JP2021527638A5 - - Google Patents
Info
- Publication number
- JP2021527638A5 JP2021527638A5 JP2020568282A JP2020568282A JP2021527638A5 JP 2021527638 A5 JP2021527638 A5 JP 2021527638A5 JP 2020568282 A JP2020568282 A JP 2020568282A JP 2020568282 A JP2020568282 A JP 2020568282A JP 2021527638 A5 JP2021527638 A5 JP 2021527638A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycloalkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862683557P | 2018-06-11 | 2018-06-11 | |
| US62/683,557 | 2018-06-11 | ||
| US201962832734P | 2019-04-11 | 2019-04-11 | |
| US62/832,734 | 2019-04-11 | ||
| PCT/US2019/036611 WO2019241292A1 (en) | 2018-06-11 | 2019-06-11 | Hepatitis b capsid assembly modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021527638A JP2021527638A (ja) | 2021-10-14 |
| JP2021527638A5 true JP2021527638A5 (enExample) | 2022-06-17 |
Family
ID=68765513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568282A Pending JP2021527638A (ja) | 2018-06-11 | 2019-06-11 | Ｂ型肝炎カプシドアセンブリモジュレーター |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10590076B2 (enExample) |
| EP (1) | EP3807246A4 (enExample) |
| JP (1) | JP2021527638A (enExample) |
| KR (1) | KR20210019489A (enExample) |
| CN (1) | CN112585118A (enExample) |
| AU (1) | AU2019284617A1 (enExample) |
| BR (1) | BR112020025073A2 (enExample) |
| CA (1) | CA3102972A1 (enExample) |
| DE (1) | DE202019005471U1 (enExample) |
| GB (1) | GB2583614B (enExample) |
| IL (1) | IL279242A (enExample) |
| PH (1) | PH12020552127A1 (enExample) |
| SG (1) | SG11202012346YA (enExample) |
| TW (1) | TW202016073A (enExample) |
| WO (1) | WO2019241292A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105101970B (zh) | 2013-01-10 | 2018-11-20 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| KR102396753B1 (ko) | 2014-06-11 | 2022-05-12 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
| WO2019185016A1 (zh) | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| SG11202011685QA (en) * | 2018-05-25 | 2020-12-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof |
| WO2019241292A1 (en) | 2018-06-11 | 2019-12-19 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| IL328538A (en) * | 2018-10-05 | 2026-07-01 | Univ Emory | Monomeric and multimeric hepatitis B antivirals |
| EA202092159A1 (ru) * | 2019-01-25 | 2020-12-15 | Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. | Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение |
| CN113365999B (zh) * | 2019-01-31 | 2023-04-14 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| WO2021058001A1 (zh) | 2019-09-29 | 2021-04-01 | 正大天晴药业集团股份有限公司 | N杂五元环化合物的晶型及其应用 |
| US12378192B2 (en) | 2019-09-29 | 2025-08-05 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof |
| EP4245372A3 (en) * | 2019-11-13 | 2023-11-22 | Xi'An Xintong Pharmaceutical Research Co., Ltd. | Hbv inhibitor and use thereof |
| US20230107941A1 (en) * | 2019-12-10 | 2023-04-06 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021178362A1 (en) * | 2020-03-03 | 2021-09-10 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021197486A1 (zh) * | 2020-04-03 | 2021-10-07 | 东莞市东阳光新药研发有限公司 | 新型螺环类化合物及其在药物中的应用 |
| US20250228818A1 (en) | 2021-10-08 | 2025-07-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical combination containing capsid protein inhibitor and reverse transcriptase inhibitor |
| CN119173508B (zh) * | 2023-01-12 | 2025-11-04 | 成都微芯药业有限公司 | 氨基噻吩类化合物、其制备方法及用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1059007A (en) | 1912-05-21 | 1913-04-15 | Benjamin F Sharp | Electrical burglar-alarm. |
| JP2005060379A (ja) * | 2003-07-31 | 2005-03-10 | Dainippon Pharmaceut Co Ltd | 複素環式化合物からなる医薬 |
| KR20070090206A (ko) | 2004-12-24 | 2007-09-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 2환식 피롤 유도체 |
| US20090012075A1 (en) | 2006-01-12 | 2009-01-08 | Miller Thomas A | Fluorinated Arylamide Derivatives |
| WO2013006394A1 (en) * | 2011-07-01 | 2013-01-10 | Institute For Hepatitis And Virus Research | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| EP2794565B1 (en) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
| WO2015011281A1 (en) * | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) * | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| PL3102572T3 (pl) * | 2014-02-06 | 2019-04-30 | Janssen Sciences Ireland Uc | Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| BR112018068177B1 (pt) * | 2016-03-09 | 2024-02-27 | Emory University | Composto, uso do composto e composição para eliminação do vírus da hepatite b com agentes antivirais |
| JOP20190024A1 (ar) * | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN108250121A (zh) | 2016-12-28 | 2018-07-06 | 上海长森药业有限公司 | 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途 |
| US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
| JP7050165B2 (ja) * | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| WO2019185016A1 (zh) * | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| SG11202011685QA (en) | 2018-05-25 | 2020-12-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof |
| WO2019241292A1 (en) | 2018-06-11 | 2019-12-19 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| CN113365999B (zh) | 2019-01-31 | 2023-04-14 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| WO2021058001A1 (zh) | 2019-09-29 | 2021-04-01 | 正大天晴药业集团股份有限公司 | N杂五元环化合物的晶型及其应用 |
| US12378192B2 (en) | 2019-09-29 | 2025-08-05 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof |
| EP4063366A4 (en) | 2019-11-22 | 2023-12-20 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | CRYSTAL FORM OF NUCLEOPROTEIN INHIBITOR AND USE THEREOF |
| US20230107941A1 (en) | 2019-12-10 | 2023-04-06 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021178362A1 (en) | 2020-03-03 | 2021-09-10 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| EP4241770A1 (en) | 2020-11-05 | 2023-09-13 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical combination containing capsid protein inhibitor and nucleoside analog |
-
2019
- 2019-06-11 WO PCT/US2019/036611 patent/WO2019241292A1/en not_active Ceased
- 2019-06-11 SG SG11202012346YA patent/SG11202012346YA/en unknown
- 2019-06-11 KR KR1020217000251A patent/KR20210019489A/ko not_active Ceased
- 2019-06-11 CA CA3102972A patent/CA3102972A1/en active Pending
- 2019-06-11 CN CN201980054009.1A patent/CN112585118A/zh active Pending
- 2019-06-11 GB GB2010185.3A patent/GB2583614B/en active Active
- 2019-06-11 AU AU2019284617A patent/AU2019284617A1/en not_active Abandoned
- 2019-06-11 TW TW108120145A patent/TW202016073A/zh unknown
- 2019-06-11 DE DE202019005471.5U patent/DE202019005471U1/de active Active
- 2019-06-11 US US16/438,361 patent/US10590076B2/en active Active
- 2019-06-11 BR BR112020025073-2A patent/BR112020025073A2/pt not_active Application Discontinuation
- 2019-06-11 EP EP19819142.1A patent/EP3807246A4/en not_active Withdrawn
- 2019-06-11 JP JP2020568282A patent/JP2021527638A/ja active Pending
- 2019-11-01 US US16/671,815 patent/US11014881B2/en not_active Expired - Fee Related
-
2020
- 2020-12-06 IL IL279242A patent/IL279242A/en unknown
- 2020-12-10 PH PH12020552127A patent/PH12020552127A1/en unknown
-
2021
- 2021-10-29 US US17/514,578 patent/US11566001B2/en active Active
-
2022
- 2022-09-19 US US17/947,593 patent/US20230062975A1/en not_active Abandoned
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