MX2017015149A - Inmunoterapia personalizada basada en vectores de suministro y usos de esta. - Google Patents
Inmunoterapia personalizada basada en vectores de suministro y usos de esta.Info
- Publication number
- MX2017015149A MX2017015149A MX2017015149A MX2017015149A MX2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A
- Authority
- MX
- Mexico
- Prior art keywords
- vectors
- subject
- disease
- immunotherapy
- peptides
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 7
- 238000009169 immunotherapy Methods 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000186781 Listeria Species 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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Abstract
Esta invención proporciona un sistema para proporcionar y crear composiciones inmunoterapéuticas personalizadas para un sujeto que tiene una enfermedad o afección, que incluye vectores de suministro de una inmunoterapia terapéutica y métodos para producir los mismos que comprenden constructos de expresión génica que expresan péptidos asociados con uno o más neoepítopos o péptidos que contienen mutaciones que son específicas para el cáncer o tejido no saludable del sujeto. Un vector de suministro de esta invención incluye vectores bacterianos que incluyen vectores bacterianos de Listeria; o vectores virales, vectores para inmunoterapia de péptidos; o vectores para inmunoterapia de ADN, que comprenden una o más proteínas de fusión que comprenden uno o más péptidos que comprenden uno o más neoepítopos presentes en muestras biológicas que portan la enfermedad obtenidas del sujeto. Esta invención proporciona, además, métodos para usar los mismos para inducir una respuesta inmunitaria contra una enfermedad o afección, que incluye un tumor o cáncer, o una infección, o una enfermedad autoinmunitaria o un rechazo de un trasplante de órganos en el sujeto.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562166591P | 2015-05-26 | 2015-05-26 | |
US201562174692P | 2015-06-12 | 2015-06-12 | |
US201562218936P | 2015-09-15 | 2015-09-15 | |
PCT/US2016/034301 WO2016191545A1 (en) | 2015-05-26 | 2016-05-26 | Personalized delivery vector-based immunotherapy and uses thereof |
Publications (1)
Publication Number | Publication Date |
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EP (1) | EP3302574A4 (es) |
JP (1) | JP2018515588A (es) |
KR (1) | KR20180026670A (es) |
CN (1) | CN107847611A (es) |
AU (1) | AU2016267155A1 (es) |
CA (1) | CA2987239A1 (es) |
HK (1) | HK1253334A1 (es) |
IL (1) | IL255851A (es) |
MA (1) | MA43362A (es) |
MX (1) | MX2017015149A (es) |
TW (1) | TW201708536A (es) |
WO (1) | WO2016191545A1 (es) |
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US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
EP2683400A4 (en) | 2011-03-11 | 2014-09-17 | Advaxis | ADJUVANZIA ON LISTERIA BASE |
SG11201405605VA (en) | 2012-03-12 | 2014-10-30 | Advaxis Inc | SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING <i>LISTERIA</i> VACCINE TREATMENT |
CA2947358A1 (en) | 2014-02-18 | 2015-08-27 | Advaxis, Inc. | Biomarker directed multi-target immunotherapy |
KR102359691B1 (ko) | 2014-04-24 | 2022-02-10 | 어드박시스, 인크. | 재조합 리스테리아 백신 균주 및 그 생산 방법 |
MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
MX2018000210A (es) * | 2015-06-24 | 2018-06-22 | Advaxis Inc | Dispositivo y proceso de fabricación de inmunoterapia personalizada basada en vectores de suministro. |
EP3362929B1 (en) * | 2015-10-12 | 2020-08-12 | Nantomics, LLC | Viral neoepitopes and uses thereof |
AU2016369519B2 (en) | 2015-12-16 | 2023-04-20 | Gritstone Bio, Inc. | Neoantigen identification, manufacture, and use |
CN109563521A (zh) | 2016-03-24 | 2019-04-02 | 河谷细胞有限公司 | 用于新表位呈递的序列排列和序列 |
CA3035473A1 (en) | 2016-09-13 | 2018-03-22 | Allergan, Inc. | Non-protein clostridial toxin compositions |
MX2019005685A (es) | 2016-11-30 | 2019-09-04 | Advaxis Inc | Composiciones inmunogenicas contra mutaciones de cancer recurrentes y metodos de uso de las mismas. |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
WO2018106699A1 (en) * | 2016-12-08 | 2018-06-14 | Nantbio, Inc. | Method of validating the triggering of an immune response to a neoepitope of a tumor with t-cells |
CN109963570A (zh) | 2017-01-21 | 2019-07-02 | 宁波知明生物科技有限公司 | 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 |
AU2018258119B2 (en) * | 2017-04-24 | 2021-04-01 | Nantcell, Inc. | Targeted neoepitope vectors and methods therefor |
IL271558B2 (en) | 2017-06-21 | 2024-01-01 | Transgene | A vaccine tailored to the individual |
WO2019006401A2 (en) * | 2017-06-30 | 2019-01-03 | Advaxis, Inc. | LISTERIA-BASED IMMUNOGENIC COMPOSITIONS COMPRISING HETERICCLIENT WILMS TUMOR PROTEIN ANTIGENS AND METHODS OF USE THEREOF |
KR20200044982A (ko) | 2017-09-19 | 2020-04-29 | 어드박시스, 인크. | 박테리아 또는 리스테리아 균주의 동결건조를 위한 조성물 및 방법 |
WO2019060835A2 (en) * | 2017-09-25 | 2019-03-28 | Nant Holdings Ip, Llc | VALIDATION OF PRESENTATION OF NEO-EPITOPE |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
CN108564661B (zh) * | 2018-01-08 | 2022-06-28 | 佛山市超体软件科技有限公司 | 一种基于增强现实场景的记录方法 |
CN110408634B (zh) * | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
WO2020024982A1 (zh) * | 2018-08-02 | 2020-02-06 | 苏州若泰医药科技有限公司 | 一种基于减毒李斯特菌激活的抗原提呈细胞的肿瘤免疫治疗组合物、制备方法和应用 |
CN111334521B (zh) * | 2018-12-18 | 2022-02-18 | 上海若泰医药科技有限公司 | 一种提高非整合减毒李斯特菌外源抗原蛋白表达的方法 |
CN113631185A (zh) * | 2019-02-27 | 2021-11-09 | 尼克塔治疗公司 | 用于治疗癌症的免疫治疗组合 |
CN117843811A (zh) * | 2019-09-30 | 2024-04-09 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
WO2023068931A1 (en) | 2021-10-21 | 2023-04-27 | Curevac Netherlands B.V. | Cancer neoantigens |
CN114134165B (zh) | 2022-01-27 | 2022-04-29 | 北京循生生物医学研究有限公司 | 一种新型hpv治疗性核酸疫苗 |
WO2023209068A1 (en) | 2022-04-28 | 2023-11-02 | Carbocalyx Gmbh | Personalized anticancer vaccine comprising glycoengineered tumour cells or tumour cell fragments |
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US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
CN1548537B (zh) * | 2002-12-27 | 2010-05-05 | 深圳市源兴生物医药科技有限公司 | 疫苗制备方法和抗肿瘤疫苗 |
CN101528254A (zh) * | 2006-07-14 | 2009-09-09 | 赛诺菲巴斯德生物制剂公司 | 通过向载体病毒蛋白中直接转座子介导插入外源免疫决定簇构建重组病毒疫苗 |
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EP2292258A1 (en) * | 2009-08-18 | 2011-03-09 | Pevion Biotech Ltd. | Multiepitope vaccine for Her2/neu-associated cancers |
EP2498808A4 (en) * | 2009-11-11 | 2014-01-08 | Advaxis | COMPOSITIONS AND METHOD FOR PREVENTING FLUID MUTATIONS IN THE TREATMENT OF TUMORS WITH HER2 / NEW OVEREXPRESSION |
DK2640842T3 (en) * | 2010-11-17 | 2018-08-13 | Aduro Biotech Inc | Methods and compositions for inducing an immune response to EGFRVIII |
DK2901341T3 (da) * | 2012-09-28 | 2019-07-15 | Univ Connecticut | Identifikation af tumorbeskyttelsesepitoper til behandling af cancere |
US10155031B2 (en) * | 2012-11-28 | 2018-12-18 | Biontech Rna Pharmaceuticals Gmbh | Individualized vaccines for cancer |
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2016
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- 2016-05-26 MX MX2017015149A patent/MX2017015149A/es unknown
- 2016-05-26 MA MA043362A patent/MA43362A/fr unknown
- 2016-05-26 CN CN201680030603.3A patent/CN107847611A/zh active Pending
- 2016-05-26 KR KR1020177036535A patent/KR20180026670A/ko unknown
- 2016-05-26 JP JP2017561358A patent/JP2018515588A/ja active Pending
- 2016-05-26 AU AU2016267155A patent/AU2016267155A1/en not_active Abandoned
- 2016-05-26 TW TW105116450A patent/TW201708536A/zh unknown
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2017
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2018
- 2018-10-02 HK HK18112627.6A patent/HK1253334A1/zh unknown
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MA43362A (fr) | 2018-10-10 |
AU2016267155A1 (en) | 2017-12-21 |
CN107847611A (zh) | 2018-03-27 |
HK1253334A1 (zh) | 2019-06-14 |
US20190381160A1 (en) | 2019-12-19 |
EP3302574A4 (en) | 2018-10-17 |
IL255851A (en) | 2018-01-31 |
EP3302574A1 (en) | 2018-04-11 |
KR20180026670A (ko) | 2018-03-13 |
WO2016191545A1 (en) | 2016-12-01 |
TW201708536A (zh) | 2017-03-01 |
JP2018515588A (ja) | 2018-06-14 |
WO2016191545A4 (en) | 2017-02-09 |
CA2987239A1 (en) | 2016-12-01 |
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