JP2021503897A - 新生抗原のためのジャンクションエピトープ提示の低減 - Google Patents

新生抗原のためのジャンクションエピトープ提示の低減 Download PDF

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JP2021503897A
JP2021503897A JP2020528117A JP2020528117A JP2021503897A JP 2021503897 A JP2021503897 A JP 2021503897A JP 2020528117 A JP2020528117 A JP 2020528117A JP 2020528117 A JP2020528117 A JP 2020528117A JP 2021503897 A JP2021503897 A JP 2021503897A
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epitopes
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ブレンダン ブリク−スリバン
ブレンダン ブリク−スリバン
トーマス フランシス バウチャー
トーマス フランシス バウチャー
ローマン ヤレンスカイ
ローマン ヤレンスカイ
ジェニファー バスビー
ジェニファー バスビー
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グリットストーン オンコロジー インコーポレイテッド
グリットストーン オンコロジー インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Urology & Nephrology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2020528117A 2017-11-22 2018-11-21 新生抗原のためのジャンクションエピトープ提示の低減 Pending JP2021503897A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023182917A JP7755628B2 (ja) 2017-11-22 2023-10-25 新生抗原のためのジャンクションエピトープ提示の低減
JP2025147998A JP2025175055A (ja) 2017-11-22 2025-09-08 新生抗原のためのジャンクションエピトープ提示の低減

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US201762590045P 2017-11-22 2017-11-22
US62/590,045 2017-11-22
PCT/US2018/062294 WO2019104203A1 (en) 2017-11-22 2018-11-21 Reducing junction epitope presentation for neoantigens

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JP2023182917A Division JP7755628B2 (ja) 2017-11-22 2023-10-25 新生抗原のためのジャンクションエピトープ提示の低減

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JP2021503897A5 JP2021503897A5 (https=) 2022-01-04

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JP2020528117A Pending JP2021503897A (ja) 2017-11-22 2018-11-21 新生抗原のためのジャンクションエピトープ提示の低減
JP2023182917A Active JP7755628B2 (ja) 2017-11-22 2023-10-25 新生抗原のためのジャンクションエピトープ提示の低減
JP2025147998A Pending JP2025175055A (ja) 2017-11-22 2025-09-08 新生抗原のためのジャンクションエピトープ提示の低減

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JP2025147998A Pending JP2025175055A (ja) 2017-11-22 2025-09-08 新生抗原のためのジャンクションエピトープ提示の低減

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US (2) US11885815B2 (https=)
EP (1) EP3714275A4 (https=)
JP (3) JP2021503897A (https=)
KR (2) KR102905054B1 (https=)
CN (1) CN111630602A (https=)
AU (2) AU2018373154B2 (https=)
CA (1) CA3083097A1 (https=)
IL (1) IL274799B2 (https=)
WO (1) WO2019104203A1 (https=)

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WO2017194170A1 (en) 2016-05-13 2017-11-16 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of proteins or protein fragments for immunotherapy
WO2018224166A1 (en) 2017-06-09 2018-12-13 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
WO2020141207A1 (en) 2019-01-03 2020-07-09 Evaxion Biotech Aps Vaccines targeting neoepitopes
US20220184191A1 (en) 2019-03-11 2022-06-16 Evaxion Biotech A/S Nucleic acid vaccination using neo-epitope encoding constructs
KR20240137107A (ko) 2019-07-16 2024-09-19 길리애드 사이언시즈, 인코포레이티드 Hiv 백신, 및 이의 제조 및 사용 방법
WO2021048400A1 (en) 2019-09-13 2021-03-18 Evaxion Biotech Aps Method for identifying t-cell epitopes
WO2021123232A1 (en) 2019-12-18 2021-06-24 Evaxion Biotech Aps Nucleic acid vaccination using neo-epitope encoding constructs
JP7617574B2 (ja) * 2020-01-07 2025-01-20 コリア アドバンスド インスティテュート オブ サイエンス アンド テクノロジー 新生抗原をスクリーニングする方法、システム及びその用途
US20230147574A1 (en) 2020-04-07 2023-05-11 Evaxion Biotech A/S Neoepitope immunotherapy with APC targeting unit
CA3183951A1 (en) 2020-07-14 2022-01-20 Birgitte Rono Apc targeting units for immunotherapy
IL303753A (en) * 2020-12-18 2023-08-01 Yeda res & development co ltd Preparations for use in the treatment of CHD2 HAPLOINSUFFICIENCY and methods for detection
US12053517B2 (en) 2021-01-14 2024-08-06 Gilead Sciences, Inc. HIV vaccines and methods of using
WO2022229966A1 (en) 2021-04-29 2022-11-03 Yeda Research And Development Co. Ltd. T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same
KR102475794B1 (ko) * 2022-08-23 2022-12-08 주식회사 테라젠바이오 합성 긴 펩타이드의 면역원성 예측 장치, 면역원성 예측 방법 및 컴퓨터 프로그램

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