BR112020008478A2 - métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia - Google Patents

métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia Download PDF

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Publication number
BR112020008478A2
BR112020008478A2 BR112020008478-6A BR112020008478A BR112020008478A2 BR 112020008478 A2 BR112020008478 A2 BR 112020008478A2 BR 112020008478 A BR112020008478 A BR 112020008478A BR 112020008478 A2 BR112020008478 A2 BR 112020008478A2
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cells
fact
cell
seq
genetically modified
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BR112020008478-6A
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English (en)
Portuguese (pt)
Inventor
Stephen Michael Burleigh
Melissa Chin
Fred Harbinski
Christopher Heath Nye
Blythe D. SATHER
Queenie Vong
Gordon Grant Welstead
Chris Wilson
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Editas Medicine, Inc.
Juno Therapeutics, Inc.
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Application filed by Editas Medicine, Inc., Juno Therapeutics, Inc. filed Critical Editas Medicine, Inc.
Publication of BR112020008478A2 publication Critical patent/BR112020008478A2/pt

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    • C12N9/14—Hydrolases (3)
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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BR112020008478-6A 2017-11-01 2018-11-01 métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia BR112020008478A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762580320P 2017-11-01 2017-11-01
US62/580,320 2017-11-01
PCT/US2018/058635 WO2019089884A2 (en) 2017-11-01 2018-11-01 Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy

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BR112020008478A2 true BR112020008478A2 (pt) 2020-10-20

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US (1) US20230061455A1 (enExample)
EP (1) EP3704251A2 (enExample)
JP (3) JP7785452B2 (enExample)
KR (1) KR102954207B1 (enExample)
CN (1) CN111527209B (enExample)
AU (2) AU2018358250B2 (enExample)
BR (1) BR112020008478A2 (enExample)
CA (1) CA3081456A1 (enExample)
IL (1) IL274299B2 (enExample)
MA (1) MA50858A (enExample)
MX (2) MX2020004608A (enExample)
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IL274299B2 (en) 2026-05-01
WO2019089884A3 (en) 2019-06-13
JP2023179469A (ja) 2023-12-19
IL274299A (en) 2020-06-30
JP7785452B2 (ja) 2025-12-15
MX2020004608A (es) 2020-10-05
AU2025223904A1 (en) 2025-09-18
AU2018358250A1 (en) 2020-05-14
EP3704251A2 (en) 2020-09-09
RU2020117752A (ru) 2021-12-01
CA3081456A1 (en) 2019-05-09
KR20200075000A (ko) 2020-06-25
WO2019089884A2 (en) 2019-05-09
AU2018358250B2 (en) 2025-06-05
MA50858A (fr) 2020-09-09
JP2021502113A (ja) 2021-01-28
CN111527209B (zh) 2024-11-12
KR102954207B1 (ko) 2026-04-16
JP2025156493A (ja) 2025-10-14
SG11202003862PA (en) 2020-05-28
MX2025010535A (es) 2025-10-01
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US20230061455A1 (en) 2023-03-02
CN111527209A (zh) 2020-08-11

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