MX2017013174A - Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y métodos para usar los mismos. - Google Patents
Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y métodos para usar los mismos.Info
- Publication number
- MX2017013174A MX2017013174A MX2017013174A MX2017013174A MX2017013174A MX 2017013174 A MX2017013174 A MX 2017013174A MX 2017013174 A MX2017013174 A MX 2017013174A MX 2017013174 A MX2017013174 A MX 2017013174A MX 2017013174 A MX2017013174 A MX 2017013174A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- mesothelin
- growth factor
- factor receptor
- epidermal growth
- Prior art date
Links
- 102000001301 EGF receptor Human genes 0.000 title abstract 2
- 108060006698 EGF receptor Proteins 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000003735 Mesothelin Human genes 0.000 abstract 1
- 108090000015 Mesothelin Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/001168—Mesothelin [MSLN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En el presente documento se proporcionan composiciones y métodos para desencadenar una respuesta inmunitaria en un sujeto. En particular, la presente divulgación se refiere a proteínas de fusión que comprenden un polipéptido de la variante III del receptor de factor de crecimiento epidérmico (EGFRvIII) y un polipéptido de mesotelina, y a métodos para desencadenar una respuesta inmunitaria usando células hospedadoras que comprenden moléculas de ácido nucleico que codifican dichas proteínas de fusión. En algunas realizaciones, las moléculas de ácido nucleico pueden codificar una proteína de fusión EGFRvIIImesotelina que comprende una secuencia de aminoácidos que es al menos i) un 90% idéntica, ii) un 95% idéntica, o iii) un 99% idéntica a EGFRvIIIx5-mesotelina35-622 tal como se expone en la SEQ ID NO: 8.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562146559P | 2015-04-13 | 2015-04-13 | |
US201562243397P | 2015-10-19 | 2015-10-19 | |
PCT/US2016/027136 WO2016168198A1 (en) | 2015-04-13 | 2016-04-12 | Epidermal growth factor receptor variant iii-mesothelin fusions and methods of using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017013174A true MX2017013174A (es) | 2018-04-11 |
Family
ID=55809232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017013174A MX2017013174A (es) | 2015-04-13 | 2016-04-12 | Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y métodos para usar los mismos. |
Country Status (22)
Country | Link |
---|---|
US (1) | US10105427B2 (es) |
EP (1) | EP3283509A1 (es) |
JP (1) | JP6782253B2 (es) |
KR (1) | KR20180002640A (es) |
CN (1) | CN107750256A (es) |
AU (1) | AU2016247887A1 (es) |
BR (1) | BR112017022076A2 (es) |
CA (1) | CA2982533A1 (es) |
CO (1) | CO2017011431A2 (es) |
CR (1) | CR20170507A (es) |
EA (1) | EA201792274A1 (es) |
EC (1) | ECSP17075380A (es) |
HK (2) | HK1250730A1 (es) |
IL (1) | IL254957A0 (es) |
MA (1) | MA44379A (es) |
MX (1) | MX2017013174A (es) |
PH (1) | PH12017502080A1 (es) |
SG (1) | SG11201708360TA (es) |
SV (1) | SV2017005545A (es) |
TW (1) | TW201710285A (es) |
UY (1) | UY36616A (es) |
WO (1) | WO2016168198A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6782253B2 (ja) | 2015-04-13 | 2020-11-11 | アデュロ バイオテック,インコーポレイテッド | 上皮増殖因子受容体変異型iii−メソテリン融合物及びこれを使用する方法 |
US9808516B2 (en) | 2015-04-13 | 2017-11-07 | Aduro Biotech, Inc. | Immunogenic fusion proteins for the treatment of cancer |
TWI765875B (zh) | 2015-12-16 | 2022-06-01 | 美商磨石生物公司 | 新抗原辨識、製造及用途 |
EP3694532A4 (en) | 2017-10-10 | 2021-07-14 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEOANTIGENS BY MEANS OF HOT SPOTS |
JP2021503897A (ja) | 2017-11-22 | 2021-02-15 | グリットストーン オンコロジー インコーポレイテッド | 新生抗原のためのジャンクションエピトープ提示の低減 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
DE69532767T2 (de) | 1994-11-28 | 2004-08-12 | Thomas Jefferson University | Peptid umfassend eine Sequenz aus einer Fusionsverbindungsstelle in einem mutierten EGF-Rezeptor vom Typ III |
CA2404164A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
WO2004006837A2 (en) | 2002-07-12 | 2004-01-22 | The Johns Hopkins University | Mesothelin vaccines and model systems |
EP2311978A1 (en) | 2002-08-20 | 2011-04-20 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
MXPA05008340A (es) | 2003-02-06 | 2006-03-13 | Cerus Corp | Microbios de vida libre modificados, composiciones de vacuna y metodos de uso de los mismos. |
KR101192652B1 (ko) | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
ATE546153T1 (de) | 2003-06-17 | 2012-03-15 | Mannkind Corp | Kombinationen von tumor-assoziierten antigenen zur behandlung von verschiedenen krebstypen |
US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
ES2532942T3 (es) * | 2006-03-01 | 2015-04-06 | Aduro Biotech | Listeria obtenida por ingeniería genética y métodos de uso de la misma |
DK2640842T3 (en) | 2010-11-17 | 2018-08-13 | Aduro Biotech Inc | Methods and compositions for inducing an immune response to EGFRVIII |
EP2938627B1 (en) * | 2012-12-27 | 2019-03-20 | Aduro Biotech, Inc. | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
CN104211814A (zh) | 2013-05-29 | 2014-12-17 | 三星电子株式会社 | 用于消耗靶膜蛋白的组合物 |
JP6782253B2 (ja) | 2015-04-13 | 2020-11-11 | アデュロ バイオテック,インコーポレイテッド | 上皮増殖因子受容体変異型iii−メソテリン融合物及びこれを使用する方法 |
US9808516B2 (en) | 2015-04-13 | 2017-11-07 | Aduro Biotech, Inc. | Immunogenic fusion proteins for the treatment of cancer |
-
2016
- 2016-04-12 JP JP2017554395A patent/JP6782253B2/ja active Active
- 2016-04-12 MX MX2017013174A patent/MX2017013174A/es unknown
- 2016-04-12 WO PCT/US2016/027136 patent/WO2016168198A1/en active Application Filing
- 2016-04-12 EP EP16718812.7A patent/EP3283509A1/en not_active Withdrawn
- 2016-04-12 BR BR112017022076-8A patent/BR112017022076A2/pt not_active Application Discontinuation
- 2016-04-12 EA EA201792274A patent/EA201792274A1/ru unknown
- 2016-04-12 CN CN201680028967.8A patent/CN107750256A/zh active Pending
- 2016-04-12 UY UY0001036616A patent/UY36616A/es not_active Application Discontinuation
- 2016-04-12 KR KR1020177031486A patent/KR20180002640A/ko unknown
- 2016-04-12 TW TW105111337A patent/TW201710285A/zh unknown
- 2016-04-12 CA CA2982533A patent/CA2982533A1/en not_active Abandoned
- 2016-04-12 CR CR20170507A patent/CR20170507A/es unknown
- 2016-04-12 US US15/097,178 patent/US10105427B2/en not_active Expired - Fee Related
- 2016-04-12 SG SG11201708360TA patent/SG11201708360TA/en unknown
- 2016-04-12 MA MA044379A patent/MA44379A/fr unknown
- 2016-04-12 AU AU2016247887A patent/AU2016247887A1/en not_active Abandoned
-
2017
- 2017-10-09 IL IL254957A patent/IL254957A0/en unknown
- 2017-10-13 SV SV2017005545A patent/SV2017005545A/es unknown
- 2017-11-07 CO CONC2017/0011431A patent/CO2017011431A2/es unknown
- 2017-11-13 EC ECIEPI201775380A patent/ECSP17075380A/es unknown
- 2017-11-16 PH PH12017502080A patent/PH12017502080A1/en unknown
-
2018
- 2018-08-06 HK HK18110071.1A patent/HK1250730A1/zh unknown
- 2018-08-10 HK HK18110280.8A patent/HK1250992A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP6782253B2 (ja) | 2020-11-11 |
KR20180002640A (ko) | 2018-01-08 |
TW201710285A (zh) | 2017-03-16 |
ECSP17075380A (es) | 2018-02-28 |
CA2982533A1 (en) | 2016-10-20 |
SG11201708360TA (en) | 2017-11-29 |
AU2016247887A1 (en) | 2017-11-02 |
MA44379A (fr) | 2019-01-23 |
CR20170507A (es) | 2018-02-13 |
EP3283509A1 (en) | 2018-02-21 |
CO2017011431A2 (es) | 2018-01-16 |
PH12017502080A1 (en) | 2018-05-07 |
IL254957A0 (en) | 2017-12-31 |
HK1250730A1 (zh) | 2019-01-11 |
BR112017022076A2 (pt) | 2018-08-14 |
EA201792274A1 (ru) | 2018-02-28 |
JP2018512166A (ja) | 2018-05-17 |
UY36616A (es) | 2016-10-31 |
HK1250992A1 (zh) | 2019-01-18 |
SV2017005545A (es) | 2018-05-11 |
US20160346369A1 (en) | 2016-12-01 |
CN107750256A (zh) | 2018-03-02 |
WO2016168198A1 (en) | 2016-10-20 |
US10105427B2 (en) | 2018-10-23 |
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