JP2021502113A5 - - Google Patents

Download PDF

Info

Publication number
JP2021502113A5
JP2021502113A5 JP2020543733A JP2020543733A JP2021502113A5 JP 2021502113 A5 JP2021502113 A5 JP 2021502113A5 JP 2020543733 A JP2020543733 A JP 2020543733A JP 2020543733 A JP2020543733 A JP 2020543733A JP 2021502113 A5 JP2021502113 A5 JP 2021502113A5
Authority
JP
Japan
Prior art keywords
cells
seq
tgfbr2
nuclease
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020543733A
Other languages
English (en)
Japanese (ja)
Other versions
JP7785452B2 (ja
JP2021502113A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/058635 external-priority patent/WO2019089884A2/en
Publication of JP2021502113A publication Critical patent/JP2021502113A/ja
Publication of JP2021502113A5 publication Critical patent/JP2021502113A5/ja
Priority to JP2023146660A priority Critical patent/JP2023179469A/ja
Priority to JP2025129240A priority patent/JP2025156493A/ja
Application granted granted Critical
Publication of JP7785452B2 publication Critical patent/JP7785452B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020543733A 2017-11-01 2018-11-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素 Active JP7785452B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023146660A JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762580320P 2017-11-01 2017-11-01
US62/580,320 2017-11-01
PCT/US2018/058635 WO2019089884A2 (en) 2017-11-01 2018-11-01 Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023146660A Division JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Publications (3)

Publication Number Publication Date
JP2021502113A JP2021502113A (ja) 2021-01-28
JP2021502113A5 true JP2021502113A5 (enExample) 2021-12-09
JP7785452B2 JP7785452B2 (ja) 2025-12-15

Family

ID=64453598

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020543733A Active JP7785452B2 (ja) 2017-11-01 2018-11-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2023146660A Pending JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A Pending JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023146660A Pending JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A Pending JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Country Status (13)

Country Link
US (1) US20230061455A1 (enExample)
EP (1) EP3704251A2 (enExample)
JP (3) JP7785452B2 (enExample)
KR (1) KR102954207B1 (enExample)
CN (1) CN111527209B (enExample)
AU (2) AU2018358250B2 (enExample)
BR (1) BR112020008478A2 (enExample)
CA (1) CA3081456A1 (enExample)
IL (1) IL274299B2 (enExample)
MA (1) MA50858A (enExample)
MX (2) MX2020004608A (enExample)
SG (1) SG11202003862PA (enExample)
WO (1) WO2019089884A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
CN110904045A (zh) * 2018-09-17 2020-03-24 中国科学院动物研究所 经修饰的t细胞、其制备方法及用途
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
AU2020265741A1 (en) * 2019-05-01 2021-11-25 Editas Medicine, Inc. Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
US12024711B2 (en) 2019-05-29 2024-07-02 Monsanto Technology Llc Methods and compositions for generating dominant short stature alleles using genome editing
MX2021014528A (es) 2019-05-29 2022-01-06 Monsanto Technology Llc Metodos y composiciones para generar alelos dominantes usando edicion del genoma.
WO2020247392A1 (en) * 2019-06-04 2020-12-10 Nkarta, Inc. Combinations of engineered natural killer cells and engineered t cells for immunotherapy
WO2021011864A1 (en) * 2019-07-18 2021-01-21 Memorial Sloan Kettering Cancer Center METHODS AND COMPOSITIONS FOR TARGETING TGF-β SIGNALING IN CD4+ HELPER T CELLS FOR CANCER IMMUNOTHERAPY
CN120905142A (zh) * 2019-11-20 2025-11-07 卡瑟里克斯私人有限公司 用于提供具有增强功能的免疫细胞的方法
AU2020405049A1 (en) * 2019-12-17 2022-06-23 The General Hospital Corporation Engineered immune cells with reduced toxicity and uses thereof
WO2021127594A1 (en) * 2019-12-18 2021-06-24 Editas Medicine, Inc. Engineered cells for therapy
JP2023517992A (ja) 2020-03-12 2023-04-27 インスティチュート フォー ベーシック サイエンス ゲノム配列変異を有する細胞死滅誘導用組成物及び該組成物を用いた細胞死滅誘導方法
CN114164231B (zh) * 2020-09-10 2024-05-17 上海邦耀生物科技有限公司 对细胞中的靶位点进行基因编辑的方法
AU2021347907A1 (en) 2020-09-23 2023-04-20 Crispr Therapeutics Ag Genetically engineered t cells with regnase-1 and/or tgfbrii disruption have improved functionality and persistence
US12171813B2 (en) 2021-02-05 2024-12-24 Christiana Care Gene Editing Institute, Inc. Methods of and compositions for reducing gene expression and/or activity
US20240197782A1 (en) * 2021-04-20 2024-06-20 Board Of Regents, The University Of Texas System Methods and compositions for genetic modification and therapeutic use of immune cells
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
US20250161487A1 (en) * 2022-01-26 2025-05-22 Orthobio Therapeutics, Inc. Gene editing to improve joint function
TW202346575A (zh) * 2022-03-23 2023-12-01 瑞士商Ｃｒｉｓｐｒ治療公司 具有ｒｅｇｎａｓｅ－１及／或ｔｇｆｂｒｉｉ破壞的抗ｃｄ８３ ｃａｒ－ｔ細胞
KR20240040035A (ko) * 2022-09-16 2024-03-27 한국과학기술연구원 유전자 가위 넉-인을 이용하여 제조한 키메릭 항원 수용체 세포 및 이의 용도
JP2026507228A (ja) 2023-03-03 2026-02-27 アーセナル バイオサイエンシズ インコーポレイテッド Ｐｓｍａ及びｃａ９を標的とするシステム
CN116515766A (zh) * 2023-06-30 2023-08-01 上海贝斯昂科生物科技有限公司 一种自然杀伤细胞、其制备方法及用途
WO2025038637A1 (en) * 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
WO2025038648A1 (en) * 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
WO2025137646A1 (en) 2023-12-22 2025-06-26 Recode Therapeutics, Inc. Gene editing methods and compositions for treating cystic fibrosis
WO2025165915A1 (en) * 2024-01-31 2025-08-07 Adicet Therapeutics, Inc. Compositions and methods for enhancing engineered t cell therapies
TW202605143A (zh) 2024-05-10 2026-02-01 美商奇諾治療有限公司 表現cd19嵌合抗原受體(car)之基因工程化t細胞及其用於同種異體細胞療法之用途

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
IN165717B (enExample) 1986-08-07 1989-12-23 Battelle Memorial Institute
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
JP2001519143A (ja) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
BR9910253A (pt) 1998-05-19 2002-09-17 Avidex Ltd Receptor de célula t solúvel
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
CA2410510A1 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
AU2001297703B2 (en) 2000-11-07 2006-10-19 City Of Hope CD19-specific redirected immune cells
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
NZ539225A (en) 2002-10-09 2006-09-29 Avidex Ltd Single chain recombinant T cell receptors
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
JP5563194B2 (ja) 2004-06-29 2014-07-30 イムノコア リミテッド 改変ｔ細胞レセプターを発現する細胞
JP2008514685A (ja) 2004-10-01 2008-05-08 メディジーン リミテッド 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター
WO2008109546A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof
PL2856876T3 (pl) 2007-03-30 2018-06-29 Memorial Sloan-Kettering Cancer Center Konstytutywna ekspresja ligandów kostymulujących na limfocytach T poddanych transferowi adoptywnemu
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
EP2486049A1 (en) 2009-10-06 2012-08-15 The Board Of Trustees Of The UniversityOf Illinois Human single-chain t cell receptors
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9987308B2 (en) 2011-03-23 2018-06-05 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
US10208086B2 (en) 2011-11-11 2019-02-19 Fred Hutchinson Cancer Research Center Cyclin A1-targeted T-cell immunotherapy for cancer
EP3594245A1 (en) 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
CN107557334B (zh) 2012-05-03 2021-06-25 弗雷德哈钦森癌症研究中心 增强亲和力的t细胞受体及其制备方法
PL3824905T3 (pl) 2012-08-20 2025-05-05 Fred Hutchinson Cancer Center Sposób i kompozycje do immunoterapii komórkowej
SG11201502598SA (en) 2012-10-02 2015-05-28 Sloan Kettering Inst Cancer Compositions and methods for immunotherapy
JP2015530122A (ja) * 2012-10-05 2015-10-15 チルドレンズ ホスピタル メディカル センター 脂腺細胞の培養及び使用方法
JP5372297B1 (ja) 2012-12-20 2013-12-18 三菱電機株式会社 車載装置及びプログラム
US10378027B2 (en) * 2013-03-15 2019-08-13 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
WO2014204723A1 (en) * 2013-06-17 2014-12-24 The Broad Institute Inc. Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
WO2015048577A2 (en) * 2013-09-27 2015-04-02 Editas Medicine, Inc. Crispr-related methods and compositions
CN106459995B (zh) * 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
CA2948728A1 (en) 2014-03-10 2015-09-17 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
WO2016073990A2 (en) 2014-11-07 2016-05-12 Editas Medicine, Inc. Methods for improving crispr/cas-mediated genome-editing
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
GB2557123B (en) * 2015-07-31 2021-11-03 Univ Minnesota Modified cells and methods of therapy
US10525082B2 (en) * 2015-09-09 2020-01-07 Seattle Children's Hospital Genetic engineering of macrophages for immunotherapy

Similar Documents

Publication Publication Date Title
JP2021502077A5 (enExample)
US20220204929A1 (en) Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir)
US20220088078A1 (en) Genetically engineered t cells with regnase-1 and/or tgfbrii disruption have improved functionality and persistence
JP2024111155A (ja) 免疫療法の改善のための遺伝子標的の組み合わせ
AU2018206401B2 (en) Genetically modified NK-92 cells with decreased CD96/TIGIT expression
AU2025223904A1 (en) Methods, compositions and components for CRISPR-CAS9 editing of TGFBR2 in T cells for immunotherapy
KR20180103923A (ko) 혈색소병증의 치료를 위한 조성물 및 방법
CN107249645A (zh) 用于选择性消除所关注细胞的方法和组合物
JP2017513520A (ja) メトトレキサートによる選択と組み合わせたＳｌｅｅｐｉｎｇ Ｂｅａｕｔｙトランスポゾンによる遺伝子改変Ｔ細胞の製造
US20220145333A1 (en) Improved process for integration of dna constructs using rna-guided endonucleases
EP3640329A1 (en) Gene editing based cancer treatment
JP2022521787A (ja) Ｒｎａ誘導型エンドヌクレアーゼを使用するｄｎａ組み込みのための改善された方法
NZ796544A (en) Methods of and compositions for reducing gene expression and/or activity
JP2023552917A5 (enExample)
TW202417626A (zh) 具有共表現的ｔｇｆｂｒ ｓｈｒｎａ之免疫細胞
KR20180018466A (ko) 면역세포의 면역조절 유전자의 활성 조절을 위한 조성물 및 그 용도
CA3106093C (en) ANTI-TUMOR COMPOSITION
KR102276940B1 (ko) 신규한 유전체 세이프 하버 및 이의 용도
WO2022015956A1 (en) Improved process for dna integration using rna-guided endonucleases
CN119220607B (zh) 编辑tim3基因获得功能强化的car-nk细胞的方法与应用
US20250222103A1 (en) Immune cells with combination gene perturbations
Greenberg et al. Extinction of expression of the translocated myc gene in somatic cell hybrids between mouse myeloma and l‐cells
Sadia et al. A unique BCR–ABL1 transcript with the insertion of intronic sequence from BCR and ABL1 genes in a patient with Philadelphia-positive chronic myeloid leukemia: a case study
de Juan The Role of Hvem and its Interaction with Btla and Cd160 in b-Cell Lymphoma Progression
WO2026006832A1 (en) Gene modulation for treating cancer