CN112585118A - 乙型肝炎衣壳装配调节剂 - Google Patents

乙型肝炎衣壳装配调节剂 Download PDF

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Publication number
CN112585118A
CN112585118A CN201980054009.1A CN201980054009A CN112585118A CN 112585118 A CN112585118 A CN 112585118A CN 201980054009 A CN201980054009 A CN 201980054009A CN 112585118 A CN112585118 A CN 112585118A
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alkyl
heterocycloalkyl
cycloalkyl
heteroaryl
aryl
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Chinese (zh)
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克里斯多佛·J·伯恩斯
格伦·科伯恩
斌·刘
姚江超
克里斯多佛·贝内塔托斯
史蒂文·A·博伊德
斯蒂芬·M·康登
托马斯·海莫威茨
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VenatoRx Pharmaceuticals Inc
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VenatoRx Pharmaceuticals Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
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  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980054009.1A 2018-06-11 2019-06-11 乙型肝炎衣壳装配调节剂 Pending CN112585118A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862683557P 2018-06-11 2018-06-11
US62/683,557 2018-06-11
US201962832734P 2019-04-11 2019-04-11
US62/832,734 2019-04-11
PCT/US2019/036611 WO2019241292A1 (en) 2018-06-11 2019-06-11 Hepatitis b capsid assembly modulators

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CN112585118A true CN112585118A (zh) 2021-03-30

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US (4) US10590076B2 (enExample)
EP (1) EP3807246A4 (enExample)
JP (1) JP2021527638A (enExample)
KR (1) KR20210019489A (enExample)
CN (1) CN112585118A (enExample)
AU (1) AU2019284617A1 (enExample)
BR (1) BR112020025073A2 (enExample)
CA (1) CA3102972A1 (enExample)
DE (1) DE202019005471U1 (enExample)
GB (1) GB2583614B (enExample)
IL (1) IL279242A (enExample)
PH (1) PH12020552127A1 (enExample)
SG (1) SG11202012346YA (enExample)
TW (1) TW202016073A (enExample)
WO (1) WO2019241292A1 (enExample)

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CN111868026A (zh) * 2018-03-30 2020-10-30 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
CN113365999A (zh) * 2019-01-31 2021-09-07 正大天晴药业集团股份有限公司 含有吡咯并杂环的衣壳蛋白装配抑制剂
WO2024149314A1 (zh) * 2023-01-12 2024-07-18 成都微芯药业有限公司 氨基噻吩类化合物、其制备方法及用途

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CN105101970B (zh) 2013-01-10 2018-11-20 维纳拓尔斯制药公司 β-内酰胺酶抑制剂
KR102396753B1 (ko) 2014-06-11 2022-05-12 베나토알엑스 파마슈티컬스, 인크. 베타-락타마제 억제제
US11247965B2 (en) 2017-12-11 2022-02-15 VenatoRx Pharmaceuticals, Inc. Hepatitis B capsid assembly modulators
SG11202011685QA (en) * 2018-05-25 2020-12-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof
WO2019241292A1 (en) 2018-06-11 2019-12-19 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
IL328538A (en) * 2018-10-05 2026-07-01 Univ Emory Monomeric and multimeric hepatitis B antivirals
EA202092159A1 (ru) * 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение
WO2021058001A1 (zh) 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 N杂五元环化合物的晶型及其应用
US12378192B2 (en) 2019-09-29 2025-08-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof
EP4245372A3 (en) * 2019-11-13 2023-11-22 Xi'An Xintong Pharmaceutical Research Co., Ltd. Hbv inhibitor and use thereof
US20230107941A1 (en) * 2019-12-10 2023-04-06 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
WO2021178362A1 (en) * 2020-03-03 2021-09-10 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
WO2021197486A1 (zh) * 2020-04-03 2021-10-07 东莞市东阳光新药研发有限公司 新型螺环类化合物及其在药物中的应用
US20250228818A1 (en) 2021-10-08 2025-07-17 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pharmaceutical combination containing capsid protein inhibitor and reverse transcriptase inhibitor

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