ES3028093T3 - Inhibitors of sarm1 - Google Patents
Inhibitors of sarm1 Download PDFInfo
- Publication number
- ES3028093T3 ES3028093T3 ES19816172T ES19816172T ES3028093T3 ES 3028093 T3 ES3028093 T3 ES 3028093T3 ES 19816172 T ES19816172 T ES 19816172T ES 19816172 T ES19816172 T ES 19816172T ES 3028093 T3 ES3028093 T3 ES 3028093T3
- Authority
- ES
- Spain
- Prior art keywords
- sarm1
- compound
- compounds
- disease
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862682033P | 2018-06-07 | 2018-06-07 | |
| PCT/US2019/035833 WO2019236879A1 (en) | 2018-06-07 | 2019-06-06 | Inhibitors of sarm1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES3028093T3 true ES3028093T3 (en) | 2025-06-18 |
Family
ID=68769462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19816172T Active ES3028093T3 (en) | 2018-06-07 | 2019-06-06 | Inhibitors of sarm1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12338238B2 (https=) |
| EP (1) | EP3801500B1 (https=) |
| JP (2) | JP2021527125A (https=) |
| CN (1) | CN112839647B (https=) |
| CA (1) | CA3102645A1 (https=) |
| ES (1) | ES3028093T3 (https=) |
| MA (1) | MA52813A (https=) |
| WO (1) | WO2019236879A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112839647B (zh) | 2018-06-07 | 2025-09-23 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| US12595252B2 (en) | 2019-06-14 | 2026-04-07 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 |
| CA3150878A1 (en) | 2019-09-12 | 2021-03-18 | Jonathan Bentley | Inhibitors of sarm1 |
| JP7528212B2 (ja) * | 2019-11-26 | 2024-08-05 | ディスアーム セラピューティクス， インコーポレイテッド | 神経保護のための方法および組成物 |
| US12606558B2 (en) | 2020-04-09 | 2026-04-21 | Disarm Therapeutics, Inc. | Condensed pyrazole derivatives as inhibitors of SARM1 |
| US12435084B2 (en) | 2020-04-09 | 2025-10-07 | Eli Lilly And Company | Indazole derivatives as inhibitors of SARM1 |
| IL298577A (en) * | 2020-05-27 | 2023-01-01 | Emendobio Inc | Biallelic silencing of sarm1 |
| TWI904906B (zh) | 2020-08-24 | 2025-11-11 | 美商達薩瑪治療公司 | Sarm1之抑制劑 |
| WO2023240084A2 (en) * | 2022-06-06 | 2023-12-14 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| EP4539840A4 (en) * | 2022-06-17 | 2026-04-15 | Sundance Biosciences Inc | Kinase Modulators and Their Methods of Use |
| WO2024158607A1 (en) | 2023-01-24 | 2024-08-02 | Disarm Therapeutics, Inc. | Substituted 1h-pyrazole-4-carboxamides as sarm1 inhibitors |
| TW202509019A (zh) * | 2023-04-27 | 2025-03-01 | 香港商維泰瑞隆（香港）生物科技有限公司 | Sarm1調節子、其製劑及用途 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1022214A (en) | 1963-01-31 | 1966-03-09 | Sterling Drug Inc | Novel 1,3-disubstituted-1,4-dihydro-4-oxo-1,7-naphthyridines and their preparation |
| US3429887A (en) | 1965-01-26 | 1969-02-25 | Sterling Drug Inc | 1,7-naphthyridine-3-carboxylic acid derivatives and their preparation |
| US3506668A (en) | 1965-01-26 | 1970-04-14 | Sterling Drug Inc | Method of preparing 8-hydroxy-quinolines |
| US3429882A (en) | 1968-03-25 | 1969-02-25 | Geigy Chem Corp | 1,2,8,9-tetraazaphenalenes |
| US3539567A (en) | 1968-04-23 | 1970-11-10 | Geigy Chem Corp | 8-carboxy-1(2h) phthalazinones |
| US3761493A (en) | 1968-04-23 | 1973-09-25 | Ciba Geigy Corp | 3-dibromomethylphthalic anhydride |
| US3624108A (en) | 1968-04-23 | 1971-11-30 | Geigy Chem Corp | 7-carboxyphthalides |
| US3542777A (en) | 1968-08-12 | 1970-11-24 | Geigy Chem Corp | Derivatives of 9-pyridylalkyl-1,2,8,9-tetraazaphenalenes |
| US3517014A (en) | 1969-06-16 | 1970-06-23 | Sterling Drug Inc | Method of preparing 8-hydroxyquinoline-3-carboxylic acids |
| US3711473A (en) | 1970-04-06 | 1973-01-16 | Ciba Geigy Corp | 3-hydrazino-1,2,8,9-tetraazaphenalenes |
| DE2449252A1 (de) | 1973-10-16 | 1975-04-17 | Fuji Photo Film Co Ltd | Waermeentwickelbares, lichtempfindliches material |
| US4207112A (en) | 1974-01-29 | 1980-06-10 | Fuji Photo Film Co., Ltd. | Heat developable light-sensitive materials |
| JPS50123331A (https=) | 1974-03-14 | 1975-09-27 | ||
| GB9310700D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Novel composition |
| WO2001081316A2 (en) | 2000-04-27 | 2001-11-01 | Abbott Laboratories | Substituted phenyl farnesyltransferase inhibitors |
| US7109208B2 (en) * | 2001-04-11 | 2006-09-19 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US20050222127A1 (en) * | 2004-03-30 | 2005-10-06 | Alcon, Inc. | Use of Rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance |
| US20060078890A1 (en) * | 2004-10-08 | 2006-04-13 | Ole Isacson | Methods for identifying parkinson's disease therapeutics |
| CN101213187B (zh) * | 2005-06-28 | 2012-06-06 | 塞诺菲-安万特股份有限公司 | 作为rho-激酶抑制剂的异喹啉衍生物 |
| RS52241B (sr) * | 2005-07-26 | 2012-10-31 | Sanofi | Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze |
| CN101277939A (zh) | 2005-09-09 | 2008-10-01 | 布里斯托尔-迈尔斯斯奎布公司 | 无环ikur抑制剂 |
| GB0605766D0 (en) | 2006-03-22 | 2006-05-03 | Ucb Sa | Process |
| US20100004244A1 (en) * | 2006-06-27 | 2010-01-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of cb2 receptor agonists for promoting neurogenesis |
| JP2009543801A (ja) * | 2006-07-13 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | 神経障害処置におけるトリフルオロメチル置換ベンズアミドの使用 |
| CA2725014C (en) * | 2008-05-30 | 2014-06-17 | Amgen Inc. | Inhibitors of pi3 kinase |
| JP2010053073A (ja) * | 2008-08-28 | 2010-03-11 | Sankyo Kasei Kk | ハロゲン化イソキノリン類の製造方法 |
| US8450363B2 (en) * | 2009-02-06 | 2013-05-28 | Elan Pharmaceuticals, Inc. | Inhibitors of Jun N-terminal kinase |
| AU2012212323A1 (en) | 2011-02-01 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
| DE102011009961A1 (de) * | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
| WO2012178022A2 (en) | 2011-06-24 | 2012-12-27 | University Of Massachusetts | Therapeutic applications targeting sarm1 |
| WO2013005157A1 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer |
| DE102012019369A1 (de) | 2012-10-02 | 2014-04-03 | Merck Patent Gmbh | 7-Azaindolderivat |
| KR20160023854A (ko) | 2013-06-24 | 2016-03-03 | 메르크 파텐트 게엠베하 | 프탈라진 유도체 |
| WO2015050471A1 (en) * | 2013-10-02 | 2015-04-09 | Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" | Carbazole compounds and methods of using same |
| WO2015102929A1 (en) * | 2013-12-30 | 2015-07-09 | Novartis Ag | Tricyclic sulfonamide derivatives |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2774923T3 (es) * | 2014-04-28 | 2020-07-23 | China Resources Pharmaceutical Holdings Company Ltd | Derivados de isoquinolinsulfonilo como inhibidores de RHO quinasa |
| EP3188730B1 (en) * | 2014-09-05 | 2019-05-01 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| CA3011189C (en) | 2016-01-14 | 2024-02-20 | Bayer Pharma Aktiengesellschaft | 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines |
| WO2018035204A1 (en) | 2016-08-16 | 2018-02-22 | Henry Ford Health System | Compositions for the treatment of neuropathic pain and sensitization of tumors to chemotherapies |
| JP7044789B2 (ja) | 2016-09-24 | 2022-03-30 | ワシントン・ユニバーシティ | Ｓａｒｍ１ ｎａｄアーゼ活性の阻害剤およびその使用 |
| US11098026B2 (en) * | 2017-03-13 | 2021-08-24 | Impetis Biosciences Limited | Fused bicyclic compounds, compositions and applications thereof |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CN112839647B (zh) | 2018-06-07 | 2025-09-23 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CA3108669A1 (en) | 2018-06-07 | 2019-12-12 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| CN109223787A (zh) | 2018-10-04 | 2019-01-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种喜树碱和新型酞嗪酮类化合物联合用药物组合物 |
| CN109336863A (zh) | 2018-10-04 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种新型酞嗪酮类btk抑制剂、制备及其应用 |
| CN109485636A (zh) | 2018-10-04 | 2019-03-19 | 南京先进生物材料与过程装备研究院有限公司 | 一种新型btk激酶抑制剂的盐酸盐及其制备方法与用途 |
| CN109180642A (zh) | 2018-10-04 | 2019-01-11 | 南京先进生物材料与过程装备研究院有限公司 | 酞嗪酮类btk抑制剂及其应用 |
| CN109293635A (zh) | 2018-10-04 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种新型btk激酶抑制剂的p晶型及其制备方法 |
| WO2020081923A1 (en) * | 2018-10-19 | 2020-04-23 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with nad+ or a nad+ precursor |
| CN109276571A (zh) | 2018-10-31 | 2019-01-29 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和新型硝基酞嗪酮btk抑制剂联合用药物组合物及其应用 |
| CN109331018A (zh) | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和硝基酞嗪酮btk抑制剂联合用药物组合物及其应用 |
| CN109481441A (zh) | 2018-10-31 | 2019-03-19 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和新型甲氧基酞嗪酮类btk抑制剂联合用药物组合物及其应用 |
| CN109172562A (zh) | 2018-10-31 | 2019-01-11 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和甲氧基酞嗪酮类btk抑制剂联合用药物组合物及其应用 |
| CN109394766A (zh) | 2018-10-31 | 2019-03-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和对苯硝基酞嗪酮类btk抑制剂联合用药物组合物及其应用 |
| EP4174170A4 (en) | 2020-06-25 | 2023-12-06 | FUJIFILM Corporation | METHOD FOR PRODUCING INTESTINAL EPITHELIAL CELLS AND USE THEREOF |
-
2019
- 2019-06-06 CN CN201980052437.0A patent/CN112839647B/zh active Active
- 2019-06-06 CA CA3102645A patent/CA3102645A1/en active Pending
- 2019-06-06 JP JP2021518045A patent/JP2021527125A/ja active Pending
- 2019-06-06 EP EP19816172.1A patent/EP3801500B1/en active Active
- 2019-06-06 ES ES19816172T patent/ES3028093T3/es active Active
- 2019-06-06 US US16/972,684 patent/US12338238B2/en active Active
- 2019-06-06 WO PCT/US2019/035833 patent/WO2019236879A1/en not_active Ceased
- 2019-06-06 MA MA052813A patent/MA52813A/fr unknown
-
2023
- 2023-11-30 JP JP2023203259A patent/JP7576145B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MA52813A (fr) | 2021-04-14 |
| JP2021527125A (ja) | 2021-10-11 |
| EP3801500A4 (en) | 2022-03-02 |
| CN112839647B (zh) | 2025-09-23 |
| CN112839647A (zh) | 2021-05-25 |
| US12338238B2 (en) | 2025-06-24 |
| EP3801500B1 (en) | 2025-03-05 |
| EP3801500A1 (en) | 2021-04-14 |
| JP2024037770A (ja) | 2024-03-19 |
| US20210261540A1 (en) | 2021-08-26 |
| WO2019236879A1 (en) | 2019-12-12 |
| JP7576145B2 (ja) | 2024-10-30 |
| CA3102645A1 (en) | 2019-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES3028093T3 (en) | Inhibitors of sarm1 | |
| ES3059247T3 (en) | Inhibitors of sarm1 | |
| ES3049432T3 (en) | Indazole derivatives as inhibitors of sarm1 | |
| US12448374B2 (en) | Inhibitors of SARM1 | |
| ES3059036T3 (en) | Condensed pyrazole derivatives as inhibitors of sarm1 | |
| TW202140437A (zh) | Sarm1抑制劑 | |
| US12441719B2 (en) | Inhibitors of SARM1 | |
| CN113164508A (zh) | 与神经保护剂组合的sarm1抑制剂 | |
| JP7746384B2 (ja) | Ｓａｒｍ１のベンゾピラゾール阻害剤 | |
| CA3102598C (en) | Inhibitors of sarm1 |