JP2020536048A5 - - Google Patents
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- Publication number
- JP2020536048A5 JP2020536048A5 JP2020512367A JP2020512367A JP2020536048A5 JP 2020536048 A5 JP2020536048 A5 JP 2020536048A5 JP 2020512367 A JP2020512367 A JP 2020512367A JP 2020512367 A JP2020512367 A JP 2020512367A JP 2020536048 A5 JP2020536048 A5 JP 2020536048A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- electron transport
- transport chain
- antimycin
- phenformin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003112 inhibitor Substances 0.000 claims description 33
- 230000027721 electron transport chain Effects 0.000 claims description 20
- -1 pheniroin Chemical compound 0.000 claims description 18
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 16
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 16
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 16
- UIFFUZWRFRDZJC-UHFFFAOYSA-N Antimycin A1 Natural products CC1OC(=O)C(CCCCCC)C(OC(=O)CC(C)C)C(C)OC(=O)C1NC(=O)C1=CC=CC(NC=O)=C1O UIFFUZWRFRDZJC-UHFFFAOYSA-N 0.000 claims description 12
- NQWZLRAORXLWDN-UHFFFAOYSA-N Antimycin-A Natural products CCCCCCC(=O)OC1C(C)OC(=O)C(NC(=O)c2ccc(NC=O)cc2O)C(C)OC(=O)C1CCCC NQWZLRAORXLWDN-UHFFFAOYSA-N 0.000 claims description 12
- UIFFUZWRFRDZJC-SBOOETFBSA-N antimycin A Chemical compound C[C@H]1OC(=O)[C@H](CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@H]1NC(=O)C1=CC=CC(NC=O)=C1O UIFFUZWRFRDZJC-SBOOETFBSA-N 0.000 claims description 12
- PVEVXUMVNWSNIG-UHFFFAOYSA-N antimycin A3 Natural products CC1OC(=O)C(CCCC)C(OC(=O)CC(C)C)C(C)OC(=O)C1NC(=O)C1=CC=CC(NC=O)=C1O PVEVXUMVNWSNIG-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 claims description 12
- 229960003243 phenformin Drugs 0.000 claims description 12
- 229940080817 rotenone Drugs 0.000 claims description 12
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 claims description 12
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 8
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 claims description 8
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 8
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 claims description 8
- 229960004111 buformin Drugs 0.000 claims description 8
- XSEUMFJMFFMCIU-UHFFFAOYSA-N buformin Chemical compound CCCC\N=C(/N)N=C(N)N XSEUMFJMFFMCIU-UHFFFAOYSA-N 0.000 claims description 8
- 229960003150 bupivacaine Drugs 0.000 claims description 8
- 229960002504 capsaicin Drugs 0.000 claims description 8
- 235000017663 capsaicin Nutrition 0.000 claims description 8
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims description 8
- 229960001214 clofibrate Drugs 0.000 claims description 8
- LTWQNYPDAUSXBC-CDJGKPBYSA-L dantrolene sodium hemiheptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1.C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)[N-]C(=O)C1 LTWQNYPDAUSXBC-CDJGKPBYSA-L 0.000 claims description 8
- 229960003878 haloperidol Drugs 0.000 claims description 8
- 229960003132 halothane Drugs 0.000 claims description 8
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims description 8
- 229960002725 isoflurane Drugs 0.000 claims description 8
- 229960004194 lidocaine Drugs 0.000 claims description 8
- 229960003105 metformin Drugs 0.000 claims description 8
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 8
- 229960005489 paracetamol Drugs 0.000 claims description 8
- 230000027756 respiratory electron transport chain Effects 0.000 claims description 8
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims description 8
- 229960001534 risperidone Drugs 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 claims description 8
- 229960002078 sevoflurane Drugs 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 230000003779 hair growth Effects 0.000 claims description 6
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 4
- CZTQZXZIADLWOZ-CRAIPNDOSA-N cefaloridine Chemical compound O=C([C@@H](NC(=O)CC=1SC=CC=1)[C@H]1SC2)N1C(C(=O)[O-])=C2C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-CRAIPNDOSA-N 0.000 claims description 4
- 229960003866 cefaloridine Drugs 0.000 claims description 4
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims description 4
- 229960001139 cefazolin Drugs 0.000 claims description 4
- 229960004397 cyclophosphamide Drugs 0.000 claims description 4
- 229960004125 ketoconazole Drugs 0.000 claims description 4
- PRWXGRGLHYDWPS-UHFFFAOYSA-L sodium malonate Chemical compound [Na+].[Na+].[O-]C(=O)CC([O-])=O PRWXGRGLHYDWPS-UHFFFAOYSA-L 0.000 claims description 4
- TXBBUSUXYMIVOS-UHFFFAOYSA-N thenoyltrifluoroacetone Chemical compound FC(F)(F)C(=O)CC(=O)C1=CC=CS1 TXBBUSUXYMIVOS-UHFFFAOYSA-N 0.000 claims description 4
- 201000004384 Alopecia Diseases 0.000 claims description 3
- 230000003676 hair loss Effects 0.000 claims description 3
- 208000002271 trichotillomania Diseases 0.000 claims description 3
- ZQLBCAUKNYXILZ-UGKGYDQZSA-N Piericidin A Natural products COc1nc(CC=C(/C)C=CCC(=C[C@H](C)[C@@H](O)C(=CC)C)C)c(C)c(O)c1OC ZQLBCAUKNYXILZ-UGKGYDQZSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- BBLGCDSLCDDALX-LKGBESRRSA-N piericidin A Chemical compound COC=1NC(C\C=C(/C)C\C=C\C(\C)=C\[C@@H](C)[C@@H](O)C(\C)=C\C)=C(C)C(=O)C=1OC BBLGCDSLCDDALX-LKGBESRRSA-N 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566031P | 2017-09-29 | 2017-09-29 | |
| US62/566,031 | 2017-09-29 | ||
| PCT/US2018/053351 WO2019067860A1 (en) | 2017-09-29 | 2018-09-28 | COMPOSITIONS AND METHODS FOR MODULATION OF HAIR GROWTH |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536048A JP2020536048A (ja) | 2020-12-10 |
| JP2020536048A5 true JP2020536048A5 (enExample) | 2021-11-18 |
Family
ID=65903207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512367A Withdrawn JP2020536048A (ja) | 2017-09-29 | 2018-09-28 | 発毛を調節するための組成物及び方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20200253917A1 (enExample) |
| EP (1) | EP3687528A4 (enExample) |
| JP (1) | JP2020536048A (enExample) |
| KR (1) | KR20200062242A (enExample) |
| CN (1) | CN111295188A (enExample) |
| AU (1) | AU2018339064A1 (enExample) |
| BR (1) | BR112020003349A2 (enExample) |
| CA (1) | CA3077359A1 (enExample) |
| CL (1) | CL2020000676A1 (enExample) |
| EA (1) | EA202090855A1 (enExample) |
| IL (1) | IL272827A (enExample) |
| MX (1) | MX2020002389A (enExample) |
| PE (1) | PE20210464A1 (enExample) |
| PH (1) | PH12020500300A1 (enExample) |
| SG (2) | SG10202109849SA (enExample) |
| WO (1) | WO2019067860A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102440809B1 (ko) | 2017-02-24 | 2022-09-05 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Mpc 저해제를 사용하여 모발 성장을 촉진하는 조성물 및 방법 |
| IL321754A (en) | 2017-06-30 | 2025-08-01 | Univ California | Compositions and methods for modulating hair growth |
| US12649736B2 (en) | 2019-12-20 | 2026-06-09 | The Regents Of The University Of California | Synthesis of compounds to promote hair growth |
| EP4172159A4 (en) | 2020-06-30 | 2024-01-10 | The Regents of the University of California | Compositions and methods for modulating hair growth |
| KR102561912B1 (ko) * | 2021-04-09 | 2023-07-31 | 차의과학대학교 산학협력단 | 세팔로틴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 탈모방지 또는 발모촉진용 조성물 |
| CN113694063A (zh) * | 2021-08-31 | 2021-11-26 | 佛山市第一人民医院（中山大学附属佛山医院） | 一种组合物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9014221D0 (en) * | 1990-06-26 | 1990-08-15 | Janssen Pharmaceutica Nv | Method of treating alopecia |
| AU2001239826B2 (en) * | 2000-02-23 | 2006-06-15 | Orentreich Foundation For The Advancement Of Science, Inc. | Methods and compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus |
| ES2312012T3 (es) * | 2004-09-17 | 2009-02-16 | Biomas Ltd. | Nuevos compuestos de telurio y su uso como inmunomodulares. |
| EP1919449A2 (en) * | 2005-06-07 | 2008-05-14 | Foamix Ltd. | Antibiotic kit and composition and uses thereof |
| US8343962B2 (en) * | 2006-03-06 | 2013-01-01 | Nuvo Research Inc. | Topical formulation |
| US9308181B2 (en) * | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| US8563500B2 (en) * | 2007-09-05 | 2013-10-22 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Methods and compounds for treating diseases caused by reactive oxygen species |
| JP2014500275A (ja) * | 2010-12-06 | 2014-01-09 | フォリカ，インコーポレイテッド | 禿頭症を治療するため、および毛髪の成長を促進するための方法 |
| CN106880693A (zh) * | 2017-03-22 | 2017-06-23 | 广州国草夏方生物科技有限公司 | 一种治疗脂溢性脱发的生发液组合物及其制备方法 |
-
2018
- 2018-09-28 JP JP2020512367A patent/JP2020536048A/ja not_active Withdrawn
- 2018-09-28 US US16/651,835 patent/US20200253917A1/en not_active Abandoned
- 2018-09-28 SG SG10202109849S patent/SG10202109849SA/en unknown
- 2018-09-28 SG SG11202001516QA patent/SG11202001516QA/en unknown
- 2018-09-28 EP EP18862674.1A patent/EP3687528A4/en not_active Withdrawn
- 2018-09-28 CN CN201880063141.4A patent/CN111295188A/zh active Pending
- 2018-09-28 AU AU2018339064A patent/AU2018339064A1/en not_active Abandoned
- 2018-09-28 MX MX2020002389A patent/MX2020002389A/es unknown
- 2018-09-28 WO PCT/US2018/053351 patent/WO2019067860A1/en not_active Ceased
- 2018-09-28 EA EA202090855A patent/EA202090855A1/ru unknown
- 2018-09-28 BR BR112020003349-9A patent/BR112020003349A2/pt not_active Application Discontinuation
- 2018-09-28 CA CA3077359A patent/CA3077359A1/en not_active Abandoned
- 2018-09-28 KR KR1020207011209A patent/KR20200062242A/ko not_active Ceased
- 2018-09-28 PE PE2020000361A patent/PE20210464A1/es unknown
-
2020
- 2020-02-10 PH PH12020500300A patent/PH12020500300A1/en unknown
- 2020-02-20 IL IL272827A patent/IL272827A/en unknown
- 2020-03-16 CL CL2020000676A patent/CL2020000676A1/es unknown