharma As | Compuestos para su uso en el tratamiento de trastornos neuromusculares |
| US20180339983A1 (en) | 2015-12-15 | 2018-11-29 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| EP3691639B1 (en) * | 2017-10-02 | 2023-11-15 | Merck Sharp & Dohme LLC | Chromane monobactam compounds for the treatment of bacterial infections |
| US11591284B2 (en) | 2017-12-14 | 2023-02-28 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US12440477B2 (en) | 2017-12-14 | 2025-10-14 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US10385028B2 (en) | 2017-12-14 | 2019-08-20 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11730714B2 (en) | 2017-12-14 | 2023-08-22 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11147788B2 (en) | 2017-12-14 | 2021-10-19 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| CN108362789B (zh) * | 2018-01-19 | 2020-09-01 | 珠海优润医药科技有限公司 | 一种阿维巴坦钠光学异构体的高效液相色谱检测方法 |
| WO2019144969A1 (zh) | 2018-01-29 | 2019-08-01 | 南京明德新药研发股份有限公司 | 用于治疗细菌感染的单环β-内酰胺化合物 |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
| KR20210083285A (ko) | 2018-11-13 | 2021-07-06 | 난징 산홈 팔마세우티칼 컴퍼니 리미티드 | 모노박탐 화합물 및 그의 사용 |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| CN114828850B (zh) * | 2019-12-19 | 2024-08-13 | 深圳嘉科生物科技有限公司 | 化合物在制药中的应用 |
| US12516048B2 (en) | 2020-08-06 | 2026-01-06 | Ningxia Academy Of Agriculture And Forestry Sciences | B-lactam compounds, their preparation and use as antibacterial agents |
| CN112661667B (zh) * | 2020-12-28 | 2023-02-03 | 浦拉司科技（上海）有限责任公司 | 一种三氟乙脒的制备方法 |
| CN115463219A (zh) * | 2021-11-09 | 2022-12-13 | 中国医学科学院医药生物技术研究所 | 包含β-内酰胺类化合物的药物组合物及其用途 |
| AU2021473165B2 (en) * | 2021-11-09 | 2025-05-22 | Guangzhou HC New Drug Research Co., Ltd. | PHARMACEUTICAL COMPOSITION CONTAINING β-LACTAM COMPOUND AND USE THEREOF |
| GEAP202416514A (en) | 2021-11-18 | 2024-08-26 | Merck Sharp & Dohme Llc | Chromane amidine monobactam antibiotics |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| CN114671910B (zh) * | 2022-04-06 | 2025-03-21 | 河南师范大学 | 一种西多福韦的绿色合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ203734A (en) * | 1982-03-31 | 1986-03-14 | Beecham Group Plc | Beta-lactam derivatives and pharmaceutical compositions |
| US4684722A (en) | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| CA2783572C (en) | 2005-12-07 | 2016-08-09 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| DK2646436T3 (en) | 2010-11-29 | 2015-06-29 | Pfizer | monobactams |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| US8969570B2 (en) * | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US20140275007A1 (en) | 2013-03-14 | 2014-09-18 | Rempex Pharmaceuticals, Inc. | Oxamazin antibiotics |
| WO2015103583A1 (en) | 2014-01-06 | 2015-07-09 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| MX373444B (es) | 2014-03-24 | 2020-04-30 | Novartis Ag | Compuestos organicos de monobactam para el tratamiento de infecciones bacterianas. |
| US20180339983A1 (en) | 2015-12-15 | 2018-11-29 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
-
2016
- 2016-12-12 US US15/775,487 patent/US20180339983A1/en not_active Abandoned
- 2016-12-12 AU AU2016371600A patent/AU2016371600B2/en active Active
- 2016-12-12 CN CN201680074091.0A patent/CN108368040B/zh active Active
- 2016-12-12 CA CA3008006A patent/CA3008006C/en active Active
- 2016-12-12 EP EP21204101.6A patent/EP3978472B1/en active Active
- 2016-12-12 WO PCT/US2016/066064 patent/WO2017106064A1/en not_active Ceased
- 2016-12-12 RU RU2018123484A patent/RU2746129C2/ru active
- 2016-12-12 KR KR1020187016482A patent/KR20180093925A/ko not_active Ceased
- 2016-12-12 MX MX2018005382A patent/MX385731B/es unknown
- 2016-12-12 EP EP16876436.3A patent/EP3390357B1/en active Active
- 2016-12-12 MA MA044083A patent/MA44083A/fr unknown
- 2016-12-12 JP JP2018530835A patent/JP7184646B2/ja active Active
-
2020
- 2020-06-25 US US16/912,146 patent/US11230543B2/en active Active
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