JP2021527125A - Ｓａｒｍ１阻害剤 - Google Patents

Ｓａｒｍ１阻害剤 Download PDF

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Publication number
JP2021527125A
JP2021527125A JP2021518045A JP2021518045A JP2021527125A JP 2021527125 A JP2021527125 A JP 2021527125A JP 2021518045 A JP2021518045 A JP 2021518045A JP 2021518045 A JP2021518045 A JP 2021518045A JP 2021527125 A JP2021527125 A JP 2021527125A
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certain embodiments
compound according
disease
sarm1
compound
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Pending
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JP2021518045A
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Japanese (ja)
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JP2021527125A5 (https=
JPWO2019236879A5 (https=
Inventor
ロバート・オーエン・ヒューズ
ラジェシュ・デブラジ
トッド・ボサナック
リチャード・アンドリュー・ジャージェス−パイク
アンドリュー・サイモン・ブリアリー
ジョナサン・ベントリー
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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Publication of JP2021527125A publication Critical patent/JP2021527125A/ja
Publication of JP2021527125A5 publication Critical patent/JP2021527125A5/ja
Publication of JPWO2019236879A5 publication Critical patent/JPWO2019236879A5/ja
Priority to JP2023203259A priority Critical patent/JP7576145B2/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021518045A 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤 Pending JP2021527125A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023203259A JP7576145B2 (ja) 2018-06-07 2023-11-30 Ｓａｒｍ１阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682033P 2018-06-07 2018-06-07
US62/682,033 2018-06-07
PCT/US2019/035833 WO2019236879A1 (en) 2018-06-07 2019-06-06 Inhibitors of sarm1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023203259A Division JP7576145B2 (ja) 2018-06-07 2023-11-30 Ｓａｒｍ１阻害剤

Publications (3)

Publication Number Publication Date
JP2021527125A true JP2021527125A (ja) 2021-10-11
JP2021527125A5 JP2021527125A5 (https=) 2022-06-22
JPWO2019236879A5 JPWO2019236879A5 (https=) 2022-06-22

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JP2021518045A Pending JP2021527125A (ja) 2018-06-07 2019-06-06 Ｓａｒｍ１阻害剤
JP2023203259A Active JP7576145B2 (ja) 2018-06-07 2023-11-30 Ｓａｒｍ１阻害剤

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Country Link
US (1) US12338238B2 (https=)
EP (1) EP3801500B1 (https=)
JP (2) JP2021527125A (https=)
CN (1) CN112839647B (https=)
CA (1) CA3102645A1 (https=)
ES (1) ES3028093T3 (https=)
MA (1) MA52813A (https=)
WO (1) WO2019236879A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3028093T3 (en) 2018-06-07 2025-06-18 Disarm Therapeutics Inc Inhibitors of sarm1
US12448374B2 (en) 2018-06-07 2025-10-21 Disarm Therapeutics, Inc. Inhibitors of SARM1
WO2020132045A1 (en) 2018-12-19 2020-06-25 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
CA3141404A1 (en) 2019-06-14 2020-12-17 Disarm Therapeutics, Inc. Inhibitors of sarm1
JP7534390B2 (ja) 2019-09-12 2024-08-14 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤
EP4065714A1 (en) * 2019-11-26 2022-10-05 Disarm Therapeutics, Inc. Methods and compositions for neuroprotection
CN115916764B (zh) * 2020-04-09 2024-09-20 达萨玛治疗公司 作为sarm1抑制剂的吲唑衍生物
US12606558B2 (en) 2020-04-09 2026-04-21 Disarm Therapeutics, Inc. Condensed pyrazole derivatives as inhibitors of SARM1
IL298577A (en) * 2020-05-27 2023-01-01 Emendobio Inc Biallelic silencing of sarm1
TW202334117A (zh) 2020-08-24 2023-09-01 美商達薩瑪治療公司 Ｓａｒｍ１之抑制劑
EP4536637A2 (en) * 2022-06-06 2025-04-16 Nico Therapeutics, Inc. Compounds, compositions, and methods
WO2023244788A1 (en) * 2022-06-17 2023-12-21 Neuron23, Inc. Kinase modulators and methods of use thereof
JP2026503618A (ja) 2023-01-24 2026-01-29 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤としての置換された１ｈ－ピラゾール－４－カルボキサミド
TW202509019A (zh) * 2023-04-27 2025-03-01 香港商維泰瑞隆（香港）生物科技有限公司 Sarm1調節子、其製劑及用途

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