IL279242A - Modulators of the hepatitis B capsid assembly - Google Patents
Modulators of the hepatitis B capsid assemblyInfo
- Publication number
- IL279242A IL279242A IL279242A IL27924220A IL279242A IL 279242 A IL279242 A IL 279242A IL 279242 A IL279242 A IL 279242A IL 27924220 A IL27924220 A IL 27924220A IL 279242 A IL279242 A IL 279242A
- Authority
- IL
- Israel
- Prior art keywords
- hepatitis
- capsid assembly
- assembly modulators
- modulators
- capsid
- Prior art date
Links
- 210000000234 capsid Anatomy 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862683557P | 2018-06-11 | 2018-06-11 | |
| US201962832734P | 2019-04-11 | 2019-04-11 | |
| PCT/US2019/036611 WO2019241292A1 (en) | 2018-06-11 | 2019-06-11 | Hepatitis b capsid assembly modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL279242A true IL279242A (en) | 2021-01-31 |
Family
ID=68765513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL279242A IL279242A (en) | 2018-06-11 | 2020-12-06 | Modulators of the hepatitis B capsid assembly |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10590076B2 (enExample) |
| EP (1) | EP3807246A4 (enExample) |
| JP (1) | JP2021527638A (enExample) |
| KR (1) | KR20210019489A (enExample) |
| CN (1) | CN112585118A (enExample) |
| AU (1) | AU2019284617A1 (enExample) |
| BR (1) | BR112020025073A2 (enExample) |
| CA (1) | CA3102972A1 (enExample) |
| DE (1) | DE202019005471U1 (enExample) |
| GB (1) | GB2583614B (enExample) |
| IL (1) | IL279242A (enExample) |
| PH (1) | PH12020552127A1 (enExample) |
| SG (1) | SG11202012346YA (enExample) |
| TW (1) | TW202016073A (enExample) |
| WO (1) | WO2019241292A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105101970B (zh) | 2013-01-10 | 2018-11-20 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| KR102396753B1 (ko) | 2014-06-11 | 2022-05-12 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
| WO2019185016A1 (zh) | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| SG11202011685QA (en) * | 2018-05-25 | 2020-12-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof |
| WO2019241292A1 (en) | 2018-06-11 | 2019-12-19 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| IL328538A (en) * | 2018-10-05 | 2026-07-01 | Univ Emory | Monomeric and multimeric hepatitis B antivirals |
| EA202092159A1 (ru) * | 2019-01-25 | 2020-12-15 | Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. | Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение |
| CN113365999B (zh) * | 2019-01-31 | 2023-04-14 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| WO2021058001A1 (zh) | 2019-09-29 | 2021-04-01 | 正大天晴药业集团股份有限公司 | N杂五元环化合物的晶型及其应用 |
| US12378192B2 (en) | 2019-09-29 | 2025-08-05 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof |
| EP4245372A3 (en) * | 2019-11-13 | 2023-11-22 | Xi'An Xintong Pharmaceutical Research Co., Ltd. | Hbv inhibitor and use thereof |
| US20230107941A1 (en) * | 2019-12-10 | 2023-04-06 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021178362A1 (en) * | 2020-03-03 | 2021-09-10 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021197486A1 (zh) * | 2020-04-03 | 2021-10-07 | 东莞市东阳光新药研发有限公司 | 新型螺环类化合物及其在药物中的应用 |
| US20250228818A1 (en) | 2021-10-08 | 2025-07-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical combination containing capsid protein inhibitor and reverse transcriptase inhibitor |
| CN119173508B (zh) * | 2023-01-12 | 2025-11-04 | 成都微芯药业有限公司 | 氨基噻吩类化合物、其制备方法及用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1059007A (en) | 1912-05-21 | 1913-04-15 | Benjamin F Sharp | Electrical burglar-alarm. |
| JP2005060379A (ja) * | 2003-07-31 | 2005-03-10 | Dainippon Pharmaceut Co Ltd | 複素環式化合物からなる医薬 |
| KR20070090206A (ko) | 2004-12-24 | 2007-09-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 2환식 피롤 유도체 |
| US20090012075A1 (en) | 2006-01-12 | 2009-01-08 | Miller Thomas A | Fluorinated Arylamide Derivatives |
| WO2013006394A1 (en) * | 2011-07-01 | 2013-01-10 | Institute For Hepatitis And Virus Research | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| EP2794565B1 (en) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
| WO2015011281A1 (en) * | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) * | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| PL3102572T3 (pl) * | 2014-02-06 | 2019-04-30 | Janssen Sciences Ireland Uc | Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| BR112018068177B1 (pt) * | 2016-03-09 | 2024-02-27 | Emory University | Composto, uso do composto e composição para eliminação do vírus da hepatite b com agentes antivirais |
| JOP20190024A1 (ar) * | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN108250121A (zh) | 2016-12-28 | 2018-07-06 | 上海长森药业有限公司 | 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途 |
| US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
| JP7050165B2 (ja) * | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| WO2019185016A1 (zh) * | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| SG11202011685QA (en) | 2018-05-25 | 2020-12-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof |
| WO2019241292A1 (en) | 2018-06-11 | 2019-12-19 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| CN113365999B (zh) | 2019-01-31 | 2023-04-14 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| WO2021058001A1 (zh) | 2019-09-29 | 2021-04-01 | 正大天晴药业集团股份有限公司 | N杂五元环化合物的晶型及其应用 |
| US12378192B2 (en) | 2019-09-29 | 2025-08-05 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof |
| EP4063366A4 (en) | 2019-11-22 | 2023-12-20 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | CRYSTAL FORM OF NUCLEOPROTEIN INHIBITOR AND USE THEREOF |
| US20230107941A1 (en) | 2019-12-10 | 2023-04-06 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021178362A1 (en) | 2020-03-03 | 2021-09-10 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| EP4241770A1 (en) | 2020-11-05 | 2023-09-13 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical combination containing capsid protein inhibitor and nucleoside analog |
-
2019
- 2019-06-11 WO PCT/US2019/036611 patent/WO2019241292A1/en not_active Ceased
- 2019-06-11 SG SG11202012346YA patent/SG11202012346YA/en unknown
- 2019-06-11 KR KR1020217000251A patent/KR20210019489A/ko not_active Ceased
- 2019-06-11 CA CA3102972A patent/CA3102972A1/en active Pending
- 2019-06-11 CN CN201980054009.1A patent/CN112585118A/zh active Pending
- 2019-06-11 GB GB2010185.3A patent/GB2583614B/en active Active
- 2019-06-11 AU AU2019284617A patent/AU2019284617A1/en not_active Abandoned
- 2019-06-11 TW TW108120145A patent/TW202016073A/zh unknown
- 2019-06-11 DE DE202019005471.5U patent/DE202019005471U1/de active Active
- 2019-06-11 US US16/438,361 patent/US10590076B2/en active Active
- 2019-06-11 BR BR112020025073-2A patent/BR112020025073A2/pt not_active Application Discontinuation
- 2019-06-11 EP EP19819142.1A patent/EP3807246A4/en not_active Withdrawn
- 2019-06-11 JP JP2020568282A patent/JP2021527638A/ja active Pending
- 2019-11-01 US US16/671,815 patent/US11014881B2/en not_active Expired - Fee Related
-
2020
- 2020-12-06 IL IL279242A patent/IL279242A/en unknown
- 2020-12-10 PH PH12020552127A patent/PH12020552127A1/en unknown
-
2021
- 2021-10-29 US US17/514,578 patent/US11566001B2/en active Active
-
2022
- 2022-09-19 US US17/947,593 patent/US20230062975A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN112585118A (zh) | 2021-03-30 |
| PH12020552127A1 (en) | 2021-07-19 |
| SG11202012346YA (en) | 2021-01-28 |
| JP2021527638A (ja) | 2021-10-14 |
| GB2583614A (en) | 2020-11-04 |
| KR20210019489A (ko) | 2021-02-22 |
| AU2019284617A1 (en) | 2021-01-28 |
| GB202010185D0 (en) | 2020-08-19 |
| WO2019241292A1 (en) | 2019-12-19 |
| US20230062975A1 (en) | 2023-03-02 |
| DE202019005471U1 (de) | 2020-09-17 |
| BR112020025073A2 (pt) | 2021-07-20 |
| EP3807246A4 (en) | 2022-03-02 |
| TW202016073A (zh) | 2020-05-01 |
| CA3102972A1 (en) | 2019-12-19 |
| US10590076B2 (en) | 2020-03-17 |
| US20220298110A1 (en) | 2022-09-22 |
| EP3807246A1 (en) | 2021-04-21 |
| US20190375708A1 (en) | 2019-12-12 |
| GB2583614B (en) | 2023-05-24 |
| US20200123105A1 (en) | 2020-04-23 |
| US11014881B2 (en) | 2021-05-25 |
| US11566001B2 (en) | 2023-01-31 |
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