JP2021512865A5 - - Google Patents
Info
- Publication number
- JP2021512865A5 JP2021512865A5 JP2020541571A JP2020541571A JP2021512865A5 JP 2021512865 A5 JP2021512865 A5 JP 2021512865A5 JP 2020541571 A JP2020541571 A JP 2020541571A JP 2020541571 A JP2020541571 A JP 2020541571A JP 2021512865 A5 JP2021512865 A5 JP 2021512865A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- compound according
- alkyl
- heteroaryl
- divalent
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024083049A JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862625153P | 2018-02-01 | 2018-02-01 | |
| US62/625,153 | 2018-02-01 | ||
| PCT/US2019/016362 WO2019152848A1 (en) | 2018-02-01 | 2019-02-01 | Lipid-like nanocomplexes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083049A Division JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021512865A JP2021512865A (ja) | 2021-05-20 |
| JPWO2019152848A5 JPWO2019152848A5 (https=) | 2022-02-03 |
| JP2021512865A5 true JP2021512865A5 (https=) | 2022-02-03 |
| JP7497045B2 JP7497045B2 (ja) | 2024-06-10 |
Family
ID=67478550
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020541571A Active JP7497045B2 (ja) | 2018-02-01 | 2019-02-01 | 脂質様ナノ複合体及びその使用 |
| JP2024083049A Active JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083049A Active JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12133855B2 (https=) |
| EP (1) | EP3746129A4 (https=) |
| JP (2) | JP7497045B2 (https=) |
| KR (1) | KR102904334B1 (https=) |
| CN (1) | CN111954542A (https=) |
| AU (1) | AU2019215157B2 (https=) |
| BR (1) | BR112020015796A2 (https=) |
| CA (1) | CA3089826A1 (https=) |
| IL (1) | IL276322B2 (https=) |
| MX (1) | MX2020007944A (https=) |
| WO (1) | WO2019152848A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| CN111954542A (zh) | 2018-02-01 | 2020-11-17 | 塔夫茨大学信托人 | 脂质样纳米复合物及其用途 |
| JP7543259B2 (ja) | 2018-10-18 | 2024-09-02 | アクイタス セラピューティクス インコーポレイテッド | 活性剤の脂質ナノ粒子送達のための脂質 |
| AU2020397956A1 (en) | 2019-12-04 | 2022-07-07 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
| JP7716112B2 (ja) * | 2020-03-02 | 2025-07-31 | トラスティーズ オブ タフツ カレッジ | 免疫細胞へのｉｎ ｖｉｖｏでのｍＲＮＡ送達のためのイミダゾール系合成リピドイド |
| CA3172423A1 (en) | 2020-03-20 | 2021-03-22 | Alex WESSELHOEFT | Circular rna compositions and methods |
| WO2021226092A1 (en) * | 2020-05-04 | 2021-11-11 | Trustees Of Tufts College | Synthetic lipid-like materials for brain delivery |
| CN116018142A (zh) * | 2020-06-12 | 2023-04-25 | 塔夫茨大学信托人 | 用于细胞内mRNA递送的PH响应性类脂质纳米颗粒 |
| WO2022016070A1 (en) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
| US20240024466A1 (en) * | 2020-12-07 | 2024-01-25 | Trustees Of Tufts College | Lipidoid compositions and methods of use thereof |
| AU2022208484A1 (en) * | 2021-01-15 | 2023-08-24 | The Brigham And Women's Hospital, Inc. | Lipid nanoparticles for targeted delivery of mrna |
| CN113402404B (zh) * | 2021-04-30 | 2022-03-11 | 苏州科锐迈德生物医药科技有限公司 | 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| TW202317767A (zh) | 2021-06-10 | 2023-05-01 | 美商歐納醫療公司 | 環狀rna組合物及方法 |
| CN113387825A (zh) * | 2021-06-10 | 2021-09-14 | 福州大学 | 长链烷基酯胺类化合物或含氟长链烷基酯胺类化合物及其公斤级制备方法 |
| EP4408825A1 (en) | 2021-09-30 | 2024-08-07 | Orna Therapeutics, Inc. | Lipid nanoparticle compositions for delivering circular polynucleotides |
| EP4430024A1 (en) | 2021-11-08 | 2024-09-18 | Orna Therapeutics, Inc. | Lipid nanoparticle compositions for delivering circular polynucleotides |
| CN114163345B (zh) * | 2021-12-15 | 2022-07-26 | 武汉滨会生物科技股份有限公司 | 一种可离子化脂质化合物及核酸体外细胞转染试剂 |
| CN114191561B (zh) * | 2021-12-15 | 2022-08-02 | 武汉滨会生物科技股份有限公司 | 一种可离子化脂质化合物在核酸药物递送系统中的应用 |
| EP4448482A2 (en) * | 2021-12-16 | 2024-10-23 | Acuitas Therapeutics, Inc. | Fluorinated cationic lipids for use in lipid nanoparticles |
| CA3242402A1 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2023179497A1 (zh) * | 2022-03-21 | 2023-09-28 | 苏州科锐迈德生物医药科技有限公司 | 一种脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN114716355B (zh) * | 2022-04-02 | 2023-09-05 | 华南理工大学 | 一种脂质化合物、包含其的组合物及应用 |
| CN114773217B (zh) * | 2022-06-20 | 2022-10-18 | 深圳市瑞吉生物科技有限公司 | 用于递送核酸的阳离子脂质化合物和组合物及用途 |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| WO2024077232A2 (en) * | 2022-10-07 | 2024-04-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for t cell targeted delivery of therapeutic agents and activation of t cells |
| WO2024102762A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Lipids and lipid nanoparticle compositions for delivering polynucleotides |
| TW202425959A (zh) | 2022-11-08 | 2024-07-01 | 美商歐納醫療公司 | 遞送多核苷酸的脂質及奈米顆粒組合物 |
| CN120390656A (zh) | 2022-11-08 | 2025-07-29 | 欧纳医疗公司 | 环状rna组合物 |
| CN116063245B (zh) * | 2022-12-05 | 2024-09-10 | 南开大学 | 一种中心可降解的mRNA脂质体纳米粒子及其制备方法和应用 |
| KR102758330B1 (ko) * | 2023-02-22 | 2025-01-23 | 주식회사 서지넥스 | 황화물을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자 |
| WO2024205657A2 (en) | 2023-03-29 | 2024-10-03 | Orna Therapeutics, Inc. | Lipids and lipid nanoparticle compositions for delivering polynucleotides |
| KR102902665B1 (ko) * | 2024-11-29 | 2025-12-22 | 이화여자대학교 산학협력단 | 에틸렌글리콜을 포함한 생분해성 이온화 지질 및 이를 이용한 약물 전달용 지질나노입자 |
| CN119320334A (zh) * | 2024-12-19 | 2025-01-17 | 国家纳米科学中心 | 具有三维空间结构的可电离脂质化合物及制备方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE682393C (de) * | 1933-04-14 | 1939-10-13 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung quaternaerer Stickstoffverbindungen |
| US4275236A (en) | 1979-12-26 | 1981-06-23 | Sherex Chemical Company, Inc. | Tertiary di-(β-hydroxy organo) amine oxides and their preparation |
| WO1997019675A2 (en) * | 1995-11-30 | 1997-06-05 | Vical Incorporated | Complex cationic lipids |
| US5994317A (en) * | 1996-04-09 | 1999-11-30 | Vical Incorporated | Quaternary cytofectins |
| JP4087637B2 (ja) | 2001-04-23 | 2008-05-21 | 信越化学工業株式会社 | エステル構造を有する新規第三級アミン化合物及びその製造方法 |
| FR2873376B1 (fr) * | 2004-07-23 | 2006-11-24 | Tetrahedron Sas | Nouveaux seleno-hydroxyacides et leurs derives, applications en nutrition, cosmetique et pharmacie |
| US9371408B2 (en) | 2011-07-12 | 2016-06-21 | General Electric Company | Polymer and method for using the same |
| CN103131227B (zh) | 2013-02-23 | 2015-05-13 | 北京化工大学 | 一种抗生物垢涂层的制备方法 |
| WO2014134445A1 (en) * | 2013-02-28 | 2014-09-04 | Tufts Unversity | Disulfide compounds for delivery of pharmaceutical agents |
| US20160082126A1 (en) * | 2013-05-13 | 2016-03-24 | Tufts University | Nanocomplexes for delivery of saporin |
| WO2014186348A2 (en) | 2013-05-14 | 2014-11-20 | Tufts University | Nanocomplexes of modified peptides or proteins |
| US9895443B2 (en) | 2013-06-26 | 2018-02-20 | Massachusetts Institute Of Technology | Multi-tailed lipids and uses thereof |
| WO2016009643A1 (ja) | 2014-07-17 | 2016-01-21 | 凸版印刷株式会社 | 熱転写受像シート及びその製造方法 |
| WO2017176974A1 (en) | 2016-04-06 | 2017-10-12 | Ohio State Innovation Foundation | Biodegradable amino-ester nanomaterials for nucleic acid delivery |
| WO2017212006A1 (en) * | 2016-06-09 | 2017-12-14 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| EP3490611A4 (en) | 2016-07-26 | 2020-04-15 | Trustees Of Tufts College | ANTIBODY-CONJUGATED NANOPARTICLES AND MEDICAL USES THEREOF |
| CN111954542A (zh) | 2018-02-01 | 2020-11-17 | 塔夫茨大学信托人 | 脂质样纳米复合物及其用途 |
-
2019
- 2019-02-01 CN CN201980023529.6A patent/CN111954542A/zh active Pending
- 2019-02-01 BR BR112020015796-1A patent/BR112020015796A2/pt active Search and Examination
- 2019-02-01 US US16/966,368 patent/US12133855B2/en active Active
- 2019-02-01 WO PCT/US2019/016362 patent/WO2019152848A1/en not_active Ceased
- 2019-02-01 MX MX2020007944A patent/MX2020007944A/es unknown
- 2019-02-01 EP EP19747806.8A patent/EP3746129A4/en active Pending
- 2019-02-01 CA CA3089826A patent/CA3089826A1/en active Pending
- 2019-02-01 IL IL276322A patent/IL276322B2/en unknown
- 2019-02-01 JP JP2020541571A patent/JP7497045B2/ja active Active
- 2019-02-01 KR KR1020207024651A patent/KR102904334B1/ko active Active
- 2019-02-01 AU AU2019215157A patent/AU2019215157B2/en not_active Expired - Fee Related
-
2023
- 2023-06-02 US US18/205,096 patent/US20230405022A1/en active Pending
-
2024
- 2024-05-22 JP JP2024083049A patent/JP7650112B2/ja active Active
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